{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:31:29Z","timestamp":1787139089388,"version":"build-2736575974"},"reference-count":250,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including metastatic cascade arising in neoplastic progression and organ fibrosis. Fibrosis is delineated by an excessive number of myofibroblasts, resulting in exuberant production of extracellular matrix (ECM) proteins, thereby compromising organ function and ultimately leading to its failure. It is now well acknowledged that a significant number of myofibroblasts result from the conversion of epithelial cells via EMT. Over the past two decades, evidence has accrued linking fibrosis to many chronic autoimmune and inflammatory diseases, including systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sj\u00f6gren\u2019s syndrome (SS), and inflammatory bowel diseases (IBD). In addition, chronic inflammatory states observed in most autoimmune and inflammatory diseases can act as a potent trigger of EMT, leading to the development of a pathological fibrotic state. In the present review, we aim to describe the current state of knowledge regarding the contribution of EMT to the pathophysiological processes of various rheumatic conditions.<\/jats:p>","DOI":"10.3390\/ijms241914481","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:36:26Z","timestamp":1695551786000},"page":"14481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-0044","authenticated-orcid":false,"given":"Julie","family":"Sarrand","sequence":"first","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-1810","authenticated-orcid":false,"given":"Muhammad S.","family":"Soyfoo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1387\/ijdb.072410mn","article-title":"Epithelial-Mesenchymal Transitions in development and disease: Old views and new perspectives","volume":"53","author":"Nieto","year":"2009","journal-title":"Int. J. Dev. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"569322","DOI":"10.3389\/fphys.2020.569322","article-title":"New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis","volume":"11","author":"Sheng","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2010.04.015","article-title":"Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming","volume":"7","author":"Golipour","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2010.04.014","article-title":"A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts","volume":"7","author":"Li","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/nm.3336","article-title":"The epigenetics of epithelial-mesenchymal plasticity in cancer","volume":"19","author":"Tam","year":"2013","journal-title":"Nat. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex networks orchestrate epithelial-mesenchymal transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.95.1.333","article-title":"Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells","volume":"95","author":"Greenburg","year":"1982","journal-title":"J. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1440-169X.2008.01070.x","article-title":"Epithelial to mesenchymal transition during gastrulation: An embryological view","volume":"50","author":"Nakaya","year":"2008","journal-title":"Dev. Growth Differ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0012-1606(82)90352-9","article-title":"Appearance and distribution of fibronectin during chick embryo gastrulation and neurulation","volume":"94","author":"Duband","year":"1982","journal-title":"Dev. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1242\/dev.126.21.4749","article-title":"Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube","volume":"126","author":"Kalcheim","year":"1999","journal-title":"Development"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1242\/dev.071209","article-title":"Epithelial-mesenchymal transitions: Insights from development","volume":"139","author":"Lim","year":"2012","journal-title":"Development"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1091\/mbc.e07-10-1078","article-title":"Erk5 controls Slug expression and keratinocyte activation during wound healing","volume":"19","author":"Arnoux","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-physiol-012110-142225","article-title":"Epithelial-mesenchymal interactions in pulmonary fibrosis","volume":"73","author":"Chapman","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrclinonc.2017.44","article-title":"EMT, CSCs, and drug resistance: The mechanistic link and clinical implications","volume":"14","author":"Shibue","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc3447","article-title":"Regulatory networks defining EMT during cancer initiation and progression","volume":"13","author":"Berx","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrc3265","article-title":"To differentiate or not\u2014Routes towards metastasis","volume":"12","author":"Brabletz","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1038\/onc.2010.215","article-title":"EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer","volume":"29","author":"Singh","year":"2010","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/path.1427","article-title":"The myofibroblast in wound healing and fibrocontractive diseases","volume":"200","author":"Gabbiani","year":"2003","journal-title":"J. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/jcb.21186","article-title":"Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?","volume":"101","author":"Radisky","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_30","first-page":"6557486","article-title":"Scorpion Venom Polypeptide Inhibits Pulmonary Epithelial-Mesenchymal Transition in Systemic Sclerosis-Interstitial Lung Disease Model Mice by Intervening TGF-beta1\/Smad Signaling Pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Evid. Based Complement. Alter. Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-019-03557-0","article-title":"Transforming growth factor beta1 promotes fibroblast-like synoviocytes migration and invasion via TGF-beta1\/Smad signaling in rheumatoid arthritis","volume":"459","author":"Zhu","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/acr.20441","article-title":"Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring","volume":"63","author":"Hsieh","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1965935","DOI":"10.1155\/2018\/1965935","article-title":"The TGF-beta1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjogren\u2019s Syndrome","volume":"2018","author":"Sisto","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","article-title":"Inflammation and EMT: An alliance towards organ fibrosis and cancer progression","volume":"1","author":"Nieto","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Jose Alcaraz, M. (2021). New potential therapeutic approaches targeting synovial fibroblasts in rheumatoid arthritis. Biochem. Pharmacol., 194.","DOI":"10.1016\/j.bcp.2021.114815"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sisto, M., Ribatti, D., and Lisi, S. (2022). Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjogren\u2019s Syndrome: Identification of New Targets. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113229"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial-mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112804","DOI":"10.1016\/j.celrep.2023.112804","article-title":"Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia","volume":"42","author":"Park","year":"2023","journal-title":"Cell Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Qi, Y., Wang, N., He, Y., Zhang, J., Zou, H., Zhang, W., Gu, W., Huang, Y., Lian, X., and Hu, J. (2017). Transforming growth factor-beta1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182680"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/febs.16021","article-title":"Epithelial-to-mesenchymal-like transition events in melanoma","volume":"289","author":"Pedri","year":"2022","journal-title":"FEBS J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41419-018-1294-2","article-title":"Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology","volume":"10","author":"Fontijn","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Keshava, S., Owens, S., Qin, W., Jeffers, A., Kyei, P., Komatsu, S., Kleam, J., Ikebe, M., Idell, S., and Tucker, T.A. (2023, August 20). The mTORC2\/SGK1\/NDRG1 Signaling Axis Is Critical for Mesomesenchymal Transition of Pleural Mesothelial Cells and the Progression of Pleural Fibrosis. Available online: https:\/\/doi.org\/10.1165\/rcmb.2023-0131OC.","DOI":"10.1165\/rcmb.2023-0131OC"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11010-012-1463-z","article-title":"PI3 kinase\/Akt\/HIF-1alpha pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis","volume":"372","author":"Li","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41556-020-00588-4","article-title":"ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration","volume":"22","author":"Aharonov","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"Berx","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Loh, C.Y., Chai, J.Y., Tang, T.F., Wong, W.F., Sethi, G., Shanmugam, M.K., Chong, P.P., and Looi, C.Y. (2019). The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells, 8.","DOI":"10.3390\/cells8101118"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kyuno, D., Takasawa, A., Kikuchi, S., Takemasa, I., Osanai, M., and Kojima, T. (2021). Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochim. Biophys. Acta Biomembr., 1863.","DOI":"10.1016\/j.bbamem.2020.183503"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/onc.2013.128","article-title":"Multilayer control of the EMT master regulators","volume":"33","author":"Zheng","year":"2014","journal-title":"Oncogene"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1593\/neo.04241","article-title":"Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro","volume":"6","author":"Xie","year":"2004","journal-title":"Neoplasia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1387\/ijdb.041794hp","article-title":"Transcriptional regulation of cadherins during development and carcinogenesis","volume":"48","author":"Peinado","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35000025","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/MCB.00323-08","article-title":"Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor","volume":"28","author":"Herranz","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/jcs.00224","article-title":"The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors","volume":"116","author":"Bolos","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1242\/jcs.00389","article-title":"Regulation of tight junctions during the epithelium-mesenchyme transition: Direct repression of the gene expression of claudins\/occludin by Snail","volume":"116","author":"Ikenouchi","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1074\/jbc.M110.168625","article-title":"Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition","volume":"286","author":"Dave","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/jcs.02465","article-title":"Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor","volume":"118","author":"Jorda","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ncb1905","article-title":"A SNAIL1-SMAD3\/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition","volume":"11","author":"Vincent","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1093\/emboj\/18.18.5073","article-title":"New mode of DNA binding of multi-zinc finger transcription factors: \u03b4EF1 family members bind with two hands to two target sites","volume":"18","author":"Remacle","year":"1999","journal-title":"EMBO J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/sj.onc.1208429","article-title":"DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells","volume":"24","author":"Eger","year":"2005","journal-title":"Oncogene"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1038\/onc.2010.102","article-title":"ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI\/SNF chromatin-remodeling protein BRG1","volume":"29","author":"Lazaro","year":"2010","journal-title":"Oncogene"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.bjc.6601685","article-title":"Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells","volume":"90","author":"Miyoshi","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.bjc.6602266","article-title":"Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma","volume":"92","author":"Miyoshi","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-beta-induced epithelial to mesenchymal transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/ncb2099","article-title":"Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.18632\/oncotarget.3052","article-title":"The microRNA-200 family: Small molecules with novel roles in cancer development, progression and therapy","volume":"6","author":"Humphries","year":"2015","journal-title":"Oncotarget"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"00138","DOI":"10.1183\/23120541.00138-2019","article-title":"miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation","volume":"5","author":"Moimas","year":"2019","journal-title":"ERJ Open Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/embor.2008.74","article-title":"A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells","volume":"9","author":"Burk","year":"2008","journal-title":"EMBO Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1158\/0008-5472.CAN-08-1942","article-title":"A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition","volume":"68","author":"Bracken","year":"2008","journal-title":"Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming Growth Factor-beta Signaling in Immunity and Cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.biopha.2018.02.090","article-title":"Central role of dysregulation of TGF-beta\/Smad in CKD progression and potential targets of its treatment","volume":"101","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20101827","article-title":"Smad7: Not only a regulator, but also a cross-talk mediator of TGF-beta signalling","volume":"434","author":"Yan","year":"2011","journal-title":"Biochem. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1074\/jbc.M115.694281","article-title":"Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-beta (TGF-beta)\/Smad Signaling","volume":"291","author":"Yan","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a022137","article-title":"Signaling Cross Talk between TGF-beta\/Smad and Other Signaling Pathways","volume":"9","author":"Luo","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41401-019-0324-7","article-title":"Ganoderic acid hinders renal fibrosis via suppressing the TGF-beta\/Smad and MAPK signaling pathways","volume":"41","author":"Geng","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"36803","DOI":"10.1074\/jbc.M005912200","article-title":"Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration","volume":"275","author":"Bakin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.molcel.2008.09.002","article-title":"TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta","volume":"31","author":"Yamashita","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ncb1780","article-title":"The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner","volume":"10","author":"Sorrentino","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: Components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrm3470","article-title":"The complex world of WNT receptor signalling","volume":"13","author":"Niehrs","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/kisup.2014.16","article-title":"Wnt\/beta-catenin signaling and kidney fibrosis","volume":"4","author":"Tan","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","article-title":"Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1016\/j.cub.2004.01.023","article-title":"Regulation of notch signaling activity","volume":"14","author":"Schweisguth","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrc1186","article-title":"The role of Notch in tumorigenesis: Oncogene or tumour suppressor?","volume":"3","author":"Radtke","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrneph.2016.54","article-title":"Developmental signalling pathways in renal fibrosis: The roles of Notch, Wnt and Hedgehog","volume":"12","author":"Edeling","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1242\/jcs.115.6.1095","article-title":"Notch: A membrane-bound transcription factor","volume":"115","author":"Kopan","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"114691","DOI":"10.1016\/j.taap.2019.114691","article-title":"Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2","volume":"380","author":"Jeong","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.200710067","article-title":"Slug is a direct Notch target required for initiation of cardiac cushion cellularization","volume":"182","author":"Niessen","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1084\/jem.20071082","article-title":"Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin","volume":"204","author":"Leong","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1073\/pnas.0802047105","article-title":"Notch signaling mediates hypoxia-induced tumor cell migration and invasion","volume":"105","author":"Sahlgren","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1158\/1078-0432.CCR-05-2570","article-title":"Notch signaling","volume":"12","author":"Miele","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12032-016-0747-7","article-title":"Notch-1 signaling activates NF-kappaB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway","volume":"33","author":"Li","year":"2016","journal-title":"Med. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"668207","DOI":"10.3389\/fimmu.2021.668207","article-title":"Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases","volume":"12","author":"Christopoulos","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: Paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: Functions and mechanisms","volume":"22","author":"Varjosalo","year":"2008","journal-title":"Genes Dev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.ajpath.2011.12.039","article-title":"Hedgehog-Gli pathway activation during kidney fibrosis","volume":"180","author":"Fabian","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-016-0509-3","article-title":"Hedgehog signaling: Modulation of cancer properies and tumor mircroenvironment","volume":"15","author":"Hanna","year":"2016","journal-title":"Mol. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/or.14.1.291","article-title":"Comparative genomics on Sonic hedgehog orthologs","volume":"14","author":"Katoh","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/382547a0","article-title":"smoothened encodes a receptor-like serpentine protein required for hedgehog signalling","volume":"382","author":"Ingham","year":"1996","journal-title":"Nature"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.onc.1209077","article-title":"Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation","volume":"25","author":"Li","year":"2006","journal-title":"Oncogene"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/35077219","article-title":"The Hedgehog and Wnt signalling pathways in cancer","volume":"411","author":"Taipale","year":"2001","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1038\/sj.onc.1203957","article-title":"The protein tyrosine kinase family of the human genome","volume":"19","author":"Robinson","year":"2000","journal-title":"Oncogene"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.bbrc.2018.01.069","article-title":"Comparison of EMT mediated tyrosine kinase inhibitor resistance in NSCLC","volume":"496","author":"Iderzorig","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1183\/09031936.00149614","article-title":"The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis","volume":"45","author":"Grimminger","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1101\/gad.225334.113","article-title":"Epithelial-mesenchymal plasticity in carcinoma metastasis","volume":"27","author":"Tsai","year":"2013","journal-title":"Genes Dev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1158\/0008-5472.CAN-10-4058","article-title":"mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways","volume":"71","author":"Gulhati","year":"2011","journal-title":"Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.molcel.2009.08.002","article-title":"RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile\/invasive gene program and phenotype in epithelial cells","volume":"35","author":"Doehn","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1038\/sj.onc.1210546","article-title":"Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition","volume":"26","author":"Julien","year":"2007","journal-title":"Oncogene"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2013.05.046","article-title":"Stabilization of Snail through AKT\/GSK-3beta signaling pathway is required for TNF-alpha-induced epithelial-mesenchymal transition in prostate cancer PC3 cells","volume":"714","author":"Wang","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1126\/science.270.5244.2008","article-title":"Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction","volume":"270","author":"Yamaguchi","year":"1995","journal-title":"Science"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: Impact on human disease and therapeutic intervention","volume":"66","author":"Schwartz","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","article-title":"JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1541-7786.MCR-11-0271","article-title":"IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway","volume":"9","author":"Yadav","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1074\/jbc.M111.295964","article-title":"Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition","volume":"287","author":"Xiong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12931-018-0728-9","article-title":"The JAK2 pathway is activated in idiopathic pulmonary fibrosis","volume":"19","author":"Milara","year":"2018","journal-title":"Respir. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-kappa B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1083\/jcb.200409067","article-title":"Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition","volume":"168","author":"Bachelder","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1038\/sj.onc.1207990","article-title":"Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells","volume":"23","author":"Barbera","year":"2004","journal-title":"Oncogene"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.onc.1209808","article-title":"NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2","volume":"26","author":"Chua","year":"2007","journal-title":"Oncogene"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ccell.2014.09.002","article-title":"Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages","volume":"26","author":"Hsu","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem. J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"20741","DOI":"10.18632\/oncotarget.15119","article-title":"IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2\/STAT3 signaling pathway","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41420-021-00437-9","article-title":"Role of interleukins in the pathogenesis of pulmonary fibrosis","volume":"7","author":"She","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1007\/s10620-018-5234-x","article-title":"IL-17A Promotes Initiation and Development of Intestinal Fibrosis Through EMT","volume":"63","author":"Zhang","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_136","first-page":"1169","article-title":"Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-kappaB\/ZEB1 signal pathway","volume":"5","author":"Gu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Wang, T., Liu, Y., Zou, J.F., and Cheng, Z.S. (2017). Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the TGF-beta1 mediated Smad2\/3 and ERK1\/2 activation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183972"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12935-020-01719-5","article-title":"The role of hypoxia in the tumor microenvironment and development of cancer stem cell: A novel approach to developing treatment","volume":"21","author":"Najafgholian","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-12-394307-1.00003-5","article-title":"Hypoxia and hypoxia signaling in tissue repair and fibrosis","volume":"296","author":"Lokmic","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molmed.2018.10.006","article-title":"Inflammation and Hypoxia: HIF and PHD Isoform Selectivity","volume":"25","author":"Watts","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0002-9440(10)63501-8","article-title":"Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells","volume":"163","author":"Imai","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1158\/0008-5472.CAN-05-3719","article-title":"Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B","volume":"66","author":"Krishnamachary","year":"2006","journal-title":"Cancer Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/MCB.00892-06","article-title":"VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail","volume":"27","author":"Evans","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s11255-020-02474-2","article-title":"Recent advances in understanding the role of hypoxia-inducible factor 1alpha in renal fibrosis","volume":"52","author":"Wei","year":"2020","journal-title":"Int. Urol. Nephrol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12931-019-1100-4","article-title":"Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis","volume":"20","author":"Cisneros","year":"2019","journal-title":"Respir. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/cas.12773","article-title":"Transforming growth factor-beta signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells","volume":"106","author":"Furuta","year":"2015","journal-title":"Cancer Sci."},{"key":"ref_147","first-page":"1425","article-title":"Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues","volume":"54","author":"Koong","year":"1994","journal-title":"Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ncb3157","article-title":"Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway","volume":"17","author":"Wei","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.matbio.2009.12.003","article-title":"Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1","volume":"29","author":"Medici","year":"2010","journal-title":"Matrix Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/15419069609014222","article-title":"Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line","volume":"4","author":"Valles","year":"1996","journal-title":"Cell Adhes. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.matbio.2011.03.007","article-title":"Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition","volume":"30","author":"Walsh","year":"2011","journal-title":"Matrix Biol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Nistico, P., Bissell, M.J., and Radisky, D.C. (2012). Epithelial-mesenchymal transition: General principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb. Perspect. Biol., 4.","DOI":"10.1101\/cshperspect.a011908"},{"key":"ref_153","first-page":"142ra195","article-title":"Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression","volume":"4","author":"Waldmann","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40265-020-01309-9","article-title":"Understanding Refractory Rheumatoid Arthritis: Implications for a Therapeutic Approach","volume":"80","author":"Melville","year":"2020","journal-title":"Drugs"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13317-020-00145-x","article-title":"Transformation of fibroblast-like synoviocytes in rheumatoid arthritis; from a friend to foe","volume":"12","author":"Mousavi","year":"2021","journal-title":"Auto Immun. Highlights"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/rheumatology\/kel065","article-title":"Synovial fibroblasts: Key players in rheumatoid arthritis","volume":"45","author":"Huber","year":"2006","journal-title":"Rheumatology"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clim.2004.12.009","article-title":"The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction","volume":"115","author":"Mor","year":"2005","journal-title":"Clin. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1582-4934.2002.tb00514.x","article-title":"Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases","volume":"6","author":"Bodolay","year":"2002","journal-title":"J. Cell. Mol. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/art.1780270803","article-title":"Quantitation of human synovial mast cells in rheumatoid arthritis and other rheumatic diseases","volume":"27","author":"Godfrey","year":"1984","journal-title":"Arthritis Rheum."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/ard.26.5.426","article-title":"Ultrastructure of synovial membrane in rheumatoid arthritis","volume":"26","author":"Ghadially","year":"1967","journal-title":"Ann. Rheum. Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.berh.2006.06.005","article-title":"The role of mesenchymal cells in the pathophysiology of inflammatory arthritis","volume":"20","author":"Meyer","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-065X.2008.00648.x","article-title":"The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis","volume":"223","author":"Noss","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_165","first-page":"1607","article-title":"Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice","volume":"149","author":"Kriegsmann","year":"1996","journal-title":"Am. J. Pathol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00002281-200305000-00015","article-title":"Apoptosis in rheumatoid arthritis","volume":"15","author":"Baier","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1080\/15384101.2021.1974790","article-title":"Fascin1 mediated release of pro-inflammatory cytokines and invasion\/migration in rheumatoid arthritis via the STAT3 pathway","volume":"20","author":"Ma","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrrheum.2009.55","article-title":"Epigenetic control in rheumatoid arthritis synovial fibroblasts","volume":"5","author":"Karouzakis","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/art.21118","article-title":"Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis","volume":"52","author":"Tolboom","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zai, Z., Lu, Z., Zhang, T., Wang, L., Qian, X., Tao, J., Peng, X., Zhang, Y., and Chen, F. (2023). Circular RNA CircCDKN2B-AS_006 Promotes the Tumor-like Growth and Metastasis of Rheumatoid Arthritis Synovial Fibroblasts by Targeting the miR-1258\/RUNX1 Axis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065880"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/ar2073","article-title":"Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal\/fibrotic characteristics","volume":"8","author":"Steenvoorden","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/ar3274","article-title":"The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis","volume":"13","author":"Ekwall","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Quintanilla, M., Montero-Montero, L., Renart, J., and Martin-Villar, E. (2019). Podoplanin in Inflammation and Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030707"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00296-009-0865-z","article-title":"Characterization of synovial tissue from arthritis patients: A proton magnetic resonance spectroscopic investigation","volume":"29","author":"Hitchon","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molimm.2012.08.018","article-title":"Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-kappaB\/HIF-1alpha pathway","volume":"53","author":"Li","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/art.41748","article-title":"Notch-1 and Notch-3 Mediate Hypoxia-Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis","volume":"73","author":"Chen","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_177","first-page":"3643265","article-title":"Baicalein Induces Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts through Inactivation of the PI3K\/Akt\/mTOR Pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Evid. Based Complement. Alter. Nat. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ajpath.2015.10.021","article-title":"Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis","volume":"186","author":"Lauzier","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Parisis, D., Chivasso, C., Perret, J., Soyfoo, M.S., and Delporte, C. (2020). Current State of Knowledge on Primary Sjogren\u2019s Syndrome, an Autoimmune Exocrinopathy. J. Clin. Med., 9.","DOI":"10.3390\/jcm9072299"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren\u2019s Syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.clim.2017.04.003","article-title":"Innate immunity in Sjogren\u2019s syndrome","volume":"182","author":"Kiripolsky","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-0714.2008.00700.x","article-title":"Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function","volume":"38","author":"Deshmukh","year":"2009","journal-title":"J. Oral Pathol. Med."},{"key":"ref_183","first-page":"1019","article-title":"Toll-like receptor in salivary glands from patients with Sjogren\u2019s syndrome: Functional analysis by human salivary gland cell line","volume":"34","author":"Kawakami","year":"2007","journal-title":"J. Rheumatol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","article-title":"Expression of functional Toll-like receptors by salivary gland epithelial cells: Increased mRNA expression in cells derived from patients with primary Sjogren\u2019s syndrome","volume":"147","author":"Spachidou","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.tripleo.2010.01.006","article-title":"Expression of Toll-like receptors 7, 8, and 9 in primary Sjogren\u2019s syndrome","volume":"109","author":"Zheng","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sjogren syndrome","volume":"2","author":"Baldini","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/ard.54.9.744","article-title":"Transforming growth factor beta 2 in labial salivary glands in Sjogren\u2019s syndrome","volume":"54","author":"Koski","year":"1995","journal-title":"Ann. Rheum. Dis."},{"key":"ref_188","first-page":"63","article-title":"Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjogren\u2019s syndrome","volume":"16","author":"Skopouli","year":"1998","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_189","first-page":"80","article-title":"Minor salivary gland fibrosis in Sjogren\u2019s syndrome is elevated, associated with focus score and not solely a consequence of aging","volume":"36","author":"Leehan","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","article-title":"TGF-beta and epithelial-to-mesenchymal transitions","volume":"24","author":"Zavadil","year":"2005","journal-title":"Oncogene"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00005-020-00591-5","article-title":"IL-6 Contributes to the TGF-beta1-Mediated Epithelial to Mesenchymal Transition in Human Salivary Gland Epithelial Cells","volume":"68","author":"Sisto","year":"2020","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/cei.13337","article-title":"Interleukin-17 and -22 synergy linking inflammation and EMT-dependent fibrosis in Sjogren\u2019s syndrome","volume":"198","author":"Sisto","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.3899\/jrheum.121362","article-title":"Expression of podoplanin in minor salivary glands increases in primary Sjogren syndrome","volume":"40","author":"Yazisiz","year":"2013","journal-title":"J. Rheumatol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41374-020-0373-z","article-title":"TGFbeta1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial-mesenchymal transition in Sjogren\u2019s syndrome","volume":"100","author":"Sisto","year":"2020","journal-title":"Lab. Investig."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"14552","DOI":"10.1038\/s41598-022-18576-z","article-title":"Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjogren\u2019s syndrome","volume":"12","author":"Noll","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/cei\/uxad020","article-title":"Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjogren\u2019s syndrome","volume":"212","author":"Riviere","year":"2023","journal-title":"Clin. Exp. Immunol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/S0140-6736(19)30546-X","article-title":"Novel paradigms in systemic lupus erythematosus","volume":"393","author":"Dorner","year":"2019","journal-title":"Lancet"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_199","unstructured":"(2021). Kidney Disease: Improving Global Outcomes Glomerular Diseases Work, G. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int., 100, S1\u2013S276."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1136\/annrheumdis-2018-213485","article-title":"Intrarenal activation of adaptive immune effectors is associated with tubular damage and impaired renal function in lupus nephritis","volume":"77","author":"Pamfil","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1042\/CS20190536","article-title":"Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis","volume":"133","author":"Zhang","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_202","first-page":"131","article-title":"The role of TGF-beta and epithelial-to mesenchymal transition in diabetic nephropathy","volume":"22","author":"Hills","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","article-title":"Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention","volume":"15","author":"Liu","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2353\/ajpath.2009.090698","article-title":"Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy","volume":"175","author":"Kizu","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"F733","DOI":"10.1152\/ajprenal.00212.2012","article-title":"Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy","volume":"303","author":"Loeffler","year":"2012","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ki.1996.65","article-title":"Expression of transforming growth factor-beta isoforms in human glomerular diseases","volume":"49","author":"Yamamoto","year":"1996","journal-title":"Kidney Int."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.prp.2016.09.008","article-title":"Epithelial-mesenchymal transition in pediatric nephropathies","volume":"212","author":"Rocha","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/art.24573","article-title":"Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid","volume":"60","author":"Yung","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1684\/ecn.2016.0373","article-title":"Effect of pro-inflammatory interleukin-17A on epithelial cell phenotype inversion in HK-2 cells in vitro","volume":"27","author":"Liu","year":"2016","journal-title":"Eur. Cytokine Netw."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1159\/000320177","article-title":"Proinflammatory\/profibrotic effects of interleukin-17A on human proximal tubule epithelium","volume":"117","author":"Dudas","year":"2011","journal-title":"Nephron. Exp. Nephrol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"12644","DOI":"10.1038\/srep12644","article-title":"Up-regulation of Serum MiR-130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"109687","DOI":"10.1016\/j.clim.2023.109687","article-title":"NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19","volume":"254","author":"Lin","year":"2023","journal-title":"Clin. Immunol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/ATVBAHA.117.309002","article-title":"Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition","volume":"37","author":"Pieterse","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"3038514","DOI":"10.1155\/2017\/3038514","article-title":"Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis","volume":"2017","author":"Liu","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3389\/fimmu.2019.00784","article-title":"FKN Facilitates HK-2 Cell EMT and Tubulointerstitial Lesions via the Wnt\/beta-Catenin Pathway in a Murine Model of Lupus Nephritis","volume":"10","author":"Fu","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_217","first-page":"3021","article-title":"The role of Stim1 in the progression of lupus nephritis in mice","volume":"13","author":"Zhang","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000517575","article-title":"YAP1 Overexpression Is Associated with Kidney Dysfunction in Lupus Nephritis","volume":"88","author":"Xie","year":"2021","journal-title":"Pathobiology"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/0886022X.2022.2058962","article-title":"Iguratimod alleviates tubulo-interstitial injury in mice with lupus","volume":"44","author":"Xue","year":"2022","journal-title":"Ren. Fail."},{"key":"ref_220","first-page":"4987323","article-title":"Jieduquyuzishen Prescription Attenuates Renal Fibrosis in MRL\/lpr Mice via Inhibiting EMT and TGF-beta1\/Smad2\/3 Pathway","volume":"2022","author":"Wu","year":"2022","journal-title":"Evid. Based Complement. Alter. Nat. Med."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: A prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.autrev.2016.01.007","article-title":"Systemic sclerosis: An update in 2016","volume":"15","author":"Desbois","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/art.38390","article-title":"Prediction of pulmonary complications and long-term survival in systemic sclerosis","volume":"66","author":"Nihtyanova","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/01.bor.0000138677.88694.a4","article-title":"Raynaud phenomenon and the vascular disease in scleroderma","volume":"16","author":"Kahaleh","year":"2004","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11926-019-0831-z","article-title":"Macrophages in Systemic Sclerosis: Novel Insights and Therapeutic Implications","volume":"21","author":"Toledo","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.autrev.2010.09.015","article-title":"Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy","volume":"10","author":"Wei","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: Current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.170.3.727","article-title":"Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation","volume":"170","author":"Khalil","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3389\/fimmu.2018.02452","article-title":"Unraveling SSc Pathophysiology; The Myofibroblast","volume":"9","author":"Vonk","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Nikitorowicz-Buniak, J., Denton, C.P., Abraham, D., and Stratton, R. (2015). Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFbeta Signaling within Lesional Scleroderma Skin. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134092"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/exd.12452","article-title":"SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro","volume":"23","author":"Jackson","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/1346-8138.12235","article-title":"Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea","volume":"40","author":"Takahashi","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2133.2010.10021.x","article-title":"Expression of SNAI1 and TWIST1 in the eccrine glands of patients with systemic sclerosis: Possible involvement of epithelial-mesenchymal transition in the pathogenesis","volume":"164","author":"Nakamura","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12931-018-0841-9","article-title":"Human alveolar epithelial cells type II are capable of TGFbeta-dependent epithelial-mesenchymal-transition and collagen-synthesis","volume":"19","author":"Goldmann","year":"2018","journal-title":"Respir. Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"13594","DOI":"10.1038\/s41598-020-70243-3","article-title":"Inhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5021\/ad.2019.31.4.365","article-title":"The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis","volume":"31","author":"Zmorzynski","year":"2019","journal-title":"Ann. Dermatol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1165\/rcmb.2010-0113OC","article-title":"Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation","volume":"45","author":"Lam","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_238","first-page":"1118","article-title":"Pivotal role of microRNA-138 in human cancers","volume":"9","author":"Yeh","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Bayati, P., Poormoghim, H., and Mojtabavi, N. (2022). Aberrant expression of miR-138 as a novel diagnostic biomarker in systemic sclerosis. Biomark. Insights, 17.","DOI":"10.1177\/11772719221135442"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Mao, J., Liu, J., Zhou, M., Wang, G., Xiong, X., and Deng, Y. (2022). Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1alpha\/VEGF signaling in systemic sclerosis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0263369"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3899\/jrheum.150088","article-title":"The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-beta and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist","volume":"42","author":"Cipriani","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Rosa, I., Romano, E., Fioretto, B.S., El Aoufy, K., Bellando-Randone, S., Matucci-Cerinic, M., and Manetti, M. (2023). Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis. Cells, 12.","DOI":"10.3390\/cells12172195"},{"key":"ref_243","first-page":"1612","article-title":"Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients: A cross-sectional study","volume":"41","author":"Chiu","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13075-020-02266-0","article-title":"The role of the oncostatin M\/OSM receptor beta axis in activating dermal microvascular endothelial cells in systemic sclerosis","volume":"22","author":"Marden","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI38379","article-title":"The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells","volume":"120","author":"Fernando","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1684\/ejd.2019.3607","article-title":"TGF-beta-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: Possible role in systemic sclerosis","volume":"29","author":"Teng","year":"2019","journal-title":"Eur. J. Dermatol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"155124","DOI":"10.1016\/j.cyto.2020.155124","article-title":"Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes","volume":"133","author":"Hassan","year":"2020","journal-title":"Cytokine"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2016.07.003","article-title":"E3 ubiquitin ligase: A potential regulator in fibrosis and systemic sclerosis","volume":"306\u2013307","author":"Huang","year":"2016","journal-title":"Cell. Immunol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13075-022-02773-2","article-title":"The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-beta signaling","volume":"24","author":"Utsunomiya","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s11010-021-04349-1","article-title":"Linagliptin ameliorates pulmonary fibrosis in systemic sclerosis mouse model via inhibition of endothelial-to-mesenchymal transition","volume":"477","author":"Pei","year":"2022","journal-title":"Mol. Cell. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14481\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:56:40Z","timestamp":1760129800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,23]]},"references-count":250,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["ijms241914481"],"URL":"https:\/\/doi.org\/10.3390\/ijms241914481","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,23]]}}}