{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:48:27Z","timestamp":1777348107095,"version":"3.51.4"},"reference-count":185,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT","award":["CF-2023-2206-"],"award-info":[{"award-number":["CF-2023-2206-"]}]},{"name":"CONACYT","award":["1008755"],"award-info":[{"award-number":["1008755"]}]},{"name":"CONACYT","award":["854550"],"award-info":[{"award-number":["854550"]}]},{"name":"Student\u2019s scholarships","award":["CF-2023-2206-"],"award-info":[{"award-number":["CF-2023-2206-"]}]},{"name":"Student\u2019s scholarships","award":["1008755"],"award-info":[{"award-number":["1008755"]}]},{"name":"Student\u2019s scholarships","award":["854550"],"award-info":[{"award-number":["854550"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), the most common neurodegenerative disease and the first cause of dementia worldwide, has no effective treatment, and its pathological mechanisms are not yet fully understood. We conducted this study to explore the proteomic differences associated with Familial Alzheimer\u2019s Disease (FAD) in olfactory ecto-mesenchymal stem cells (MSCs) derived from PSEN1 (A431E) mutation carriers compared with healthy donors paired by age and gender through two label-free liquid chromatography-mass spectrometry approaches. The first analysis compared carrier 1 (patient with symptoms, P1) and its control (healthy donor, C1), and the second compared carrier 2 (patient with pre-symptoms, P2) with its respective control cells (C2) to evaluate whether the protein alterations presented in the symptomatic carrier were also present in the pre-symptom stages. Finally, we analyzed the differentially expressed proteins (DEPs) for biological and functional enrichment. These proteins showed impaired expression in a stage-dependent manner and are involved in energy metabolism, vesicle transport, actin cytoskeleton, cell proliferation, and proteostasis pathways, in line with previous AD reports. Our study is the first to conduct a proteomic analysis of MSCs from the Jalisco FAD patients in two stages of the disease (symptomatic and presymptomatic), showing these cells as a new and excellent in vitro model for future AD studies.<\/jats:p>","DOI":"10.3390\/ijms241612606","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:08:59Z","timestamp":1691575739000},"page":"12606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer\u2019s Disease Reveals New Insights for AD Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Lory","family":"Roch\u00edn-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Jim\u00e9nez-Acosta","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Ram\u00edrez-Reyes","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00f3mica, Prote\u00f3mica y Metabol\u00f3mica, Laboratorio Nacional de Servicios Experimentales (LaNSE), Centro de Investigaci\u00f3n y de Estudios Avanzados, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Figueroa-Corona","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Orozco-Barajas","sequence":"additional","affiliation":[{"name":"Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-8117","authenticated-orcid":false,"given":"Marco","family":"Meraz-R\u00edos","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26224","DOI":"10.1073\/pnas.1912954116","article-title":"Alzheimer\u2019s disease: A clinical perspective and future nonhuman primate research opportunities","volume":"116","author":"Haque","year":"2019","journal-title":"Proc. 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