{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:08:16Z","timestamp":1788188896337,"version":"build-2803163510"},"reference-count":153,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d (INPer)","award":["2019-1-20"],"award-info":[{"award-number":["2019-1-20"]}]},{"name":"Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d (INPer)","award":["3300-11402-01-575-17"],"award-info":[{"award-number":["3300-11402-01-575-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>There is a high frequency of overweight and obesity in women of reproductive age. Women who start pregnancy with overweight or obesity have an increased risk of developing maternal obstetric complications such as gestational hypertension, pre-eclampsia, gestational diabetes mellitus, postpartum hemorrhage, and requiring C-section to resolve the pregnancy with a higher risk of C-section surgical site infection. Excessive weight in pregnancy is characterized by dysregulation of adipokines, the functions of which partly explain the predisposition of pregnant women with overweight or obesity to these maternal obstetric complications. This review compiles, organizes, and analyzes the most recent studies on adipokines in pregnant women with excess weight and the potential pathophysiological mechanisms favoring the development of maternal pregnancy complications.<\/jats:p>","DOI":"10.3390\/ijms241914678","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:55:54Z","timestamp":1695880554000},"page":"14678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-8341","authenticated-orcid":false,"given":"Jorge","family":"Valencia-Ortega","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Reproducci\u00f3n Humana, Instituto Nacional de Perinatolog\u00eda-Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-8296","authenticated-orcid":false,"given":"Juan Mario","family":"Solis-Paredes","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-6156","authenticated-orcid":false,"given":"Renata","family":"Saucedo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-9021","authenticated-orcid":false,"given":"Guadalupe","family":"Estrada-Gutierrez","sequence":"additional","affiliation":[{"name":"Research Division, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Camacho-Arroyo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Reproducci\u00f3n Humana, Instituto Nacional de Perinatolog\u00eda-Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global epidemiology and pathogenesis","volume":"15","year":"2019","journal-title":"Nat. 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