{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:28:33Z","timestamp":1790436513460,"version":"4.1.0"},"reference-count":260,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-EGA-10"],"award-info":[{"award-number":["TKP2021-EGA-10"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["RRF-2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00012"]}]},{"name":"National Laboratory on Human Reproduction","award":["TKP2021-EGA-10"],"award-info":[{"award-number":["TKP2021-EGA-10"]}]},{"name":"National Laboratory on Human Reproduction","award":["RRF-2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for\/contribute to the long-term consequences.<\/jats:p>","DOI":"10.3390\/ijms241713564","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:19:39Z","timestamp":1693556379000},"page":"13564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Long-Term Effects of ART on the Health of the Offspring"],"prefix":"10.3390","volume":"24","author":[{"given":"Hamid","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, P\u00e9cs University, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-5961","authenticated-orcid":false,"given":"Leili","family":"Aghebati-Maleki","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"},{"name":"Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Rashidiani","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical School, P\u00e9cs University, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timea","family":"Csabai","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"Endocrine Studies, Centre of Excellence, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory of Human Reproduction, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-5601","authenticated-orcid":false,"given":"Obodo Basil","family":"Nnaemeka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Faculty of Health Sciences, P\u00e9cs University, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-9667","authenticated-orcid":false,"given":"Julia","family":"Szekeres-Bartho","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"Endocrine Studies, Centre of Excellence, P\u00e9cs University, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory of Human Reproduction, 7624 P\u00e9cs, Hungary"},{"name":"MTA\u2014PTE Human Reproduction Research Group, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.rbmo.2013.10.013","article-title":"Health outcomes of children born after IVF\/ICSI: A review of current expert opinion and literature","volume":"28","author":"Fauser","year":"2014","journal-title":"Reprod. 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