{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:29:43Z","timestamp":1792096183695,"version":"4.4.0"},"reference-count":72,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin Province Innovative and Entrepreneurial Talent Funding Project","award":["2023RY16"],"award-info":[{"award-number":["2023RY16"]}]},{"name":"Jilin Province Innovative and Entrepreneurial Talent Funding Project","award":["2020-12M-5-001"],"award-info":[{"award-number":["2020-12M-5-001"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2023RY16"],"award-info":[{"award-number":["2023RY16"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2020-12M-5-001"],"award-info":[{"award-number":["2020-12M-5-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Non-alcoholic steatohepatitis (NASH) is one of the most prevalent diseases worldwide; it is characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Here, a Western diet combined with low-dose weekly carbon tetrachloride was fed to C57BL\/6J mice for 12 weeks to build a NASH model to investigate the attenuating effects and possible mechanisms of Lactiplantibacillus plantarum LPJZ-658. Hepatic pathology, lipid profiles, and gene expression were assessed. The metabolomic profiling of the serum was performed. The composition structure of gut microbiota was profiled using 16s rRNA sequencing. The results show that LPJZ-658 treatment significantly attenuated liver injury, steatosis, fibrosis, and inflammation in NASH mice. Metabolic pathway analysis revealed that several pathways, such as purine metabolism, glycerophospholipid metabolism, linoleic acid metabolism, and primary bile acid biosynthesis, were associated with NASH. Notably, we found that treatment with LPJZ-658 regulated the levels of bile acids (BAs) in the serum. Moreover, LPJZ-658 restored NASH-induced gut microbiota dysbiosis. The correlation analysis deduced obvious interactions between BAs and gut microbiota. The current study indicates that LPJZ-658 supplementation protects against NASH progression, which is accompanied by alternating BA metabolic and modulating gut microbiota.<\/jats:p>","DOI":"10.3390\/ijms241813997","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:34:12Z","timestamp":1694554452000},"page":"13997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lactiplantibacillus plantarum LPJZ-658 Improves Non-Alcoholic Steatohepatitis by Modulating Bile Acid Metabolism and Gut Microbiota in Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Liming","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liquan","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Future Technology, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Li","sequence":"additional","affiliation":[{"name":"Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-1859","authenticated-orcid":false,"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-2573","authenticated-orcid":false,"given":"Cuiqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2001-12925","article-title":"Nonalcoholic steatohepatitis: Definition and pathology","volume":"21","author":"Brunt","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of Nonalcoholic Steatohepatitis","volume":"150","author":"Machado","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/hep4.1127","article-title":"Targeting bile acids and lipotoxicity for NASH treatment","volume":"1","author":"Chiang","year":"2017","journal-title":"Hepatol. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Forlano, R., Sivakumar, M., Mullish, B.H., and Manousou, P. (2022). Gut Microbiota-A Future Therapeutic Target for People with Non-Alcoholic Fatty Liver Disease: A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158307"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: Metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lin, H.Y., Yang, Y.L., Wang, P.W., Wang, F.S., and Huang, Y.H. (2020). The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond. Cells, 9.","DOI":"10.3390\/cells9041041"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41575-021-00502-9","article-title":"Metabolomics and lipidomics in NAFLD: Biomarkers and non-invasive diagnostic tests","volume":"18","author":"Masoodi","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.jhep.2017.11.025","article-title":"Role of bile acids in the gut-liver axis","volume":"68","author":"Schneider","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.3748\/wjg.v27.i22.3010","article-title":"Role of bile acids in liver diseases mediated by the gut microbiome","volume":"27","author":"Shao","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/MEG.0b013e328345c8c7","article-title":"Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis","volume":"23","author":"Dasarathy","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/hep.31604","article-title":"Hepatocyte Nuclear Factor 4alpha Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice)","volume":"73","author":"Xu","year":"2021","journal-title":"Hepatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100222","DOI":"10.1016\/j.jhepr.2020.100222","article-title":"NASH-related increases in plasma bile acid levels depend on insulin resistance","volume":"3","author":"Grzych","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrd.2017.60","article-title":"Liver disease: Conscious uncoupling in NASH","volume":"16","author":"Villanueva","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biopha.2017.03.039","article-title":"Breviscapine confers a neuroprotective efficacy against transient focal cerebral ischemia by attenuating neuronal and astrocytic autophagy in the penumbra","volume":"90","author":"Pengyue","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3945\/jn.108.101808","article-title":"Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats","volume":"139","author":"Esposito","year":"2009","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mohamad Nor, M.H., Ayob, N., Mokhtar, N.M., Raja Ali, R.A., Tan, G.C., Wong, Z., Shafiee, N.H., Wong, Y.P., Mustangin, M., and Nawawi, K.N.M. (2021). The Effect of Probiotics (MCP((R)) BCMC((R)) Strains) on Hepatic Steatosis, Small Intestinal Mucosal Immune Function, and Intestinal Barrier in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients, 13.","DOI":"10.3390\/nu13093192"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1017\/S0007114517000204","article-title":"Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: A pilot, randomised, double-blind, placebo-controlled, clinical trial","volume":"117","author":"Mofidi","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1007\/s00253-014-5752-1","article-title":"Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice","volume":"98","author":"Xin","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.molmet.2019.08.020","article-title":"Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice","volume":"29","author":"Zhao","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.toxlet.2015.03.002","article-title":"Inhibition of miR122a by Lactobacillus rhamnosus GG culture supernatant increases intestinal occludin expression and protects mice from alcoholic liver disease","volume":"234","author":"Zhao","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jnutbio.2014.10.016","article-title":"Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease","volume":"26","author":"Zhang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/pr501121c","article-title":"Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice","volume":"14","author":"Shi","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Deng, L., Liu, L., Fu, T., Li, C., Jin, N., Zhang, H., Li, C., Liu, Y., and Zhao, C. (2023). Genome Sequence and Evaluation of Safety and Probiotic Potential of Lactiplantibacillus plantarum LPJZ-658. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061620"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Liu, L., Li, L., Li, C., Wang, H., Zhang, X., Ren, Q., Zhang, H., Jin, N., Li, C., and Zhao, C. (2023). Effects of Lactiplantibacillus plantarum LPJZ-658 Supplementation on the Production, Meat Quality, Intestinal Morphology, and Cecal Microbiota of Broilers Chickens. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061549"},{"key":"ref_28","first-page":"447","article-title":"Non-alcoholic fatty liver disease: Epidemiology, clinical course, investigation, and treatment","volume":"111","author":"Weiss","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00018-016-2161-x","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"73","author":"Liu","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Castillo, V., Figueroa, F., Gonzalez-Pizarro, K., Jopia, P., and Ibacache-Quiroga, C. (2021). Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review. Foods, 10.","DOI":"10.3390\/foods10081719"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12967-022-03543-z","article-title":"Modulation of hepatic stellate cells by Mutaflor((R)) probiotic in non-alcoholic fatty liver disease management","volume":"20","author":"Hany","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1475-2859-13-S1-S7","article-title":"Towards a better understanding of Lactobacillus rhamnosus GG-host interactions","volume":"13","author":"Segers","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/hep.30975","article-title":"Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice","volume":"71","author":"Liu","year":"2020","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/qjmed\/hcp158","article-title":"Pathogenesis of non-alcoholic fatty liver disease","volume":"103","author":"Dowman","year":"2010","journal-title":"QJM Int. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.lfs.2014.09.027","article-title":"Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice","volume":"118","author":"Lee","year":"2014","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcmgh.2019.04.007","article-title":"Metabolic Targets in Nonalcoholic Fatty Liver Disease","volume":"8","author":"Esler","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_37","first-page":"e00029","article-title":"Nonalcoholic fatty liver disease: Pathogenesis and intervention","volume":"2","author":"Hao","year":"2023","journal-title":"Precis. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41419-022-04812-x","article-title":"B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.fshw.2022.10.026","article-title":"High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2","volume":"12","author":"Gao","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jhep.2023.01.024","article-title":"An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease","volume":"78","author":"Lee","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/s42255-023-00801-2","article-title":"Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice","volume":"5","author":"Weiss","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41467-018-03072-8","article-title":"Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195\/miR4668 maturation","volume":"9","author":"Guo","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbadis.2016.11.029","article-title":"The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer","volume":"1863","author":"Iizuka","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jhep.2008.05.025","article-title":"Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells","volume":"49","author":"Ma","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/jhep.2003.50048","article-title":"Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease","volume":"37","author":"Li","year":"2003","journal-title":"Hepatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1572-0241.2007.01774.x","article-title":"Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis","volume":"103","author":"Wieckowska","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/s-0043-118666","article-title":"Pivotal Role of TNF-alpha in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model","volume":"50","author":"Kakino","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"40161","DOI":"10.1074\/jbc.M112.417014","article-title":"Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production","volume":"287","author":"Landes","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"102585","DOI":"10.1016\/j.psj.2023.102585","article-title":"Combined effects of sodium butyrate and xylo-oligosaccharide on growth performance, anti-inflammatory and antioxidant capacity, intestinal morphology and microbiota of broilers at early stage","volume":"102","author":"Deng","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00535-012-0527-x","article-title":"Inflammation and fibrogenesis in steatohepatitis","volume":"47","author":"Fujii","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-0041-1731707","article-title":"Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities","volume":"41","author":"Radun","year":"2021","journal-title":"Semin. Liver Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1136\/gutjnl-2020-323202","article-title":"From the origin of NASH to the future of metabolic fatty liver disease","volume":"70","author":"Geier","year":"2021","journal-title":"Gut"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s42255-019-0074-3","article-title":"Metabolic Messengers: Fibroblast growth factor 15\/19","volume":"1","author":"Gadaleta","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1194\/jlr.R054114","article-title":"Intestinal transport and metabolism of bile acids","volume":"56","author":"Dawson","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gottlieb, A., and Canbay, A. (2019). Why Bile Acids Are So Important in Non-Alcoholic Fatty Liver Disease (NAFLD) Progression. Cells, 8.","DOI":"10.3390\/cells8111358"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/hep.29359","article-title":"The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids","volume":"67","author":"Puri","year":"2018","journal-title":"Hepatology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3748\/wjg.15.1677","article-title":"Bile-acid-induced cell injury and protection","volume":"15","author":"Perez","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mendez-Sanchez, N., Cruz-Ramon, V.C., Ramirez-Perez, O.L., Hwang, J.P., Barranco-Fragoso, B., and Cordova-Gallardo, J. (2018). New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072034"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: Interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.21037\/hbsn.2019.09.07","article-title":"Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model","volume":"9","author":"Jena","year":"2020","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1017\/S1466252316000153","article-title":"Bacterial bile salt hydrolase: An intestinal microbiome target for enhanced animal health","volume":"17","author":"Geng","year":"2016","journal-title":"Anim. Health Res. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome","volume":"105","author":"Jones","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1039\/D1FO00560J","article-title":"Beneficial impacts of fermented celery (Apium graveolens L.) juice on obesity prevention and gut microbiota modulation in high-fat diet fed mice","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e1800612","DOI":"10.1002\/mnfr.201800612","article-title":"SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis","volume":"63","author":"Chen","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Claesson, M.J., O\u2019Sullivan, O., Wang, Q., Nikkila, J., Marchesi, J.R., Smidt, H., de Vos, W.M., Ross, R.P., and O\u2019Toole, P.W. (2009). Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006669"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/13997\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:49:30Z","timestamp":1760129370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/13997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":72,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241813997"],"URL":"https:\/\/doi.org\/10.3390\/ijms241813997","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,12]]}}}