{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:19:06Z","timestamp":1791865146541,"version":"4.3.4"},"reference-count":154,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-07076"],"award-info":[{"award-number":["RGPIN-2019-07076"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["PJT-180290"],"award-info":[{"award-number":["PJT-180290"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RGPIN-2019-07076"],"award-info":[{"award-number":["RGPIN-2019-07076"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-180290"],"award-info":[{"award-number":["PJT-180290"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The enteric nervous system (ENS), known as the intrinsic nervous system of the gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes. Fascinating questions surrounding the generation of cellular diversity in the ENS have captivated ENS biologists for a considerable time, particularly with recent advancements in cell type-specific transcriptomics at both population and single-cell levels. However, the current focus of research in this field is predominantly restricted to the study of enteric neuron subtypes, while the investigation of enteric glia subtypes significantly lags behind. Despite this, enteric glial cells (EGCs) are increasingly recognized as equally important regulators of numerous bowel functions. Moreover, a subset of postnatal EGCs exhibits remarkable plasticity and multipotency, distinguishing them as critical entities in the context of advancing regenerative medicine. In this review, we aim to provide an updated overview of the current knowledge on this subject, while also identifying key questions that necessitate future exploration.<\/jats:p>","DOI":"10.3390\/ijms241512475","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T10:21:39Z","timestamp":1691230899000},"page":"12475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Harnessing the Power of Enteric Glial Cells\u2019 Plasticity and Multipotency for Advancing Regenerative Medicine"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1194-8372","authenticated-orcid":false,"given":"Marie A.","family":"Lef\u00e8vre","sequence":"first","affiliation":[{"name":"D\u00e9partement des Sciences Biologiques, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), Montreal, QC H3C 3P8, Canada"},{"name":"Centre D\u2019excellence en Recherche Sur Les Maladies Orphelines\u2014Fondation Courtois (CERMO-FC), Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montreal, QC H2X 3Y7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Soret","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences Biologiques, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), Montreal, QC H3C 3P8, Canada"},{"name":"Centre D\u2019excellence en Recherche Sur Les Maladies Orphelines\u2014Fondation Courtois (CERMO-FC), Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montreal, QC H2X 3Y7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-0776","authenticated-orcid":false,"given":"Nicolas","family":"Pilon","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences Biologiques, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), Montreal, QC H3C 3P8, Canada"},{"name":"Centre D\u2019excellence en Recherche Sur Les Maladies Orphelines\u2014Fondation Courtois (CERMO-FC), Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montreal, QC H2X 3Y7, Canada"},{"name":"D\u00e9partement de P\u00e9diatrie, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","article-title":"Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu. 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