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Plan","award":["2022JJ13SN064"],"award-info":[{"award-number":["2022JJ13SN064"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We used an in vitro model of the human brain immune microenvironment to simulate hypoxic-ischemic brain injury (HIBI) and treatment with human umbilical cord mesenchymal stem cells (hUMSCs) to address the transformation barriers of gene differences between animals and humans in preclinical research. A co-culture system, termed hNAME, consisted of human hippocampal neurons (N), astrocytes (A), microglia (M), and brain microvascular endothelial cells (E). Flow cytometry measured the apoptosis rates of neurons and endothelial cells. hNAME-neurons and endothelial cells experienced more severe damage than monolayer cells, particularly after 48 h and 24 h of reoxygenation (OGD48\/R24). Western blotting identified neuroinflammatory response markers, including HIF-1\u03b1, C1q, C3, TNF-\u03b1, and iNOS. Inflammatory factors originated from the glial chamber rather than the neurons and vascular endothelial chambers. A gradual increase in the release of inflammatory factors was observed as the OGD and reoxygenation times increased, peaking at OGD48\/R24. The hNAME value was confirmed in human umbilical cord mesenchymal stem cells (hUMSCs). Treatment with hUMSCs resulted in a notable decrease in the severity of neuronal and endothelial cell damage in hNAME. The hNAME is an ideal in vitro model for simulating the immune microenvironment of the human brain because of the interactions between neurons, vessels, astrocytes, and microglia.<\/jats:p>","DOI":"10.3390\/ijms241814208","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:17:30Z","timestamp":1695003450000},"page":"14208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Human Brain Model Mimicking Umbilical Cord Mesenchymal Stem Cells for the Treatment of Hypoxic-Ischemic Brain Injury"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-7731","authenticated-orcid":false,"given":"Xidan","family":"Li","sequence":"first","affiliation":[{"name":"Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China"},{"name":"Liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine, Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic Microorganisms, Dalian Innovation Institute of Stem Cell and Precision Medicine, Dalian 116085, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China"},{"name":"Liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine, Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic Microorganisms, Dalian Innovation Institute of Stem Cell and Precision Medicine, Dalian 116085, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[{"name":"Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian 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116085, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China"},{"name":"Liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine, Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic Microorganisms, Dalian Innovation Institute of Stem Cell and Precision Medicine, Dalian 116085, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[{"name":"Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China"},{"name":"Liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine, Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic 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Neurol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ni.3666","article-title":"The movers and shapers in immune privilege of the CNS","volume":"18","author":"Engelhardt","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eabo7649","DOI":"10.1126\/science.abo7649","article-title":"Transforming the understanding of brain immunity","volume":"380","author":"Castellani","year":"2023","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cell.2020.05.050","article-title":"Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity","volume":"182","author":"Nguyen","year":"2020","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-020-2777-8","article-title":"Negative feedback control of neuronal activity by microglia","volume":"586","author":"Badimon","year":"2020","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41590-022-01208-z","article-title":"Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation","volume":"23","author":"Yshii","year":"2022","journal-title":"Nat. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"eadc9020","DOI":"10.1126\/science.adc9020","article-title":"Molecular basis of astrocyte diversity and morphology across the CNS in health and disease","volume":"378","author":"Endo","year":"2022","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia Biology: One Century of Evolving Concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.it.2020.07.009","article-title":"Microglia and Astrocyte Crosstalk in Immunity","volume":"41","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fimmu.2020.01024","article-title":"Interaction of Microglia and Astrocytes in the Neurovascular Unit","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-021-03734-6","article-title":"Astrocytic interleukin-3 programs microglia and limits Alzheimer\u2019s disease","volume":"595","author":"McAlpine","year":"2021","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jnc.13424","article-title":"Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer\u2019s disease","volume":"136","author":"Lian","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_15","unstructured":"GBD 2019 Stroke Collaborators (2021). Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol., 20, 795\u2013820."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What Is Acute Ischemic Stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pneurobio.2018.01.004","article-title":"Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research","volume":"163\u2013164","author":"Zhao","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1007\/s12035-022-02967-4","article-title":"Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges","volume":"59","author":"Khodabakhsh","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4103\/1673-5374.339002","article-title":"Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia\/ischemia in rats","volume":"17","author":"Zou","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_20","first-page":"4443","article-title":"PTBP-1 and TNF-\u03b1\/NF-\u03baB are involved in repair mechanisms of human umbilical cord mesenchymal stem cell transplantation in mice with spinal cord injury","volume":"14","author":"Cao","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jcp.24683","article-title":"3D cell culture systems: Advantages and applications","volume":"230","author":"Ravi","year":"2015","journal-title":"J. Cell Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"118924","DOI":"10.1016\/j.carbpol.2021.118924","article-title":"3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing","volume":"278","author":"Millan","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1038\/s41467-021-24775-5","article-title":"Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids","volume":"12","author":"Cho","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2014.11.003","article-title":"3D in vitro modeling of the central nervous system","volume":"125","author":"Hopkins","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13578-022-00887-3","article-title":"Three-dimensional in vitro culture models in oncology research","volume":"12","author":"Jubelin","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ryu, N.E., Lee, S.H., and Park, H. (2019). Spheroid Culture System Methods and Applications for Mesenchymal Stem Cells. Cells, 8.","DOI":"10.3390\/cells8121620"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ncb3312","article-title":"Organoids as an in vitro model of human development and disease","volume":"18","author":"Fatehullah","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmed.2017.02.007","article-title":"Disease Modeling in Stem Cell-Derived 3D Organoid Systems","volume":"23","author":"Dutta","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1013311","DOI":"10.3389\/fimmu.2022.1013311","article-title":"Microglia autophagy in ischemic stroke: A double-edged sword","volume":"13","author":"Peng","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/glia.23505","article-title":"Unique role for dentate gyrus microglia in neuroblast survival and in VEGF-induced activation","volume":"67","author":"Kreisel","year":"2019","journal-title":"Glia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13287-019-1207-z","article-title":"Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury","volume":"10","author":"Thomi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"113700","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.7150\/thno.33872","article-title":"Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice","volume":"9","author":"Xian","year":"2019","journal-title":"Theranostics"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14208\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:52:40Z","timestamp":1760129560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":35,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241814208"],"URL":"https:\/\/doi.org\/10.3390\/ijms241814208","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]}}}