{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:56:35Z","timestamp":1776261395598,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AgResearch Limited through the Strategic Science Investment","award":["A19079"],"award-info":[{"award-number":["A19079"]}]},{"name":"AgResearch Limited through the Strategic Science Investment","award":["A21246"],"award-info":[{"award-number":["A21246"]}]},{"name":"AgResearch Limited through the Strategic Science Investment","award":["3710040"],"award-info":[{"award-number":["3710040"]}]},{"name":"New Zealand National Science Challenge, High-Value Nutrition Program, Ministry for Business, Innovation and Employment","award":["A19079"],"award-info":[{"award-number":["A19079"]}]},{"name":"New Zealand National Science Challenge, High-Value Nutrition Program, Ministry for Business, Innovation and Employment","award":["A21246"],"award-info":[{"award-number":["A21246"]}]},{"name":"New Zealand National Science Challenge, High-Value Nutrition Program, Ministry for Business, Innovation and Employment","award":["3710040"],"award-info":[{"award-number":["3710040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ectopic lipid accumulation, including intra-pancreatic fat deposition (IPFD), exacerbates type 2 diabetes risk in susceptible individuals. Dysregulated circulating microRNAs (miRNAs) have been identified as correlating with clinical measures of pancreatitis, pancreatic cancer and type 1 diabetes. The aim of the current study was therefore to examine the association between circulating abundances of candidate miRNAs, IPFD and liver fat deposition as quantified using magnetic resonance imaging (MRI) and spectroscopy (MRS). Asian Chinese (n = 34; BMI = 26.7 \u00b1 4.2 kg\/m2) and European Caucasian (n = 34; BMI = 28.0 \u00b1 4.5 kg\/m2) females from the TOFI_Asia cohort underwent MRI and MRS analysis of pancreas (MR-%IPFD) and liver fat (MR-%liver fat), respectively, to quantify ectopic lipid deposition. Plasma miRNA abundances of a subset of circulatory miRNAs associated with IPFD and liver fat deposition were quantified by qRT-PCR. miR-21-3p and miR-320a-5p correlated with MR-%IPFD, plasma insulin and HOMA2-IR, but not MR-%liver fat. MR-%IPFD remained associated with decreasing miR-21-3p abundance following multivariate regression analysis. miR-21-3p and miR-320a were demonstrated to be negatively correlated with MR-%IPFD, independent of ethnicity. For miR-21-3p, this relationship persists with the inclusion of MR-%liver fat in the model, suggesting the potential for a wider application as a specific circulatory correlate of IPFD.<\/jats:p>","DOI":"10.3390\/ijms241814393","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T21:08:36Z","timestamp":1695330516000},"page":"14393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circulatory miRNAs as Correlates of Elevated Intra-Pancreatic Fat Deposition in a Mixed Ethnic Female Cohort: The TOFI_Asia Study"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-1282","authenticated-orcid":false,"given":"Farha","family":"Ramzan","sequence":"first","affiliation":[{"name":"Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-9925","authenticated-orcid":false,"given":"Ivana R.","family":"Sequeira-Bisson","sequence":"additional","affiliation":[{"name":"The High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand"},{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland 1010, New Zealand"},{"name":"The Riddet Institute, Massey University, Palmerston North 4410, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise W.","family":"Lu","sequence":"additional","affiliation":[{"name":"The High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand"},{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"School of Kinesiology, The University of British Columbia, Vancouver, BC V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall F.","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-9356","authenticated-orcid":false,"given":"Mark H.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-8378","authenticated-orcid":false,"given":"Sally D.","family":"Poppitt","sequence":"additional","affiliation":[{"name":"The High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand"},{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland 1010, New Zealand"},{"name":"The Riddet Institute, Massey University, Palmerston North 4410, New Zealand"},{"name":"Department of Medicine, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cameron-Smith","sequence":"additional","affiliation":[{"name":"Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"},{"name":"School of Agriculture, Food and Ecosystem Sciences, The University of Melbourne, Melbourne 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S2213-8587(19)30084-1","article-title":"Visceral and Ectopic Fat, Atherosclerosis, and Cardiometabolic Disease: A Position Statement","volume":"7","author":"Neeland","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes","volume":"12","author":"Valerio","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.3748\/wjg.v22.i34.7660","article-title":"Exploring the Metabolic Syndrome: Nonalcoholic Fatty Pancreas Disease","volume":"22","author":"Catanzaro","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/CIRCRESAHA.119.316337","article-title":"Nonalcoholic Fatty Liver Disease Pandemic Fuels the Upsurge in Cardiovascular Diseases","volume":"126","author":"Cai","year":"2020","journal-title":"Circ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/13651820701504157","article-title":"Nonalcoholic Fatty Pancreas Disease","volume":"9","author":"Mathur","year":"2007","journal-title":"HPB"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Caldart, F., de Pretis, N., Luchini, C., Ciccocioppo, R., and Frulloni, L. (2023). Pancreatic Steatosis and Metabolic Pancreatic Disease: A New Entity?. Intern. Emerg. Med., 1\u201310.","DOI":"10.1007\/s11739-023-03364-y"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tem.2003.09.008","article-title":"Lipid Overload and Overflow: Metabolic Trauma and the Metabolic Syndrome","volume":"14","author":"Unger","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e2918","DOI":"10.1002\/dmrr.2918","article-title":"Ectopic Fat Accumulation in the Pancreas and Its Biomarkers: A Systematic Review and Meta-Analysis","volume":"33","author":"Singh","year":"2017","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e0177154","DOI":"10.1371\/journal.pone.0177154","article-title":"Pancreatic Fat Content by Magnetic Resonance Imaging in Subjects with Prediabetes, Diabetes, and Controls from a General Population without Cardiovascular Disease","volume":"12","author":"Heber","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e0174660","DOI":"10.1371\/journal.pone.0174660","article-title":"Quantification of Intrapancreatic Fat in Type 2 Diabetes by MRI","volume":"12","author":"Hollingsworth","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e3858","DOI":"10.1097\/MD.0000000000003858","article-title":"Noninvasive Fat Quantification of the Liver and Pancreas May Provide Potential Biomarkers of Impaired Glucose Tolerance and Type 2 Diabetes","volume":"95","author":"Dong","year":"2016","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s41366-021-00854-x","article-title":"Untargeted Metabolomics Reveals Plasma Metabolites Predictive of Ectopic Fat in Pancreas and Liver as Assessed by Magnetic Resonance Imaging: The TOFI_Asia Study","volume":"45","author":"Wu","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.molmet.2017.06.020","article-title":"MicroRNAs as Stress Regulators in Pancreatic Beta Cells and Diabetes","volume":"6","author":"LaPierre","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e000096","DOI":"10.1136\/bmjgast-2016-000096","article-title":"Circulating MiRNA in Patients with Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease","volume":"3","author":"Mehta","year":"2016","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Goncalves, B.D.S., Meadows, A., Pereira, D.G., Puri, R., and Pillai, S.S. (2023). Insight into the Inter-Organ Crosstalk and Prognostic Role of Liver-Derived MicroRNAs in Metabolic Disease Progression. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061597"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"892672","DOI":"10.3389\/fendo.2022.892672","article-title":"Contribution of Liver and Pancreatic Islet Crosstalk to \u03b2-Cell Function\/Dysfunction in the Presence of Fatty Liver","volume":"13","author":"Ampuero","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00079.2016","article-title":"Biological Roles of MicroRNAs in the Control of Insulin Secretion and Action","volume":"49","author":"Calderari","year":"2017","journal-title":"Physiol. Genom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e0186480","DOI":"10.1371\/journal.pone.0186480","article-title":"Circulating MicroRNA-375 as Biomarker of Pancreatic Beta Cell Death and Protection of Beta Cell Mass by Cytoprotective Compounds","volume":"12","author":"Song","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/1440-1681.12940","article-title":"Down-Regulation of MicroRNA-375 Regulates Adipokines and Inhibits Inflammatory Cytokines by Targeting AdipoR2 in Non-Alcoholic Fatty Liver Disease","volume":"45","author":"Lei","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1101\/gad.1781009","article-title":"Integration of MicroRNA MiR-122 in Hepatic Circadian Gene Expression","volume":"23","author":"Gatfield","year":"2009","journal-title":"Genes Dev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tem.2009.05.007","article-title":"Meta-Regulation: MicroRNA Regulation of Glucose and Lipid Metabolism","volume":"20","author":"Lynn","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.asjsur.2022.04.032","article-title":"Identification of Key MicroRNAs in Exosomes Derived from Patients with the Severe Acute Pancreatitis","volume":"46","author":"Qu","year":"2023","journal-title":"Asian J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13000-015-0272-6","article-title":"MiR-21, MiR-34a, MiR-198 and MiR-217 as Diagnostic and Prognostic Biomarkers for Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma","volume":"10","author":"Kiss","year":"2015","journal-title":"Diagn. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Al-Muhtaresh, H.A., and Al-Kafaji, G. (2018). Evaluation of Two-Diabetes Related MicroRNAs Suitability as Earlier Blood Biomarkers for Detecting Prediabetes and Type 2 Diabetes Mellitus. J. Clin. Med., 7.","DOI":"10.3390\/jcm7020012"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41598-017-01904-z","article-title":"Circulating MiRNA-21-5p as a Diagnostic Biomarker for Pancreatic Cancer: Evidence from Comprehensive MiRNA Expression Profiling Analysis and Clinical Validation","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"40019","DOI":"10.1038\/srep40019","article-title":"Novel Blood-Based MicroRNA Biomarker Panel for Early Diagnosis of Chronic Pancreatitis","volume":"7","author":"Xin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fphys.2022.819606","article-title":"Pancreas Fat, an Early Marker of Metabolic Risk? A Magnetic Resonance Study of Chinese and Caucasian Women: TOFI_Asia Study","volume":"13","author":"Sequeira","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"(2018). Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care, 41, S13\u2013S27.","DOI":"10.2337\/dc18-S002"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2016.12.012","article-title":"Ectopic Fat Accumulation in the Pancreas and Its Clinical Relevance: A Systematic Review, Meta-Analysis, and Meta-Regression","volume":"69","author":"Singh","year":"2017","journal-title":"Metabolism"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pet\u00e4j\u00e4, E.M., and Yki-J\u00e4rvinen, H. (2016). Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD-A Systematic Review. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050633"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.biopha.2018.08.164","article-title":"MiR-21-3p Aggravates Injury in Rats with Acute Hemorrhagic Necrotizing Pancreatitis by Activating TRP Signaling Pathway","volume":"107","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kury\u0142owicz, A., Wicik, Z., Owczarz, M., Jonas, M.I., Kotlarek, M., \u015awierniak, M., Lisik, W., Jonas, M., Noszczyk, B., and Puzianowska-Ku\u017anicka, M. (2018). NGS Reveals Molecular Pathways Affected by Obesity and Weight Loss-Related Changes in MiRNA Levels in Adipose Tissue. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010066"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6823-11-7","article-title":"Gene-Chip Studies of Adipogenesis-Regulated MicroRNAs in Mouse Primary Adipocytes and Human Obesity","volume":"11","author":"Keller","year":"2011","journal-title":"BMC Endocr. Disord."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1261\/rna.033308.112","article-title":"Disease-Linked MicroRNA-21 Exhibits Drastically Reduced MRNA Binding and Silencing Activity in Healthy Mouse Liver","volume":"18","author":"Androsavich","year":"2012","journal-title":"RNA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1136\/gutjnl-2015-310822","article-title":"Stress-Activated MiR-21\/MiR-21* in Hepatocytes Promotes Lipid and Glucose Metabolic Disorders Associated with High-Fat Diet Consumption","volume":"65","author":"Calo","year":"2016","journal-title":"Gut"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000519621","article-title":"Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis","volume":"15","author":"Ko","year":"2022","journal-title":"Obes. Facts"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00018-023-04855-z","article-title":"Intrapancreatic Fat, Pancreatitis, and Pancreatic Cancer","volume":"80","author":"Lilly","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1111\/j.1440-1681.2009.05207.x","article-title":"Changes in MicroRNA (MiR) Profile and Effects of Mir-320 in Insulin-Resistant 3t3-L1 Adipocytes","volume":"36","author":"Ling","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2337\/dc10-0760","article-title":"Ethnic Differences in Pancreatic Fat Accumulation and Its Relationship with Other Fat Depots and Inflammatory Markers","volume":"34","author":"Ventura","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/rna.8.4.16029","article-title":"Population Differences in MicroRNA Expression and Biological Implications","volume":"8","author":"Huang","year":"2011","journal-title":"RNA Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02788443","article-title":"Effects of Sex and Age on Pancreatic Secretion","volume":"1","author":"Tiscornia","year":"1986","journal-title":"Int. J. Pancreatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/oby.22994","article-title":"Visceral Adiposity and Glucoregulatory Peptides Are Associated with Susceptibility to Type 2 Diabetes: The TOFI_Asia Study","volume":"28","author":"Sequeira","year":"2020","journal-title":"Obesity"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis Model Assessment: Insulin Resistance and \u03b2-Cell Function from Fasting Plasma Glucose and Insulin Concentrations in Man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e0181594","DOI":"10.1371\/journal.pone.0181594","article-title":"Acute Resistance Exercise Modulates MicroRNA Expression Profiles: Combined Tissue and Circulatory Targeted Analyses","volume":"12","author":"Markworth","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00592-019-01406-6","article-title":"Circulatory MiRNA Biomarkers of Metabolic Syndrome","volume":"57","author":"Ramzan","year":"2020","journal-title":"Acta Diabetol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e0153200","DOI":"10.1371\/journal.pone.0153200","article-title":"Comparison of Methodologies to Detect Low Levels of Hemolysis in Serum for Accurate Assessment of Serum MicroRNAs","volume":"11","author":"Shah","year":"2016","journal-title":"PLoS ONE"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing Real-Time PCR Data by the Comparative CT Method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:54:57Z","timestamp":1760129697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/18\/14393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":48,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ijms241814393"],"URL":"https:\/\/doi.org\/10.3390\/ijms241814393","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}