{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T06:14:27Z","timestamp":1774764867845,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The early identification of women with an increased risk of preeclampsia (PE) is desirable, but apart from soluble fms-like tyrosine kinase-1 (sFlt-1), few biomarkers have previously been identified as relevant for predicting preeclampsia. Since kinases and phosphatases regulate critical biological processes and previous evidence suggests a potential role of these molecules in preeclampsia, we performed this systematic review and metanalysis. The objective was to determine if there are kinases and phosphatases whose serum levels are different between women with and without PE, being relevant biomarkers of PE. We followed the recommendations of Cochrane and the Preferred Reported Items for Systematic Reviews and Metanalysis (PRISMA) to perform this study. The MESH terms preeclampsia, kinases, phosphatases, angiopoietins, soluble tyrosine protein kinase receptor (sTIE2), and cellular-mesenchymal-epithelial transition factor (c-MET) were combined to find relevant articles in the PubMed, PROSPERO, and Cochrane databases. Then, a qualitative and quantitative analysis was performed in R Studio software. From 580 abstracts identified, 37 were included in the final analysis, which comprised 24,211 pregnant women (2879 with PE and 21,332 women without PE [HP]. The pooled analysis showed that serum creatine kinase (CK) (SMD: 2.43, CI 95% 0.25\u20134.62) was significantly higher in PE, whereas sTIE2 and anti-angiogenic factor soluble c-Met (sMet)were significantly lower in PE than in HP (SMD: \u22120.23, CI95% \u22120.37 to \u22120.09; and SMD:0.24, CI95% 0.01\u20130.47, respectively). Adenosine monophosphate-activated protein kinase (AMPK), angiopoietin-1 (ANG-1), angiopoietin-2 (ANG-2), the ratio angiopoietin-1\/angiopoietin-2, acid phosphatase, and alkaline phosphatase were not different between women with PE and HP. In summary CK, sTIE2, and c-MET are relevant biomarkers of PE. It is desirable to incorporate them into current models for PE prediction to evaluate their utility as biomarkers.<\/jats:p>","DOI":"10.3390\/ijms241612842","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T09:57:02Z","timestamp":1692179822000},"page":"12842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influential Serum Kinases (Non-sFlt-1) and Phosphatases in Preeclampsia\u2014Systemic Review and Metanalysis"],"prefix":"10.3390","volume":"24","author":[{"given":"Karla Cecilia","family":"Marrufo-Gallegos","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Hospital General de Mexico, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Rafael","family":"Villaf\u00e1n-Bernal","sequence":"additional","affiliation":[{"name":"Immunogenomics and Metabolic Diseases, Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-8463","authenticated-orcid":false,"given":"Salvador","family":"Espino-y-Sosa","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico"},{"name":"Centro de Investigacion en Ciencias de la Salud, Universidad Anahuac, Mexico City 52786, Mexico"},{"name":"American British Cowdray Medical Center IAP, Ob\/Gyn Department, Mexico City 01120, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-9021","authenticated-orcid":false,"given":"Guadalupe","family":"Estrada-Gutierrez","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1535-4226","authenticated-orcid":false,"given":"Iris Paola","family":"Guzm\u00e1n-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Faculty of Chemical-Biological Sciences, Universidad Aut\u00f3noma de Guerrero, Chilpancingo 39030, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3857","authenticated-orcid":false,"given":"Raigam Jafet","family":"Martinez-Portilla","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-4133","authenticated-orcid":false,"given":"Johnatan","family":"Torres-Torres","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Hospital General de Mexico, Mexico City 06720, Mexico"},{"name":"Clinical Research Branch, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico"},{"name":"American British Cowdray Medical Center IAP, Ob\/Gyn Department, Mexico City 01120, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N. 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