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The escalating issue of population aging significantly exacerbates the prevalence of OA, thereby imposing an immense annual economic burden on societies worldwide. The current therapeutic landscape falls short in offering reliable pharmaceutical interventions and efficient treatment methodologies to tackle this growing problem. However, the scientific community continues to dedicate significant efforts towards advancing OA treatment research. Contemporary studies have discovered that the progression of OA may be slowed through the strategic influence on peroxisome proliferator-activated receptors (PPARs). PPARs are ligand-activated receptors within the nuclear hormone receptor family. The three distinctive subtypes\u2014PPAR\u03b1, PPAR\u03b2\/\u03b4, and PPAR\u03b3\u2014find expression across a broad range of cellular terminals, thus managing a multitude of intracellular metabolic operations. The activation of PPAR\u03b3 and PPAR\u03b1 has been shown to efficaciously modulate the NF-\u03baB signaling pathway, AP-1, and other oxidative stress-responsive signaling conduits, leading to the inhibition of inflammatory responses. Furthermore, the activation of PPAR\u03b3 and PPAR\u03b1 may confer protection to chondrocytes by exerting control over its autophagic behavior. In summation, both PPAR\u03b3 and PPAR\u03b1 have emerged as promising potential targets for the development of effective OA treatments.<\/jats:p>","DOI":"10.3390\/ijms241713137","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:06:48Z","timestamp":1692871608000},"page":"13137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Osteoarthritis: Role of Peroxisome Proliferator-Activated Receptors"],"prefix":"10.3390","volume":"24","author":[{"given":"Weibei","family":"Sheng","sequence":"first","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichang","family":"Wang","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Qin","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-3746","authenticated-orcid":false,"given":"Siyang","family":"Cao","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Wei","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Weng","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zheng, S., Tu, L., Cicuttini, F., Zhu, Z., Han, W., Antony, B., Wluka, A.E., Winzenberg, T., Aitken, D., and Blizzard, L. 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