{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:38:10Z","timestamp":1789087090267,"version":"build-2803163510"},"reference-count":185,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been shown in the literature. Given the need for specific biomarkers to improve OP and FM management, common miRNAs might provide promising tracks for future prevention and treatment. The aim of this review is to identify miRNAs described in OP and FM, and dysregulated in the same direction in both pathologies. The PubMed database was searched until June 2023, with a clear mention of OP, FM, and miRNA expression. Clinical trials, case\u2013control, and cross-sectional studies were included. Gray literature was not searched. Out of the 184 miRNAs found in our research, 23 are shared by OP and FM: 7 common miRNAs are dysregulated in the same direction for both pathologies (3 up-, 4 downregulated). The majority of these common miRNAs are involved in the Wnt pathway and the cholinergic system and a possible link has been highlighted. Further studies are needed to explore this relationship. Moreover, the harmonization of technical methods is necessary to confirm miRNAs shared between OP and FM.<\/jats:p>","DOI":"10.3390\/ijms241713513","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:14:41Z","timestamp":1693473281000},"page":"13513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Common miRNAs of Osteoporosis and Fibromyalgia: A Review"],"prefix":"10.3390","volume":"24","author":[{"given":"Soline","family":"Philippe","sequence":"first","affiliation":[{"name":"Platform of Clinical Investigation Department, Inserm CIC 1405, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1264-0465","authenticated-orcid":false,"given":"Marine","family":"Delay","sequence":"additional","affiliation":[{"name":"Platform of Clinical Investigation Department, Inserm CIC 1405, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France"},{"name":"Inserm 1107, Neuro-Dol, University Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-8444","authenticated-orcid":false,"given":"Nicolas","family":"Macian","sequence":"additional","affiliation":[{"name":"Platform of Clinical Investigation Department, Inserm CIC 1405, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Morel","sequence":"additional","affiliation":[{"name":"Platform of Clinical Investigation Department, Inserm CIC 1405, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Eva","family":"Pickering","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","first-page":"737","article-title":"A Case-Control Analysis of the Associations between Fibromyalgia Syndrome and Osteoporosis","volume":"24","author":"Lichtenstein","year":"2022","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S2213-8587(22)00012-2","article-title":"Osteoporosis in Men","volume":"10","author":"Vilaca","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S2213-8587(19)30378-X","article-title":"Reducing the Treatment Gap in Osteoporosis","volume":"8","author":"Compston","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hackshaw, K.V. (2021). The Search for Biomarkers in Fibromyalgia. Diagnostics, 11.","DOI":"10.3390\/diagnostics11020156"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Paola, R.D., Cuzzocrea, S., and Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083891"},{"key":"ref_7","first-page":"1065","article-title":"Fibromyalgia: One Year in Review 2022","volume":"40","author":"Giorgi","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR Revised Recommendations for the Management of Fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/papr.12857","article-title":"Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia","volume":"20","author":"Pickering","year":"2020","journal-title":"Pain Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13063-015-0659-4","article-title":"Fibromyalgia, Milnacipran and Experimental Pain Modulation: Study Protocol for a Double Blind Randomized Controlled Trial","volume":"16","author":"Macian","year":"2015","journal-title":"Trials"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00296-017-3725-2","article-title":"Prevalence of Fibromyalgia in General Population and Patients, a Systematic Review and Meta-Analysis","volume":"37","author":"Heidari","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 Revisions to the 2010\/2011 Fibromyalgia Diagnostic Criteria","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF02563822","article-title":"High Bone Turnover in Fibromyalgia","volume":"46","author":"Appelboom","year":"1990","journal-title":"Calcif. Tissue Int."},{"key":"ref_14","first-page":"2642","article-title":"Fibromyalgia: A Risk Factor for Osteoporosis","volume":"26","author":"Swezey","year":"1999","journal-title":"J. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00296-016-3625-x","article-title":"Bone Mineral Density Is Decreased in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis","volume":"37","author":"Upala","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_16","unstructured":"Mateos Chapparo, F. (2011). Revista de Osteoporosis Y Metabolismo Mineral, Publicaci\u00f3n Oficial SEIOMM."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s10067-017-3683-9","article-title":"Association between Low Bone Mineral Density and Fibromyalgia: A Meta-Analysis","volume":"36","author":"Lee","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1744806918819944","DOI":"10.1177\/1744806918819944","article-title":"Fibromyalgia: Genetics and Epigenetics Insights May Provide the Basis for the Development of Diagnostic Biomarkers","volume":"15","author":"Gerra","year":"2019","journal-title":"Mol. Pain"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pickering, M.-E., Millet, M., Rousseau, J.-C., Croset, M., Szulc, P., Borel, O., Sornay Rendu, E., and Chapurlat, R. (2019). Selected Serum MicroRNA, Abdominal Aortic Calcification and Risk of Osteoporotic Fracture. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216947"},{"key":"ref_20","first-page":"4784","article-title":"Functions of MicroRNAs in Osteoporosis","volume":"21","author":"Ge","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a Big Role in Gene Regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"BSR20180453","DOI":"10.1042\/BSR20180453","article-title":"The Emerging Role of MicroRNAs in Bone Remodeling and Its Therapeutic Implications for Osteoporosis","volume":"38","author":"Feng","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1530\/EJE-16-0583","article-title":"Expression of MicroRNAs That Regulate Bone Turnover in the Serum of Postmenopausal Women with Low Bone Mass and Vertebral Fractures","volume":"176","author":"Yavropoulou","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ko, N.-Y., Chen, L.-R., and Chen, K.-H. (2020). The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144886"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40659-020-00309-z","article-title":"The Roles of MiRNA, LncRNA and CircRNA in the Development of Osteoporosis","volume":"53","author":"Yang","year":"2020","journal-title":"Biol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116068","DOI":"10.1016\/j.bone.2021.116068","article-title":"Osteoporosis, Fracture, Osteoarthritis & Sarcopenia: A Systematic Review of Circulating MicroRNA Association","volume":"152","author":"Jones","year":"2021","journal-title":"Bone"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jpain.2019.12.002","article-title":"Epigenetic and MiRNA Expression Changes in People with Pain: A Systematic Review","volume":"21","author":"Polli","year":"2020","journal-title":"J. Pain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1007\/s12035-016-0235-2","article-title":"Circulating MicroRNA Profiles as Liquid Biopsies for the Characterization and Diagnosis of Fibromyalgia Syndrome","volume":"54","author":"Masotti","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00296-014-3139-3","article-title":"Profile of Circulating MicroRNAs in Fibromyalgia and Their Relation to Symptom Severity: An Exploratory Study","volume":"35","author":"Bjersing","year":"2015","journal-title":"Rheumatol. Int."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Erbacher, C., Vaknine, S., Moshitzky, G., Lobentanzer, S., Eisenberg, L., Evdokimov, D., Sommer, C., Greenberg, D.S., Soreq, H., and \u00dc\u00e7eyler, N. (2022). Distinct CholinomiR Blood Cell Signature as a Potential Modulator of the Cholinergic System in Women with Fibromyalgia Syndrome. Cells, 11.","DOI":"10.3390\/cells11081276"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bjersing, J.L., Lundborg, C., Bokarewa, M.I., and Mannerkorpi, K. (2013). Profile of Cerebrospinal MicroRNAs in Fibromyalgia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078762"},{"key":"ref_32","first-page":"499","article-title":"Gut Microbiome and Serum Metabolome Analyses Identify Molecular Biomarkers and Altered Glutamate Metabolism in Fibromyalgia","volume":"46","author":"Abecia","year":"2019","journal-title":"eBio Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Braun, A., Evdokimov, D., Frank, J., Sommer, C., and \u00dc\u00e7eyler, N. (2020). MiR103a-3p and MiR107 Are Related to Adaptive Coping in a Cluster of Fibromyalgia Patients. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239286"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cerd\u00e1-Olmedo, G., Mena-Dur\u00e1n, A.V., Monsalve, V., and Oltra, E. (2015). Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121903"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/j.pain.0000000000000668","article-title":"Increased Cutaneous MiR-Let-7d Expression Correlates with Small Nerve Fiber Pathology in Patients with Fibromyalgia Syndrome","volume":"157","author":"Leinders","year":"2016","journal-title":"Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115444","DOI":"10.1016\/j.bone.2020.115444","article-title":"MiR-1-3p Regulates the Differentiation of Mesenchymal Stem Cells to Prevent Osteoporosis by Targeting Secreted Frizzled-Related Protein 1","volume":"137","author":"Gu","year":"2020","journal-title":"Bone"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/jog.14307","article-title":"Searching for Valuable Differentially Expressed MiRNAs in Postmenopausal Osteoporosis by RNA Sequencing","volume":"46","author":"Wang","year":"2020","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s11596-020-2306-x","article-title":"Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-Throughput Sequencing","volume":"40","author":"Shao","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"ref_39","first-page":"456","article-title":"MicroRNA-9-5p Promotes Osteoporosis Development through Inhibiting Osteogenesis and Promoting Adipogenesis via Targeting Wnt3a","volume":"23","author":"Zhang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"BSR20191405","DOI":"10.1042\/BSR20191405","article-title":"MiR-128 Inhibits the Osteogenic Differentiation in Osteoporosis by down-Regulating SIRT6 Expression","volume":"39","author":"Zhao","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_41","first-page":"1383","article-title":"Circulating MicroRNAs, MiR-10b-5p, MiR-328-3p, MiR-100 and Let-7, Are Associated with Osteoblast Differentiation in Osteoporosis","volume":"11","author":"Chen","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1210\/jc.2016-2365","article-title":"Circulating MicroRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures","volume":"101","author":"Kocijan","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"115105","DOI":"10.1016\/j.bone.2019.115105","article-title":"Serum MicroRNAs as Novel Biomarkers for Osteoporotic Vertebral Fractures","volume":"130","author":"Zarecki","year":"2020","journal-title":"Bone"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gene.2018.08.074","article-title":"Serum MiRNAs MiR-140-3p and MiR-23b-3p as Potential Biomarkers for Osteoporosis and Osteoporotic Fracture in Postmenopausal Mexican-Mestizo Women","volume":"679","author":"Quiterio","year":"2018","journal-title":"Gene"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e11251","DOI":"10.7717\/peerj.11251","article-title":"Long Non-Coding RNA Taurine Upregulated Gene 1 Is Downregulated in Osteoporosis and Influences the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells","volume":"9","author":"Teng","year":"2021","journal-title":"PeerJ"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/1440-1681.12912","article-title":"MiR-96 Regulates Bone Metabolism by Targeting Osterix","volume":"45","author":"Liu","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1002\/jcb.26907","article-title":"Long Noncoding RNA MALAT1 Promotes Osterix Expression to Regulate Osteogenic Differentiation by Targeting MiRNA-143 in Human Bone Marrow-Derived Mesenchymal Stem Cells","volume":"119","author":"Gao","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/rej.2019.2239","article-title":"MiR-151a-3p Promotes Postmenopausal Osteoporosis by Targeting SOCS5 and Activating JAK2\/STAT3 Signaling","volume":"23","author":"Fu","year":"2020","journal-title":"Rejuvenation Res"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.2147\/CIA.S289613","article-title":"MicroRNA-151a-3p Functions in the Regulation of Osteoclast Differentiation: Significance to Postmenopausal Osteoporosis","volume":"16","author":"He","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.7150\/thno.34493","article-title":"Circulating MiR-338 Cluster Activities on Osteoblast Differentiation: Potential Diagnostic and Therapeutic Targets for Postmenopausal Osteoporosis","volume":"9","author":"Lin","year":"2019","journal-title":"Theranostics"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.ygeno.2021.03.028","article-title":"Comparative Profile of Exosomal MicroRNAs in Postmenopausal Women with Various Bone Mineral Densities by Small RNA Sequencing","volume":"113","author":"Kong","year":"2021","journal-title":"Genomics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bone.2018.11.001","article-title":"Bone and Muscle Specific Circulating MicroRNAs in Postmenopausal Women Based on Osteoporosis and Sarcopenia Status","volume":"120","author":"Chen","year":"2019","journal-title":"Bone"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1210\/clinem\/dgac293","article-title":"Circulating MicroRNAs as Biomarkers of Osteoporosis and Fragility Fractures","volume":"107","author":"Ciuffi","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2147\/CIA.S235197","article-title":"LncRNA GAS5 Is Upregulated in Osteoporosis and Downregulates MiR-21 to Promote Apoptosis of Osteoclasts","volume":"15","author":"Cong","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_55","first-page":"6221","article-title":"Bone Marrow Stem Cells-Derived Exosomes Extracted from Osteoporosis Patients Inhibit Osteogenesis via MicroRNA-21\/SMAD7","volume":"22","author":"Jiang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"15861","DOI":"10.1038\/s41598-017-16113-x","article-title":"MiRNAs in Bone Tissue Correlate to Bone Mineral Density and Circulating MiRNAs Are Gender Independent in Osteoporotic Patients","volume":"7","author":"Kelch","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/1354750X.2014.935957","article-title":"Plasma MiRNA Levels Correlate with Sensitivity to Bone Mineral Density in Postmenopausal Osteoporosis Patients","volume":"19","author":"Li","year":"2014","journal-title":"Biomarkers"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-015-0036-z","article-title":"Serum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture","volume":"97","author":"Panach","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/jbmr.2175","article-title":"Five Freely Circulating MiRNAs and Bone Tissue MiRNAs Are Associated with Osteoporotic Fractures","volume":"29","author":"Seeliger","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"ref_60","first-page":"245","article-title":"The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGF\u03b2-1, Sclerostin, RANKL\/OPG Ratio, and Physical Activity","volume":"51","author":"Suarjana","year":"2019","journal-title":"Acta Med. Indones"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e3216","DOI":"10.1002\/jgm.3216","article-title":"MicroRNA-23 Suppresses Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Targeting the MEF2C-Mediated MAPK Signaling Pathway","volume":"22","author":"Jiang","year":"2020","journal-title":"J. Gene Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/abbs\/gmy006","article-title":"MiRNA-133a Is Involved in the Regulation of Postmenopausal Osteoporosis through Promoting Osteoclast Differentiation","volume":"50","author":"Li","year":"2018","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.12659\/MSM.894323","article-title":"MiR-133 Is Involved in Estrogen Deficiency-Induced Osteoporosis through Modulating Osteogenic Differentiation of Mesenchymal Stem Cells","volume":"21","author":"Lv","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, L., Moore, B.T., Peng, X.-H., Fang, X., Lappe, J.M., Recker, R.R., and Xiao, P. (2012). MiR-133a in Human Circulating Monocytes: A Potential Biomarker Associated with Postmenopausal Osteoporosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034641"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1080\/21655979.2021.1982323","article-title":"LncRNA ROR\/MiR-145-5p Axis Modulates the Osteoblasts Proliferation and Apoptosis in Osteoporosis","volume":"12","author":"Fu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jbmr.3892","article-title":"Circulating MicroRNA-19b Identified From Osteoporotic Vertebral Compression Fracture Patients Increases Bone Formation","volume":"35","author":"Sun","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_67","first-page":"3719919","article-title":"Circulating MicroRNA Expression, Vitamin D, and Hypercortisolism as Predictors of Osteoporosis in Elderly Postmenopausal Women","volume":"2021","author":"Alghadir","year":"2021","journal-title":"Dis. Markers"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00508-016-1141-3","article-title":"MiR-148a the Epigenetic Regulator of Bone Homeostasis Is Increased in Plasma of Osteoporotic Postmenopausal Women","volume":"128","author":"Bedene","year":"2016","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"De-Ugarte, L., Yoskovitz, G., Balcells, S., G\u00fcerri-Fern\u00e1ndez, R., Martinez-Diaz, S., Mellibovsky, L., Urreizti, R., Nogu\u00e9s, X., Grinberg, D., and Garc\u00eda-Giralt, N. (2015). MiRNA Profiling of Whole Trabecular Bone: Identification of Osteoporosis-Related Changes in MiRNAs in Human Hip Bones. BMC Med. Genom., 8.","DOI":"10.1186\/s12920-015-0149-2"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s12276-020-0475-0","article-title":"LncRNA DANCR and MiR-320a Suppressed Osteogenic Differentiation in Osteoporosis by Directly Inhibiting the Wnt\/\u03b2-Catenin Signaling Pathway","volume":"52","author":"Wang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Guo, X., Wei, S., Xu, F., Cai, X., Wang, H., and Ding, R. (2020). MicroRNA-532-5p Is Implicated in the Regulation of Osteoporosis by Forkhead Box O1 and Osteoblast Differentiation. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03317-y"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"111171","DOI":"10.1016\/j.mce.2021.111171","article-title":"Estrogen Promotes LncRNA H19 Expression to Regulate Osteogenic Differentiation of BMSCs and Reduce Osteoporosis via MiR-532-3p\/SIRT1 Axis","volume":"527","author":"Li","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"C57","DOI":"10.1152\/ajpcell.00211.2018","article-title":"Let-7c Regulates Proliferation and Osteodifferentiation of Human Adipose-Derived Mesenchymal Stem Cells under Oxidative Stress by Targeting SCD-1","volume":"316","author":"Zhou","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.027","article-title":"Differentially Circulating MiRNAs after Recent Osteoporotic Fractures Can Influence Osteogenic Differentiation","volume":"79","author":"Weilner","year":"2015","journal-title":"Bone"},{"key":"ref_75","first-page":"1498","article-title":"Systematic Analysis of LncRNAs, MRNAs, CircRNAs and MiRNAs in Patients with Postmenopausal Osteoporosis","volume":"10","author":"Jin","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3892\/mmr.2021.12350","article-title":"LncRNA GAS5 Regulates Angiogenesis by Targeting MiR-10a-3p\/VEGFA in Osteoporosis","volume":"24","author":"Wu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1080\/21655979.2021.1977766","article-title":"MicroRNA-15a-5p Plays a Role in Osteogenic MC3T3-E1 Cells Differentiation by Targeting PDCD4 (Programmed Cell Death 4) via Wnt\/\u03b2-Catenin Dependent Signaling Pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13018-022-03072-x","article-title":"LPS-Inducible CircAtp9b Is Highly Expressed in Osteoporosis and Promotes the Apoptosis of Osteoblasts by Reducing the Formation of Mature MiR-17-92a","volume":"17","author":"Feng","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2021.02.118","article-title":"By Inhibiting ADCY5, MiR-18a-3p Promotes Osteoporosis and Possibly Contributes to Spinal Fracture","volume":"550","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/21655979.2021.2005743","article-title":"MicroRNA MiR-18a-3p Promotes Osteoporosis and Possibly Contributes to Spinal Fracture by Inhibiting the Glutamate AMPA Receptor Subunit 1 Gene (GRIA1)","volume":"13","author":"Zhao","year":"2022","journal-title":"Bioengineered"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbrc.2019.06.083","article-title":"MiRNA-19a-3p Alleviates the Progression of Osteoporosis by Targeting HDAC4 to Promote the Osteogenic Differentiation of HMSCs","volume":"516","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Xiaoling, G., Shuaibin, L., and Kailu, L. (2020). MicroRNA-19b-3p Promotes Cell Proliferation and Osteogenic Differentiation of BMSCs by Interacting with LncRNA H19. BMC Med. Genet., 21.","DOI":"10.1186\/s12881-020-0948-y"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3892\/etm.2021.10124","article-title":"Overexpression of MiRNA-22-3p Attenuates Osteoporosis by Targeting MAPK14","volume":"22","author":"Jia","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1139\/bcb-2017-0243","article-title":"Reduced MiR-144-3p Expression in Serum and Bone Mediates Osteoporosis Pathogenesis by Targeting RANK","volume":"96","author":"Wang","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"151926","DOI":"10.1016\/j.acthis.2022.151926","article-title":"MicroRNA-25-3p Suppresses Osteogenic Differentiation of BMSCs in Patients with Osteoporosis by Targeting ITGB3","volume":"124","author":"Yu","year":"2022","journal-title":"Acta Histochem."},{"key":"ref_86","first-page":"298","article-title":"MiR-26a Regulates the Expression of Serum IGF-1 in Patients with Osteoporosis and Its Effect on Proliferation and Apoptosis of Mouse Chondrocytes","volume":"21","author":"Yuan","year":"2021","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_87","first-page":"73","article-title":"MiRNA-27a-3p Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells through Targeting ATF3","volume":"23","author":"Fu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s10753-021-01583-z","article-title":"Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt\/\u03b2-Catenin Pathway","volume":"45","author":"Wang","year":"2022","journal-title":"Inflammation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3892\/mmr.2020.11246","article-title":"MiR-27a-3p Negatively Regulates Osteogenic Differentiation of MC3T3-E1 Preosteoblasts by Targeting Osterix","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000445621","article-title":"MiR-27a Is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis","volume":"39","author":"You","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1080\/21655979.2021.1967711","article-title":"Long Non-Coding RNA XIST Promotes Osteoporosis by Inhibiting the Differentiation of Bone Marrow Mesenchymal Stem Cell by Sponging MiR-29b-3p That Suppresses Nicotinamide N-Methyltransferase","volume":"12","author":"Yu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"581545","DOI":"10.3389\/fcell.2020.581545","article-title":"Extracellular Vesicle-Encapsulated MiR-29b-3p Released From Bone Marrow-Derived Mesenchymal Stem Cells Underpins Osteogenic Differentiation","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s10020-020-00219-6","article-title":"Long Noncoding RNA HCG18 Inhibits the Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Osteoporosis by Targeting MiR-30a-5p\/NOTCH1 Axis","volume":"26","author":"Che","year":"2020","journal-title":"Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4314\/tjpr.v16i3.20","article-title":"Evaluation of MicroRNA 125b as a Potential Biomarker for Postmenopausal Osteoporosis","volume":"16","author":"Chen","year":"2017","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_95","first-page":"8721","article-title":"LncRNA XIXT Promotes Osteogenic Differentiation of Bone Mesenchymal Stem Cells and Alleviates Osteoporosis Progression by Targeting MiRNA-30a-5p","volume":"23","author":"Zhang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/acel.12484","article-title":"Secreted Microvesicular MiR-31 Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells","volume":"15","author":"Weilner","year":"2016","journal-title":"Aging Cell"},{"key":"ref_97","first-page":"3459","article-title":"CircRNA_0048211 Protects Postmenopausal Osteoporosis through Targeting MiRNA-93-5p to Regulate BMP2","volume":"24","author":"Qiao","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.7754\/Clin.Lab.2019.190327","article-title":"Aberrant Expression of MiR-100 in Plasma of Patients with Osteoporosis and Its Potential Diagnostic Value","volume":"65","author":"Ding","year":"2019","journal-title":"Clin. Lab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s13577-022-00764-8","article-title":"MiR-100-5p Inhibits Osteogenic Differentiation of Human Bone Mesenchymal Stromal Cells by Targeting TMEM135","volume":"35","author":"Wang","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1038\/s41598-018-26525-y","article-title":"Circulating MicroRNAs as Potential Diagnostic Biomarkers for Osteoporosis","volume":"8","author":"Mandourah","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.3892\/mmr.2014.2024","article-title":"MicroRNA-125b Suppresses the Proliferation and Osteogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells","volume":"9","author":"Chen","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2147\/DMSO.S288338","article-title":"Overexpression of MiR125b Promotes Osteoporosis Through MiR-125b-TRAF6 Pathway in Postmenopausal Ovariectomized Rats","volume":"14","author":"Wang","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.reth.2021.09.004","article-title":"Circ_0134944 Inhibits Osteogenesis through MiR-127-5p\/PDX1\/SPHK1 Pathway","volume":"18","author":"Zhang","year":"2021","journal-title":"Regen. Ther."},{"key":"ref_104","first-page":"2393","article-title":"MicroRNA-135a-5p Is Involved in Osteoporosis Progression through Regulation of Osteogenic Differentiation by Targeting RUNX2","volume":"18","author":"Shi","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_105","first-page":"1042","article-title":"Abnormal Expression of MiR-135b-5p in Bone Tissue of Patients with Osteoporosis and Its Role and Mechanism in Osteoporosis Progression","volume":"19","author":"Chen","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Yu, Y., Yao, P., Wang, Z., and Xie, W. (2020). Down-Regulation of FTX Promotes the Differentiation of Osteoclasts in Osteoporosis through the Notch1 Signaling Pathway by Targeting MiR-137. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03458-0"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s13577-020-00352-8","article-title":"MiR-140-3p Aggregates Osteoporosis by Targeting PTEN and Activating PTEN\/PI3K\/AKT Signaling Pathway","volume":"33","author":"Yin","year":"2020","journal-title":"Hum. Cell"},{"key":"ref_108","first-page":"270","article-title":"MiR-144 Promotes the Proliferation and Differentiation of Bone Mesenchymal Stem Cells by Downregulating the Expression of SFRP1","volume":"20","author":"Tang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zhao, S.-L., Wen, Z.-X., Mo, X.-Y., Zhang, X.-Y., Li, H.-N., Cheung, W.-H., Fu, D., Zhang, S.-H., Wan, Y., and Chen, B.-L. (2022). Bone-Metabolism-Related Serum MicroRNAs to Diagnose Osteoporosis in Middle-Aged and Elderly Women. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112872"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5047243","DOI":"10.1155\/2020\/5047243","article-title":"Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study","volume":"2020","author":"Nakashima","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1080\/21655979.2021.2011632","article-title":"LncRNA MIAT Can Regulate the Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Targeting MiR-150-5p","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"108331","DOI":"10.1016\/j.abb.2020.108331","article-title":"Evaluation of Circulating MiRNA-208a-3p, MiRNA-155-5p and MiRNA-637 as Potential Non-Invasive Biomarkers and the Possible Mechanistic Insights into Pre- and Postmenopausal Osteoporotic Females","volume":"684","author":"Ismail","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/kjm2.12423","article-title":"Overexpression of LncRNA-NEF Regulates the MiR-155\/PTEN Axis to Inhibit Adipogenesis and Promote Osteogenesis","volume":"37","author":"Ming","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"19372","DOI":"10.1038\/s41598-021-98789-w","article-title":"Serum MicroRNAs in Osteoporotic Fracture and Osteoarthritis: A Genetic and Functional Study","volume":"11","author":"Pertusa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"dgz300","DOI":"10.1210\/clinem\/dgz300","article-title":"Circulating MiR-181c-5p and MiR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis","volume":"105","author":"Ma","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00223-014-9935-7","article-title":"Analysis of the Bone MicroRNome in Osteoporotic Fractures","volume":"96","author":"Sumillera","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e971","DOI":"10.7717\/peerj.971","article-title":"Identification of MiR-194-5p as a Potential Biomarker for Postmenopausal Osteoporosis","volume":"3","author":"Meng","year":"2015","journal-title":"PeerJ"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"108960","DOI":"10.1016\/j.biopha.2019.108960","article-title":"MicroRNA-200a-3p Accelerates the Progression of Osteoporosis by Targeting Glutaminase to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells","volume":"116","author":"Lv","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_119","first-page":"5804","article-title":"MiR-203 Is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis","volume":"22","author":"Qiao","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_120","first-page":"5098","article-title":"MiR-203 Is Involved in Osteoporosis by Regulating DKK1 and Inhibiting Osteogenic Differentiation of MSCs","volume":"22","author":"Xia","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1002\/jcb.29599","article-title":"Noncoding RNA MiR-205-5p Mediates Osteoporosis Pathogenesis and Osteoblast Differentiation by Regulating RUNX2","volume":"121","author":"Huang","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"113119","DOI":"10.1016\/j.yexcr.2022.113119","article-title":"LncRNA KCNQ1OT1 Promotes Osteogenic Differentiation via MiR-205-5p\/RICTOR Axis","volume":"415","author":"Yang","year":"2022","journal-title":"Exp. Cell Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40001-021-00480-3","article-title":"MiR-206 Regulates the Progression of Osteoporosis via Targeting HDAC4","volume":"26","author":"Lu","year":"2021","journal-title":"Eur. J. Med. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/term.3215","article-title":"The Function and Mechanism of the MiR-210-3p\/KRAS Axis in Bone Marrow-Derived Mesenchymal Stem Cell from Patients with Osteoporosis","volume":"15","author":"Hu","year":"2021","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1080\/21655979.2021.2017626","article-title":"MicroRNA-211-5p Predicts the Progression of Postmenopausal Osteoporosis and Attenuates Osteogenesis by Targeting Dual Specific Phosphatase 6","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"15518","DOI":"10.1002\/jcb.28818","article-title":"Insight into the Possible Role of MiR-214 in Primary Osteoporosis via Osterix","volume":"120","author":"Mohamad","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Yin, Z., Shen, J., Wang, Q., Wen, L., Qu, W., and Zhang, Y. (2022). MiR-215-5p Regulates Osteoporosis Development and Osteogenic Differentiation by Targeting XIAP. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-022-05731-w"},{"key":"ref_128","first-page":"526","article-title":"LncRNA TERC Alleviates the Progression of Osteoporosis by Absorbing MiRNA-217 to Upregulate RUNX2","volume":"24","author":"Gao","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_129","first-page":"949","article-title":"Circ-VANGL1 Promotes the Progression of Osteoporosis by Absorbing MiRNA-217 to Regulate RUNX2 Expression","volume":"23","author":"Yang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"109063","DOI":"10.1016\/j.steroids.2022.109063","article-title":"MiR-221-5p\/Smad3 Axis in Osteoclastogenesis and Its Function: Potential Therapeutic Target for Osteoporosis","volume":"185","author":"Guo","year":"2022","journal-title":"Steroids"},{"key":"ref_131","first-page":"126","article-title":"MicroRNA-221 Is Involved in the Regulation of Osteoporosis through Regulates RUNX2 Protein Expression and Osteoblast Differentiation","volume":"9","author":"Zhang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"119273","DOI":"10.1016\/j.lfs.2021.119273","article-title":"Mechanism of Dexmedetomidine Regulating Osteogenesis-Angiogenesis Coupling through the MiR-361-5p\/VEGFA Axis in Postmenopausal Osteoporosis","volume":"275","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s11626-019-00344-5","article-title":"MiR-363-3p Is Activated by MYB and Regulates Osteoporosis Pathogenesis via PTEN\/PI3K\/AKT Signaling Pathway","volume":"55","author":"Li","year":"2019","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_134","first-page":"7766","article-title":"MiRNA-365a-3p Promotes the Progression of Osteoporosis by Inhibiting Osteogenic Differentiation via Targeting RUNX2","volume":"23","author":"Cheng","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_135","first-page":"7247","article-title":"MiR-373 Promotes the Osteogenic Differentiation of BMSCs from the Estrogen Deficiency Induced Osteoporosis","volume":"23","author":"Li","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_136","first-page":"11043","article-title":"Teriparatide Alleviates Osteoporosis by Promoting Osteogenic Differentiation of HMSCs via MiR-375\/RUNX2 Axis","volume":"23","author":"Lei","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"12482","DOI":"10.1080\/21655979.2021.2006863","article-title":"Knockdown of Long Non-Coding RNA HOTAIR Promotes Bone Marrow Mesenchymal Stem Cell Differentiation by Sponging MicroRNA MiR-378g That Inhibits Nicotinamide N-Methyltransferase","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_138","first-page":"3659","article-title":"MicroRNA-410 Participates in the Pathological Process of Postmenopausal Osteoporosis by Downregulating Bone Morphogenetic Protein-2","volume":"18","author":"Zhang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Cao, Z., Moore, B.T., Wang, Y., Peng, X.-H., Lappe, J.M., Recker, R.R., and Xiao, P. (2014). MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097098"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1016\/j.injury.2022.08.047","article-title":"MicroRNA-455-3p Promotes Osteoblast Differentiation via Targeting HDAC2","volume":"53","author":"Ma","year":"2022","journal-title":"Injury"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"101479","DOI":"10.1016\/j.mcp.2019.101479","article-title":"MiRNA-483-5p Is Involved in the Pathogenesis of Osteoporosis by Promoting Osteoclast Differentiation","volume":"49","author":"Li","year":"2020","journal-title":"Mol. Cell. Probes"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.18632\/aging.202552","article-title":"Silencing of MiR-483-5p Alleviates Postmenopausal Osteoporosis by Targeting SATB2 and PI3K\/AKT Pathway","volume":"13","author":"Zhao","year":"2021","journal-title":"Aging"},{"key":"ref_143","first-page":"1571","article-title":"MiR-483-3p Promotes the Osteogenesis of Human Osteoblasts by Targeting Dikkopf 2 (DKK2) and the Wnt Signaling Pathway","volume":"46","author":"Zhou","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_144","first-page":"4792","article-title":"MiR-485-5p Promotes Osteoporosis via Targeting Osterix","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbrc.2021.05.098","article-title":"MiR-486-3p Promotes Osteogenic Differentiation of BMSC by Targeting CTNNBIP1 and Activating the Wnt\/\u03b2-Catenin Pathway","volume":"566","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1186\/s13018-020-02043-4","article-title":"MicroRNA-497-5p Stimulates Osteoblast Differentiation through HMGA2-Mediated JNK Signaling Pathway","volume":"15","author":"Zhao","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_147","first-page":"7757","article-title":"LncRNA GAS5 Overexpression Alleviates the Development of Osteoporosis through Promoting Osteogenic Differentiation of MSCs via Targeting MicroRNA-498 to Regulate RUNX2","volume":"23","author":"Feng","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/jbmr.2032","article-title":"MiR-503 Regulates Osteoclastogenesis via Targeting RANK","volume":"29","author":"Chen","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jb\/mvaa033","article-title":"MicroRNA-548-3p Overexpression Inhibits Proliferation, Migration and Invasion in Osteoblast-like Cells by Targeting STAT1 and MAFB","volume":"168","author":"Almeraya","year":"2020","journal-title":"J. Biochem."},{"key":"ref_150","first-page":"6791","article-title":"MicroRNA-579-3p Promotes the Progression of Osteoporosis by Inhibiting Osteogenic Differentiation of Mesenchymal Stem Cells through Regulating Sirt1","volume":"23","author":"Luo","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/08923973.2022.2052895","article-title":"MicroRNA-582-3p Regulates Osteoporosis through Regulating Homeobox A10 and Osteoblast Differentiation","volume":"44","author":"Yin","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.2147\/IJGM.S350081","article-title":"Lipopolysaccharide-Induced LncRNA TMC3-AS1 Is Highly Expressed in Osteoporosis and Promotes Osteoblast Apoptosis by Suppressing the Formation of Mature MiR-708","volume":"15","author":"Chen","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/1535370218806828","article-title":"Identification of MiR-708-5p in Peripheral Blood Monocytes: Potential Marker for Postmenopausal Osteoporosis in Mexican-Mestizo Population","volume":"243","author":"Quiterio","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1080\/21655979.2021.2009618","article-title":"MicroRNA MiR-874-3p Inhibits Osteoporosis by Targeting Leptin (LEP)","volume":"12","author":"Mei","year":"2021","journal-title":"Bioengineered"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s13018-019-1399-z","article-title":"The Mechanism of MiR-889 Regulates Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells","volume":"14","author":"Xu","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13018-020-01775-7","article-title":"MiR-920 Promotes Osteogenic Differentiation of Human Bone Mesenchymal Stem Cells by Targeting HOXA7","volume":"15","author":"Zha","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13018-020-02147-x","article-title":"MiR-1249-5p Regulates the Osteogenic Differentiation of ADSCs by Targeting PDX1","volume":"16","author":"Yang","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_158","first-page":"5464","article-title":"Identification of MicroRNAs in Human Circulating Monocytes of Postmenopausal Osteoporotic Mexican-Mestizo Women: A Pilot Study","volume":"14","author":"Quiterio","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/cbin.11585","article-title":"MiRNA-1271-5p Regulates Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting Forkhead Box O1 (FOXO1)","volume":"45","author":"Yang","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_160","first-page":"1","article-title":"MicroRNA-1286 Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells to Promote the Progression of Osteoporosis via Regulating FZD4 Expression","volume":"24","author":"Zhou","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_161","first-page":"4541","article-title":"MicroRNA-1297 Promotes the Progression of Osteoporosis through Regulation of Osteogenesis of Bone Marrow Mesenchymal Stem Cells by Targeting WNT5A","volume":"23","author":"Wang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Du, M., Wu, B., Fan, S., Liu, Y., Ma, X., and Fu, X. (2020). SNHG14 Induces Osteogenic Differentiation of Human Stromal (Mesenchymal) Stem Cells in Vitro by Downregulating MiR-2861. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03506-9"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41598-017-00641-7","article-title":"SNPs in Bone-Related MiRNAs Are Associated with the Osteoporotic Phenotype","volume":"7","author":"Olmos","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1476-4598-9-252","article-title":"MicroRNA Roles in Beta-Catenin Pathway","volume":"9","author":"Huang","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.biopha.2017.05.020","article-title":"Tuning of Major Signaling Networks (TGF-\u03b2, Wnt, Notch and Hedgehog) by MiRNAs in Human Stem Cells Commitment to Different Lineages: Possible Clinical Application","volume":"91","author":"Aval","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"9392132","DOI":"10.1155\/2016\/9392132","article-title":"Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases","volume":"2016","author":"Shi","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Shang, X., B\u00f6ker, K.O., Taheri, S., Hawellek, T., Lehmann, W., and Schilling, A.F. (2021). The Interaction between MicroRNAs and the Wnt\/\u03b2-Catenin Signaling Pathway in Osteoarthritis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189887"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnmol.2014.00009","article-title":"Predicted Overlapping MicroRNA Regulators of Acetylcholine Packaging and Degradation in Neuroinflammation-Related Disorders","volume":"7","author":"Nadorp","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt Signal Transduction Pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00198-022-06523-7","article-title":"Role of Wnt Signaling and Sclerostin in Bone and as Therapeutic Targets in Skeletal Disorders","volume":"34","author":"Marini","year":"2023","journal-title":"Osteoporos. Int."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Gao, Y., Patil, S., and Jia, J. (2021). The Development of Molecular Biology of Osteoporosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158182"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bone.2015.02.009","article-title":"Wnt Signaling in Bone and Muscle","volume":"80","author":"Rudnicki","year":"2015","journal-title":"Bone"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"822382","DOI":"10.3389\/fpsyt.2022.822382","article-title":"Aberrations in the Cross-Talks Among Redox, Nuclear Factor-\u03baB, and Wnt\/\u03b2-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome","volume":"13","author":"Maes","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Cordaro, M., Siracusa, R., Impellizzeri, D., Trovato Salinaro, A., Scuto, M., Ontario, M.L., Crea, R., Cuzzocrea, S., and Di Paola, R. (2021). Wnt\/\u03b2-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox\u00ae. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111683"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"ref_176","first-page":"3082","article-title":"Effect of Wnt Signaling Pathway on Pathogenesis and Intervention of Neuropathic Pain","volume":"16","author":"Zhao","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neubiorev.2021.10.021","article-title":"The Role of the Vagus Nerve in Fibromyalgia Syndrome","volume":"131","author":"Martins","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1217717","DOI":"10.1155\/2022\/1217717","article-title":"Analgesic Medication in Fibromyalgia Patients: A Cross-Sectional Study","volume":"2022","author":"Aster","year":"2022","journal-title":"Pain Res. Manag."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"106405","DOI":"10.1016\/j.intimp.2020.106405","article-title":"Cholinergic Control of Bone Development and Beyond","volume":"83","author":"Spieker","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_180","first-page":"124","article-title":"Cholinergic Regulation of Bone","volume":"13","author":"Eimar","year":"2013","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"111575","DOI":"10.1016\/j.celrep.2022.111575","article-title":"Cholinergic Receptor-Wnt Pathway Controls Immune Activation by Sensing Intestinal Dysfunction","volume":"41","author":"Ren","year":"2022","journal-title":"Cell Rep."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2018.04.017","article-title":"Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection","volume":"48","author":"Labed","year":"2018","journal-title":"Immunity"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Takahashi, T., Shiraishi, A., and Murata, J. (2018). The Coordinated Activities of NAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030738"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.crvi.2016.12.001","article-title":"The microRNAs as biomarkers: What prospects?","volume":"340","author":"Zendjabil","year":"2017","journal-title":"C. R. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13513\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:43:47Z","timestamp":1760129027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/17\/13513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":185,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241713513"],"URL":"https:\/\/doi.org\/10.3390\/ijms241713513","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}