{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:35:44Z","timestamp":1778002544075,"version":"3.51.4"},"reference-count":96,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:00:00Z","timestamp":1692489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is a connective tissue disease characterized by a wide spectrum of clinical features, extending from a benign glandular disease to an aggressive systemic disorder and\/or lymphoma. The pathogenesis of Sj\u00f6gren\u2019s syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The studies based on the animal models of SS provided significant insight in SS disease pathogenesis and management. The aim of this review is to summarize current studies on animal models with primary SS-like symptoms and discuss the impact of these studies on better understanding pathogenesis and management of Sj\u00f6gren\u2019s syndrome. Databases PubMed, Web of Science, Scopus and Cochrane library were searched for summarizing studies on animal models in SS. Available data demonstrate that animal models are highly important for our understanding of SS disease.<\/jats:p>","DOI":"10.3390\/ijms241612995","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:33:11Z","timestamp":1692581591000},"page":"12995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lessons from Animal Models in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3390","volume":"24","author":[{"given":"Diana","family":"Mieliauskait\u0117","sequence":"first","affiliation":[{"name":"State Research Institute Center for Innovative Medicine, Department of Experimental, Preventive and Clinical Medicine, LT-08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilius","family":"Kontenis","sequence":"additional","affiliation":[{"name":"State Research Institute Center for Innovative Medicine, Department of Experimental, Preventive and Clinical Medicine, LT-08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almantas","family":"\u0160iaurys","sequence":"additional","affiliation":[{"name":"State Research Institute Center for Innovative Medicine, Department of Immunology, LT-08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12026-016-8844-4","article-title":"Primary Sj\u00f6gren\u2019s syndrome: Clinical phenotypes, outcome and the development of biomarkers","volume":"65","author":"Goules","year":"2017","journal-title":"Immunol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren\u2019s syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"594096","DOI":"10.3389\/fimmu.2020.594096","article-title":"Primary Sj\u00f6gren\u2019s Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development","volume":"11","author":"Goules","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/rheumatology\/ket427","article-title":"Primary Sjogren\u2019s syndrome as a multi-organ disease: Impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients","volume":"53","author":"Baldini","year":"2014","journal-title":"Rheumatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1136\/annrheumdis-2014-206860","article-title":"Is primary Sj\u00f6gren\u2019s syndrome an orphan disease? A critical appraisal of prevalence studies in Europe","volume":"74","author":"Cornec","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/acr.22115","article-title":"Epidemiology of primary Sjogren\u2019s syndrome in a French multiracial\/multiethnic area","volume":"66","author":"Maldini","year":"2014","journal-title":"Arthritis. Care. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.55563\/clinexprheumatol\/88dyrn","article-title":"Searching for the \u201cX Factor\u201d in Sj\u00f6gren\u2019s Syndrome Female Predilection","volume":"39","author":"Chatzis","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/annrheumdis-2016-209952","article-title":"Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren\u2019s syndrome at diagnosis in 8310 patients: A cross-sectional study from the big data Sjogren project consortium","volume":"76","author":"Zeher","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13145","DOI":"10.1111\/sji.13145","article-title":"Disease mechanisms in Sj\u00f6gren\u2019s syndrome: What do we know?","volume":"95","author":"Jonsson","year":"2022","journal-title":"Scand. J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.2174\/1381612824666181016154033","article-title":"From molecular mechanism to the etiology of Sjogren syndrome","volume":"24","author":"Wei","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chivasso, C., Sarrand, J., Perret, J., Delporte, C., and Soyfoo, M.S. (2021). The involvement of innate and adaptive immunity in the initiation and perpetuation of Sjogren\u2019s syndrome. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020658"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Shimizu, T., Nakamura, H., and Kawakami, A. (2021). Role of the innate immunity signaling pathway in the pathogenesis of Sjogren\u2019s syndrome. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063090"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eaap8855","DOI":"10.1126\/sciimmunol.aap8855","article-title":"TLR7 escapes X chromosome inactivation in immune cells","volume":"3","author":"Souyris","year":"2018","journal-title":"Sci. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.clim.2017.03.007","article-title":"Insight into pathogenesis of Sjogren\u2019s syndrome: Dissection on autoimmune infiltrates and epithelial cells","volume":"182","author":"Goules","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2009.05133.x","article-title":"Th1 and Th17 cells: Adversaries and collaborators","volume":"1183","author":"Damsker","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.immuni.2015.09.003","article-title":"Interleukin-23-Independent IL-17 production regulates intestinal epithelial permeability","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/rheumatology\/key330","article-title":"Genetics and epigenetics in primary Sj\u00f6gren\u2019s syndrome","volume":"60","author":"Rasmussen","year":"2021","journal-title":"Rheumatology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5928232","DOI":"10.1155\/2021\/5928232","article-title":"Advances in Pathogenesis of Sj\u00f6gren\u2019s Syndrome","volume":"2021","author":"Tian","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11154","DOI":"10.1038\/s41598-021-90569-w","article-title":"Gene expression alterations in salivary gland epithelia of Sjogren\u2019s syndrome patients are associated with clinical and histopathological manifestations","volume":"11","author":"Cruz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/rheumatology\/kez050","article-title":"The role of stroma and epithelial cells in primary Sj\u00f6gren\u2019s syndrome","volume":"60","author":"Asam","year":"2021","journal-title":"Rheumatology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.31138\/mjr.31.4.424","article-title":"Interaction of human salivary gland epithelial cells with B lymphocytes: Implications in the pathogenesis of Sj\u00f6gren\u2019s syndrome","volume":"31","author":"Kapsogeorgou","year":"2020","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"407031","DOI":"10.1155\/2011\/407031","article-title":"Dysfunction of lacrimal and salivary glands in Sjogren\u2019s syndrome: Nonimmunologic injury in preinflammatory phase and mouse model","volume":"2011","author":"Hayashi","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/ar2676","article-title":"Differential gene expression in the salivary gland during development and onset of xerostomia in Sjogren\u2019s syndrome-like disease of the C57BL\/6.NODAec1Aec2 mouse","volume":"11","author":"Nguyen","year":"2009","journal-title":"Arthritis. Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/labinvest.3700487","article-title":"Early pathogenic events associated with Sjogren\u2019s syndrome (SjS)-like disease of the NOD mouse using microarray analysis","volume":"86","author":"Killedar","year":"2006","journal-title":"Lab. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)65027-4","article-title":"Severe destructive autoimmune lesions with aging in murine Sjogren\u2019s syndrome through fas-mediated apoptosis","volume":"156","author":"Ishimaru","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12628","DOI":"10.1073\/pnas.0405099101","article-title":"Aromatase deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren\u2019s syndrome","volume":"101","author":"Shim","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1084\/jem.20080174","article-title":"Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren\u2019s syndrome-like autoimmune exocrinopathy","volume":"205","author":"Ishimaru","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0002-9440(10)63505-5","article-title":"Development of autoimmune exocrinopathy resembling Sj\u00f6gren\u2019s syndrome in estrogen-deficient mice of healthy background","volume":"163","author":"Ishimaru","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3389\/fimmu.2018.02362","article-title":"Gene expression profiling of lacrimal glands identifies the ectopic expression of mhc ii on glandular cells as a presymptomatic feature in a mouse model of primary Sjogren\u2019s syndrome","volume":"9","author":"Yin","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1034\/j.1601-0825.2002.02846.x","article-title":"Current issues in Sjogren\u2019s syndrome","volume":"8","author":"Jonsson","year":"2002","journal-title":"Oral. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jaut.2010.08.004","article-title":"Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjogren\u2019s syndrome-like sialoadenitis","volume":"35","author":"Iizuka","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3389\/fimmu.2017.01384","article-title":"B cells are indispensable for a novel mouse model of primary Sjogren\u2019s syndrome","volume":"8","author":"Zheng","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Soriano-Romani, L., Contreras-Ruiz, L., Lopez-Garcia, A., Diebold, Y., and Masli, S. (2018). Topical application of TGF-beta-activating peptide, KRFK, prevents inflammatory manifestations in the TSP-1-deficient mouse model of chronic ocular inflammation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010009"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"974648","DOI":"10.3389\/fimmu.2022.974648","article-title":"Th17 cells in primary Sj\u00f6gren\u2019s syndrome negatively correlate with increased Roseburia and Coprococcus","volume":"13","author":"Xin","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_35","first-page":"1988","article-title":"CD4+CXCR5+ follicular helper T cells in salivary gland promote B cells maturation in patients with primary Sjogren\u2019s syndrome","volume":"7","author":"Jin","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/annrheumdis-2013-204584","article-title":"Th17 cells play a critical role in the development of experimental Sjogren\u2019s syndrome","volume":"74","author":"Lin","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clim.2013.02.024","article-title":"Follicular helper T cells may play an important role in the severity of primary Sjogren\u2019s syndrome","volume":"147","author":"Szabo","year":"2013","journal-title":"Clin. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/eji.201142238","article-title":"Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease","volume":"42","author":"Johnson","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_39","first-page":"86e95","article-title":"Thrombospondin-derived peptide attenuates Sjogren\u2019s syndrome-associated ocular surface inflammation in mice","volume":"188","author":"Mir","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/mi.2016.83","article-title":"Agerelated spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells","volume":"10","author":"Coursey","year":"2017","journal-title":"Mucosal. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1292\/jvms.67.955","article-title":"Different effects on the inflammatory lesions in the lacrimal and salivary glands after neonatal thymectomy in IQI\/Jic mice, a model for Sjogren\u2019s syndrome","volume":"67","author":"Takada","year":"2005","journal-title":"J. Vet. Med. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cyto.2014.02.009","article-title":"Early events in Sjogren\u2019s syndrome pathogenesis: The importance of innate immunity in disease initiation","volume":"67","author":"Kramer","year":"2014","journal-title":"Cytokine"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Peck, A.B., Nguyen, C.Q., and Ambrus, J.L. (2021). Upregulated chemokine and Rho-GTPase genes define immune cell emigration into salivary glands of Sj\u00f6gren\u2019s syndrome-susceptible C57BL\/6.NOD-Aec1Aec2 mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137176"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/bjh.13192","article-title":"Sj\u00f6gren Syndrome-associated lymphomas: An update on pathogenesis and management","volume":"168","author":"Nocturne","year":"2015","journal-title":"Br. J. Haematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3389\/fimmu.2020.01158","article-title":"Recent advances in mouse models of Sj\u00f6gren\u2019s syndrome","volume":"11","author":"Gao","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/j.ypmed.2011.12.019","article-title":"N-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice","volume":"54","author":"Crupi","year":"2012","journal-title":"Prev. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1073\/pnas.95.13.7538","article-title":"Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sj\u00f6gren\u2019s syndrome","volume":"95","author":"Robinson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/cbin.11236","article-title":"Dysregulated interleukin 11 in primary Sj\u00f6gren\u2019s syndrome contributes to apoptosis of glandular epithelial cells","volume":"44","author":"Ye","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhou, P., Chen, J., He, J., Zheng, T., Yunis, J., Makota, V., Alexandre, Y.O., Gong, F., Zhang, X., and Xie, W. (2021). Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009858"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/s41467-018-04974-3","article-title":"Act1 is a negative regulator in T and B cells via direct inhibition of STAT3","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4049\/jimmunol.1401118","article-title":"A crucial role of ROR\u03b3t in the development of spontaneous sialadenitis-like Sj\u00f6gren\u2019s syndrome","volume":"194","author":"Iizuka","year":"2015","journal-title":"J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0022034519837240","article-title":"Targeted TNF-\u03b1 overexpression drives salivary gland inflammation","volume":"98","author":"Limaye","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4049\/jimmunol.1501061","article-title":"The expression of BAFF is controlled by IRF transcription factors","volume":"196","author":"Johansson","year":"2016","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jaut.2010.06.012","article-title":"Activation of the type I interferon pathway in primary Sjogren\u2019s syndrome","volume":"35","author":"Mavragani","year":"2010","journal-title":"J. Autoimm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/art.40589","article-title":"JAK-1 inhibition suppresses interferon-induced BAFF production in human salivary gland","volume":"70","author":"Lee","year":"2018","journal-title":"Arthr. Rheum."},{"key":"ref_56","first-page":"95","article-title":"JAK\/STAT pathway targeting in primary Sj\u00f6gren syndrome","volume":"3","author":"Gandolfo","year":"2022","journal-title":"Rheum. Immunol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s10753-020-01322-w","article-title":"Inhibition of JAK-STAT signaling by baricitinib reduces interferon-\u03b3-induced CXCL10 production in human salivary gland ductal cells","volume":"44","author":"Aota","year":"2021","journal-title":"Inflammation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.clim.2017.04.009","article-title":"Systemic manifestations of primary Sj\u00f6gren\u2019s syndrome in the NOD.B10Sn-H2(b)\/J mouse model","volume":"183","author":"Kiripolsky","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.clim.2014.12.010","article-title":"The osteopontin transgenic mouse is a new model for Sjogren\u2019s syndrome","volume":"157","author":"Kramer","year":"2015","journal-title":"Clin. Immun."},{"key":"ref_60","first-page":"236","article-title":"Expression of osteopontin in labial glands of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"44","author":"Wang","year":"2012","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ajpath.2014.09.006","article-title":"Aromatase controls Sj\u00f6gren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue associated macrophages","volume":"185","author":"Iwasa","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.exer.2014.07.017","article-title":"Does estrogen deficiency cause lacrimal gland inflammation and aqueousdeficient dry eye in mice?","volume":"127","author":"Darabab","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"676010","DOI":"10.3389\/fimmu.2021.676010","article-title":"TLR7 signaling drives the development of Sj\u00f6gren\u2019s syndrome","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s13105-015-0388-x","article-title":"Interrelationship between lymphocytes and leptin in fat depots of obese mice revealed by changes in nutritional status","volume":"71","author":"Dray","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.prp.2016.08.009","article-title":"Leptin and leptin receptors in salivary glands of primary Sjogren\u2019s syndrome","volume":"212","author":"Erbasan","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bbrc.2016.11.121","article-title":"Leptin\/OB-R signaling is elevated in mice with Sjogren\u2019s syndrome and is implicated in disease pathogenesis","volume":"482","author":"Xu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Stepp, M.A., Pal-Ghosh, S., Tadvalkar, G., Williams, A., Pflugfelder, S., and de Paiva, C. (2018). Reduced corneal innervation in the CD25 null model of Sj\u00f6gren syndrome. Int. J. Mech. Sci., 19.","DOI":"10.3390\/ijms19123821"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10238-021-00728-6","article-title":"Sj\u00f6gren\u2019s syndrome: A systemic autoimmune disease","volume":"22","author":"Negrini","year":"2022","journal-title":"Clin. Exp. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev-genet-102108-134143","article-title":"The functional annotation of mammalian genomes: The challenge of phenotyping","volume":"43","author":"Brown","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jobcr.2020.12.001","article-title":"Studying Sj\u00f6gren\u2019s syndrome in mice: What is the best available model?","volume":"11","author":"Abughanam","year":"2021","journal-title":"J. Oral. Biol. Craniofac. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"649896","DOI":"10.3389\/fmed.2021.649896","article-title":"CRISPR\/Cas: Advances, limitations, and applications for precision cancer research","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2014.10.004","article-title":"A chimeric human-mouse model of Sj\u00f6gren\u2019s syndrome","volume":"156","author":"Young","year":"2015","journal-title":"Clin. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_74","first-page":"74","article-title":"The microbiome in autoimmune diseases","volume":"195","author":"Shoenfeld","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40168-020-00875-0","article-title":"Microbiome definition re-visited: Old concepts and new challenges","volume":"8","author":"Berg","year":"2020","journal-title":"Microbiome"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/annrheumdis-2019-216631","article-title":"The microbiome in rheumatology: Where are we and where should we go?","volume":"79","author":"Manasson","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.18240\/ijo.2022.11.19","article-title":"Gastrointestinal microbiome and primary Sj\u00f6gren\u2019s syndrome: A review of the literature and conclusions","volume":"15","author":"Yao","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1187906","DOI":"10.3389\/fimmu.2023.1187906","article-title":"Gut microbiota and Sj\u00f6gren\u2019s syndrome: A two-sample Mendelian randomization study","volume":"14","author":"Cao","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41577-019-0144-5","article-title":"Mining the microbiota for microbial and metabolite-based immunotherapies","volume":"19","author":"Skelly","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri.2017.111","article-title":"The hygiene hypothesis in autoimmunity: The role of pathogens and commensals","volume":"18","author":"Bach","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Cano-Ortiz, A., Laborda-Illanes, A., Plaza-Andrades, I., Membrillo Del Pozo, A., Villarrubia Cuadrado, A., Rodr\u00edguez Calvo de Mora, M., Leiva-Gea, I., Sanchez-Alcoholado, L., and Queipo-Ortu\u00f1o, M.I. (2020). Connection between the gut microbiome, systemic inflammation, gut permeability and FOXP3 expression in patients with primary Sj\u00f6gren\u2019s syndrome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228733"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"918619","DOI":"10.3389\/fimmu.2022.918619","article-title":"A glimpse into the microbiome of Sj\u00f6gren\u2019s syndrome","volume":"13","author":"Deng","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/odi.12472","article-title":"The microbiome-systemic diseases connection","volume":"22","author":"Harmsen","year":"2016","journal-title":"Oral. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wang, C.J., Zaheer, M., Bian, F., Quach, D., Swennes, A.G., Britton, R.A., Pflugfelder, S.C., and de Paiva, C.S. (2018). Sj\u00f6gren-like lacrimal keratoconjunctivitis in germ-free mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020565"},{"key":"ref_85","first-page":"608377","article-title":"Immune privilege: The microbiome and uveitis","volume":"11","author":"Heissigerova","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/annrheumdis-2014-206297","article-title":"Interaction between innate immunity and Ro52-induced antibody causes Sj\u00f6gren\u2019s syndrome-like disorder in mice","volume":"75","author":"Szczerba","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2018.06.004","article-title":"Protective role of commensal bacteria in Sj\u00f6gren syndrome","volume":"93","author":"Zaheer","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaut.2017.11.003","article-title":"Th17 cells in primary Sj\u00f6gren\u2019s syndrome: Pathogenicity and plasticity","volume":"87","author":"Verstappen","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yanagisawa, N., Ueshiba, H., Abe, Y., Kato, H., Higuchi, T., and Yagi, J. (2018). Outer membrane protein of gut commensal microorganism induces autoantibody production and extra-intestinal gland inflammation in mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103241"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/odi.12649","article-title":"Flagellar filament structural protein induces Sj\u00f6gren\u2019s syndrome-like sialadenitis in mice","volume":"23","author":"Higuchi","year":"2017","journal-title":"Oral. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the holobiont: How microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Fakharian, F., Thirugnanam, S., Welsh, D.A., Kim, W.-K., Rappaport, J., Bittinger, K., and Rout, N. (2023). The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071849"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kim, J., Choi, S.H., Kim, Y.J., Jeong, H.J., Ryu, J.S., Lee, H.J., Kim, T.W., Im, S.H., Oh, J.Y., and Kim, M.K. (2017). Clinical effect of IRT-5 probiotics on immune modulation of autoimmunity or alloimmunity in the eye. Nutrients, 9.","DOI":"10.3390\/nu9111166"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.61.3.42","article-title":"IRT5 probiotics changes immune modulatory protein expression in the extraorbital lacrimal glands of an autoimmune dry eye mouse model","volume":"61","author":"Choi","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"100758","DOI":"10.1016\/j.preteyeres.2019.04.002","article-title":"Immune privilege in corneal transplantation","volume":"72","author":"Hori","year":"2019","journal-title":"Prog. Retin. Eye Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/16\/12995\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:37:58Z","timestamp":1760128678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/16\/12995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,20]]},"references-count":96,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241612995"],"URL":"https:\/\/doi.org\/10.3390\/ijms241612995","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,20]]}}}