{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:17:43Z","timestamp":1790399863592,"version":"4.1.0"},"reference-count":115,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo de Ciencia y Tecnolog\u00eda del Estado de Puebla","award":["240\/2023"],"award-info":[{"award-number":["240\/2023"]}]},{"name":"CONACYT-DAAD Fellowship","award":["240\/2023"],"award-info":[{"award-number":["240\/2023"]}]},{"name":"Emmy Noether Grant","award":["240\/2023"],"award-info":[{"award-number":["240\/2023"]}]},{"name":"DFG","award":["240\/2023"],"award-info":[{"award-number":["240\/2023"]}]},{"name":"German Cancer Research Center","award":["240\/2023"],"award-info":[{"award-number":["240\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones alters global chromatin structure and gene expression, promoting the development and progression of fibrosis. Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. We discuss the preclinical evidence that suggests that EP300 inhibition can attenuate fibrosis-related molecular processes, including extracellular matrix deposition, inflammation, and epithelial-to-mesenchymal transition. We also highlight the contributions of small molecule inhibitors and gene therapy approaches targeting EP300 as novel therapies against fibrosis.<\/jats:p>","DOI":"10.3390\/ijms241512302","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T09:06:44Z","timestamp":1690880804000},"page":"12302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-3106","authenticated-orcid":false,"given":"Karla","family":"Rubio","sequence":"first","affiliation":[{"name":"International Laboratory EPIGEN, Consejo de Ciencia y Tecnolog\u00eda del Estado de Puebla (CONCYTEP), Instituto de Ciencias, Ecocampus Valsequillo, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla (BUAP), Puebla 72570, Mexico"},{"name":"Laboratoire IMoPA, Universit\u00e9 de Lorraine, CNRS, UMR 7365, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Molina-Herrera","sequence":"additional","affiliation":[{"name":"International Laboratory EPIGEN, Consejo de Ciencia y Tecnolog\u00eda del Estado de Puebla (CONCYTEP), Instituto de Ciencias, Ecocampus Valsequillo, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla (BUAP), Puebla 72570, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-8617","authenticated-orcid":false,"given":"Andrea","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"International Laboratory EPIGEN, Consejo de Ciencia y Tecnolog\u00eda del Estado de Puebla (CONCYTEP), Instituto de Ciencias, Ecocampus Valsequillo, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla (BUAP), Puebla 72570, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hury Viridiana","family":"Hern\u00e1ndez-Gald\u00e1mez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-IPN), Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-8547","authenticated-orcid":false,"given":"Carolina","family":"Pi\u00f1a-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV-IPN), Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Araujo-Ramos","sequence":"additional","affiliation":[{"name":"Emmy Noether Research Group Epigenetic Machineries and Cancer, Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-7928","authenticated-orcid":false,"given":"Indrabahadur","family":"Singh","sequence":"additional","affiliation":[{"name":"Emmy Noether Research Group Epigenetic Machineries and Cancer, Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1053\/j.gastro.2018.02.015","article-title":"P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts","volume":"154","author":"Dou","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/hep.31617","article-title":"Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C-C Motif Chemokine Ligand 2\u2013Mediated Angiocrine Signaling","volume":"73","author":"Gao","year":"2021","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/jid.2012.479","article-title":"p300 Is Elevated in Systemic Sclerosis and Its Expression Is Positively Regulated by TGF-\u03b2: Epigenetic Feed-Forward Amplification of Fibrosis","volume":"133","author":"Ghosh","year":"2013","journal-title":"J. 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