{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:19:25Z","timestamp":1774869565869,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Scientific Foundation, Regional grant, Chelyabinsk Region","award":["#23-15-20040"],"award-info":[{"award-number":["#23-15-20040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.<\/jats:p>","DOI":"10.3390\/ijms241814343","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T21:26:32Z","timestamp":1695245192000},"page":"14343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation"],"prefix":"10.3390","volume":"24","author":[{"given":"Vadim E.","family":"Tseilikman","sequence":"first","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav A.","family":"Shatilov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim S.","family":"Zhukov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Buksha","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandr E.","family":"Epitashvily","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya A.","family":"Lipatov","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim R.","family":"Aristov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandr G.","family":"Koshelev","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina N.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitrii S.","family":"Traktirov","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-7873","authenticated-orcid":false,"given":"Viktoriya A.","family":"Maistrenko","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Kamel","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey V.","family":"Buhler","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena G.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana S.","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton A.","family":"Pashkov","sequence":"additional","affiliation":[{"name":"Federal Neurosurgical Center, 630048 Novosibirsk, Russia"},{"name":"Department of Data Collection and Processing Systems, Novosibirsk State Technical University, 630087 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim V.","family":"Kon\u2019kov","sequence":"additional","affiliation":[{"name":"Zelman Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-6677","authenticated-orcid":false,"given":"Jurica","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia"},{"name":"Center for Artificial Intelligence and Cyber Security, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga B.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u2018Biomedical Technologies\u2019, School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Faculty of Fundamental Medicine, Chelyabinsk State University,  454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Manukhina, E.B., Tseilikman, V., Karpenko, M.N., Pestereva, N., Tseilikman, O., Komelkova, M., Kondashevskaya, M.V., Goryacheva, A.V., Lapshin, M., and Platkovskii, P.O. 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