{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:33:54Z","timestamp":1784547234822,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province","award":["2022A1515011140"],"award-info":[{"award-number":["2022A1515011140"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["202201020502"],"award-info":[{"award-number":["202201020502"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["81671264"],"award-info":[{"award-number":["81671264"]}]},{"name":"Guangzhou Municipal Science and Technology Planning Project","award":["2022A1515011140"],"award-info":[{"award-number":["2022A1515011140"]}]},{"name":"Guangzhou Municipal Science and Technology Planning Project","award":["202201020502"],"award-info":[{"award-number":["202201020502"]}]},{"name":"Guangzhou Municipal Science and Technology Planning Project","award":["81671264"],"award-info":[{"award-number":["81671264"]}]},{"name":"National Natural Science Foundation of China","award":["2022A1515011140"],"award-info":[{"award-number":["2022A1515011140"]}]},{"name":"National Natural Science Foundation of China","award":["202201020502"],"award-info":[{"award-number":["202201020502"]}]},{"name":"National Natural Science Foundation of China","award":["81671264"],"award-info":[{"award-number":["81671264"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It is reported that retinal abnormities are related to Alzheimer\u2019s disease (AD) in patients and animal models. However, it is unclear whether the retinal abnormities appear in the mouse model of sporadic Alzheimer\u2019s disease (sAD) induced by acrolein. We investigated the alterations of retinal function and structure, the levels of \u03b2-amyloid (A\u03b2) and phosphorylated Tau (p-Tau) in the retina, and the changes in the retinal vascular system in this mouse model. We demonstrated that the levels of A\u03b2 and p-Tau were increased in the retinas of mice from the acrolein groups. Subsequently, a decreased amplitudes of b-waves in the scotopic and photopic electroretinogram (ERG), decreased thicknesses of the retinal nerve fiber layer (RNFL) in the retina, and slight retinal venous beading were found in the mice induced by acrolein. We propose that sAD mice induced by acrolein showed abnormalities in the retina, which may provide a valuable reference for the study of the retina in sAD.<\/jats:p>","DOI":"10.3390\/ijms241713576","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:19:39Z","timestamp":1693556379000},"page":"13576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acrolein Induces Retinal Abnormalities of Alzheimer\u2019s Disease in Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Shuyi","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan 528000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangjian","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Institute for Vision and Eye Research, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbiao","family":"Pi","sequence":"additional","affiliation":[{"name":"School of Medicine, Sun Yat-sen University, Shenzhen 528406, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyou","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2021). 2021 Alzheimer\u2019s disease facts and figures. 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