{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:08:26Z","timestamp":1779314906321,"version":"3.51.4"},"reference-count":180,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Fund of China","award":["82271789"],"award-info":[{"award-number":["82271789"]}]},{"name":"National Science Fund of China","award":["UDF01002461"],"award-info":[{"award-number":["UDF01002461"]}]},{"name":"National Science Fund of China","award":["HZQB-KCZYB-2020056"],"award-info":[{"award-number":["HZQB-KCZYB-2020056"]}]},{"name":"Fund of Shenzhen Commission of Science, Technology and Innovation","award":["82271789"],"award-info":[{"award-number":["82271789"]}]},{"name":"Fund of Shenzhen Commission of Science, Technology and Innovation","award":["UDF01002461"],"award-info":[{"award-number":["UDF01002461"]}]},{"name":"Fund of Shenzhen Commission of Science, Technology and Innovation","award":["HZQB-KCZYB-2020056"],"award-info":[{"award-number":["HZQB-KCZYB-2020056"]}]},{"name":"University Developmental Fund, the Chinese University of Hong Kong, Shenzhen, China","award":["82271789"],"award-info":[{"award-number":["82271789"]}]},{"name":"University Developmental Fund, the Chinese University of Hong Kong, Shenzhen, China","award":["UDF01002461"],"award-info":[{"award-number":["UDF01002461"]}]},{"name":"University Developmental Fund, the Chinese University of Hong Kong, Shenzhen, China","award":["HZQB-KCZYB-2020056"],"award-info":[{"award-number":["HZQB-KCZYB-2020056"]}]},{"name":"Fund from Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation","award":["82271789"],"award-info":[{"award-number":["82271789"]}]},{"name":"Fund from Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation","award":["UDF01002461"],"award-info":[{"award-number":["UDF01002461"]}]},{"name":"Fund from Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation","award":["HZQB-KCZYB-2020056"],"award-info":[{"award-number":["HZQB-KCZYB-2020056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The SARS-CoV-2 virus, causing the devastating COVID-19 pandemic, has been reported to affect platelets and cause increased thrombotic events, hinting at the possible bidirectional interactions between platelets and the virus. In this review, we discuss the potential mechanisms underlying the increased thrombotic events as well as altered platelet count and activity in COVID-19. Inspired by existing knowledge on platelet\u2013pathogen interactions, we propose several potential antiviral strategies that platelets might undertake to combat SARS-CoV-2, including their abilities to internalize the virus, release bioactive molecules to interfere with viral infection, and modulate the functions of immune cells. Moreover, we discuss current and potential platelet-targeted therapeutic strategies in controlling COVID-19, including antiplatelet drugs, anticoagulants, and inflammation-targeting treatments. These strategies have shown promise in clinical settings to alleviate the severity of thrombo-inflammatory complications and reduce the mortality rate among COVID-19 patients. In conclusion, an in-depth understanding of platelet\u2013SARS-CoV-2 interactions may uncover novel mechanisms underlying severe COVID-19 complications and could provide new therapeutic avenues for managing this disease.<\/jats:p>","DOI":"10.3390\/ijms241814133","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:54:13Z","timestamp":1694746453000},"page":"14133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19"],"prefix":"10.3390","volume":"24","author":[{"given":"Junyi","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conglei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological Findings of COVID-19 Associated with Acute Respiratory Distress Syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir. 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