{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:53:41Z","timestamp":1791824021318,"version":"4.3.4"},"reference-count":42,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2022-310"],"award-info":[{"award-number":["075-15-2022-310"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alkylresorcinols (ARs) are polyphenolic compounds with a wide spectrum of biological activities and are potentially involved in the regulation of host metabolism. The present study aims to establish whether ARs can be produced by the human gut microbiota and to evaluate alterations in content in stool samples as well as metabolic activity of the gut microbiota of C57BL, db\/db, and LDLR (\u2212\/\u2212) mice according to diet specifications and olivetol (5-n-pentylresorcinol) supplementation to estimate the regulatory potential of ARs. Gas chromatography with mass spectrometric detection was used to quantitatively analyse AR levels in mouse stool samples; faecal microbiota transplantation (FMT) from human donors to germ-free mice was performed to determine whether the intestinal microbiota could produce AR molecules; metagenome sequencing analysis of the mouse gut microbiota followed by reconstruction of its metabolic activity was performed to investigate olivetol\u2019s regulatory potential. A significant increase in the amounts of individual members of AR homologues in stool samples was revealed 14 days after FMT. Supplementation of 5-n-Pentylresorcinol to a regular diet influences the amounts of several ARs in the stool of C57BL\/6 and LDLR (\u2212\/\u2212) but not db\/db mice, and caused a significant change in the predicted metabolic activity of the intestinal microbiota of C57BL\/6 and LDLR (\u2212\/\u2212) but not db\/db mice. For the first time, we have shown that several ARs can be produced by the intestinal microbiota. Taking into account the dependence of AR levels in the gut on olivetol supplementation and microbiota metabolic activity, AR can be assumed to be potential quorum-sensing molecules, which also influence gut microbiota composition and host metabolism.<\/jats:p>","DOI":"10.3390\/ijms241814206","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:25:26Z","timestamp":1694993126000},"page":"14206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota"],"prefix":"10.3390","volume":"24","author":[{"given":"Anastasia A.","family":"Zabolotneva","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov Str., Moscow 117997, Russia"},{"name":"Russian National Medical Research Center for Endocrinology, 11 Dm. Ulyanova Str., Moscow 117036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei M.","family":"Gaponov","sequence":"additional","affiliation":[{"name":"Center for Digital and Translational Biomedicine \u00abCenter for Molecular Health\u00bb, 32 Nakhimovskiy prospekt, Moscow 117218, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Roumiantsev","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov Str., Moscow 117997, Russia"},{"name":"Russian National Medical Research Center for Endocrinology, 11 Dm. Ulyanova Str., Moscow 117036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya Yu.","family":"Vasiliev","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-7012","authenticated-orcid":false,"given":"Tatiana V.","family":"Grigoryeva","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg I.","family":"Kit","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Yu.","family":"Zlatnik","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey Yu.","family":"Maksimov","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Goncharova","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna A.","family":"Novikova","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9032-1558","authenticated-orcid":false,"given":"Svetlana A.","family":"Appolonova","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-2903","authenticated-orcid":false,"given":"Pavel A.","family":"Markin","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr V.","family":"Shestopalov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov Str., Moscow 117997, Russia"},{"name":"Russian National Medical Research Center for Endocrinology, 11 Dm. Ulyanova Str., Moscow 117036, Russia"},{"name":"Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela Str., Moscow 117997, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","article-title":"Human Gut Microbiota\/Microbiome in Health and Diseases: A Review","volume":"113","author":"Gomaa","year":"2020","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4667607","DOI":"10.1155\/2022\/4667607","article-title":"An Overview of Alkylresorcinols Biological Properties and Effects","volume":"2022","author":"Zabolotneva","year":"2022","journal-title":"J. Nutr. 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