{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:08Z","timestamp":1789425428773,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bicuspid aortic valve (BAV) is the most commonly encountered congenital malformation in the pediatric population, associated with aortic leaflet degeneration and aortopathy. However, studies on BAV and its complications in children are limited. We present the case of a 16-year-old with type 1B BAV with a raphe with fusion between the right and non-coronary cusps who exhibited severe aortic stenosis, regurgitation, and progressive dilatation of the ascending aorta. Surgical intervention, including aortic valve and aortic root replacement, was performed due to the patient\u2019s deteriorating condition. Histopathological examination revealed degenerative changes and calcifications in the aortic valve and mucoid fibrosis in the ascending aorta. The results are consistent with BAV patients being predisposed to aortic stenosis and regurgitation due to increased mechanical stress and hemodynamic abnormalities. Although more common in adults and a rare complication in pediatric patients, calcification was previously observed concurrently with rapid valve degeneration in our daily practice. Further studies are needed to improve our understanding of the mechanisms underlying BAV-related complications and refine treatment strategies for pediatric patients.<\/jats:p>","DOI":"10.3390\/ijms241814027","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:08:21Z","timestamp":1694581701000},"page":"14027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Importance of Aortic Valve Bicuspid Phenotype in Valvular Evolution in Pediatric Patients: A Case Report and Literature Mini-Review"],"prefix":"10.3390","volume":"24","author":[{"given":"Amalia","family":"F\u0103g\u0103r\u0103\u0219an","sequence":"first","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540136 Targu Mures, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-5118","authenticated-orcid":false,"given":"Simona","family":"Gurzu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania"},{"name":"Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin-Bogdan","family":"Satala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania"},{"name":"Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1521-3503","authenticated-orcid":false,"given":"Asmaa Carla","family":"Hag\u0103u","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, 540136 Targu Mures, Romania"},{"name":"Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Spaziani, G., Girolami, F., Arcieri, L., Calabri, G.B., Porcedda, G., Di Filippo, C., Surace, F.C., Pozzi, M., and Favilli, S. 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