{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:40:04Z","timestamp":1781660404471,"version":"3.54.5"},"reference-count":142,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometrial decidualization is a uterine process essential for spiral artery remodeling, embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and spiral artery remodeling are important contributing factors in preeclampsia, a major disorder in pregnancy. Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood volume and pressure. ANP is also generated in non-cardiac tissues, such as the uterus and placenta. In recent human genome-wide association studies, multiple loci with genes involved in natriuretic peptide signaling are associated with gestational hypertension and preeclampsia. In cellular experiments and mouse models, uterine ANP has been shown to stimulate endometrial decidualization, increase TNF-related apoptosis-inducing ligand expression and secretion, and enhance apoptosis in arterial smooth muscle cells and endothelial cells. In placental trophoblasts, ANP stimulates adenosine 5\u2032-monophosphate-activated protein kinase and the mammalian target of rapamycin complex 1 signaling, leading to autophagy inhibition and protein kinase N3 upregulation, thereby increasing trophoblast invasiveness. ANP deficiency impairs endometrial decidualization and spiral artery remodeling, causing a preeclampsia-like phenotype in mice. These findings indicate the importance of natriuretic peptide signaling in pregnancy. This review discusses the role of ANP in uterine biology and potential implications of impaired ANP signaling in preeclampsia.<\/jats:p>","DOI":"10.3390\/ijms241512309","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T09:06:44Z","timestamp":1690880804000},"page":"12309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-9315","authenticated-orcid":false,"given":"Qingyu","family":"Wu","sequence":"first","affiliation":[{"name":"Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: A systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: Pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: Current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e163422","DOI":"10.1172\/jci.insight.163422","article-title":"Vascular changes in the cycling and early pregnant uterus","volume":"8","author":"Massri","year":"2023","journal-title":"JCI Insight"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S886","DOI":"10.1016\/j.ajog.2020.09.039","article-title":"Decidualization resistance in the origin of preeclampsia","volume":"226","author":"Cordero","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.placenta.2017.06.005","article-title":"Emerging role for dysregulated decidualization in the genesis of preeclampsia","volume":"60","author":"Conrad","year":"2017","journal-title":"Placenta"},{"key":"ref_10","first-page":"E8468","article-title":"Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology","volume":"114","author":"Dominguez","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.preghy.2017.07.148","article-title":"Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20weeks\u2019 gestation in pregnancies complicated by preeclampsia","volume":"10","author":"Liao","year":"2017","journal-title":"Pregnancy Hypertens."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.06.029","article-title":"Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)","volume":"569","author":"Song","year":"2015","journal-title":"Gene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e051121191003","DOI":"10.2174\/1573403X17666210202102210","article-title":"Atrial Natriuretic Peptide: Structure, Function, and Physiological Effects: A Narrative Review","volume":"17","author":"Rao","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41569-020-0381-0","article-title":"Cardiac natriuretic peptides","volume":"17","author":"Goetze","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e151053","DOI":"10.1172\/JCI151053","article-title":"Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling","volume":"131","author":"Zhang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature10897","article-title":"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy","volume":"484","author":"Cui","year":"2012","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2012.11.016","article-title":"Role of corin and atrial natriuretic peptide in preeclampsia","volume":"34","author":"Zhou","year":"2013","journal-title":"Placenta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41591-023-02374-9","article-title":"Polygenic prediction of preeclampsia and gestational hypertension","volume":"9","author":"Honigberg","year":"2023","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jamacardio.2023.1312","article-title":"Genetic Risk Factors Associated with Preeclampsia and Hypertensive Disorders of Pregnancy","volume":"8","author":"Tyrmi","year":"2023","journal-title":"JAMA Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"R778","DOI":"10.1152\/ajpregu.00104.2014","article-title":"Diverse mechanisms for body fluid regulation in teleost fishes","volume":"307","author":"Takei","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ygcen.2008.03.021","article-title":"Exploring novel hormones essential for seawater adaptation in teleost fish","volume":"157","author":"Takei","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2108\/zs140142","article-title":"From aquatic to terrestrial life: Evolution of the mechanisms for water acquisition","volume":"32","author":"Takei","year":"2015","journal-title":"Zool. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1095-6433(99)00178-6","article-title":"Natriuretic peptides in fish physiology","volume":"125","author":"Loretz","year":"2000","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00360-003-0408-y","article-title":"Comparative aspects of natriuretic peptide physiology in non-mammalian vertebrates: A review","volume":"174","author":"Toop","year":"2004","journal-title":"J. Comp. Physiol. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/bj2410265","article-title":"The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor","volume":"241","author":"Thibault","year":"1987","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1073\/pnas.150149097","article-title":"Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme","volume":"97","author":"Yan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1042\/BST20190760","article-title":"Function and regulation of corin in physiology and disease","volume":"48","author":"Dong","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16900","DOI":"10.1074\/jbc.M201503200","article-title":"Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes","volume":"277","author":"Wu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1046\/j.1432-1033.2000.01806.x","article-title":"Localization of the mosaic transmembrane serine protease corin to heart myocytes","volume":"267","author":"Hooper","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1074\/jbc.274.21.14926","article-title":"Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart","volume":"274","author":"Yan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1373\/clinchem.2010.153908","article-title":"Corin is present in the normal human heart, kidney, and blood, with pro-B-type natriuretic peptide processing in the circulation","volume":"57","author":"Ichiki","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/dev.011031","article-title":"The serine protease Corin is a novel modifier of the Agouti pathway","volume":"135","author":"Lindon","year":"2008","journal-title":"Development"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"He, M., Zhou, T., Niu, Y., Feng, W., Gu, X., Xu, W., Zhang, S., Wang, Z., Zhang, Y., and Wang, C. (2021). The protease corin regulates electrolyte homeostasis in eccrine sweat glands. PLoS Biol., 19.","DOI":"10.1371\/journal.pbio.3001090"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/humrep\/det028","article-title":"Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua","volume":"28","author":"Ye","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/term.2514","article-title":"Role of the protease corin in chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"12","author":"Zhou","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/CS20120517","article-title":"Reduced urinary corin levels in patients with chronic kidney disease","volume":"124","author":"Fang","year":"2013","journal-title":"Clin. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"673497","DOI":"10.3389\/fphys.2021.673497","article-title":"Distribution of Cardiac and Renal Corin and Proprotein Convertase Subtilisin\/Kexin-6 in the Experimental Model of Cardio-Renal Syndrome of Various Severities","volume":"12","author":"Khoury","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1073\/pnas.0407234102","article-title":"Hypertension in mice lacking the proatrial natriuretic peptide convertase corin","volume":"102","author":"Chan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0008-6363(01)00331-5","article-title":"The renal urodilatin system: Clinical implications","volume":"51","author":"Forssmann","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1373\/clinchem.2010.143883","article-title":"Processing of pro-B-type natriuretic peptide: Furin and corin as candidate convertases","volume":"56","author":"Semenov","year":"2010","journal-title":"Clin. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCRESAHA.108.177352","article-title":"Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity","volume":"103","author":"Wang","year":"2008","journal-title":"Circ. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"R639","DOI":"10.1152\/ajpregu.00074.2015","article-title":"Pro-B-type natriuretic peptide is cleaved intracellularly: Impact of distance between O-glycosylation and cleavage sites","volume":"309","author":"Nishikimi","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25847","DOI":"10.1074\/jbc.M301223200","article-title":"Furin-mediated processing of Pro-C-type natriuretic peptide","volume":"278","author":"Wu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"20545","DOI":"10.1074\/jbc.272.33.20545","article-title":"Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin","volume":"272","author":"Sawada","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Moyes, A.J., and Hobbs, A.J. (2019). C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092281"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e2116470119","DOI":"10.1073\/pnas.2116470119","article-title":"C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis","volume":"119","author":"Aubdool","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1152\/physrev.00022.2015","article-title":"Molecular Physiology of Membrane Guanylyl Cyclase Receptors","volume":"96","author":"Kuhn","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.2007.144253","article-title":"Natriuretic peptide C receptor signalling in the heart and vasculature","volume":"586","author":"Rose","year":"2008","journal-title":"J. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F1047","DOI":"10.1152\/ajprenal.00164.2014","article-title":"ANP-induced signaling cascade and its implications in renal pathophysiology","volume":"308","author":"Theilig","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/jcem-65-4-765","article-title":"Effect of physiological levels of atrial natriuretic peptide on hormone secretion: Inhibition of angiotensin-induced aldosterone secretion and renin release in normal man","volume":"65","author":"Cuneo","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gu, X., Wang, K., Li, W., He, M., Zhou, T., Liu, M., Wu, Q., and Dong, N. (2023). Corin Deficiency Diminishes Intestineal Sodium Excretion in Mice. Biology, 12.","DOI":"10.3390\/biology12070945"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.1990.70.3.665","article-title":"Diverse biological actions of atrial natriuretic peptide","volume":"70","author":"Brenner","year":"1990","journal-title":"Physiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.328","article-title":"Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure","volume":"41","author":"Larson","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/CIRCRESAHA.115.306325","article-title":"Cardiac actions of atrial natriuretic peptide: New visions of an old friend","volume":"116","author":"Kuhn","year":"2015","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Forte, M., Madonna, M., Schiavon, S., Valenti, V., Versaci, F., Zoccai, G.B., Frati, G., and Sciarretta, S. (2019). Cardiovascular Pleiotropic Effects of Natriuretic Peptides. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163874"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/CIRCRESAHA.109.208314","article-title":"Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart","volume":"106","author":"Kinoshita","year":"2010","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00395-010-0098-z","article-title":"Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: Role of cGMP-dependent protein kinase and RGS2","volume":"105","author":"Klaiber","year":"2010","journal-title":"Basic. Res. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/CIRCRESAHA.116.306082","article-title":"Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of \u03b2-adrenoceptor-stimulated contractility in early cardiac hypertrophy","volume":"116","author":"Perera","year":"2015","journal-title":"Circ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e002423","DOI":"10.1161\/JAHA.115.002423","article-title":"Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events","volume":"4","author":"Ulvila","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/MCO.0b013e32836510ed","article-title":"Natriuretic peptides and fat metabolism","volume":"16","author":"Moro","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrendo.2013.234","article-title":"A heart-adipose tissue connection in the regulation of energy metabolism","volume":"10","author":"Collins","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1172\/JCI64526","article-title":"Natriuretic peptides enhance the oxidative capacity of human skeletal muscle","volume":"122","author":"Engeli","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"48617","DOI":"10.1074\/jbc.M303713200","article-title":"Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes","volume":"278","author":"Sengenes","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.2337\/db08-0649","article-title":"Atrial natriuretic peptide induces postprandial lipid oxidation in humans","volume":"57","author":"Birkenfeld","year":"2008","journal-title":"Diabetes"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1172\/JCI59701","article-title":"Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes","volume":"122","author":"Bordicchia","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"108075","DOI":"10.1016\/j.celrep.2020.108075","article-title":"Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis","volume":"32","author":"Carper","year":"2020","journal-title":"Cell Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhang, X., Li, W., Zhou, T., Liu, M., Wu, Q., and Dong, N. (2022). Corin Deficiency Alters Adipose Tissue Phenotype and Impairs Thermogenesis in Mice. Biology, 11.","DOI":"10.3390\/biology11081101"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0143-4004(98)90055-8","article-title":"Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts","volume":"19","author":"Craven","year":"1998","journal-title":"Placenta"},{"key":"ref_71","first-page":"1307","article-title":"Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues","volume":"78","author":"Gerbes","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"429.e1","DOI":"10.1016\/j.ajog.2008.05.019","article-title":"Atrial natriuretic peptide production and natriuretic peptide receptors in the human uterus and their effect on myometrial relaxation","volume":"199","author":"Cootauco","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.12659\/MSM.915449","article-title":"Is Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPR-A) Expression in Human Placenta and Decidua Normal?","volume":"25","author":"Tan","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1677\/joe.0.1530345","article-title":"Regulation of the natriuretic peptide system in rat uterus during the estrous cycle","volume":"153","author":"Reis","year":"1997","journal-title":"J. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/1933719110385136","article-title":"Expression of the vasoactive proteins AT1, AT2, and ANP by pregnancy-induced mouse uterine natural killer cells","volume":"18","author":"Hatta","year":"2011","journal-title":"Reprod. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1210\/endo.136.10.7664642","article-title":"Characterization and distribution of natriuretic peptide receptors in the rat uterus","volume":"136","author":"Fujio","year":"1995","journal-title":"Endocrinology"},{"key":"ref_77","first-page":"547","article-title":"Atrial natriuretic peptide receptors in human endometrial stromal cells","volume":"75","author":"Gililland","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e69584","DOI":"10.7554\/eLife.69584","article-title":"Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes","volume":"10","author":"Mika","year":"2021","journal-title":"eLife"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: Of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin. Reprod. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/plac.2001.0738","article-title":"Comparative developmental anatomy of the murine and human definitive placentae","volume":"23","author":"Georgiades","year":"2002","journal-title":"Placenta"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<250::AID-DVG7>3.0.CO;2-5","article-title":"Combinatorial interactions regulating cardiac transcription","volume":"22","author":"Durocher","year":"1998","journal-title":"Dev. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"38390","DOI":"10.1074\/jbc.M205686200","article-title":"Genomic structures of the human and murine corin genes and functional GATA elements in their promoters","volume":"277","author":"Pan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_83","first-page":"2235","article-title":"Mouse GATA-4: A retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart","volume":"13","author":"Arceci","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19425","DOI":"10.1073\/pnas.2003913117","article-title":"Kr\u00fcppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajmg.a.30257","article-title":"Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: A population-based Swedish cohort study","volume":"130A","author":"Cnattingius","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/s41467-020-19733-6","article-title":"Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women","volume":"11","author":"Steinthorsdottir","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/HYPERTENSIONAHA.117.10688","article-title":"Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1","volume":"72","author":"Gray","year":"2018","journal-title":"Hypertension"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Johnson, M.P., Brennecke, S.P., East, C.E., G\u00f6ring, H.H., Kent, J.W., Dyer, T.D., Said, J.M., Roten, L.T., Iversen, A.C., and Abraham, L.J. (2012). Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033666"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ng.3895","article-title":"Variants in the fetal genome near FLT1 are associated with risk of preeclampsia","volume":"49","author":"McGinnis","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jogc.2020.08.010","article-title":"Family History of Hypertension, Cardiovascular Disease, or Diabetes and Risk of Developing Preeclampsia: A Systematic Review","volume":"43","author":"Kay","year":"2021","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lewandowska, M. (2021). The Association of Familial Hypertension and Risk of Gestational Hypertension and Preeclampsia. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18137045"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e001713","DOI":"10.1161\/CIRCGENETICS.117.001713","article-title":"Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population","volume":"10","author":"Salo","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"eaam6870","DOI":"10.1126\/scisignal.aam6870","article-title":"Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance","volume":"10","author":"Wu","year":"2017","journal-title":"Sci. Signal"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"9837","DOI":"10.1111\/jcmm.16931","article-title":"Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice","volume":"25","author":"Cheng","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2017.12.001","article-title":"Aberrant pro-atrial natriuretic peptide\/corin\/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia","volume":"11","author":"Gu","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrm934","article-title":"Furin at the cutting edge: From protein traffic to embryogenesis and disease","volume":"3","author":"Thomas","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd3699","article-title":"The biology and therapeutic targeting of the proprotein convertases","volume":"11","author":"Seidah","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e70753","DOI":"10.7554\/eLife.70753","article-title":"Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia","volume":"10","author":"Cordero","year":"2021","journal-title":"eLife"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014A review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.7839143","article-title":"Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension","volume":"267","author":"John","year":"1995","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.regpep.2013.08.006","article-title":"Gestational hypertension in atrial natriuretic peptide knockout mice and the developmental origins of salt-sensitivity and cardiac hypertrophy","volume":"186","author":"Armstrong","year":"2013","journal-title":"Regul. Pept."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"S819","DOI":"10.1016\/j.ajog.2020.08.108","article-title":"Proteinuria during pregnancy: Definition, pathophysiology, methodology, and clinical significance","volume":"226","author":"Lindheimer","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.amjcard.2010.08.073","article-title":"Effect of pre-eclampsia-eclampsia on major cardiovascular events among peripartum women in Taiwan","volume":"107","author":"Lin","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1136\/heartjnl-2015-308098","article-title":"Left ventricular hypertrophy after hypertensive pregnancy disorders","volume":"101","author":"Scantlebury","year":"2015","journal-title":"Heart"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1095\/biolreprod.115.132696","article-title":"Onset and Regression of Pregnancy-Induced Cardiac Alterations in Gestationally Hypertensive Mice: The Role of the Natriuretic Peptide System","volume":"93","author":"Ventura","year":"2015","journal-title":"Biol. Reprod."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11010-014-2003-9","article-title":"Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction","volume":"391","author":"Armstrong","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11010-015-2498-8","article-title":"Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring","volume":"408","author":"Ventura","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.preghy.2020.05.007","article-title":"Aberrant corin and PCSK6 in placentas of the maternal hyperinsulinemia IUGR rat model","volume":"21","author":"Abassi","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.ajpath.2019.12.012","article-title":"Placental Overexpression of Soluble CORIN in Preeclampsia","volume":"190","author":"Degrelle","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cjca.2018.11.001","article-title":"Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia","volume":"35","author":"Baird","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nm.3920","article-title":"PCSK6-mediated corin activation is essential for normal blood pressure","volume":"21","author":"Chen","year":"2015","journal-title":"Nat. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s10020-021-00335-x","article-title":"Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome","volume":"27","author":"Zhao","year":"2021","journal-title":"Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kr\u00fcppel-like factors in health and diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/ncb1974","article-title":"KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer","volume":"11","author":"Gumireddy","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e1681","DOI":"10.1038\/cddis.2015.48","article-title":"KLF17 empowers TGF-\u03b2\/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression","volume":"6","author":"Ali","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.arcmed.2014.06.005","article-title":"Reduced Kr\u00fcppel-like factor 17 (KLF17) expression correlates with poor survival in patients with gastric cancer","volume":"45","author":"Peng","year":"2014","journal-title":"Arch. Med. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.1038\/s41598-019-50149-5","article-title":"Characterization of biklf\/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development","volume":"9","author":"Suzuki","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.diff.2010.01.003","article-title":"Involvement of Neptune in induction of the hatching gland and neural crest in the Xenopus embryo","volume":"79","author":"Kurauchi","year":"2010","journal-title":"Differentiation"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0143-4004(81)80042-2","article-title":"Review article: Trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals","volume":"2","author":"Pijnenborg","year":"1981","journal-title":"Placenta"},{"key":"ref_121","first-page":"190","article-title":"Human placental trophoblast invasion and differentiation: A particular focus on Wnt signaling","volume":"4","author":"Pollheimer","year":"2013","journal-title":"Front. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/aji.12466","article-title":"Decidual Control of Trophoblast Invasion","volume":"75","author":"Sharma","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preghy.2018.11.003","article-title":"Decidual cells from women with preeclampsia exhibit inadequate decidualization and reduced sFlt1 suppression","volume":"15","author":"Sahu","year":"2019","journal-title":"Pregnancy Hypertens."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1471-0528.1978.tb10501.x","article-title":"Maternal plasma and amniotic fluid prolactin levels in normal and hypertensive pregnancy","volume":"85","author":"Yuen","year":"1978","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1074\/jbc.275.1.189","article-title":"Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells","volume":"275","author":"Liao","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s10495-012-0730-5","article-title":"Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress","volume":"17","author":"Kim","year":"2012","journal-title":"Apoptosis"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Binder, N.K., Beard, S., de Alwis, N., Fato, B.R., Nguyen, T.V., Kaitu\u2032u-Lino, T.J., and Hannan, N.J. (2023). Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076182"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1095\/biolreprod54.4.834","article-title":"Expression of atrial natriuretic peptide by third-trimester placental cytotrophoblasts in women","volume":"54","author":"Graham","year":"1996","journal-title":"Biol. Reprod."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1477-7827-3-56","article-title":"Human trophoblast function during the implantation process","volume":"3","author":"Shalev","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e60266","DOI":"10.7554\/eLife.60266","article-title":"Single nuclei RNA-seq of mouse placental labyrinth development","volume":"9","author":"Marsh","year":"2020","journal-title":"eLife"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1469-7580.2008.01039.x","article-title":"Trophoblast-mediated spiral artery remodelling: A role for apoptosis","volume":"215","author":"Whitley","year":"2009","journal-title":"J. Anat."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e22779","DOI":"10.1096\/fj.202200833RRR","article-title":"ANP promotes HTR-8\/SVneo cell invasion by upregulating protein kinase N 3 via autophagy inhibition","volume":"37","author":"Chu","year":"2023","journal-title":"FASEB J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/15548627.2022.2115675","article-title":"NPPA\/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart","volume":"19","author":"Forte","year":"2023","journal-title":"Autophagy"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s00018-023-04777-w","article-title":"Atrial natriuretic peptide stimulates autophagy\/mitophagy and improves mitochondrial function in chronic heart failure","volume":"80","author":"Raffa","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/hrt.2008.164145","article-title":"Molecular forms of natriuretic peptides in heart failure and their implications","volume":"96","author":"Wu","year":"2010","journal-title":"Heart"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2217\/bmm-2019-0158","article-title":"ProANP and proBNP in plasma as biomarkers of heart failure","volume":"13","author":"Davidovski","year":"2019","journal-title":"Biomark. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40292-021-00483-5","article-title":"The Natriuretic Peptides for Hypertension Treatment","volume":"29","author":"Rubattu","year":"2022","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"107863","DOI":"10.1016\/j.pharmthera.2021.107863","article-title":"The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications","volume":"227","author":"Kuwahara","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ichiki, T., Jinno, A., and Tsuji, Y. (2022). Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States. Biology, 11.","DOI":"10.3390\/biology11060859"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12309\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:23:51Z","timestamp":1760127831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":142,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241512309"],"URL":"https:\/\/doi.org\/10.3390\/ijms241512309","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,1]]}}}