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Safra Center for Bioinformatics at Tel Aviv University","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"The Koret-UC Berkeley-Tel Aviv University Initiative in Computational Biology and Bioinformatics","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"Kodesz Institute for Technologies in Healthcare","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"Tel Aviv University Healthy Longevity Research Center","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"Djerassi-Elias Institute of Oncology","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"Kirschman Dvora Eleonora Fund for Parkinson\u2019s Disease; Tel Aviv University Innovation Laboratories (TILabs)","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]},{"name":"Tel Aviv University Innovation Laboratories (TILabs)","award":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"],"award-info":[{"award-number":["no. 945151; PSY-PGx","no. 3-17928; ArtiPro"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.<\/jats:p>","DOI":"10.3390\/ijms241612908","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:15:48Z","timestamp":1692267348000},"page":"12908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment"],"prefix":"10.3390","volume":"24","author":[{"given":"Tehila","family":"Cohen","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-6124","authenticated-orcid":false,"given":"Noam","family":"Shomron","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Edmond J Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Tel Aviv University Innovation Labs (TILabs), Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"h6161","DOI":"10.1136\/bmj.h6161","article-title":"Post-traumatic stress disorder","volume":"351","author":"Bisson","year":"2015","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neubiorev.2016.08.023","article-title":"Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation","volume":"71","author":"Careaga","year":"2016","journal-title":"Neurosci. 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