{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:08:18Z","timestamp":1789852098774,"version":"4.0.1"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1117302B"],"award-info":[{"award-number":["TCVGH-1117302B"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1127318C"],"award-info":[{"award-number":["TCVGH-1127318C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["NSC 112-2314-B-075B-018-"],"award-info":[{"award-number":["NSC 112-2314-B-075B-018-"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH112-004"],"award-info":[{"award-number":["KSVGH112-004"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Council, Taiwan","award":["TCVGH-1117302B"],"award-info":[{"award-number":["TCVGH-1117302B"]}]},{"name":"National Science and Technology Council, Taiwan","award":["TCVGH-1127318C"],"award-info":[{"award-number":["TCVGH-1127318C"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSC 112-2314-B-075B-018-"],"award-info":[{"award-number":["NSC 112-2314-B-075B-018-"]}]},{"name":"National Science and Technology Council, Taiwan","award":["KSVGH112-004"],"award-info":[{"award-number":["KSVGH112-004"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["TCVGH-1117302B"],"award-info":[{"award-number":["TCVGH-1117302B"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["TCVGH-1127318C"],"award-info":[{"award-number":["TCVGH-1127318C"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["NSC 112-2314-B-075B-018-"],"award-info":[{"award-number":["NSC 112-2314-B-075B-018-"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["KSVGH112-004"],"award-info":[{"award-number":["KSVGH112-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic autoimmune skin disease with a significant impact on quality of life and potential for severe comorbidities. Inflammation in the skin is induced by immune cells that overexpress pro-inflammatory cytokines, with the Th17 cell playing a crucial role. NLRP3 inflammasome activation is associated with inflammatory diseases and abnormal T cell differentiation. 3H-1,2-dithiole-3-thione (D3T), isolated from cruciferous vegetables, has anti-inflammatory effects and inhibits Th17 differentiation. This study aimed to investigate how D3T reduces skin inflammation and modulates Th17 cell differentiation by inhibiting NLRP3 inflammasome activation. In an imiquimod-induced psoriasis mouse model, D3T treatment demonstrated significant reductions in ear thickness, skin redness, and scaling compared to a control group. Our study also observed decreased expression of ki-67, NLRP3 inflammasome, and cleaved caspase-1 in skin samples, reduced levels of IL-6 and IL-17A in serum samples, and inhibition of Th17 differentiation after D3T application. D3T could also inhibit the expression of NLRP3, caspase-1, and IL-1\u03b2 in TNF-\u03b1 stimulated HaCaT cells. The mechanical study also revealed that D3T could inhibit NLRP3 inflammasome activation by inhibiting the JNK pathway in HaCaT cells. These results indicate that targeting NLRP3 inflammasome activation is a promising strategy in the treatment of psoriasis.<\/jats:p>","DOI":"10.3390\/ijms241713528","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:14:41Z","timestamp":1693473281000},"page":"13528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of NLRP3 Inflammasome Activation by 3H-1,2-Dithiole-3-Thione: A Potential Therapeutic Approach for Psoriasis Treatment"],"prefix":"10.3390","volume":"24","author":[{"given":"Meng-Chieh","family":"Shih","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-0729","authenticated-orcid":false,"given":"Chia-Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Children\u2019s Medical Center, Taichung Veterans General Hospital, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-3656","authenticated-orcid":false,"given":"En-Chih","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, MacKay Medical College, New Taipei City 252, Taiwan"},{"name":"Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yang","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Taichung Veterans General Hospital, Taichung 407, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Integrated Care Center of Psoriatic Disease, Taichung Veterans General Hospital, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-5762","authenticated-orcid":false,"given":"Ling-Jung","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"The Doctoral Program of Clinical and Experimental Medicine, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0944-7473","authenticated-orcid":false,"given":"Ting-Yu","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-0613","authenticated-orcid":false,"given":"Sheng-Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Integrated Care Center of Psoriatic Disease, Taichung Veterans General Hospital, Taichung 407, Taiwan"},{"name":"Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan"},{"name":"Institute of Biomedical Sciences, College of Life Sciences, National Chung Hsing University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J. 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