{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:30:41Z","timestamp":1787657441897,"version":"build-2736575974"},"reference-count":111,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed.<\/jats:p>","DOI":"10.3390\/ijms241512200","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:28:46Z","timestamp":1690766926000},"page":"12200","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-5594","authenticated-orcid":false,"given":"Linda","family":"Sangalli","sequence":"first","affiliation":[{"name":"College of Dental Medicine\u2014Illinois, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8647-0567","authenticated-orcid":false,"given":"Bradley","family":"Eli","sequence":"additional","affiliation":[{"name":"Facial Pain Specialists, San Diego, CA 92121,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachi","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Facial Pain Specialists, San Diego, CA 92121,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Sabagh","sequence":"additional","affiliation":[{"name":"Facial Pain Specialists, San Diego, CA 92121,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fricton","sequence":"additional","affiliation":[{"name":"Division of TMD and Orofacial Pain, University of Minnesota Schoof of Dentistry, Minneapolis, MN 55455, USA"},{"name":"Minnesota Head and Neck Pain Clinic, Plymouth, MN 55447, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","unstructured":"Okeson, J.P. 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