{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:40:15Z","timestamp":1774280415017,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting molecular alterations found in intraventricular glioblastoma (IVGBM), which are rare. We present a case series of nine IVGBMs, including molecular alterations found in standardized next-generation sequencing (NGS). We queried the clinical charts, operative notes, pathology reports, and radiographic images of nine patients with histologically confirmed IVGBM treated at our institution (1995\u20132021). Routine NGS was performed on resected tumor tissue of two patients. In this retrospective case series of nine patients (22% female, median (range) age: 64.3 (36\u201385) years), the most common tumor locations were the atrium of the right lateral ventricle (33%) and the septum pellucidum (33%). Five patients had preoperative hydrocephalus, which was managed with intraoperative external ventricular drains in three patients and ventriculoperitoneal shunts in one patient. Hydrocephalus was managed with subtotal resection of a fourth ventricular IVGBM in one patient. The most common surgical approach was transcortical intraventricular (56%). Gross total resection was achieved in two patients, subtotal resection was achieved in six patients, and one patient received a biopsy only. Immunohistochemistry for IDH1 R132H mutant protein was performed in four cases and was negative in all four. Genetic alterations common in glioblastoma, IDH-wildtype, were seen in two cases with available NGS data, including EGFR gene amplification, TERT promoter mutation, PTEN mutation, trisomy of chromosome 7, and monosomy of chromosome 10. Following surgical resection, four patients received adjuvant chemoradiation. Median survival among our cohort was 4.7 months (IQR: 0.9\u20135.8 months). Management of IVGBM is particularly challenging due to their anatomical location, presentation with obstructive hydrocephalus, and fast growth, necessitating prompt intervention. Additional studies are needed to better understand the genetic landscape of IVGBM compared to parenchymal glioblastoma and may further elucidate the unique pathophysiology of these rare tumors.<\/jats:p>","DOI":"10.3390\/ijms241713285","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T01:56:57Z","timestamp":1693187817000},"page":"13285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management and Molecular Characterization of Intraventricular Glioblastoma: A Single-Institution Case Series"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-9662","authenticated-orcid":false,"given":"Megan","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-9068","authenticated-orcid":false,"given":"Joshua","family":"Materi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin K.","family":"Gujar","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-3269","authenticated-orcid":false,"given":"Karisa","family":"Schreck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debraj","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Weingart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-4786","authenticated-orcid":false,"given":"Henry","family":"Brem","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin J.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calixto-Hope G.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Bettegowda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordina","family":"Rincon-Torroella","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11060-011-0738-7","article-title":"Improved survival time trends for glioblastoma using the SEER 17 population-based registries","volume":"107","author":"Koshy","year":"2012","journal-title":"J. Neuro Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom","year":"2022","journal-title":"Neuro Oncol."},{"key":"ref_3","first-page":"3","article-title":"Glioblastoma Multiforme: A Review of its Epidemiology and Pathogenesis through Clinical Presentation and Treatment","volume":"18","author":"Hanif","year":"2017","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2176\/nmc.30.676","article-title":"Tumors at the trigone of the lateral ventricle\u2014Clinical analysis of eight cases","volume":"30","author":"Andoh","year":"1990","journal-title":"Neurol. Med. Chir."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1042-3680(03)00062-7","article-title":"Intraventricular gliomas","volume":"14","author":"Dumont","year":"2003","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.7863\/jum.1997.16.4.285","article-title":"Fetal intraventricular glioblastoma: Ultraso-nographic, magnetic resonance imaging, and pathologic findings","volume":"16","author":"Guibaud","year":"1997","journal-title":"J. Ultrasound Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1259\/bjr\/41022799","article-title":"Case report. Glioblastoma multiforme presenting as a haemorrhagic minimally enhancing mass of the trigone","volume":"82","author":"Hambly","year":"2009","journal-title":"Br. J. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1055\/s-0035-1560048","article-title":"Third Ventricular Glioblastoma Multiforme: Case Report and Literature Review","volume":"76","author":"Hariri","year":"2015","journal-title":"J. Neurol. Surg. Rep."},{"key":"ref_9","first-page":"30","article-title":"Primary intraventricular brain tumor (glioblastoma multiforme) in a child 2 years and 7 months","volume":"2","author":"Karmilov","year":"1978","journal-title":"Pediatr. Akusherstvo I Ginekol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3340\/jkns.2008.44.6.405","article-title":"Intraventricular glioblastoma multiforme with previous history of intracerebral hem-orrhage: A case report","volume":"44","author":"Kim","year":"2008","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/02688690701452776","article-title":"Intraventricular glioblastoma: A paediatric case report","volume":"21","author":"Klein","year":"2007","journal-title":"Br. J. Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00512054","article-title":"Spinal metastases of cerebral glioma. Case report","volume":"19","author":"Koch","year":"1996","journal-title":"Neurosurg. Rev."},{"key":"ref_13","first-page":"1475","article-title":"Well-Circumscribed, Minimally Enhancing Glioblastoma Multiforme of the Trigone: A Case Report and Review of the Literature","volume":"26","author":"Park","year":"2005","journal-title":"Am. J. Neuroradiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.clineuro.2004.12.012","article-title":"Third ventricle glioblastoma. Case report and review of literature","volume":"108","author":"Prieto","year":"2006","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/MPH.0b013e3181e34138","article-title":"Intraventricular glioblastoma multiforme: A pediatric case report","volume":"32","author":"Sarsilmaz","year":"2010","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/02688690701867254","article-title":"Glioblastoma multiforme of the lateral ventricle: Report of nine cases","volume":"22","author":"Secer","year":"2008","journal-title":"Br. J. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1148\/55.6.852","article-title":"Intraventricular glioblastoma multiforme with the pneumographic characteristics of intraventricular epidermoids; a case report with a critical analysis","volume":"55","author":"Shapiro","year":"1950","journal-title":"Radiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e688","DOI":"10.1016\/j.ejrad.2011.06.046","article-title":"Primarily solid intraventricular brain tumors","volume":"81","author":"Fenchel","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.wneu.2015.12.079","article-title":"Intraventricular Glioblastomas","volume":"88","author":"Nsir","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/jamaoncol.2022.2844","article-title":"World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas: A Review","volume":"8","author":"Berger","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.lpm.2018.04.015","article-title":"The 2016 World Health Organization classification of tumours of the central nervous system","volume":"47","author":"Villa","year":"2018","journal-title":"Presse M\u00e9dicale"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jmoldx.2022.08.006","article-title":"Optimizing Insertion and Deletion Detection Using Next-Generation Sequencing in the Clinical Laboratory","volume":"24","author":"Craven","year":"2022","journal-title":"J. Mol. Diagn."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000113784","article-title":"Report on 16 Intraventricular Brain Tumors: A Clinical Study","volume":"2","author":"Lakke","year":"1969","journal-title":"Eur. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature02301","article-title":"Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration","volume":"427","author":"Sanai","year":"2004","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1097\/00007611-196012000-00004","article-title":"Subarachnoid neoplasia: Incidence and problems of diagnosis","volume":"53","author":"Wagner","year":"1960","journal-title":"South. Med. J."},{"key":"ref_27","first-page":"115","article-title":"A survey of cerebrospinal fluid cytology","volume":"34","author":"Rich","year":"1969","journal-title":"Bull. Los Angel. Neurol. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e1763","DOI":"10.1634\/theoncologist.2020-0258","article-title":"Leptomeningeal Spread in Glioblastoma: Diagnostic and Therapeutic Challenges","volume":"25","author":"Birzu","year":"2020","journal-title":"Oncologist"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0090-3019(01)00459-1","article-title":"Spinal leptomeningeal metastasis from cerebral glioblastoma multiforme presenting with radicular pain: Case report and literature review","volume":"56","author":"Alatakis","year":"2001","journal-title":"Surg. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF01105903","article-title":"Third ventricular glioblastoma multiforme: Case report","volume":"20","author":"Lee","year":"1997","journal-title":"Neurosurg. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.wneu.2017.11.106","article-title":"Intraventricular Glioblastoma Multiforme in A Child with L2-Hydroxyglutaric Aciduria","volume":"110","author":"Tan","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02648725.2023.2177034","article-title":"Effects of gross total resection and subtotal resection on survival outcomes of glioma patients: A meta-analysis","volume":"1","author":"Shi","year":"2023","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.2147\/CMAR.S206033","article-title":"High dose vs low dose irradiation of the subventricular zone in patients with glioblastoma\u2014A systematic review and meta-analysis","volume":"11","author":"Kacso","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ijrobp.2013.02.014","article-title":"Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection","volume":"86","author":"Chen","year":"2013","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.radonc.2015.07.032","article-title":"Glioblastoma recurrence patterns near neural stem cell regions","volume":"116","author":"Chen","year":"2015","journal-title":"Radiother. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"790976","DOI":"10.3389\/fonc.2022.790976","article-title":"The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling","volume":"12","author":"Beiriger","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_38","first-page":"1378","article-title":"MR Imaging, MGMT Promoter Methylation Features and Prognostic Analysis of Subventricular Zone Contacting IDH Wild-type Glioblastoma","volume":"19","author":"Liu","year":"2023","journal-title":"Curr. Med. Imaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00381-022-05522-7","article-title":"Clinical features and prognostic significance of tumor involved with sub-ventricular zone in pediatric glioblastoma: A 10-year experience in a single hospital","volume":"38","author":"Jiao","year":"2022","journal-title":"Childs Nerv. Syst."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s12094-020-02448-x","article-title":"Influence of glioblastoma contact with the subventricular zone on survival and recurrence patterns","volume":"23","author":"Comas","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00234-021-02742-7","article-title":"Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma","volume":"64","author":"Schuuring","year":"2022","journal-title":"Neuroradiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1080\/0284186X.2020.1794032","article-title":"Subventricular zone contacting glioblastoma: Tumor size, molecular biological factors and patient survival","volume":"59","author":"Hallaert","year":"2020","journal-title":"Acta Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/OTT.S39429","article-title":"Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: Prognostic significance","volume":"5","author":"Iacoangeli","year":"2012","journal-title":"OncoTargets Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-319-12048-5_2","article-title":"Glioma Biology and Molecular Markers","volume":"Volume 163","author":"Cohen","year":"2015","journal-title":"Current Understanding and Treatment of Gliomas"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The Somatic Genomic Landscape of Glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s40478-021-01304-5","article-title":"IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation","volume":"9","author":"Barresi","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/pjp.2021.106439","article-title":"Molecular classification of glioblastoma based on immunohistochemical expression of EGFR, PDGFRA, NF1, IDH1, p53 and PTEN proteins","volume":"72","author":"Jankowska","year":"2021","journal-title":"Pol. J. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrclinonc.2016.204","article-title":"Advances in the molecular genetics of gliomas\u2014Implications for classification and therapy","volume":"14","author":"Reifenberger","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccr.2005.07.004","article-title":"Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces ma-lignant astrocytoma","volume":"8","author":"Zhu","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40478-020-00951-4","article-title":"Fusions involving BCOR and CREBBP are rare events in infiltrating glioma","volume":"8","author":"Pisapia","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jnen\/nlz011","article-title":"Recurrent EP300-BCOR Fusions in Pediatric Gliomas with Distinct Clinicopathologic Features","volume":"78","author":"Torre","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lobbous, M., Bernstock, J.D., Coffee, E., Friedman, G.K., Metrock, L.K., Chagoya, G., Elsayed, G., Nakano, I., Hackney, J.R., and Korf, B.R. (2020). An Update on Neurofibromatosis Type 1-Associated Gliomas. Cancers, 12.","DOI":"10.3390\/cancers12010114"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e227734","DOI":"10.1136\/bcr-2018-227734","article-title":"Successful treatment of a TSC2-mutant glioblastoma with everolimus","volume":"12","author":"Zureick","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1349-7006.2004.tb02195.x","article-title":"Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage","volume":"95","author":"Yoshida","year":"2004","journal-title":"Cancer Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"vdab050","DOI":"10.1093\/noajnl\/vdab050","article-title":"The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma","volume":"3","author":"Dono","year":"2021","journal-title":"Neuro Oncol. Adv."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Goldstein, M., Gabriel, N., Inkman, M., Zhang, J., and Dahiya, S. (2021). DDRE-32. SETD2 histone methyltransferase mutation status predicts treatment response in glioblastoma: Strategies to overcome chemoresistance. Neuro Oncol., 23.","DOI":"10.1093\/neuonc\/noab196.316"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/neup.12759","article-title":"Intraventricular mucin-producing glioblastoma arising in the septum pellucidum at the frontal horn of the lateral ventricle: A case report","volume":"41","author":"Takigawa","year":"2021","journal-title":"Neuropathology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:39:55Z","timestamp":1760128795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,27]]},"references-count":57,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241713285"],"URL":"https:\/\/doi.org\/10.3390\/ijms241713285","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,27]]}}}