{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:25:52Z","timestamp":1779099952806,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Medical University of Bialystok","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Medical University of Bialystok","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Medical University of Bialystok","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Medical University of Bialystok","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Medical University of Bialystok","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Medical University of Bialystok","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Medical University of Bialystok","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Medical University of Bialystok","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Medical University of Bialystok","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Medical University of Bialystok","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Medical University of Bialystok","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Medical University of Bialystok","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Medical University of Bialystok","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Medical University of Bialystok","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Medical University of Bialystok","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Medical University of Bialystok","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Medical University of Bialystok","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Medical University of Bialystok","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Medical University of Bialystok","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Medical University of Bialystok","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Medical University of Bialystok","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Medical University of Bialystok","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Swedish Research Council","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Swedish Research Council","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Swedish Research Council","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Swedish Research Council","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Research Council","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Swedish Research Council","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Swedish Research Council","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Swedish Research Council","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Swedish Research Council","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Swedish Research Council","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Swedish Research Council","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Swedish Research Council","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Swedish Research Council","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Swedish Research Council","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Swedish Research Council","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Research Council","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Swedish Research Council","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Swedish Research Council","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Swedish Research Council","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Swedish Research Council","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Swedish Research Council","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Swedish Research Council","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Swedish Research Council","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Swedish State Support for Clinical Research","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Swedish State Support for Clinical Research","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Swedish State Support for Clinical Research","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Swedish State Support for Clinical Research","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish State Support for Clinical Research","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Swedish State Support for Clinical Research","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Swedish State Support for Clinical Research","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Swedish State Support for Clinical Research","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Swedish State Support for Clinical Research","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Swedish State Support for Clinical Research","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Swedish State Support for Clinical Research","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Swedish State Support for Clinical Research","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Swedish State Support for Clinical Research","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Swedish State Support for Clinical Research","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Swedish State Support for Clinical Research","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish State Support for Clinical Research","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Swedish State Support for Clinical Research","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Swedish State Support for Clinical Research","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Swedish State Support for Clinical Research","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Swedish State Support for Clinical Research","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Swedish State Support for Clinical Research","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Swedish State Support for Clinical Research","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Swedish State Support for Clinical Research","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Alzheimer Drug Discovery Foundation (ADDF)","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"AD Strategic Fund and the Alzheimer\u2019s Association","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor, Hj\u00e4rnfonden","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Swedish Research Council VR","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Swedish Research Council VR","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Swedish Research Council VR","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Swedish Research Council VR","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Research Council VR","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Swedish Research Council VR","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Swedish Research Council VR","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Swedish Research Council VR","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Swedish Research Council VR","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Swedish Research Council VR","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Swedish Research Council VR","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Swedish Research Council VR","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Swedish Research Council VR","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Swedish Research Council VR","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Swedish Research Council VR","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Research Council VR","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Swedish Research Council VR","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Swedish Research Council VR","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Swedish Research Council VR","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Swedish Research Council VR","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Swedish Research Council VR","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Swedish Research Council VR","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Swedish Research Council VR","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Swedish Alzheimer Foundation","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Swedish Alzheimer Foundation","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Swedish Alzheimer Foundation","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Swedish Alzheimer Foundation","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Alzheimer Foundation","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Swedish Alzheimer Foundation","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Swedish Alzheimer Foundation","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Swedish Alzheimer Foundation","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Swedish Alzheimer Foundation","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Swedish Alzheimer Foundation","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Swedish Alzheimer Foundation","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Swedish Alzheimer Foundation","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Swedish Alzheimer Foundation","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Swedish Alzheimer Foundation","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Swedish Alzheimer Foundation","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Alzheimer Foundation","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Swedish Alzheimer Foundation","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Swedish Alzheimer Foundation","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Swedish Alzheimer Foundation","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Swedish Alzheimer Foundation","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Swedish Alzheimer Foundation","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Swedish Alzheimer Foundation","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Swedish Alzheimer Foundation","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"National Institute of Health","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"National Institute of Health","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"National Institute of Health","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"National Institute of Health","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"National Institute of Health","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"National Institute of Health","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"National Institute of Health","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"National Institute of Health","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"National Institute of Health","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"National Institute of Health","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"National Institute of Health","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"National Institute of Health","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"National Institute of Health","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"National Institute of Health","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"National Institute of Health","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"National Institute of Health","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"National Institute of Health","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"National Institute of Health","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"National Institute of Health","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"National Institute of Health","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"National Institute of Health","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"National Institute of Health","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"National Institute of Health","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Swedish Brain Foundation","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Swedish Brain Foundation","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Swedish Brain Foundation","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Swedish Brain Foundation","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Brain Foundation","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Swedish Brain Foundation","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Swedish Brain Foundation","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Swedish Brain Foundation","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Swedish Brain Foundation","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Swedish Brain Foundation","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Swedish Brain Foundation","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Swedish Brain Foundation","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Swedish Brain Foundation","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Swedish Brain Foundation","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Swedish Brain Foundation","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Swedish Brain Foundation","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Swedish Brain Foundation","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Swedish Brain Foundation","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Swedish Brain Foundation","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Swedish Brain Foundation","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Swedish Brain Foundation","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Swedish Brain Foundation","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Swedish Brain Foundation","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Magnus Bergvalls Stiftelse, \u00c5hl\u00e9n-Stiftelsen","award":["#213027"],"award-info":[{"award-number":["#213027"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["B.SUB.23.549"],"award-info":[{"award-number":["B.SUB.23.549"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["B.SUB.23.500"],"award-info":[{"award-number":["B.SUB.23.500"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["101053962"],"award-info":[{"award-number":["101053962"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#AF-968238"],"award-info":[{"award-number":["#AF-968238"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#AF-939767"],"award-info":[{"award-number":["#AF-939767"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#AF-980791"],"award-info":[{"award-number":["#AF-980791"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["R21AG078538"],"award-info":[{"award-number":["R21AG078538"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["R21AG080705"],"award-info":[{"award-number":["R21AG080705"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["FO2022-0311"],"award-info":[{"award-number":["FO2022-0311"]}]},{"name":"Stiftelsen Gamla Tj\u00e4narinnor, the Swedish Dementia Foundation (Demensfonden), and Gun och Bertil Stohnes Stiftelse","award":["#213027"],"award-info":[{"award-number":["#213027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In addition to amyloid and tau pathology in the central nervous system (CNS), inflammatory processes and synaptic dysfunction are highly important mechanisms involved in the development and progression of dementia diseases. In the present study, we conducted a comparative analysis of selected pro-inflammatory proteins in the CNS with proteins reflecting synaptic damage and core biomarkers in mild cognitive impairment (MCI) and early Alzheimer\u2019s disease (AD). To our knowledge, no studies have yet compared CXCL12 and CX3CL1 with markers of synaptic disturbance in cerebrospinal fluid (CSF) in the early stages of dementia. The quantitative assessment of selected proteins in the CSF of patients with MCI, AD, and non-demented controls (CTRL) was performed using immunoassays (single- and multiplex techniques). In this study, increased CSF concentration of CX3CL1 in MCI and AD patients correlated positively with neurogranin (r = 0.74; p &lt; 0.001, and r = 0.40; p = 0.020, respectively), ptau181 (r = 0.49; p = 0.040), and YKL-40 (r = 0.47; p = 0.050) in MCI subjects. In addition, elevated CSF levels of CXCL12 in the AD group were significantly associated with mini-mental state examination score (r = \u22120.32; p = 0.040). We found significant evidence to support an association between CX3CL1 and neurogranin, already in the early stages of cognitive decline. Furthermore, our findings indicate that CXCL12 might be a useful marker for tract severity of cognitive impairment.<\/jats:p>","DOI":"10.3390\/ijms241713166","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:06:48Z","timestamp":1692871608000},"page":"13166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Relationships between Cerebrospinal Fluid Glial (CXCL12, CX3CL, YKL-40) and Synaptic Biomarkers (Ng, NPTXR) in Early Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Agnieszka","family":"Kulczy\u0144ska-Przybik","sequence":"first","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-017X","authenticated-orcid":false,"given":"Maciej","family":"Dulewicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Doroszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Borawska","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"S\u0142owik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jagiellonian University, 30-688 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK"},{"name":"UK Dementia Research Institute at UCL, London WC1N 3AR, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China"},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792-2460, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hanrieder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK"},{"name":"SciLifeLab, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 M\u00f6lndal, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-8479","authenticated-orcid":false,"given":"Barbara","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland"},{"name":"Department of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"937486","DOI":"10.3389\/fnagi.2022.937486","article-title":"Global, Regional, and National Burden of Alzheimer\u2019s Disease and Other Dementias, 1990\u20132019","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of Neurodegenerative Diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer\u2019s Disease: Pathogenesis, Diagnostics, and Therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2012.04.011","article-title":"Stromal Cell-Derived Factor 1\u03b1 Decreases \u03b2-Amyloid Deposition in Alzheimer\u2019s Disease Mouse Model","volume":"1459","author":"Wang","year":"2012","journal-title":"Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/1673-5374.314303","article-title":"Inhibition of CXCR4\/CXCL12 Signaling: A Translational Perspective for Alzheimer\u2019s Disease Treatment","volume":"17","author":"Gavriel","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-2007-969029","article-title":"Platelets and Stromal Cell-Derived Factor-1 in Progenitor Cell Recruitment","volume":"33","author":"Stellos","year":"2007","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3233\/JAD-2008-15107","article-title":"Decreased CXCL12 (SDF-1) Plasma Levels in Early Alzheimer\u2019s Disease: A Contribution to a Deficient Hematopoietic Brain Support?","volume":"15","author":"Laske","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.107.714691","article-title":"Platelet-Derived Stromal Cell-Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells","volume":"117","author":"Stellos","year":"2008","journal-title":"Circulation"},{"key":"ref_9","first-page":"8342","article-title":"Neuroinflammation in Alzheimer\u2019s Disease: Chemokines Produced by Astrocytes and Chemokine Receptors","volume":"7","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/89490","article-title":"CXCR4-Activated Astrocyte Glutamate Release via TNFalpha: Amplification by Microglia Triggers Neurotoxicity","volume":"4","author":"Bezzi","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-1326-5-7","article-title":"GSK3 and P53\u2014Is There a Link in Alzheimer\u2019s Disease?","volume":"5","author":"Proctor","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1677\/JME-06-0032","article-title":"CXC Chemokine Receptor 4 Regulates Neuronal Migration and Axonal Pathfinding in the Developing Nervous System: Implications for Neuronal Regeneration in the Adult Brain","volume":"38","author":"Stumm","year":"2007","journal-title":"J. Mol. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mcn.2017.09.001","article-title":"Astrocytic Expression of the CXCL12 Receptor, CXCR7\/ACKR3 Is a Hallmark of the Diseased, but Not Developing CNS","volume":"85","author":"Puchert","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s12031-021-01809-7","article-title":"Peripheral Blood Biomarkers CXCL12 and TNFRSF13C Associate with Cerebrospinal Fluid Biomarkers and Infiltrating Immune Cells in Alzheimer Disease","volume":"71","author":"Wu","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/JAD-2008-15311","article-title":"Decreased Plasma and Cerebrospinal Fluid Levels of Stem Cell Factor in Patients with Early Alzheimer\u2019s Disease","volume":"15","author":"Laske","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/1533317513518651","article-title":"The Potential Role of Chemokines in Alzheimer\u2019s Disease Pathogenesis","volume":"29","author":"Azizi","year":"2014","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13195-015-0161-y","article-title":"Neurogranin and YKL-40: Independent Markers of Synaptic Degeneration and Neuroinflammation in Alzheimer\u2019s Disease","volume":"7","author":"Hellwig","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/alz.12612","article-title":"Potential Role of Chitinase-3-like Protein 1 (CHI3L1\/YKL-40) in Neurodegeneration and Alzheimer\u2019s Disease","volume":"19","author":"Connolly","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"eaax3519","DOI":"10.1126\/scitranslmed.aax3519","article-title":"Chi3l1\/YKL-40 Is Controlled by the Astrocyte Circadian Clock and Regulates Neuroinflammation and Alzheimer\u2019s Disease Pathogenesis","volume":"12","author":"Lananna","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_20","first-page":"4637073","article-title":"Fractalkine\/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease","volume":"2023","year":"2023","journal-title":"Neural Plast."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s Disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32713","DOI":"10.1074\/jbc.M111.254268","article-title":"CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-Independent Cognitive Deficits in a Mouse Model of Alzheimer Disease","volume":"286","author":"Cho","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16241","DOI":"10.1523\/JNEUROSCI.3667-11.2011","article-title":"CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity","volume":"31","author":"Rogers","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/1567205013666151116125714","article-title":"Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and P-Tau Accumulation in Alzheimer\u2019s Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?","volume":"13","author":"Merino","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1515\/cclm-2019-0428","article-title":"Liquid Biopsy of Cerebrospinal Fluid Identifies Neuronal Pentraxin Receptor (NPTXR) as a Biomarker of Progression of Alzheimer\u2019s Disease","volume":"57","author":"Lim","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/14737175.2016.1204234","article-title":"Synaptic Degeneration and Neurogranin in the Pathophysiology of Alzheimer\u2019s Disease","volume":"17","author":"Lista","year":"2017","journal-title":"Expert. Rev. Neurother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13195-015-0124-3","article-title":"Characterization of the Postsynaptic Protein Neurogranin in Paired Cerebrospinal Fluid and Plasma Samples from Alzheimer\u2019s Disease Patients and Healthy Controls","volume":"7","author":"Kvartsberg","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3233\/JAD-170220","article-title":"The Relationship between Markers of Inflammation and Degeneration in the Central Nervous System and the Blood-Brain Barrier Impairment in Alzheimer\u2019s Disease","volume":"59","author":"Muszyski","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kulczy\u0144ska-Przybik, A., Dulewicz, M., Doroszkiewicz, J., Borawska, R., Litman-Zawadzka, A., Arslan, D., Ku\u0142akowska, A., Kochanowicz, J., and Mroczko, B. (2022). Comparative Analysis of Neurodegeneration and Axonal Dysfunction Biomarkers in the Cerebrospinal Fluid of Patients with Multiple Sclerosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11144122"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4103\/1673-5374.232486","article-title":"Association between Alzheimer\u2019s Disease Pathogenesis and Early Demyelination and Oligodendrocyte Dysfunction","volume":"13","author":"Dong","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3233\/JAD-170994","article-title":"Bone-Marrow-Derived Microglia-Like Cells Ameliorate Brain Amyloid Pathology and Cognitive Impairment in a Mouse Model of Alzheimer\u2019s Disease","volume":"64","author":"Kawanishi","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"147127","DOI":"10.1016\/j.brainres.2020.147127","article-title":"Postsynaptic Damage and Microglial Activation in AD Patients Could Be Linked CXCR4\/CXCL12 Expression Levels","volume":"1749","author":"Sanfilippo","year":"2020","journal-title":"Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Andr\u00e9s-Benito, P., Povedano, M., Dom\u00ednguez, R., Marco, C., Colomina, M.J., L\u00f3pez-P\u00e9rez, \u00d3., Santana, I., Baldeiras, I., Mart\u00ednez-Yel\u00e1mos, S., and Zerr, I. (2020). Increased C-x-c Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228680"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fncel.2014.00065","article-title":"CXCL12 Chemokine and Its Receptors as Major Players in the Interactions between Immune and Nervous Systems","volume":"8","author":"Guyon","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.taap.2011.06.006","article-title":"Chemokines, Macrophage Inflammatory Protein-2 and Stromal Cell-Derived Factor-1\u03b1, Suppress Amyloid \u03b2-Induced Neurotoxicity","volume":"256","author":"Raman","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-200506","article-title":"Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer\u2019s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers","volume":"78","author":"Gavriel","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/10409231003628015","article-title":"ADAM-17: The Enzyme That Does It All","volume":"45","author":"Gooz","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10563","DOI":"10.1074\/jbc.M109.035477","article-title":"Interactions between Chemokines: Regulation of Fractalkine\/CX 3CL1 Homeostasis by SDF\/CXCL12 in Cortical Neurons","volume":"285","author":"Cook","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-017-0200-1","article-title":"Absence of CX3CR1 Impairs the Internalization of Tau by Microglia","volume":"12","author":"Perea","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of Tau Pathology by the Microglial Fractalkine Receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"135078","DOI":"10.1016\/j.neulet.2020.135078","article-title":"Decreased Cerebrospinal Fluid Neuronal Pentraxin Receptor Is Associated with PET-A\u03b2 Load and Cerebrospinal Fluid A\u03b2 in a Pilot Study of Alzheimer\u2019s Disease","volume":"731","author":"Lim","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/glia.24101","article-title":"Microglia Control Glutamatergic Synapses in the Adult Mouse Hippocampus","volume":"70","author":"Basilico","year":"2022","journal-title":"Glia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fncel.2014.00233","article-title":"CX3CL1 Is Up-Regulated in the Rat Hippocampus during Memory-Associated Synaptic Plasticity","volume":"8","author":"Sheridan","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The Diagnosis of Mild Cognitive Impairment Due to Alzheimer\u2019s Disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association Workgroups on Diagnostic Guidelines for Alzheimer\u2019s Disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The Diagnosis of Dementia Due to Alzheimer\u2019s Disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association Workgroups on Diagnostic Guidelines for Alzheimer\u2019s Disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00702-009-0277-y","article-title":"Neurochemical Dementia Diagnostics: A Simple Algorithm for Interpretation of the CSF Biomarkers","volume":"116","author":"Lewczuk","year":"2009","journal-title":"J. Neural Transm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/JAD-141050","article-title":"Evaluation of Visinin-Like Protein 1 Concentrations in the Cerebrospinal Fluid of Patients with Mild Cognitive Impairment as a Dynamic Biomarker of Alzheimer\u2019s Disease","volume":"43","author":"Mroczko","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13166\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:38:12Z","timestamp":1760128692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":47,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241713166"],"URL":"https:\/\/doi.org\/10.3390\/ijms241713166","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]}}}