{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:06:56Z","timestamp":1790809616338,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"DEUTSCHE FORSCHUNGSGEMEINSCHAFT","doi-asserted-by":"publisher","award":["HO 6929\/2-1"],"award-info":[{"award-number":["HO 6929\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DEUTSCHE FORSCHUNGSGEMEINSCHAFT","doi-asserted-by":"publisher","award":["3\/2022 GI"],"award-info":[{"award-number":["3\/2022 GI"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009560","name":"UKGM GIESSEN","doi-asserted-by":"publisher","award":["HO 6929\/2-1"],"award-info":[{"award-number":["HO 6929\/2-1"]}],"id":[{"id":"10.13039\/501100009560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009560","name":"UKGM GIESSEN","doi-asserted-by":"publisher","award":["3\/2022 GI"],"award-info":[{"award-number":["3\/2022 GI"]}],"id":[{"id":"10.13039\/501100009560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent investigation has revealed the significant role of Cathelicidin antimicrobial peptide (CAMP) in infection defense and innate immunity processes in adipose tissue. Meanwhile, knowledge of its regulation and functions in metabolic contexts as an adipokine remains sparce. The present study investigated the postprandial regulation of circulating CAMP levels during oral glucose tolerance tests (OGTTs). Eighty-six metabolically healthy volunteers participated in a standardized 75 g-2 h-OGTT setting. The effects of exogenous glucose, insulin, and incretins on CAMP expression in human adipocyte culture (cell-line SGBS) were studied in vitro. CAMP concentrations in blood serum samples were measured by ELISA techniques and adipocyte gene expression levels were quantified by real-time PCR. Of note, base-line CAMP serum quantities were negatively correlated with HDL cholesterol levels as well as with the anti-inflammatory adipokine adiponectin. During the 2 h following glucose ingestion, a significant rise in circulating CAMP concentrations was observed in considerable contrast to reduced quantities of fatty acid binding proteins (FABP) 2 and 4 and dipeptidyl peptidase 4 (DPP4). In SGBS adipocytes, neither differing glucose levels nor insulin or incretin treatment significantly induced CAMP mRNA levels. According to our data, glucose represents a positive postprandial regulator of systemic CAMP. This effect apparently is not mediated by the regulatory impact of glucose metabolism on adipocyte CAMP expression.<\/jats:p>","DOI":"10.3390\/ijms241612901","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:15:48Z","timestamp":1692267348000},"page":"12901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating Concentrations of Cathelicidin Anti-Microbial Peptide (CAMP) Are Increased during Oral Glucose Tolerance Test"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-7850","authenticated-orcid":false,"given":"Alexandra","family":"H\u00f6pfinger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Giessen University Hospital, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karrasch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Giessen University Hospital, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sch\u00e4ffler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Giessen University Hospital, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4054-1971","authenticated-orcid":false,"given":"Andreas","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Giessen University Hospital, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global epidemiology and pathogenesis","volume":"15","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","unstructured":"Engin, A. (2017). Advances in Experimental Medicine and Biology, Springer."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/cob.12203","article-title":"A systematic review of reviews: Exploring the relationship between obesity, weight loss and health-related quality of life","volume":"7","author":"Kolotkin","year":"2017","journal-title":"Clin. Obes."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7326\/0003-4819-138-1-200301070-00008","article-title":"Obesity in Adulthood and Its Consequences for Life Expectancy: A Life-Table Analysis","volume":"138","author":"Peeters","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000471488","article-title":"The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function","volume":"10","author":"Goossens","year":"2017","journal-title":"Obes. Facts"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol.\u2014Cell Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"827281","DOI":"10.3389\/fimmu.2021.827281","article-title":"Editorial: The Immunomodulatory Roles of Adipocytes","volume":"12","author":"Bradley","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5315602","DOI":"10.1155\/2017\/5315602","article-title":"Innate Immunity of Adipose Tissue in Rodent Models of Local and Systemic Staphylococcus aureus Infection","volume":"2017","author":"Schmid","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155663","DOI":"10.1016\/j.cyto.2021.155663","article-title":"The adipokine C1q\/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes","volume":"148","author":"Karrasch","year":"2021","journal-title":"Cytokine"},{"key":"ref_12","first-page":"169","article-title":"Serum Levels and Adipose Tissue Gene Expression of Cathelicidin Antimicrobial Peptide (CAMP) in Obesity and During Weight Loss","volume":"53","author":"Hochberg","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.plipres.2004.05.001","article-title":"Fatty acid-binding proteins\u2014Insights from genetic manipulations","volume":"43","author":"Haunerland","year":"2004","journal-title":"Prog. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.274.5291.1377","article-title":"Uncoupling of Obesity from Insulin Resistance through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein","volume":"274","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cmet.2004.12.008","article-title":"Adipocyte\/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes","volume":"1","author":"Maeda","year":"2005","journal-title":"Cell Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.metabol.2009.02.024","article-title":"Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers","volume":"58","author":"Karakas","year":"2009","journal-title":"Metabolism"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1388-1981(99)00200-0","article-title":"Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine","volume":"1483","author":"Alpers","year":"2000","journal-title":"Biochim. Biophys. Acta\u2014Mol. Cell Biol. Lipids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/ajcn\/85.1.102","article-title":"FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women","volume":"85","author":"Weiss","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"Drucker","year":"2006","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0140-6736(14)61217-4","article-title":"HDL and cardiovascular disease","volume":"384","author":"Rader","year":"2014","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.biochi.2012.06.030","article-title":"Adiponectin: Anti-inflammatory and cardioprotective effects","volume":"94","year":"2012","journal-title":"Biochimie"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tem.2017.01.003","article-title":"Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation","volume":"28","author":"Moschen","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, S., Yang, L., Chen, P., Jin, H., Xie, X., Yang, M., Gao, T., Hu, C., and Yu, X. (2016). Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146605"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/oby.20954","article-title":"FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms","volume":"23","author":"Mita","year":"2015","journal-title":"Obesity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EC-20-0484","article-title":"The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility","volume":"10","author":"Cristelo","year":"2021","journal-title":"Endocr. Connect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e3057","DOI":"10.1002\/dmrr.3057","article-title":"Serum cathelicidin as a marker for diabetic nephropathy in patients with type 1 diabetes","volume":"34","author":"Ahmed","year":"2018","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1900\/RDS.2021.17.30","article-title":"Vitamin D and Cathelicidin (LL-37) Status in Patients with Type 2 Diabetes and Staphylococcus aureus Nasal Carriage","volume":"17","author":"Plataki","year":"2021","journal-title":"Rev. Diabet. Stud."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/cei.12316","article-title":"Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity","volume":"177","author":"Brauner","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"H\u00f6pfinger, A., Karrasch, T., Sch\u00e4ffler, A., and Schmid, A. (2023). Circulating Levels of Cathelicidin Antimicrobial Peptide (CAMP) Are Affected by Oral Lipid Ingestion. Nutrients, 15.","DOI":"10.3390\/nu15133021"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.ijo.0801520","article-title":"Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation","volume":"25","author":"Wabitsch","year":"2001","journal-title":"Int. J. Obes."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/s41366-022-01199-9","article-title":"20 Years with SGBS cells\u2014A versatile in vitro model of human adipocyte biology","volume":"46","author":"Tews","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.micpath.2016.06.002","article-title":"Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control","volume":"97","year":"2016","journal-title":"Microb. Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1210\/jc.2011-0342","article-title":"In vivo suppression of visfatin by oral glucose uptake: Evidence for a novel incretin-like effect by glucagon-like peptide-1 (GLP-1)","volume":"96","author":"Bala","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-0032-1333299","article-title":"Regulation and Function of C1Q\/TNF-related Protein-5 (CTRP-5) in the Context of Adipocyte Biology","volume":"121","author":"Schmid","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/16\/12901\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:36:00Z","timestamp":1760128560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/16\/12901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":34,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241612901"],"URL":"https:\/\/doi.org\/10.3390\/ijms241612901","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]}}}