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investigaci\u00f3n en salud (PFIS contracts)","award":["CP20\/00122"],"award-info":[{"award-number":["CP20\/00122"]}]},{"name":"Contratos predoctorales de formaci\u00f3n en investigaci\u00f3n en salud (PFIS contracts)","award":["FI22\/00213"],"award-info":[{"award-number":["FI22\/00213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this cross-sectional study, we evaluated the associations of inflammation and hemoglobin with coronary artery disease (CAD) in subjects with type 2 diabetes mellitus (T2DM) and preserved kidney function. We recruited 638 participants\u2014254 with T2DM\u2014subjected to coronary angiography with no known cardiovascular disease, normal glomerular filtration rates, and without albuminuria. The hemoglobin and serum levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), were measured. Multivariable analyses showed that inflammatory markers were not related to the severity of the stenosis in the group of subjects with diabetes. Conversely, inflammatory cytokines and albuminuria were directly related to the percentage of stenosis in subjects without T2DM (R2 = 0.038, p &lt; 0.001). Patients with diabetes presented lower hemoglobin levels, particularly in those who also had significant CAD (14.4 [13.6\u201315.1] vs. 13.6 [12.2\u201314.8] g\/dL, p = 0.03). Similarly, hemoglobin levels and albuminuria were inversely related to the severity of stenosis exclusively in subjects with diabetes, even after adjusting for multiple confounding factors (R2 = 0.081, p &lt; 0.001). We conclude that reductions in hemoglobin levels in subjects with T2DM and normoalbuminuria may constitute a more relevant risk factor for CAD than inflammation.<\/jats:p>","DOI":"10.3390\/ijms241814131","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:54:13Z","timestamp":1694746453000},"page":"14131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-7347","authenticated-orcid":false,"given":"Javier","family":"Donate-Correa","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38000 Santa Cruz de Tenerife, Spain"},{"name":"RICORS2040 (RD21\/0005\/0013), Instituto de Salud Carlos III, 28000 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-0956","authenticated-orcid":false,"given":"Ernesto","family":"Mart\u00edn-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-6332","authenticated-orcid":false,"given":"Carmen","family":"Mora-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"},{"name":"RICORS2040 (RD21\/0005\/0013), Instituto de Salud Carlos III, 28000 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Gonz\u00e1lez-Luis","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mart\u00edn-Olivera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-7474","authenticated-orcid":false,"given":"Juan F.","family":"Navarro-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de Candelaria (HUNSC), 38000 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38000 Santa Cruz de Tenerife, Spain"},{"name":"RICORS2040 (RD21\/0005\/0013), Instituto de Salud Carlos III, 28000 Madrid, Spain"},{"name":"Servicio de Nefrolog\u00eda, HUNSC, 38000 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (IDF) (2021). 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