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Interestingly, in previous research, we observed elevated levels of vascular endothelial growth factor A (VEGFA) in TAT from patients with ischemic cardiomyopathy (IC), particularly in those over 70 years old. Moreover, in contrast to subcutaneous adipose tissue (SAT), TAT in elderly individuals exhibits enhanced angiogenic properties and the ability to stimulate tube formation. This makes TAT a promising candidate for angiogenic therapies and the regeneration of ischemic tissues following coronary surgery. MicroRNAs (miRNAs) have emerged as attractive therapeutic targets, especially those that regulate angiogenic processes. The study\u2019s purpose is to determine the miRNA network associated with both the VEGFA pathway regulation and the enrichment of age-linked angiogenesis in the TAT. RT-PCR was used to analyze angiogenic miRNAs and the expression levels of their predicted target genes in both TAT and SAT from elderly and middle-aged patients treated with coronary artery bypass graft surgery. miRTargetLink Human was used to search for miRNAs and their target genes. PANTHER was used to annotate the biological processes of the predicted targets. The expression of miR-15b-5p and miR-29a-3p was significantly upregulated in the TAT of elderly compared with middle-aged patients. Interestingly, VEGFA and other angiogenic targets were significantly upregulated in the TAT of elderly patients. Specifically: JAG1, PDGFC, VEGFA, FGF2, KDR, NOTCH2, FOS, PDGFRA, PDGFRB, and RHOB were upregulated, while PIK3CG and WNT7A were downregulated. Our results provide strong evidence of a miRNA\/mRNA interaction network linked with age-associated TAT angiogenic enrichment in patients with IC.<\/jats:p>","DOI":"10.3390\/ijms241914456","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:36:26Z","timestamp":1695551786000},"page":"14456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Network Comprised of miR-15b and miR-29a Is Involved in Vascular Endothelial Growth Factor Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-9117","authenticated-orcid":false,"given":"Adriana Mariel","family":"Gentile","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29580 Malaga, 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Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1161\/CIR.0000000000000985","article-title":"Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association","volume":"144","author":"Damluji","year":"2021","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/ATVBAHA.108.166496","article-title":"Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis","volume":"29","author":"Kondo","year":"2009","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/PRS.0b013e3181954d08","article-title":"Aging and diabetes impair the neovascular potential of adipose-derived stromal cells","volume":"123","author":"Chang","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-9-10","article-title":"Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning","volume":"9","author":"Efimenko","year":"2011","journal-title":"J. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nagata, T. (2012). Senescence, InTech. Chapter 31.","DOI":"10.5772\/1905"},{"key":"ref_8","first-page":"1263","article-title":"Thymus fat as an attractive source of angiogenic factors in elderly subjects with myocardial ischemia","volume":"35","author":"Murri","year":"2012","journal-title":"AGE"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00441-009-0867-x","article-title":"Angiogenic properties of adult human thymus fat","volume":"338","author":"Salas","year":"2009","journal-title":"Cell Tissue Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Holmes, D.I., and Zachary, I. (2005). The vascular endothelial growth factor (VEGF) family: Angiogenic factors in health and disease. Genome Biol., 6.","DOI":"10.1186\/gb-2005-6-2-209"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s11011-021-00739-y","article-title":"Emerging role of non-coding RNA in health and disease","volume":"36","author":"Bhatti","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10557-019-06893-x","article-title":"The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury","volume":"33","author":"Siebert","year":"2019","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Enright, A.J., John, B., Gaul, U., Tuschl, T., Sander, C., and Marks, D.S. (2003). MicroRNA targets in Drosophila. Genome Biol., 5.","DOI":"10.1186\/gb-2003-5-1-r1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.omtn.2021.06.019","article-title":"miR-21 mimic blocks obesity in mice: A novel therapeutic option","volume":"26","author":"Lhamyani","year":"2021","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Oliva-Olivera, W., Co\u00edn-Arag\u00fcez, L., Salas, J., Lhamyani, S., Gentile, A.-M., Garc\u00eda, E.S., Hmadcha, A., Zayed, H., Vega-Rioja, A., and Tinahones, F.J. (2015). Myocardial Ischemic Subject\u2019s Thymus Fat: A Novel Source of Multipotent Stromal Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144401"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1089\/ten.tea.2020.0170","article-title":"The Role of Angiogenesis-Inducing microRNAs in Vascular Tissue Engineering","volume":"26","author":"Ding","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/acel.12252","article-title":"miR-125a-5p impairs endothelial cell angiogenesis in aging mice via RTEF -1 downregulation","volume":"13","author":"Che","year":"2014","journal-title":"Aging Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"MacLean, J.A., King, M.L., Okuda, H., and Hayashi, K. (2016). WNT7A Regulation by miR-15b in Ovarian Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156109"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1111\/brv.12428","article-title":"Clustered miRNAs and their role in biological functions and diseases","volume":"93","author":"Kabekkodu","year":"2018","journal-title":"Biol. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.3892\/mmr.2017.7230","article-title":"Downregulation of microRNA-195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"18837","DOI":"10.18632\/oncotarget.7719","article-title":"High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCRESAHA.115.306829","article-title":"Bach1 Represses Wnt\/\u03b2-Catenin Signaling and Angiogenesis","volume":"117","author":"Jiang","year":"2015","journal-title":"Circ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3389\/fgene.2020.00947","article-title":"MicroRNA Expression Profiling of Bone Marrow\u2013Derived Proangiogenic Cells (PACs) in a Mouse Model of Hindlimb Ischemia: Modulation by Classical Cardiovascular Risk Factors","volume":"11","author":"Desjarlais","year":"2020","journal-title":"Front. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lim, H.N., Jang, J.-P., Han, J.M., Jang, J.-H., Ahn, J.S., and Jung, H.J. (2018). Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis. Molecules, 23.","DOI":"10.3390\/molecules23030563"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/15569527.2017.1375943","article-title":"Effects of sunitinib and bevacizumab on VEGF and miRNA levels on corneal neovascularization","volume":"37","author":"Cakmak","year":"2017","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.numecd.2015.11.010","article-title":"Long-acting insulin analog detemir displays reduced effects on adipocyte differentiation of human subcutaneous and visceral adipose stem cells","volume":"26","author":"Cignarelli","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gaebler, N., Haggenm\u00fcller, B., Kapapa, M., Serra, A., Tews, D., Funcke, J.-B., Brandt, S., Ioannidis, V., Sch\u00f6n, M., and M\u00f6ller, P. (2019). Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205204"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/oby.22363","article-title":"miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes","volume":"27","author":"Gentile","year":"2018","journal-title":"Obesity"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12263-016-0524-4","article-title":"Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes","volume":"11","author":"Hindy","year":"2016","journal-title":"Genes Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/ATVBAHA.120.314731","article-title":"Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation","volume":"40","author":"Boucher","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/CIRCRESAHA.119.315246","article-title":"Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes","volume":"126","author":"Chen","year":"2019","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1080\/21623945.2021.1987634","article-title":"Sprouty1 regulates gonadal white adipose tissue growth through a PDGFR\u03b1\/\u03b2-Akt pathway","volume":"10","author":"Yang","year":"2021","journal-title":"Adipocyte"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13577-011-0033-0","article-title":"The effect of C3 transferase on human adipose-derived stem cells","volume":"24","author":"Kakudo","year":"2011","journal-title":"Hum. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.gendis.2022.07.006","article-title":"JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1","volume":"10","author":"Liu","year":"2023","journal-title":"Genes Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1152\/japplphysiol.00112.2018","article-title":"Understanding angiogenesis during aging: Opportunities for discoveries and new models","volume":"125","author":"Hodges","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e23725","DOI":"10.1002\/jcla.23725","article-title":"PI3 kinase signaling pathway in hematopoietic cancers: A glance in miRNA\u2019s role","volume":"35","author":"Roshandel","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_38","first-page":"3824","article-title":"Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma","volume":"8","author":"Semba","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref_39","first-page":"e1772","article-title":"Differences in the neovascular potential of thymus versus subcutaneous adipose-derived stem cells from patients with myocardial ischaemia","volume":"12","author":"Lhamyani","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00125-019-4969-z","article-title":"VEGF-A and blood vessels: A beta cell perspective","volume":"62","author":"Staels","year":"2019","journal-title":"Diabetologia"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"44735","DOI":"10.18632\/oncotarget.8203","article-title":"Molecular and clinical significance of fibroblast growth factor 2 (FGF2\/bFGF) in malignancies of solid and hematological cancers for personalized therapies","volume":"7","author":"Akl","year":"2016","journal-title":"Oncotarget"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Nakamura, Y. (2021). Multiple Therapeutic Applications of RBM-007, an Anti-FGF2 Aptamer. Cells, 10.","DOI":"10.3390\/cells10071617"},{"key":"ref_43","first-page":"125","article-title":"Platelet-derived growth factor D promotes the angiogenic capacity of endothelial progenitor cells","volume":"19","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1089\/ten.teb.2021.0160","article-title":"Microvascular Fragments in Microcirculation Research and Regenerative Medicine","volume":"28","author":"Laschke","year":"2022","journal-title":"Tissue Eng. Part B Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14456\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:56:14Z","timestamp":1760129774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":44,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["ijms241914456"],"URL":"https:\/\/doi.org\/10.3390\/ijms241914456","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]}}}