{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:23:57Z","timestamp":1778858637206,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPESP","award":["#2015\/21890-0"],"award-info":[{"award-number":["#2015\/21890-0"]}]},{"name":"FAPESP","award":["#2017\/02739-4"],"award-info":[{"award-number":["#2017\/02739-4"]}]},{"name":"FAPESP","award":["#2018\/20637-7"],"award-info":[{"award-number":["#2018\/20637-7"]}]},{"name":"FAPESP","award":["#2021\/08188-5"],"award-info":[{"award-number":["#2021\/08188-5"]}]},{"name":"FAPESP","award":["#301771\/2019-7"],"award-info":[{"award-number":["#301771\/2019-7"]}]},{"name":"FAPESP","award":["#302997\/2022-9"],"award-info":[{"award-number":["#302997\/2022-9"]}]},{"name":"CAPES","award":["#2015\/21890-0"],"award-info":[{"award-number":["#2015\/21890-0"]}]},{"name":"CAPES","award":["#2017\/02739-4"],"award-info":[{"award-number":["#2017\/02739-4"]}]},{"name":"CAPES","award":["#2018\/20637-7"],"award-info":[{"award-number":["#2018\/20637-7"]}]},{"name":"CAPES","award":["#2021\/08188-5"],"award-info":[{"award-number":["#2021\/08188-5"]}]},{"name":"CAPES","award":["#301771\/2019-7"],"award-info":[{"award-number":["#301771\/2019-7"]}]},{"name":"CAPES","award":["#302997\/2022-9"],"award-info":[{"award-number":["#302997\/2022-9"]}]},{"name":"CNPq","award":["#2015\/21890-0"],"award-info":[{"award-number":["#2015\/21890-0"]}]},{"name":"CNPq","award":["#2017\/02739-4"],"award-info":[{"award-number":["#2017\/02739-4"]}]},{"name":"CNPq","award":["#2018\/20637-7"],"award-info":[{"award-number":["#2018\/20637-7"]}]},{"name":"CNPq","award":["#2021\/08188-5"],"award-info":[{"award-number":["#2021\/08188-5"]}]},{"name":"CNPq","award":["#301771\/2019-7"],"award-info":[{"award-number":["#301771\/2019-7"]}]},{"name":"CNPq","award":["#302997\/2022-9"],"award-info":[{"award-number":["#302997\/2022-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer during pregnancy presents a delicate coexistence, imposing ethical and professional challenges on both the patient and medical team. In this study, we aimed to explore in a pre-clinical model the impact of tumour evolution in serum, placental and foetal metabolomics profiles during pregnancy in a time-course manner. Pregnant Wistar rats were distributed into two experimental groups: Control (C) and Walker-256 tumour-bearing (W). The rats were euthanised on three different gestational periods: at 12 days post-conception (dpc), at 16 dpc, and at 19 dpc. Serum, placenta and foetal metabolomic profiles were performed by 1H-NMR spectra following the analyses using Chenomx NMR Analysis Software V8.3. The tumour evolution was exponential, affecting the placental metabolomic profile during all the pregnancy stages. The placental tissue in tumour-bearing dams developed at a lower speed, decreasing the foetus\u2019s weight. Associated with the serum metabolomic changes related to tumour growth, the placental metabolomic alterations impacted many metabolic pathways related to energy provision, protein synthesis and signalling, which directly harmed the foetus\u2019s development. The development of the foetus is clearly affected by the damage induced by the tumour evolution, which alters the metabolic profile of both the serum and the placenta, impairing early embryonic development.<\/jats:p>","DOI":"10.3390\/ijms241713026","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:46:22Z","timestamp":1692665182000},"page":"13026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Placental, Foetal, and Maternal Serum Metabolomic Profiles in Pregnancy-Associated Cancer: Walker-256 Tumour Model in a Time-Course Analysis"],"prefix":"10.3390","volume":"24","author":[{"given":"Carla","family":"De Moraes Salgado","sequence":"first","affiliation":[{"name":"Nutrition and Cancer Laboratory, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Sao Paulo 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00eds Rosa","family":"Viana","sequence":"additional","affiliation":[{"name":"Nutrition and Cancer Laboratory, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Sao Paulo 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-756X","authenticated-orcid":false,"given":"Maria Cristina Cintra","family":"Gomes-Marcondes","sequence":"additional","affiliation":[{"name":"Nutrition and Cancer Laboratory, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Sao Paulo 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","unstructured":"Bernard, W.S., and Christopher, P.W. 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