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The most discussed changes include synovial inflammation, the massive destruction of articular cartilage and ongoing joint destruction accompanied by massive joint pain in the later stadium. Either the increased apoptosis of chondrocytes or the insufficient apoptosis of inflammatory macrophages and synovial fibroblasts are likely to underly this process. In this review, we discuss the current state of research on the pathogenesis of OA with special regard to the involvement of apoptosis.<\/jats:p>","DOI":"10.3390\/ijms241713028","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:46:22Z","timestamp":1692665182000},"page":"13028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions"],"prefix":"10.3390","volume":"24","author":[{"given":"Frederike","family":"Werry","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Mazur","sequence":"additional","affiliation":[{"name":"Soft Tissue & Orthopaedic Surgery Service, Department for Small Animals, College of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars F. H.","family":"Theyse","sequence":"additional","affiliation":[{"name":"Soft Tissue & Orthopaedic Surgery Service, Department for Small Animals, College of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Edlich","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13770-021-00397-2","article-title":"Emerging Concepts of Endotypes\/Phenotypes in Regenerative Medicine for Osteoarthritis","volume":"19","author":"Im","year":"2022","journal-title":"Tissue Eng. Regen. 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