{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:54:40Z","timestamp":1791374080777,"version":"4.3.1"},"reference-count":42,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["2023R1A2C1005434"],"award-info":[{"award-number":["2023R1A2C1005434"]}]},{"name":"National Research Foundation of Korea","award":["K2309251"],"award-info":[{"award-number":["K2309251"]}]},{"name":"Korea University Medical College","award":["2023R1A2C1005434"],"award-info":[{"award-number":["2023R1A2C1005434"]}]},{"name":"Korea University Medical College","award":["K2309251"],"award-info":[{"award-number":["K2309251"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and angiogenesis of ovarian cancer. In this study, we analyzed the conditioned media in SKOV3 ovarian cancer cell lines treated with catecholamines to identify secreted proteins responding to chronic stress. Here, we observed that epinephrine and norepinephrine enhanced the secretion and mRNA expression of CXC-chemokines (CXCL1, 2, 3, and 8). Neutralizing antibodies to CXCL8 and CXCL8 receptor (CXCR2) inhibitors significantly reduced catecholamine-mediated invasion of SKOV3 cells. Finally, we found that the concentration of CXCL1 and CXCL8 in the plasma of ovarian cancer patients increased with stage progression. Taken together, these findings suggest that stress-related catecholamines may influence ovarian cancer progression through the secretion of CXC-chemokines.<\/jats:p>","DOI":"10.3390\/ijms241814104","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:54:13Z","timestamp":1694746453000},"page":"14104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines"],"prefix":"10.3390","volume":"24","author":[{"given":"Hyun Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea"},{"name":"Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea"},{"name":"Antibody Research Institute, Kookmin University, Seoul 02707, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-1697","authenticated-orcid":false,"given":"Ha Kyun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yul Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-3184","authenticated-orcid":false,"given":"Kyun","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea"},{"name":"Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea"},{"name":"Antibody Research Institute, Kookmin University, Seoul 02707, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/0033-2909.130.4.601","article-title":"Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry","volume":"130","author":"Segerstrom","year":"2004","journal-title":"Psychol. 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