{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:00:50Z","timestamp":1780441250309,"version":"3.54.1"},"reference-count":103,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["314711\/2021-0"],"award-info":[{"award-number":["314711\/2021-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["EXC 2067\/1-390729940"],"award-info":[{"award-number":["EXC 2067\/1-390729940"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["UVic-FAPESP SPRINT 1\/2018"],"award-info":[{"award-number":["UVic-FAPESP SPRINT 1\/2018"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq; Brazil) Research Productivity Fellowship","award":["314711\/2021-0"],"award-info":[{"award-number":["314711\/2021-0"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq; Brazil) Research Productivity Fellowship","award":["EXC 2067\/1-390729940"],"award-info":[{"award-number":["EXC 2067\/1-390729940"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq; Brazil) Research Productivity Fellowship","award":["UVic-FAPESP SPRINT 1\/2018"],"award-info":[{"award-number":["UVic-FAPESP SPRINT 1\/2018"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["314711\/2021-0"],"award-info":[{"award-number":["314711\/2021-0"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["EXC 2067\/1-390729940"],"award-info":[{"award-number":["EXC 2067\/1-390729940"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["UVic-FAPESP SPRINT 1\/2018"],"award-info":[{"award-number":["UVic-FAPESP SPRINT 1\/2018"]}]},{"name":"University of Victoria","award":["314711\/2021-0"],"award-info":[{"award-number":["314711\/2021-0"]}]},{"name":"University of Victoria","award":["EXC 2067\/1-390729940"],"award-info":[{"award-number":["EXC 2067\/1-390729940"]}]},{"name":"University of Victoria","award":["UVic-FAPESP SPRINT 1\/2018"],"award-info":[{"award-number":["UVic-FAPESP SPRINT 1\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without effective therapy. Evidence suggests that lifestyle factors can modulate disease onset and progression, and environmental enrichment (EE) has emerged as a potential approach to mitigate the progression and severity of neurodegenerative processes. Wild-type (WT) and yeast artificial chromosome (YAC) 128 mice were exposed to different EE conditions. Animals from cohort 1 were exposed to EE between postnatal days 21 and 60, and animals from cohort 2 were exposed to EE between postnatal days 60 and 120. Motor and non-motor behavioral tests were employed to evaluate the effects of EE on HD progression. Monoamine levels, hippocampal cell proliferation, neuronal differentiation, and dendritic arborization were also assessed. Here we show that EE had an antidepressant-like effect and slowed the progression of motor deficits in HD mice. It also reduced monoamine levels, which correlated with better motor performance, particularly in the striatum. EE also modulated neuronal differentiation in the YAC128 hippocampus. These results confirm that EE can impact behavior, hippocampal neuroplasticity, and monoamine levels in YAC128 mice, suggesting this could be a therapeutic strategy to modulate neuroplasticity deficits in HD. However, further research is needed to fully understand EE\u2019s mechanisms and long-term effects as an adjuvant therapy for this debilitating condition.<\/jats:p>","DOI":"10.3390\/ijms241612607","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:11:22Z","timestamp":1691662282000},"page":"12607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington\u2019s Disease Effects in YAC128 Mice"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-8560","authenticated-orcid":false,"given":"Evelini","family":"Pl\u00e1cido","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-7746","authenticated-orcid":false,"given":"Priscilla","family":"Gomes Welter","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Wink","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-1530","authenticated-orcid":false,"given":"Gabriela Duarte","family":"Karasiak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1679-1727","authenticated-orcid":false,"given":"Tiago Fleming","family":"Outeiro","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"},{"name":"Max Planck Institute for Natural Sciences, 37075 G\u00f6ttingen, Germany"},{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne NE1 7RU, UK"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), 18147 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-4611","authenticated-orcid":false,"given":"Alcir Luiz","family":"Dafre","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"},{"name":"Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-1662","authenticated-orcid":false,"given":"Joana","family":"Gil-Mohapel","sequence":"additional","affiliation":[{"name":"Island Medical Program, Faculty of Medicine, University of British Columbia and Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia S.","family":"Brocardo","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"},{"name":"Department of Morphological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref_1","first-page":"317","article-title":"On Chorea","volume":"15","author":"Huntington","year":"1872","journal-title":"Med. 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