{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:47:27Z","timestamp":1788173247582,"version":"build-2803163510"},"reference-count":63,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0210202-02"],"award-info":[{"award-number":["E0210202-02"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jeonbuk National University","award":["E0210202-02"],"award-info":[{"award-number":["E0210202-02"]}]},{"name":"BK21FOUR 21st Century of Medical Science Creative Human Resource Development Center","award":["E0210202-02"],"award-info":[{"award-number":["E0210202-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fallopia japonica (Asian knotweed) is a medicinal herb traditionally used to treat inflammation, among other conditions. However, the effects of F. japonica root extract (FJE) on airway inflammation associated with combined allergic rhinitis and asthma (CARAS) and the related mechanisms have not been investigated. This study examined the effect of FJE against CARAS in an ovalbumin (OVA)-induced CARAS mouse model. Six-week-old male BALB\/c mice were randomly segregated into six groups. Mice were sensitized intraperitoneally with OVA on days 1, 8, and 15, and administered saline, Dexamethasone (1.5 mg\/kg), or FJE (50, 100, or 200 mg\/kg) once a day for 16 days. Nasal symptoms, inflammatory cells, OVA-specific immunoglobulins, cytokine production, mast cell activation, and nasal histopathology were assessed. Administration of FJE down-regulated OVA-specific IgE and up-regulated OVA-specific IgG2a in serum. FJE reduced the production of T helper (Th) type 2 cytokines, and the Th1 cytokine levels were enhanced in nasal and bronchoalveolar lavage fluid. Moreover, FJE positively regulated allergic responses by reducing the accumulation of inflammatory cells, improving nasal and lung histopathological characteristics, and inhibiting inflammation-associated cytokines. FJE positively modulated the IL-33\/TSLP\/NF-B signaling pathway, which is involved in regulating inflammatory cells, immunoglobulin levels, and pro-inflammatory cytokines at the molecular level.<\/jats:p>","DOI":"10.3390\/ijms241512514","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:37:31Z","timestamp":1691390251000},"page":"12514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33\/TSLP\/NF-\u03baB Signaling Pathway"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-0848","authenticated-orcid":false,"given":"Juan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Jing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1013-8527","authenticated-orcid":false,"given":"Thi Van","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Nan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"},{"name":"Institute for Medical Sciences, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea"},{"name":"Department of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-7161","authenticated-orcid":false,"given":"Hee Soon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea"},{"name":"Department of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-9743","authenticated-orcid":false,"given":"Ok Hee","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"},{"name":"Institute for Medical Sciences, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref_1","unstructured":"Asher, I. (2018). The Global Asthma Report 2018. Global Asthma Network, 1\u201392. Available online: http:\/\/globalasthmanetwork.org\/Global%20asthma%20Report%202018%20Embargo.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Brozek","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105718","DOI":"10.1016\/j.intimp.2019.105718","article-title":"Combined allergic rhinitis and asthma syndrome (CARAS)","volume":"74","author":"Monteiro","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.intimp.2013.04.011","article-title":"Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis","volume":"16","author":"Jung","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13601-019-0303-6","article-title":"Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: An EAACI position paper","volume":"10","author":"Hox","year":"2020","journal-title":"Clin. Transl. Allergy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/00002018-200023010-00002","article-title":"Safety of inhaled and intranasal corticosteroids: Lessons for the new millennium","volume":"23","author":"Lipworth","year":"2000","journal-title":"Drug Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"103991","DOI":"10.1016\/j.jff.2020.103991","article-title":"Oral administration of polyphenol-rich Sargassum horneri suppresses particulate matter exacerbated airway inflammation in murine allergic asthma: Relevance to the TLR mediated NF-\u03baB pathway inhibition","volume":"71","author":"Herath","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_9","first-page":"p4099","article-title":"Polyphenolic compounds and experimentally induced allergic asthma","volume":"38","author":"Franova","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-94-007-4549-0_12","article-title":"Polyphenols and Their Components in Experimental Allergic Asthma","volume":"756","author":"Joskova","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/BF02977330","article-title":"Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin","volume":"30","author":"Jung","year":"2007","journal-title":"Arch. Pharmacal Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1002\/mnfr.200900297","article-title":"Blackcurrant proanthocyanidins augment IFN-gamma-induced suppression of IL-4 stimulated CCL26 secretion in alveolar epithelial cells","volume":"54","author":"Hurst","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2332\/allergolint.09-OA-0118","article-title":"Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells","volume":"59","author":"Iwamura","year":"2010","journal-title":"Allergol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"787032","DOI":"10.3389\/fphar.2022.787032","article-title":"Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: A Systematic Review","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1046\/j.1365-294X.2003.01816.x","article-title":"Patch establishment and development of a clonal plant, Polygonum cuspidatum, on Mount Fuji","volume":"12","author":"Zhou","year":"2003","journal-title":"Mol. Ecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.vph.2004.01.003","article-title":"Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component rasveratrol on acyl-coenzyme A\u2013cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells","volume":"40","author":"Park","year":"2004","journal-title":"Vasc. Pharmacol."},{"key":"ref_17","first-page":"S1","article-title":"Effects of polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players","volume":"4","author":"Zahedi","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cucu, A.-A., Baci, G.-M., Dezsi, \u015e., Nap, M.-E., Beteg, F.I., Bonta, V., Bobi\u015f, O., Caprio, E., and Dezmirean, D.S. (2021). New Approaches on Japanese Knotweed (Fallopia japonica) Bioactive Compounds and Their Potential of Pharmacological and Beekeeping Activities: Challenges and Future Directions. Plants, 10.","DOI":"10.3390\/plants10122621"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jbiosc.2014.09.008","article-title":"Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents","volume":"119","author":"Lee","year":"2015","journal-title":"J. Biosci. Bioeng."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shen, M.-Y., Liu, Y.-J., Don, M.-J., Liu, H.-Y., Chen, Z.-W., Mettling, C., Corbeau, P., Chiang, C.-K., Jang, Y.-S., and Li, T.-H. (2011). Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. PLoS ONE, 6.","DOI":"10.1371\/annotation\/e81927cf-e940-4604-acfa-44b5655e40a3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/jn\/135.12.2767","article-title":"Resveratrol inhibits TNF-alpha-induced proliferation and matrix metalloproteinase expression in human vascular smooth muscle cells","volume":"135","author":"Lee","year":"2005","journal-title":"J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ACI.0000000000000133","article-title":"Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation","volume":"15","author":"Divekar","year":"2015","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_23","first-page":"197","article-title":"Regulation of the expression of interleukin-4 and interleukin-5 by the signal pathway of PKC-NF-kappaB in T lymphocyte of allergic rhinitis","volume":"20","author":"Liu","year":"2006","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4049\/jimmunol.1701455","article-title":"Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease","volume":"200","author":"Li","year":"2018","journal-title":"J. Immunol."},{"key":"ref_25","first-page":"283","article-title":"Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study","volume":"16","author":"Enomoto","year":"2006","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000486959","article-title":"Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis","volume":"175","author":"Lv","year":"2018","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1016\/j.jaci.2004.08.043","article-title":"Inflammatory mediators in allergic rhinitis","volume":"114","author":"Gelfand","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pupt.2016.09.004","article-title":"Eucalyptol attenuates cigarette smoke-induced acute lung inflammation and oxidative stress in the mouse","volume":"41","author":"Okuro","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_29","first-page":"3597","article-title":"In vivo and in vitro antiallergic and antiinflammatory effects of Dryopteris crassirhizoma through the modulation of the NFkB signaling pathway in an ovalbumininduced allergic asthma mouse model","volume":"22","author":"Piao","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000076440","article-title":"Antigen-specific versus total immunoglobulin synthesis: Total IgE and IgG1, but not IgG2a levels predict murine antigen-specific responses","volume":"133","author":"Lewkowich","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-3024.1994.tb00306.x","article-title":"The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni","volume":"16","author":"Mountford","year":"1994","journal-title":"Parasite Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jmii.2015.05.007","article-title":"Lower levels of IgG1 in comparison with IgG2a are associated with protective immunity against Leishmania tropica infection in BALB\/c mice","volume":"50","author":"Rostamian","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1067\/mai.2001.115569","article-title":"Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis","volume":"108","author":"Skoner","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.coi.2009.09.007","article-title":"New roles for mast cells in modulating allergic reactions and immunity against pathogens","volume":"21","author":"Hofmann","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1590\/S0074-02761997000800009","article-title":"Interleukin-4 and interleukin-5 as targets for the inhibition of eosinophilic inflammation and allergic airways hyperreactivity","volume":"92","author":"Foster","year":"1997","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nm734","article-title":"Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma","volume":"8","author":"Kuperman","year":"2002","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/eji.200940045","article-title":"Role of Treg in immune regulation of allergic diseases","volume":"40","author":"Palomares","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40733-015-0012-4","article-title":"Genetic and epigenetic studies of FOXP3 in asthma and allergy","volume":"1","author":"Marques","year":"2015","journal-title":"Asthma Res. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-0030-1250435","article-title":"PPARalpha activation by culinary herbs and spices","volume":"77","author":"Mueller","year":"2011","journal-title":"Planta Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1002\/stem.1241","article-title":"Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice","volume":"30","author":"Sun","year":"2012","journal-title":"Stem Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1073\/pnas.95.6.3071","article-title":"Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns","volume":"95","author":"Peterson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/09629350120054518","article-title":"Anti-inflammatory cytokines in asthma and allergy: Interleukin-10, interleukin-12, interferon-gamma","volume":"10","author":"Chung","year":"2001","journal-title":"Mediat. Inflamm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3389\/fimmu.2019.00705","article-title":"NF-kappaB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration","volume":"10","author":"Dorrington","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2008.09.003","article-title":"Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease","volume":"121","author":"Edwards","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"BSR20212681","DOI":"10.1042\/BSR20212681","article-title":"Fructus Amomi extract attenuates nasal inflammation by restoring Th1\/Th2 balance and down-regulation of NF-kappaB phosphorylation in OVA-induced allergic rhinitis","volume":"42","author":"Fan","year":"2022","journal-title":"Biosci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/j.ddmec.2012.09.003","article-title":"TSLP: A Key Regulator of Asthma Pathogenesis","volume":"9","author":"West","year":"2012","journal-title":"Drug Discov. Today Dis. Mech."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1073\/pnas.0607305104","article-title":"Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB","volume":"104","author":"Lee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/all.12593","article-title":"IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: Airway smooth muscle crosstalk","volume":"70","author":"Kaur","year":"2015","journal-title":"Allergy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/alr.22206","article-title":"Sentinels at the wall: Epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation","volume":"9","author":"Patel","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.12659\/MSM.915080","article-title":"Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway","volume":"25","author":"Hua","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/aps.2017.147","article-title":"Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model","volume":"39","author":"Song","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11655-014-1898-z","article-title":"Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model","volume":"21","author":"Wang","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JBR-160121","article-title":"The in vitro evaluation of isolated procyanidins as modulators of cytokine-induced eotaxin production in human alveolar epithelial cells","volume":"6","author":"Coleman","year":"2016","journal-title":"J. Berry Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jff.2017.01.036","article-title":"Suppression of CCL26 and CCL11 generation in human alveolar epithelial cells by apple extracts containing procyanidins","volume":"31","author":"Sawyer","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.fshw.2023.03.045","article-title":"Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages","volume":"12","author":"Tie","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jnutbio.2019.01.013","article-title":"Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: In vivo and in vitro studies","volume":"67","author":"Chen","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_60","first-page":"5373","article-title":"Mitochondrial dysfunction and redox imbalance as a diagnostic marker of \u201cfree radical diseases\u201d","volume":"37","author":"Georgieva","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"113923","DOI":"10.1016\/j.bcp.2020.113923","article-title":"The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling","volume":"175","author":"Zhu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.intimp.2017.08.029","article-title":"Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release","volume":"52","author":"Bui","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_63","first-page":"39","article-title":"The effects of sildenafil on smoke induced lung inflammation in rats","volume":"38","author":"Vural","year":"2016","journal-title":"Malays. J. Pathol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12514\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:27:12Z","timestamp":1760128032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":63,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241512514"],"URL":"https:\/\/doi.org\/10.3390\/ijms241512514","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,7]]}}}