{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:13:37Z","timestamp":1781223217007,"version":"3.54.1"},"reference-count":28,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ammosov North-Eastern Federal University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The results of a comprehensive study of the patterns of structural and functional changes in bone tissue samples after combined (ozone + radiation) sterilization are presented. The study used a different approach to the sterilization process with selective ozone or radiation exposure and an integral, combined one, based on a combined ozone\u2013oxygen treatment of bone samples at the first stage and radiation at the second. The methods of IR spectroscopy, scanning electron microscopy with a prefix for elemental analysis, atomic force microscopy, and mechanical analysis with determination of elastic-plastic properties (Vickers microhardness index) were used in the work. It is shown that the ozone exposure used at the first stage of the combined sterilization process of bone implants does not lead to negative consequences with respect to their properties and characteristics. The results obtained serve as a scientific and methodological basis for the further improvement and optimization of sterilization technologies (including combined). They also offer a comprehensive justification of the parameters of sterilization regimes to ensure the safety of using bone implants during reconstructive operations, minimizing structural and functional changes in bone matter, and creating effective health-saving technologies and the possibility of using them for various biomedical applications.<\/jats:p>","DOI":"10.3390\/ijms241914426","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T03:44:42Z","timestamp":1695354282000},"page":"14426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Influence of Combined Sterilization Factors on the Structural and Functional Characteristics of Bone Implants"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-5932","authenticated-orcid":false,"given":"Nadezhda","family":"Nikolaeva","sequence":"first","affiliation":[{"name":"Radiation Technologies Laboratory, Institute of Physics and Technology, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Rozanov","sequence":"additional","affiliation":[{"name":"Radiation Technologies Laboratory, Institute of Physics and Technology, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, Russia"},{"name":"Physical Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia"},{"name":"Scientific and Educational-Methodical Center of Biomedical Technology, The All-Russian Research Institute of Medicinal and Aromatic Plants, 117216 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-046X","authenticated-orcid":false,"given":"Alexander","family":"Chernyaev","sequence":"additional","affiliation":[{"name":"Radiation Technologies Laboratory, Institute of Physics and Technology, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, Russia"},{"name":"Physical Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Matveychuk","sequence":"additional","affiliation":[{"name":"Scientific and Educational-Methodical Center of Biomedical Technology, The All-Russian Research Institute of Medicinal and Aromatic Plants, 117216 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2047-3871","authenticated-orcid":false,"given":"Milena","family":"Makarova","sequence":"additional","affiliation":[{"name":"Radiation Technologies Laboratory, Institute of Physics and Technology, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, March 26). Global Observatory on Donation and Transplantations. Available online: http:\/\/www.transplant-observatory.org\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00011-022-01616-9","article-title":"Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics","volume":"71","author":"Sapra","year":"2022","journal-title":"Inflamm. 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