{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:39:53Z","timestamp":1786991993659,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM","award":["QYZD20220002"],"award-info":[{"award-number":["QYZD20220002"]}]},{"name":"Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM","award":["82071357"],"award-info":[{"award-number":["82071357"]}]},{"name":"Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM","award":["2019YFA0405600"],"award-info":[{"award-number":["2019YFA0405600"]}]},{"name":"Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM","award":["202004j07020020"],"award-info":[{"award-number":["202004j07020020"]}]},{"name":"Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM","award":["2022AH051258"],"award-info":[{"award-number":["2022AH051258"]}]},{"name":"National Natural Science Foundation of China","award":["QYZD20220002"],"award-info":[{"award-number":["QYZD20220002"]}]},{"name":"National Natural Science Foundation of China","award":["82071357"],"award-info":[{"award-number":["82071357"]}]},{"name":"National Natural Science Foundation of China","award":["2019YFA0405600"],"award-info":[{"award-number":["2019YFA0405600"]}]},{"name":"National Natural Science Foundation of China","award":["202004j07020020"],"award-info":[{"award-number":["202004j07020020"]}]},{"name":"National Natural Science Foundation of China","award":["2022AH051258"],"award-info":[{"award-number":["2022AH051258"]}]},{"name":"Ministry of Science and Technology of China","award":["QYZD20220002"],"award-info":[{"award-number":["QYZD20220002"]}]},{"name":"Ministry of Science and Technology of China","award":["82071357"],"award-info":[{"award-number":["82071357"]}]},{"name":"Ministry of Science and Technology of China","award":["2019YFA0405600"],"award-info":[{"award-number":["2019YFA0405600"]}]},{"name":"Ministry of Science and Technology of China","award":["202004j07020020"],"award-info":[{"award-number":["202004j07020020"]}]},{"name":"Ministry of Science and Technology of China","award":["2022AH051258"],"award-info":[{"award-number":["2022AH051258"]}]},{"name":"Key Research and Development Plan Program of Anhui Province","award":["QYZD20220002"],"award-info":[{"award-number":["QYZD20220002"]}]},{"name":"Key Research and Development Plan Program of Anhui Province","award":["82071357"],"award-info":[{"award-number":["82071357"]}]},{"name":"Key Research and Development Plan Program of Anhui Province","award":["2019YFA0405600"],"award-info":[{"award-number":["2019YFA0405600"]}]},{"name":"Key Research and Development Plan Program of Anhui Province","award":["202004j07020020"],"award-info":[{"award-number":["202004j07020020"]}]},{"name":"Key Research and Development Plan Program of Anhui Province","award":["2022AH051258"],"award-info":[{"award-number":["2022AH051258"]}]},{"name":"Anhui Provincial Scientific Research Project of higher education","award":["QYZD20220002"],"award-info":[{"award-number":["QYZD20220002"]}]},{"name":"Anhui Provincial Scientific Research Project of higher education","award":["82071357"],"award-info":[{"award-number":["82071357"]}]},{"name":"Anhui Provincial Scientific Research Project of higher education","award":["2019YFA0405600"],"award-info":[{"award-number":["2019YFA0405600"]}]},{"name":"Anhui Provincial Scientific Research Project of higher education","award":["202004j07020020"],"award-info":[{"award-number":["202004j07020020"]}]},{"name":"Anhui Provincial Scientific Research Project of higher education","award":["2022AH051258"],"award-info":[{"award-number":["2022AH051258"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>CHD7, an encoding ATP-dependent chromodomain helicase DNA-binding protein 7, has been identified as the causative gene involved in CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia choanae, Retardation of growth and\/or development, Genital abnormalities and Ear abnormalities). Although studies in rodent models have expanded our understanding of CHD7, its role in oligodendrocyte (OL) differentiation and myelination in zebrafish is still unclear. In this study, we generated a chd7-knockout strain with CRISPR\/Cas9 in zebrafish. We observed that knockout (KO) of chd7 intensely impeded the oligodendrocyte progenitor cells\u2019 (OPCs) migration and myelin formation due to massive expression of chd7 in oilg2+ cells, which might provoke upregulation of the MAPK signal pathway. Thus, our study demonstrates that chd7 is critical to oligodendrocyte migration and myelination during early development in zebrafish and describes a mechanism potentially associated with CHARGE syndrome.<\/jats:p>","DOI":"10.3390\/ijms241713535","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:14:41Z","timestamp":1693473281000},"page":"13535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deletion of the chd7 Hinders Oligodendrocyte Progenitor Cell Development and Myelination in Zebrafish"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8743-8475","authenticated-orcid":false,"given":"Lingyu","family":"Shi","sequence":"first","affiliation":[{"name":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-5272","authenticated-orcid":false,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China"},{"name":"Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/500273","article-title":"Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation","volume":"78","author":"Lalani","year":"2006","journal-title":"Am. 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