{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:42:40Z","timestamp":1794336160131,"version":"4.9.0"},"reference-count":150,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}]},{"name":"National Natural Science Foundation of China","award":["81271410"],"award-info":[{"award-number":["81271410"]}]},{"name":"National Natural Science Foundation of China","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}]},{"name":"National Natural Science Foundation of China","award":["CJ1205A0240018"],"award-info":[{"award-number":["CJ1205A0240018"]}]},{"name":"Henan Natural Science Foundation of China","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}]},{"name":"Henan Natural Science Foundation of China","award":["81271410"],"award-info":[{"award-number":["81271410"]}]},{"name":"Henan Natural Science Foundation of China","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}]},{"name":"Henan Natural Science Foundation of China","award":["CJ1205A0240018"],"award-info":[{"award-number":["CJ1205A0240018"]}]},{"name":"Henan University","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}]},{"name":"Henan University","award":["81271410"],"award-info":[{"award-number":["81271410"]}]},{"name":"Henan University","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}]},{"name":"Henan University","award":["CJ1205A0240018"],"award-info":[{"award-number":["CJ1205A0240018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) and Alzheimer\u2019s disease (AD) are the most common rapidly developing neurodegenerative diseases that lead to serious health and socio-economic consequences. Ferroptosis is a non-apoptotic form of cell death; there is growing evidence to support the notion that ferroptosis is involved in a variety of pathophysiological contexts, and there is increasing interest in the role of ferroptosis in PD and AD. Simultaneously, cells may have evolved four defense systems to counteract the toxic effects of ferroptosis occasioned by lipid peroxidation. This review, which focuses on the analysis of ferroptosis in the PD and AD context, outlines four cellular defense systems against ferroptosis and how each of them is involved in PD and AD.<\/jats:p>","DOI":"10.3390\/ijms241814108","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:54:13Z","timestamp":1694746453000},"page":"14108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Role of Cellular Defense Systems of Ferroptosis in Parkinson\u2019s Disease and Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Jie","family":"Chu","sequence":"first","affiliation":[{"name":"School of Physical Education, Henan University, Kaifeng 475004, China"},{"name":"Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Physical Education, Henan University, Kaifeng 475004, China"},{"name":"Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-2487","authenticated-orcid":false,"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China"},{"name":"College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3392","authenticated-orcid":false,"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Physical Education, Henan University, Kaifeng 475004, China"},{"name":"Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in Parkinson\u2019s disease","volume":"20","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Li, J., Xu, Y., Liu, T., Xu, Y., Zhao, X., and Wei, J. (2023). The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097994"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ta, M., Blauwendraat, C., Antar, T., Leonard, H.L., Singleton, A.B., Nalls, M.A., Iwaki, H., Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI), and the Fox Investigation for New Discovery of Biomarkers (2023). Genome-Wide Meta-Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer\u2019s Disease and Parkinson\u2019s Disease Cohorts. Mov. Disord. Off. J. Mov. Disord. Soc.","DOI":"10.1002\/mds.29511"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2121987119","DOI":"10.1073\/pnas.2121987119","article-title":"A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria","volume":"119","author":"Wu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","article-title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","volume":"608","author":"Mishima","year":"2022","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Xie, L.H., Fefelova, N., Pamarthi, S.H., and Gwathmey, J.K. (2022). Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease. Cells, 11.","DOI":"10.3390\/cells11172726"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lee, J., and Roh, J.L. (2023). Unleashing Ferroptosis in Human Cancers: Targeting Ferroptosis Suppressor Protein 1 for Overcoming Therapy Resistance. Antioxidants, 12.","DOI":"10.3390\/antiox12061218"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.molmed.2022.02.003","article-title":"Ferroptosis in Parkinson\u2019s disease: Glia-neuron crosstalk","volume":"28","author":"Wang","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Schneider","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"H891","DOI":"10.1152\/ajpheart.00259.2019","article-title":"Guidelines for evaluating myocardial cell death","volume":"317","author":"Mishra","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119432","DOI":"10.1016\/j.bbamcr.2023.119432","article-title":"Surveying the landscape of emerging and understudied cell death mechanisms","volume":"1870","author":"Leak","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp-2022-330052","article-title":"CSF ferritin in the clinicopathological progression of Alzheimer\u2019s disease and associations with APOE and inflammation biomarkers","volume":"94","author":"Ayton","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting Ferroptosis to Iron Out Cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and ferroptosis in the management of metabolic diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106210","DOI":"10.1016\/j.nbd.2023.106210","article-title":"NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1(G93A) mutation and exerts neuroprotection in amyotrophic lateral sclerosis","volume":"184","author":"Yang","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e165228","DOI":"10.1172\/JCI165228","article-title":"Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons","volume":"133","author":"Sun","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1007\/s12035-020-02277-7","article-title":"New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e1904197","DOI":"10.1002\/adma.201904197","article-title":"Recent Progress in Ferroptosis Inducers for Cancer Therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e20210518","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2300325","DOI":"10.1002\/advs.202300325","article-title":"Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41574-022-00721-3","article-title":"The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism","volume":"18","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s13238-014-0119-z","article-title":"Iron homeostasis and tumorigenesis: Molecular mechanisms and therapeutic opportunities","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100860","DOI":"10.1016\/j.mam.2020.100860","article-title":"Iron: The cancer connection","volume":"75","author":"Torti","year":"2020","journal-title":"Mol. Asp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Holbein, B.E., and Lehmann, C. (2023). Dysregulated Iron Homeostasis as Common Disease Etiology and Promising Therapeutic Target. Antioxidants, 12.","DOI":"10.3390\/antiox12030671"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"La Rosa, P., Petrillo, S., Fiorenza, M.T., Bertini, E.S., and Piemonte, F. (2020). Ferroptosis in Friedreich\u2019s Ataxia: A Metal-Induced Neurodegenerative Disease. Biomolecules, 10.","DOI":"10.3390\/biom10111551"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10741-018-9700-5","article-title":"Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: An update","volume":"23","author":"Gordan","year":"2018","journal-title":"Heart Fail. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2020.11.024","article-title":"Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1","volume":"81","author":"Yan","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"121110","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20140857","article-title":"T cell lipid peroxidation induces ferroptosis and prevents immunity to infection","volume":"212","author":"Matsushita","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12964-022-01025-9","article-title":"The Warburg effect modulates DHODH role in ferroptosis: A review","volume":"21","author":"Amos","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41392-021-00656-7","article-title":"DHODH tangoing with GPX4 on the ferroptotic stage","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13046-022-02518-8","article-title":"CircLRFN5 inhibits the progression of glioblastoma via PRRX2\/GCH1 mediated ferroptosis","volume":"41","author":"Jiang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41419-021-03452-x","article-title":"Characterization of ferroptosis in kidney tubular cell death under diabetic conditions","volume":"12","author":"Kim","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41590-020-0699-0","article-title":"Redox homeostasis maintained by GPX4 facilitates STING activation","volume":"21","author":"Jia","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: New insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","article-title":"Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration","volume":"12","author":"Hambright","year":"2017","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcp.29903","article-title":"Involvement of GPX4 in irisin\u2019s protection against ischemia reperfusion-induced acute kidney injury","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress","volume":"33","author":"Tsoi","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41467-023-36446-8","article-title":"A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase","volume":"14","author":"Jin","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-023-05787-z","article-title":"Molecular characterization of AIFM2\/FSP1 inhibition by iFSP1-like molecules","volume":"14","author":"Schulte","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hendricks, J.M., Doubravsky, C.E., Wehri, E., Li, Z., Roberts, M.A., Deol, K.K., Lange, M., Lasheras-Otero, I., Momper, J.D., and Dixon, S.J. (2023). Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem. Biol., in press.","DOI":"10.1016\/j.chembiol.2023.04.007"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41467-022-29905-1","article-title":"A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers","volume":"13","author":"Koppula","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41586-023-06255-6","article-title":"Phase separation of FSP1 promotes ferroptosis","volume":"619","author":"Nakamura","year":"2023","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: A key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/JLB.1A0422-211R","article-title":"Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells","volume":"112","author":"Guo","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1038\/s41467-021-24712-6","article-title":"Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury","volume":"12","author":"Tonnus","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"eaaw7852","DOI":"10.1126\/scitranslmed.aaw7852","article-title":"Identification of DHODH as a therapeutic target in small cell lung cancer","volume":"11","author":"Li","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pharmthera.2018.10.012","article-title":"Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer","volume":"195","author":"Madak","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.chembiol.2019.10.012","article-title":"Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism","volume":"27","author":"Abt","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2020.06.019","article-title":"Mitochondrial Metabolism as a Target for Cancer Therapy","volume":"32","author":"Vasan","year":"2020","journal-title":"Cell Metab."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"596","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Eichwald, T., da Silva, L.B., Staats Pires, A.C., Niero, L., Schnorrenberger, E., Filho, C.C., Esp\u00edndola, G., Huang, W.L., Guillemin, G.J., and Abdenur, J.E. (2023). Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor. Antioxidants, 12.","DOI":"10.3390\/antiox12051037"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10565-022-09778-2","article-title":"Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases","volume":"39","author":"Lv","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.jid.2017.05.019","article-title":"The Nrf2\/GCH1\/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade","volume":"137","author":"Xue","year":"2017","journal-title":"J. Investig. Derm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114241","DOI":"10.1016\/j.biopha.2023.114241","article-title":"Ferroptosis in life: To be or not to be","volume":"159","author":"Xu","year":"2023","journal-title":"Biomed. Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","article-title":"Genetics and Pathogenesis of Parkinson\u2019s Syndrome","volume":"18","author":"Ye","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12974-023-02723-y","article-title":"The reciprocal interactions between microglia and T cells in Parkinson\u2019s disease: A double-edged sword","volume":"20","author":"Xu","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature23664","article-title":"Human iPS cell-derived dopaminergic neurons function in a primate Parkinson\u2019s disease model","volume":"548","author":"Kikuchi","year":"2017","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e13694","DOI":"10.1111\/acel.13694","article-title":"Adaptive cellular response of the substantia nigra dopaminergic neurons upon age-dependent iron accumulation","volume":"21","author":"Kwon","year":"2022","journal-title":"Aging Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"110358","DOI":"10.1016\/j.celrep.2022.110358","article-title":"Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological \u03b1-synuclein","volume":"38","author":"Sterling","year":"2022","journal-title":"Cell Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1212\/WNL.0000000000009878","article-title":"Patterns of striatal dopamine depletion in early Parkinson disease: Prognostic relevance","volume":"95","author":"Chung","year":"2020","journal-title":"Neurology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41422-023-00808-0","article-title":"Structural genomics of the human dopamine receptor system","volume":"33","author":"Xu","year":"2023","journal-title":"Cell Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1089\/ars.2021.0218","article-title":"Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders","volume":"37","author":"David","year":"2022","journal-title":"Antioxid. Redox Signal"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2017.01.004","article-title":"Ferroptosis and cell death mechanisms in Parkinson\u2019s disease","volume":"104","author":"Guiney","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2018.09.033","article-title":"Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration","volume":"133","author":"Masaldan","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC","volume":"94","author":"Gouel","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41531-021-00199-2","article-title":"Parkinson\u2019s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI","volume":"7","author":"Depierreux","year":"2021","journal-title":"NPJ Park. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1093\/brain\/awab191","article-title":"The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson\u2019s disease","volume":"144","author":"Biondetti","year":"2021","journal-title":"Brain"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1007\/s12035-020-02049-3","article-title":"Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells","volume":"57","author":"Sun","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/cddiscovery.2017.13","article-title":"MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells","volume":"3","author":"Ito","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"102431","DOI":"10.1016\/j.isci.2021.102431","article-title":"Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis","volume":"24","author":"Song","year":"2021","journal-title":"iScience"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/mds.27659","article-title":"Parkinson\u2019s disease age at onset genome-wide association study: Defining heritability, genetic loci, and \u03b1-synuclein mechanisms","volume":"34","author":"Blauwendraat","year":"2019","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.freeradbiomed.2019.06.007","article-title":"Interrogating Parkinson\u2019s disease associated redox targets: Potential application of CRISPR editing","volume":"144","author":"Artyukhova","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"108373","DOI":"10.1016\/j.pharmthera.2023.108373","article-title":"Molecular mechanisms of ferroptosis and their involvement in brain diseases","volume":"244","author":"Costa","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"101890","DOI":"10.1016\/j.pneurobio.2020.101890","article-title":"Ferroptosis and its potential role in the physiopathology of Parkinson\u2019s Disease","volume":"196","author":"Bouchaoui","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/EBC20210017","article-title":"Ferroptosis and NRF2: An emerging battlefield in the neurodegeneration of Alzheimer\u2019s disease","volume":"65","author":"Lane","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in Alzheimer\u2019s disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41418-018-0173-9","article-title":"Ferroptosis and necroinflammation, a yet poorly explored link","volume":"26","author":"Proneth","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-6-8","article-title":"Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson\u2019s brain","volume":"6","author":"Bellinger","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"134625","DOI":"10.1016\/j.chemosphere.2022.134625","article-title":"Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity","volume":"301","author":"Vellingiri","year":"2022","journal-title":"Chemosphere"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"42","DOI":"10.31083\/j.fbl2803042","article-title":"Protective Effects of Querectin against MPP(+)-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway","volume":"28","author":"Jiang","year":"2023","journal-title":"Front. Biosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The Metabolic Underpinnings of Ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Yue, M., Wei, J., Chen, W., Hong, D., Chen, T., and Fang, X. (2022). Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson\u2019s Disease via Inhibiting Ferroptosis. Nutrients, 14.","DOI":"10.3390\/nu14224886"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-018-0701-2","article-title":"The metabolite BH4 controls T cell proliferation in autoimmunity and cancer","volume":"563","author":"Cronin","year":"2018","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41392-020-00456-5","article-title":"Oral berberine improves brain dopa\/dopamine levels to ameliorate Parkinson\u2019s disease by regulating gut microbiota","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/cns.13745","article-title":"Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson\u2019s disease","volume":"28","author":"Pu","year":"2022","journal-title":"CNS Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1016\/j.csbj.2022.09.018","article-title":"Revealing a novel contributing landscape of ferroptosis-related genes in Parkinson\u2019s disease","volume":"20","author":"Jian","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40035-020-00212-3","article-title":"GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson\u2019s disease: A two-cohort case-control study","volume":"9","author":"Pan","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1093\/brain\/awx110","article-title":"Rare GCH1 heterozygous variants contributing to Parkinson\u2019s disease","volume":"140","author":"Xu","year":"2017","journal-title":"Brain"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13195-023-01271-0","article-title":"Prevalence of treated patients with Alzheimer\u2019s disease: Current trends and COVID-19 impact","volume":"15","author":"Olazaran","year":"2023","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jns.2019.06.008","article-title":"Clinical utility of serum hepcidin and iron profile measurements in Alzheimer\u2019s disease","volume":"403","author":"Kweon","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jalz.2013.01.014","article-title":"Vitamin E and memantine in Alzheimer\u2019s disease: Clinical trial methods and baseline data","volume":"10","author":"Dysken","year":"2014","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2020.07.012","article-title":"Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP\/PS1 mice","volume":"158","author":"Xu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s13311-018-0656-x","article-title":"Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice","volume":"15","author":"Belaidi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/bpa.12704","article-title":"Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP\/PS1 mice","volume":"29","author":"McIntosh","year":"2019","journal-title":"Brain Pathol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41380-020-0762-0","article-title":"Amyloidogenic processing of Alzheimer\u2019s disease \u03b2-amyloid precursor protein induces cellular iron retention","volume":"25","author":"Tsatsanis","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_127","first-page":"S445","article-title":"Elevated age-related cortical iron, ferritin and amyloid plaques in APP(swe)\/PS1(deltaE9) transgenic mouse model of Alzheimer\u2019s disease","volume":"68","author":"Tanila","year":"2019","journal-title":"Physiol. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.01.002","article-title":"Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer\u2019s disease: Pathogenesis, diagnostics, and therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13578-022-00807-5","article-title":"\u03b2-amyloid protein induces mitophagy-dependent ferroptosis through the CD36\/PINK\/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer\u2019s disease","volume":"12","author":"Li","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3233\/JAD-180317","article-title":"Postmortem T2*- Weighted MRI Imaging of Cortical Iron Reflects Severity of Alzheimer\u2019s Disease","volume":"65","author":"Bulk","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Dusek, P., Hofer, T., Alexander, J., Roos, P.M., and Aaseth, J.O. (2022). Cerebral Iron Deposition in Neurodegeneration. Biomolecules, 12.","DOI":"10.3390\/biom12050714"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.freeradbiomed.2012.02.043","article-title":"Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain","volume":"52","author":"Yoo","year":"2012","journal-title":"Free Radic. Biology Med."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Dar, N.J., Na, R., and Ran, Q. (2022). Functional Deficits of 5\u00d7FAD Neural Stem Cells Are Ameliorated by Glutathione Peroxidase 4. Cells, 11.","DOI":"10.3390\/cells11111770"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"108002","DOI":"10.1016\/j.intimp.2021.108002","article-title":"Tetrahydroxy stilbene glycoside ameliorates Alzheimer\u2019s disease in APP\/PS1 mice via glutathione peroxidase related ferroptosis","volume":"99","author":"Gao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A Mitigates Alzheimer\u2019s-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2\/GPX4 Axis Activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"998292","DOI":"10.3389\/fnagi.2022.998292","article-title":"Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer\u2019s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1\/Nrf2 pathway","volume":"14","author":"Yang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1073\/pnas.1715554115","article-title":"Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer\u2019s disease pathogenesis","volume":"115","author":"Zhou","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"106779","DOI":"10.1016\/j.phrs.2023.106779","article-title":"ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis","volume":"193","author":"Li","year":"2023","journal-title":"Pharm. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2022.11.018","article-title":"Ketone Body \u03b2-Hydroxybutyric Acid Ameliorates Dopaminergic Neuron Injury Through Modulating Zinc Finger Protein 36\/Acyl-CoA Synthetase Long-Chain Family Member Four Signaling Axis-Mediated Ferroptosis","volume":"509","author":"Yu","year":"2023","journal-title":"Neuroscience"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7769355","DOI":"10.1155\/2022\/7769355","article-title":"Quercetin Protects against MPP(+)\/MPTP-Induced Dopaminergic Neuron Death in Parkinson\u2019s Disease by Inhibiting Ferroptosis","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/1673-5374.343892","article-title":"DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson\u2019s disease","volume":"18","author":"Hu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1039\/D2FO00357K","article-title":"Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1-Nrf2 protein-protein interaction from Penthorum chinense Pursh. attenuates 6-hydroxydopamine-induced ferroptosis in zebrafish and dopaminergic neurons","volume":"13","author":"Sun","year":"2022","journal-title":"Food Funct."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"102103","DOI":"10.1016\/j.jchemneu.2022.102103","article-title":"The neuroprotective effects of paeoniflorin against MPP(+)-induced damage to dopaminergic neurons via the Akt\/Nrf2\/GPX4 pathway","volume":"122","author":"Wang","year":"2022","journal-title":"J. Chem. Neuroanat."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cbin.11505","article-title":"\u03b1-Lipoic acid alleviates ferroptosis in the MPP(+) -induced PC12 cells via activating the PI3K\/Akt\/Nrf2 pathway","volume":"45","author":"Liu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s11064-021-03262-9","article-title":"Benefits of Iron Chelators in the Treatment of Parkinson\u2019s Disease","volume":"46","author":"Zeng","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11064-020-03186-w","article-title":"Idebenone Ameliorates Rotenone-Induced Parkinson\u2019s Disease in Rats Through Decreasing Lipid Peroxidation","volume":"46","author":"Yavuz","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_148","first-page":"154762","article-title":"Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13020-022-00634-3","article-title":"Salidroside attenuates neuronal ferroptosis by activating the Nrf2\/HO1 signaling pathway in A\u03b2(1-42)-induced Alzheimer\u2019s disease mice and glutamate-injured HT22 cells","volume":"17","author":"Yang","year":"2022","journal-title":"Chin. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"104931","DOI":"10.1016\/j.neuint.2020.104931","article-title":"Supplementation with \u03b3-glutamylcysteine (\u03b3-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD","volume":"144","author":"Liu","year":"2021","journal-title":"Neurochem. Int."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:51:03Z","timestamp":1760129463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":150,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241814108"],"URL":"https:\/\/doi.org\/10.3390\/ijms241814108","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}