{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:26:00Z","timestamp":1789471560969,"version":"build-2803163510"},"reference-count":57,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council of Taiwan","award":["NSTC 110-2622-B-037-001"],"award-info":[{"award-number":["NSTC 110-2622-B-037-001"]}]},{"name":"National Science and Technology Council of Taiwan","award":["NSTC112-2314-B-037-114-MY3"],"award-info":[{"award-number":["NSTC112-2314-B-037-114-MY3"]}]},{"name":"National Science and Technology Council of Taiwan","award":["MOST111-2314-B-037-045"],"award-info":[{"award-number":["MOST111-2314-B-037-045"]}]},{"name":"National Science and Technology Council of Taiwan","award":["KMU-TC112A02"],"award-info":[{"award-number":["KMU-TC112A02"]}]},{"name":"Regenerative Medicine and Cell Therapy Research Center of Kaohsiung Medical University","award":["NSTC 110-2622-B-037-001"],"award-info":[{"award-number":["NSTC 110-2622-B-037-001"]}]},{"name":"Regenerative Medicine and Cell Therapy Research Center of Kaohsiung Medical University","award":["NSTC112-2314-B-037-114-MY3"],"award-info":[{"award-number":["NSTC112-2314-B-037-114-MY3"]}]},{"name":"Regenerative Medicine and Cell Therapy Research Center of Kaohsiung Medical University","award":["MOST111-2314-B-037-045"],"award-info":[{"award-number":["MOST111-2314-B-037-045"]}]},{"name":"Regenerative Medicine and Cell Therapy Research Center of Kaohsiung Medical University","award":["KMU-TC112A02"],"award-info":[{"award-number":["KMU-TC112A02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The delayed healing of chronic wounds, such as diabetic foot ulcers (DFUs), is a clinical problem. Few dressings can promote wound healing by satisfying the demands of chronic wound exudate management and tissue granulation. Therefore, the aim of this study was to prepare a high-absorption polyurethane (PU) foam dressing modified by polyethylene glycol (PEG) and triethoxysilane (APTES) to promote wound healing. PEG-modified (PUE) and PEG\/APTES-modified (PUESi) dressings were prepared by self-foaming reactions. Gauze and PolyMem were used as controls. Next, Fourier transform-infrared spectroscopy, thermomechanical analyses, scanning electron microscopy and tensile strength, water absorption, anti-protein absorption, surface dryness and biocompatibility tests were performed for in vitro characterization. Wound healing effects were further investigated in nondiabetic (non-DM) and diabetes mellitus (DM) rat models. The PUE and PUESi groups exhibited better physicochemical properties than the gauze and PolyMem groups. Moreover, PUESi dressing showed better anti-adhesion properties and absorption capacity with deformation. Furthermore, the PUESi dressing shortened the inflammatory phase and enhanced collagen deposition in both the non-DM and DM animal models. To conclude, the PUESi dressing not only was fabricated with a simple and effective strategy but also enhanced wound healing via micronegative-pressure generation by its high absorption compacity with deformation.<\/jats:p>","DOI":"10.3390\/ijms241512506","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:37:31Z","timestamp":1691390251000},"page":"12506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Multifunctional Polyethylene Glycol\/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-0795","authenticated-orcid":false,"given":"Chiu-Fang","family":"Chen","sequence":"first","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng-Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"},{"name":"Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-5009","authenticated-orcid":false,"given":"Yur-Ren","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"},{"name":"Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"},{"name":"Academic Clinical Programme for Musculoskeletal Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-6979","authenticated-orcid":false,"given":"Chih-Kuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-9685","authenticated-orcid":false,"given":"Tzer-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Oral Medicine, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan"},{"name":"School of Dentistry, National Cheng Kung University, Tainan 701, Taiwan"},{"name":"Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu 300092, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-7472","authenticated-orcid":false,"given":"Yan-Hsiung","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.7748\/ns.19.7.62.s59","article-title":"Exudate and care of the peri-wound 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