{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:36:15Z","timestamp":1780511775143,"version":"3.54.1"},"reference-count":63,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T00:00:00Z","timestamp":1694908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Politehnica of Bucharest"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The current study reports on the fabrication of composite scaffolds based on polycaprolactone (PCL) and cerium (Ce)-containing powders, followed by their characterization from compositional, structural, morphological, optical and biological points of view. First, CeO2, Ce-doped calcium phosphates and Ce-substituted bioglass were synthesized by wet-chemistry methods (precipitation\/coprecipitation and sol-gel) and subsequently loaded on PCL fibres processed by electrospinning. The powders were proven to be nanometric or micrometric, while the investigation of their phase composition showed that Ce was present as a dopant within the crystal lattice of the obtained calcium phosphates or as crystalline domains inside the glassy matrix. The best bioactivity was attained in the case of Ce-containing bioglass, while the most pronounced antibacterial effect was visible for Ce-doped calcium phosphates calcined at a lower temperature. The scaffolds were composed of either dimensionally homogeneous fibres or mixtures of fibres with a wide size distribution and beads of different shapes. In most cases, the increase in polymer concentration in the precursor solution ensured the achievement of more ordered fibre mats. The immersion in SBF for 28 days triggered an incipient degradation of PCL, evidenced mostly through cracks and gaps. In terms of biological properties, the composite scaffolds displayed a very good biocompatibility when tested with human osteoblast cells, with a superior response for the samples consisting of the polymer and Ce-doped calcium phosphates.<\/jats:p>","DOI":"10.3390\/ijms241814201","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:36:45Z","timestamp":1694932605000},"page":"14201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development and Characterization of Electrospun Composites Built on Polycaprolactone and Cerium-Containing Phases"],"prefix":"10.3390","volume":"24","author":[{"given":"Cristiana","family":"Plocon","sequence":"first","affiliation":[{"name":"University Politehnica of Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-8191","authenticated-orcid":false,"given":"Alexandru","family":"Evanghelidis","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-5545","authenticated-orcid":false,"given":"Monica","family":"Enculescu","sequence":"additional","affiliation":[{"name":"National Institute for Materials Physics, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Isopencu","sequence":"additional","affiliation":[{"name":"University Politehnica of Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-1094","authenticated-orcid":false,"given":"Ovidiu","family":"Oprea","sequence":"additional","affiliation":[{"name":"University Politehnica of Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-6002","authenticated-orcid":false,"given":"Mihaela","family":"Bacalum","sequence":"additional","affiliation":[{"name":"National Institute of Physics and Nuclear Engineering, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-6441","authenticated-orcid":false,"given":"Mina","family":"Raileanu","sequence":"additional","affiliation":[{"name":"National Institute of Physics and Nuclear Engineering, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Jinga","sequence":"additional","affiliation":[{"name":"University Politehnica of Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-8459","authenticated-orcid":false,"given":"Cristina","family":"Busuioc","sequence":"additional","affiliation":[{"name":"University Politehnica of Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41578-020-0209-x","article-title":"Engineered biomaterials for in situ tissue regeneration","volume":"5","author":"Gaharwar","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1208\/s12249-022-02419-1","article-title":"Biomaterials for tissue engineering applications and current updates in the field: A comprehensive review","volume":"23","author":"Eldeeb","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kim, B.W. (2018). Clinical Regenerative Medicine in Urology, Springer.","DOI":"10.1007\/978-981-10-2723-9"},{"key":"ref_4","first-page":"22","article-title":"A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications","volume":"4","author":"Li","year":"2018","journal-title":"Bioact. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e0016","DOI":"10.5041\/RMMJ.10402","article-title":"Bioresorbable scaffolds: Current technology and future perspectives","volume":"11","author":"Forrestal","year":"2020","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2100860","DOI":"10.1002\/adem.202100860","article-title":"Morphological control of freeze-structured scaffolds by selective temperature and material control in the ice-templating process","volume":"24","author":"Seifert","year":"2022","journal-title":"Adv. Eng. Mater."},{"key":"ref_7","unstructured":"Perale, G., and Hilborn, J. (2017). Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine, Woodhead Publishing."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00914037.2015.1103241","article-title":"Polycaprolactone-based biomaterials for tissue engineering and drug delivery: Current scenario and challenges","volume":"65","author":"Mondal","year":"2016","journal-title":"Int. J. Polym. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Abdelaziz, A.G., Nageh, H., Abdo, S.M., Abdalla, M.S., Amer, A.A., Abdal-Hay, A., and Barhoum, A. (2023). A review of 3D polymeric scaffolds for bone tissue engineering: Principles, fabrication techniques, immunomodulatory roles, and challenges. Bioengineering, 10.","DOI":"10.3390\/bioengineering10020204"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1007\/s00289-021-03865-w","article-title":"Polycaprolactone-based materials in wound healing applications","volume":"79","author":"Raina","year":"2022","journal-title":"Polym. Bull."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102984","DOI":"10.1016\/j.jddst.2021.102984","article-title":"Anticancer efficiency of doxorubicin and berberine-loaded PCL nanofibers in preventing local breast cancer recurrence","volume":"67","author":"Mozaffari","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108488","DOI":"10.1016\/j.matdes.2020.108488","article-title":"Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds","volume":"188","author":"Liu","year":"2020","journal-title":"Mater. Des."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yang, X., Wang, Y., Zhou, Y., Chen, J., and Wan, Q. (2021). The application of polycaprolactone in three-dimensional printing scaffolds for bone tissue engineering. Polymers, 13.","DOI":"10.3390\/polym13162754"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2019.05.004","article-title":"Degradation mechanisms of polycaprolactone in the context of chemistry, geometry and environment","volume":"96","author":"Bartnikowski","year":"2019","journal-title":"Prog. Polym. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dias, J.R., Sousa, A., Augusto, A., Bartolo, P.J., and Granja, P.L. (2022). Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study. Polymers, 14.","DOI":"10.3390\/polym14163397"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100721","DOI":"10.1016\/j.pmatsci.2020.100721","article-title":"Electrospinning for tissue engineering applications","volume":"117","author":"Rahmati","year":"2021","journal-title":"Prog. Mater. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00396-022-04997-9","article-title":"An overview on electrospinning and its advancement toward hard and soft tissue engineering applications","volume":"300","author":"Muthukrishnan","year":"2022","journal-title":"Colloid. Polym. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.eurpolymj.2015.01.028","article-title":"Porous electrospun polycaprolactone (PCL) fibres by phase separation","volume":"69","author":"Katsogiannis","year":"2015","journal-title":"Eur. Polym. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1038\/s41598-018-20714-5","article-title":"Plasma modification of poly lactic acid solutions to generate high quality electrospun PLA nanofibers","volume":"8","author":"Rezaei","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10965-016-1002-9","article-title":"Hydrolytic degradation and morphological characterization of electrospun poly(glycolic acid) [PGA] thin films of different molecular weights containing TiO2 nanoparticles","volume":"23","author":"Rodriguez","year":"2016","journal-title":"J. Polym. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"209049","DOI":"10.1155\/2014\/209049","article-title":"Fabrication of nanohydroxyapatite\/poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications","volume":"2014","author":"Hassan","year":"2014","journal-title":"J. Nanomater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10601325.2011.528288","article-title":"Preparation, characterization and cell attachment studies of electrospun multi-scale poly(caprolactone) fibrous scaffolds for tissue engineering","volume":"48","author":"Shalumon","year":"2010","journal-title":"J. Macromol. Sci. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e10262","DOI":"10.1002\/btm2.10262","article-title":"Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects","volume":"7","author":"Natarajan","year":"2021","journal-title":"Bioeng. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109758","DOI":"10.1016\/j.compositesb.2022.109758","article-title":"The role of rare earth elements in bone tissue engineering scaffolds\u2014A review","volume":"235","author":"Gao","year":"2022","journal-title":"Compos. B Eng."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Paduraru, A.V., Musuc, A.M., Oprea, O.C., Trusca, R., Iordache, F., Vasile, B.S., and Andronescu, E. (2021). Synthesis and characterization of photoluminescent Ce(III) and Ce(IV) substituted hydroxyapatite nanomaterials by co-precipitation method: Cytotoxicity and biocompatibility evaluation. Nanomaterials, 11.","DOI":"10.3390\/nano11081911"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11342","DOI":"10.1021\/acsami.6b03100","article-title":"Europium-containing mesoporous bioactive glass scaffolds for stimulating in vitro and in vivo osteogenesis","volume":"8","author":"Wu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejmp.2020.06.007","article-title":"Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy","volume":"75","author":"Nakayama","year":"2020","journal-title":"Phys. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fifere, N., Airinei, A., Asandulesa, M., Rotaru, A., Ursu, E.L., and Doroftei, F. (2022). Investigating the vibrational, magnetic and dielectric properties, and antioxidant activity of cerium oxide nanoparticles. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213883"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Qi1, M., Li, W., Zheng, X., Li, X., Sun, Y., Wang, Y., Li, C., and Wang, L. (2020). Cerium and its oxidant-based nanomaterials for antibacterial applications: A state-of-the-art review. Front. Mater., 7, 213.","DOI":"10.3389\/fmats.2020.00213"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s40843-019-9471-7","article-title":"Antibacterial mechanism and activity of cerium oxide nanoparticles","volume":"62","author":"Zhang","year":"2019","journal-title":"Sci. China Mater."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pellavio, G., Sommi, P., Anselmi-Tamburini, U., DeMichelis, M.P., Coniglio, S., and Laforenza, U. (2022). Cerium oxide nanoparticles regulate oxidative stress in HeLa cells by increasing the aquaporin-mediated hydrogen peroxide permeability. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810837"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e5308","DOI":"10.1002\/aoc.5308","article-title":"Biosynthesis of cerium oxide nanoparticles and its cytotoxicity survey against colon cancer cell line","volume":"34","author":"Miri","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Pop, O.L., Mesaros, A., Vodnar, D.C., Suharoschi, R., Tabaran, F., Magerusan, L., Todor, I.S., Diaconeasa, Z., Balint, A., and Ciontea, L. (2020). Cerium oxide nanoparticles and their efficient antibacterial application in vitro against gram-positive and gram-negative pathogens. Nanomaterials, 10.","DOI":"10.3390\/nano10081614"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33782","DOI":"10.1039\/D0RA04287K","article-title":"Recent advances and future perspectives of sol-gel derived porous bioactive glasses: A review","volume":"10","author":"Deshmukh","year":"2020","journal-title":"RSC Adv."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shcherbakov, A.B., Reukov, V.V., Yakimansky, A.V., Krasnopeeva, E.L., Ivanova, O.S., Popov, A.L., and Ivanov, V.K. (2021). CeO2 nanoparticle-containing polymers for biomedical applications: A review. Polymers, 13.","DOI":"10.3390\/polym13060924"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e16568","DOI":"10.1016\/j.heliyon.2023.e16568","article-title":"Antimicrobial activity of ion-substituted calcium phosphates: A systematic review","volume":"9","author":"Kamphof","year":"2023","journal-title":"Heliyon"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-018-0153-7","article-title":"Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells","volume":"23","author":"Janarthanan","year":"2019","journal-title":"Biomater. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Malavasi, G., Salvatori, R., Zambon, A., Lusvardi, G., Rigamonti, L., Chiarini, L., and Anesi, A. (2019). Cytocompatibility of potential bioactive cerium-doped glasses based on 45S5. Materials, 12.","DOI":"10.3390\/ma12040594"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20910","DOI":"10.1016\/j.ceramint.2019.07.080","article-title":"Mesoporous bioactive glasses doped with cerium: Investigation over enzymatic-like mimetic activities and bioactivity","volume":"45","author":"Nicolini","year":"2019","journal-title":"Ceram. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.msec.2018.12.044","article-title":"Novel calcium phosphate\/PCL graded samples: Design and development in view of biomedical applications","volume":"97","author":"Petit","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10856-020-06382-w","article-title":"Scaffolds of PCL combined to bioglass: Synthesis, characterization and biological performance","volume":"31","author":"Avelino","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.micromeso.2018.09.029","article-title":"Cerium-containing mesoporous bioactive glasses: Material characterization, in vitro bioactivity, biocompatibility and cytotoxicity evaluation","volume":"276","author":"Atkinson","year":"2019","journal-title":"Micropor. Mesopor. Mater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100041","DOI":"10.1016\/j.mtbio.2020.100041","article-title":"Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities","volume":"5","author":"Zheng","year":"2020","journal-title":"Mater. Today Bio."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Leu Alexa, R., Cucuruz, A., Ghitulica, C.D., Voicu, G., Stamat, L.R., Dinescu, S., Vlasceanu, G.M., Stavarache, C., Ianchis, R., and Iovu, H. (2022). 3D printable composite biomaterials based on GelMA and hydroxyapatite powders doped with cerium ions for bone tissue regeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031841"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"26985","DOI":"10.1016\/j.ceramint.2020.07.175","article-title":"Cerium-doped calcium phosphates precipitated on bacterial cellulose platform by mineralization","volume":"46","author":"Sousa","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s10965-022-03208-x","article-title":"Development and characterization of PCL membranes incorporated with Zn-doped bioactive glass produced by electrospinning for osteogenesis evaluation","volume":"29","author":"Fernandes","year":"2011","journal-title":"J. Polym. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1007\/s10904-020-01527-4","article-title":"Nano-rods structured cerium oxide Platform for cholesterol biosensor","volume":"30","author":"Anh","year":"2020","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jallcom.2009.12.053","article-title":"Synthesis, characterization and photoluminescence of CeO2 nanoparticles by a facile method at room temperature","volume":"493","author":"Wang","year":"2010","journal-title":"J. Alloys Compd."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Katashev, A., Dekhtyar, Y., and Spigulis, J. (2008, January 16\u201320). Fourier transform infrared spectra of technologically modified calcium phosphates. Proceedings of the 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, Riga, Latvia.","DOI":"10.1007\/978-3-540-69367-3"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.surfcoat.2018.11.008","article-title":"Akermanite-based coatings grown by pulsed laser deposition for metallic implants employed in orthopaedics","volume":"357","author":"Negrea","year":"2019","journal-title":"Surf. Coat. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17587","DOI":"10.1007\/s10854-017-7695-7","article-title":"Controlled hydrothermal synthesis and optical properties of 3D flower-like CeO2 building with 3D hierarchical porous structure","volume":"28","author":"Gao","year":"2017","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"129374","DOI":"10.1016\/j.snb.2020.129374","article-title":"Morphology-controlled synthesis of CeO2 nanocrystals and their facet-dependent gas sensing properties","volume":"330","author":"Bi","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_53","first-page":"44","article-title":"Synthesis, structural and optical behavior of cerium oxide nanoparticles by co-precipitation method","volume":"4","author":"Ramjeyanthi","year":"2018","journal-title":"Int. J. Sci. Res. Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13067","DOI":"10.1021\/acs.energyfuels.0c02192","article-title":"Hydroelectric cell based on cerium oxide decorated reduced graphene oxide (CeO2-rG) nanocomposite generates green electricity by room temperature water splitting","volume":"34","author":"Bharggava","year":"2020","journal-title":"Energy Fuels"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Atkinson, I., Seciu-Grama, A.M., Petrescu, S., Culita, D., Mocioiu, O.C., Voicescu, M., Mitran, R.A., Lincu, D., Prelipcean, A.M., and Craciunescu, O. (2022). Cerium-containing mesoporous bioactive glasses (MBGs)-derived scaffolds with drug delivery capability for potential tissue engineering applications. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061169"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"20875","DOI":"10.1038\/s41598-021-00222-9","article-title":"Interrelationships between the structural, spectroscopic, and antibacterial properties of nanoscale (<50 nm) cerium oxides","volume":"11","author":"Iqbal","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_57","first-page":"338","article-title":"Structural and morphological investigation of polycaprolactone multi-component scaffold containing collagen microsphere\/bioglass nanoparticles","volume":"7","author":"Sahrapeyma","year":"2022","journal-title":"Nanomed. Res. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"122352","DOI":"10.1016\/j.matchemphys.2019.122352","article-title":"Growth of bone like hydroxyapatite and cell viability studies on CeO2 doped CaO-P2O5-MgO-SiO2 bioceramics","volume":"243","author":"Kaur","year":"2020","journal-title":"Mater. Phys. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"055008","DOI":"10.1088\/1748-6041\/10\/5\/055008","article-title":"Novel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regeneration","volume":"10","author":"Morais","year":"2015","journal-title":"Biomed. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"109971","DOI":"10.1016\/j.msec.2019.109971","article-title":"Cerium (III) and (IV) containing mesoporous glasses\/alginate beads for bone regeneration: Bioactivity, biocompatibility and reactive oxygen species activity","volume":"105","author":"Varini","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lusvardi, G., Sgarbi Stabellini, F., and Salvatori, R. (2019). P2O5-free cerium containing glasses: Bioactivity and cytocompatibility evaluation. Materials, 12.","DOI":"10.3390\/ma12193267"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/0885328216651392","article-title":"Bioactivity of Y2O3 and CeO2 doped SiO2-SrO-Na2O glass-ceramics","volume":"31","author":"Placek","year":"2016","journal-title":"J. Biomater. Appl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity?","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:52:32Z","timestamp":1760129552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,17]]},"references-count":63,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241814201"],"URL":"https:\/\/doi.org\/10.3390\/ijms241814201","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,17]]}}}