{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:23:02Z","timestamp":1789694582651,"version":"4.0.1"},"reference-count":232,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qinghai Provincial Key Laboratory for Application of High-Altitude Medicine","award":["2022-ZJ-Y15"],"award-info":[{"award-number":["2022-ZJ-Y15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that these anucleate and abundant blood cells not only play a role in hemostasis, but also have important functions in inflammation and immunity. Platelets are not only affected by kidney disease, but may also contribute to kidney disease progression by mediating inflammation and immune effects. This review summarizes the current evidence regarding platelet abnormalities in renal disease, and the multiple effects of platelets on kidney disease progression. The relationship between platelets and kidney disease is still being explored, and further research can provide mechanistic insights into the relationship between thrombosis, bleeding, and inflammation related to kidney disease, and elucidate targeted therapies for patients with kidney disease.<\/jats:p>","DOI":"10.3390\/ijms241914724","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:48:13Z","timestamp":1695966493000},"page":"14724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Platelets in Renal Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Drolma","family":"Gomchok","sequence":"first","affiliation":[{"name":"Research Center for High Altitude Medicine, School of Medicine, Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri-Li","family":"Ge","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, School of Medicine, Qinghai University, Xining 810001, China"},{"name":"Key Laboratory for Application for High Altitude Medicine, Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-4737","authenticated-orcid":false,"given":"Tana","family":"Wuren","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, School of Medicine, Qinghai University, Xining 810001, China"},{"name":"Key Laboratory for Application for High Altitude Medicine, Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute Kidney Injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.kint.2019.07.012","article-title":"A Single Number for Advocacy and Communication\u2014Worldwide More than 850 Million Individuals Have Kidney Diseases","volume":"96","author":"Jager","year":"2019","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ITC66","DOI":"10.7326\/AITC201711070","article-title":"Acute Kidney Injury","volume":"167","author":"Levey","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of Chronic Kidney Disease: An Update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of Maladaptive Repair after AKI Leading to Accelerated Kidney Ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2014.08.002","article-title":"Patterning the Renal Vascular Bed","volume":"36","author":"Herzlinger","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41581-021-00411-9","article-title":"Phenotypic Diversity and Metabolic Specialization of Renal Endothelial Cells","volume":"17","author":"Dumas","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41581-018-0098-z","article-title":"Endothelium Structure and Function in Kidney Health and Disease","volume":"15","author":"Fakhouri","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41581-021-00413-7","article-title":"Targeting Immune Cell Metabolism in Kidney Diseases","volume":"17","author":"Basso","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2004-835678","article-title":"Platelet Dysfunction in Renal Failure","volume":"30","author":"Boccardo","year":"2004","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1055\/s-0042-1758119","article-title":"Crucial Stepping Stones in Platelet History","volume":"49","author":"Hvas","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet Biology and Functions: New Concepts and Clinical Perspectives","volume":"16","author":"Heemskerk","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1160\/TH12-03-0153","article-title":"Alteration of the Platelet Transcriptome in Chronic Kidney Disease","volume":"108","author":"Maltais","year":"2012","journal-title":"Thromb. Haemost."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yun, S.-H., Sim, E.-H., Goh, R.-Y., Park, J.-I., and Han, J.-Y. (2016). Platelet Activation: The Mechanisms and Potential Biomarkers. Biomed. Res. Int., 2016.","DOI":"10.1155\/2016\/9060143"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/09537100120068170","article-title":"The Platelet Release Reaction: Granules\u2019 Constituents, Secretion and Functions","volume":"12","author":"Rendu","year":"2001","journal-title":"Platelets"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet Physiology","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10555-017-9677-x","article-title":"Normal Platelet Function","volume":"36","author":"Holinstat","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eaav5928","DOI":"10.1126\/scitranslmed.aav5928","article-title":"Platelets Release Mitochondrial Antigens in Systemic Lupus Erythematosus","volume":"13","author":"Melki","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chaudhary, P.K., Kim, S., and Kim, S. (2022). An Insight into Recent Advances on Platelet Function in Health and Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116022"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.leukres.2007.02.008","article-title":"Giulio Bizzozero and the Discovery of Platelets","volume":"31","author":"Ribatti","year":"2007","journal-title":"Leuk. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"781857","DOI":"10.1155\/2014\/781857","article-title":"Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis","volume":"2014","author":"Ghoshal","year":"2014","journal-title":"Sci. World J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-2008-1041236","article-title":"Overview of Hemostasis and Thrombosis","volume":"11","author":"Brott","year":"1991","journal-title":"Semin. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.blre.2011.03.002","article-title":"Platelets at Work in Primary Hemostasis","volume":"25","author":"Broos","year":"2011","journal-title":"Blood Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1160\/TH14-12-1067","article-title":"The Role of Platelets in Inflammation","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/JLB.4MR0620-701R","article-title":"Innate Immune Receptors in Platelets and Platelet-Leukocyte Interactions","volume":"108","author":"Prb","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000444807","article-title":"Platelet Interaction with Innate Immune Cells","volume":"43","author":"Kral","year":"2016","journal-title":"Transfus. Med. Hemother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871529X1401140724093505","article-title":"Renal Endothelial Dysfunction in Acute Kidney Ischemia Reperfusion Injury","volume":"14","author":"Basile","year":"2014","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000327131","article-title":"Does Uremia Cause Vascular Dysfunction?","volume":"34","author":"Brunet","year":"2011","journal-title":"Kidney Blood Press. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"da Cunha, R.S., Santos, A.F., Barreto, F.C., and Stinghen, A.E.M. (2020). How Do Uremic Toxins Affect the Endothelium?. Toxins, 12.","DOI":"10.3390\/toxins12060412"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1046\/j.1523-1755.63.s84.15.x","article-title":"Endothelial Permeability in Uremia","volume":"63","author":"Harper","year":"2003","journal-title":"Kidney Int. Suppl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ccc.2019.11.002","article-title":"Platelet Activation and Endothelial Cell Dysfunction","volume":"36","author":"Parker","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13054-018-2292-6","article-title":"The Glycocalyx: A Novel Diagnostic and Therapeutic Target in Sepsis","volume":"23","author":"Uchimido","year":"2019","journal-title":"Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jth.14371","article-title":"Derangement of the Endothelial Glycocalyx in Sepsis","volume":"17","author":"Iba","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ccc.2019.12.007","article-title":"Endothelial Glycocalyx","volume":"36","author":"Jedlicka","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12967-019-1875-6","article-title":"Fibroblast Growth Factor 23, Endothelium Biomarkers and Acute Kidney Injury in Critically-Ill Patients","volume":"17","author":"Arruda","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41581-021-00489-1","article-title":"Renal Microvascular Endothelial Cell Responses in Sepsis-Induced Acute Kidney Injury","volume":"18","author":"Molema","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dou, L., and Jourde-Chiche, N. (2019). Endothelial Toxicity of High Glucose and Its By-Products in Diabetic Kidney Disease. Toxins, 11.","DOI":"10.3390\/toxins11100578"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"659013","DOI":"10.3389\/fmed.2021.659013","article-title":"Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease","volume":"8","author":"Mahtal","year":"2021","journal-title":"Front. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Regier, M., Drost, C.C., Rauen, M., Pavenst\u00e4dt, H., Rovas, A., K\u00fcmpers, P., Vink, H., Long, R.M., Linke, W.A., and Nofer, J.-R. (2022). A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK\/MAPK Signaling and Protects against Damage Induced by CKD Serum. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415520"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Liew, H., Roberts, M.A., Pope, A., and McMahon, L.P. (2021). Endothelial Glycocalyx Damage in Kidney Disease Correlates with Uraemic Toxins and Endothelial Dysfunction. BMC Nephrol., 22.","DOI":"10.1186\/s12882-020-02219-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ajpath.2022.11.003","article-title":"Reduction of Endothelial Glycocalyx on Peritubular Capillaries in Chronic Kidney Disease","volume":"193","author":"Ermert","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtcvs.2016.03.079","article-title":"Syndecan-1 Improves Severe Acute Kidney Injury Prediction after Pediatric Cardiac Surgery","volume":"152","author":"Meneses","year":"2016","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13054-015-0741-z","article-title":"Glycocalyx and Sepsis-Induced Alterations in Vascular Permeability","volume":"19","author":"Chelazzi","year":"2015","journal-title":"Crit. Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1186\/cc10559","article-title":"Sepsis Induces Albuminuria and Alterations in the Glomerular Filtration Barrier: A Morphofunctional Study in the Rat","volume":"15","author":"Adembri","year":"2011","journal-title":"Crit. Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/EJA.0000000000000085","article-title":"Protection of Glycocalyx Decreases Platelet Adhesion after Ischaemia\/Reperfusion: An Animal Study","volume":"31","author":"Chappell","year":"2014","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/cvr\/cvp097","article-title":"Antithrombin Reduces Shedding of the Endothelial Glycocalyx Following Ischaemia\/Reperfusion","volume":"83","author":"Chappell","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/ALN.0b013e3182289988","article-title":"Sevoflurane Reduces Leukocyte and Platelet Adhesion after Ischemia-Reperfusion by Protecting the Endothelial Glycocalyx","volume":"115","author":"Chappell","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1155\/S1110724304402034","article-title":"Nitric Oxide as a Unique Bioactive Signaling Messenger in Physiology and Pathophysiology","volume":"2004","author":"Tuteja","year":"2004","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric Oxide Synthases: Regulation and Function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1073\/pnas.87.13.5193","article-title":"An L-Arginine\/Nitric Oxide Pathway Present in Human Platelets Regulates Aggregation","volume":"87","author":"Radomski","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0049-3848(97)00233-8","article-title":"L-Arginine Infusion Decreases Platelet Aggregation through an Intraplatelet Nitric Oxide Release","volume":"88","author":"Marietta","year":"1997","journal-title":"Thromb. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric Oxide and Endothelial Dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e003764","DOI":"10.1161\/JAHA.112.003764","article-title":"Circulating Microparticles Carry a Functional Endothelial Nitric Oxide Synthase That Is Decreased in Patients with Endothelial Dysfunction","volume":"2","author":"Horn","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016112798829760","article-title":"The Role of Nitric Oxide on Endothelial Function","volume":"10","author":"Tousoulis","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12933-023-01827-2","article-title":"L-Arginine in Diabetes: Clinical and Preclinical Evidence","volume":"22","author":"Forzano","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Semenikhina, M., Stefanenko, M., Spires, D.R., Ilatovskaya, D.V., and Palygin, O. (2022). Nitric-Oxide-Mediated Signaling in Podocyte Pathophysiology. Biomolecules, 12.","DOI":"10.3390\/biom12060745"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5049\/EBP.2008.6.1.27","article-title":"Nitric Oxide in the Kidney: Its Physiological Role and Pathophysiological Implications","volume":"6","author":"Lee","year":"2008","journal-title":"Electrolyte Blood Press."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1124\/jpet.104.074427","article-title":"Endothelial Nitric Oxide Contributes to the Renal Protective Effects of Ischemic Preconditioning","volume":"312","author":"Yamasowa","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1046\/j.1523-1755.2000.00109.x","article-title":"Lipopolysaccharide Impairs Endothelial Nitric Oxide Synthesis in Rat Renal Arteries","volume":"57","author":"Piepot","year":"2000","journal-title":"Kidney Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"F1044","DOI":"10.1152\/ajprenal.00136.2004","article-title":"Endothelial Nitric Oxide Synthase-Deficient Mice Exhibit Increased Susceptibility to Endotoxin-Induced Acute Renal Failure","volume":"287","author":"Wang","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F25","DOI":"10.1152\/ajprenal.90531.2008","article-title":"Diminished NO Generation by Injured Endothelium and Loss of Macula Densa nNOS May Contribute to Sustained Acute Kidney Injury after Ischemia-Reperfusion","volume":"296","author":"Kwon","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41581-018-0015-5","article-title":"The Role of Platelets in Acute Kidney Injury","volume":"14","author":"Jansen","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/01.HYP.31.5.1047","article-title":"Review of Alterations in Endothelial Nitric Oxide Production in Diabetes: Protective Role of Arginine on Endothelial Dysfunction","volume":"31","author":"Pieper","year":"1998","journal-title":"Hypertension"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/1389203717666160627074017","article-title":"L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes","volume":"18","author":"Hu","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2337\/diacare.23.5.658","article-title":"Hemodynamic Effects of Acute Hyperglycemia in Type 2 Diabetic Patients","volume":"23","author":"Marfella","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0272-6386(97)90491-1","article-title":"Impact of Nitric Oxide on Blood Pressure in Hemodialysis Patients","volume":"30","author":"Madore","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00041552-199607000-00012","article-title":"Nitric Oxide Mediates the Cardiovascular Instability of Haemodialysis Patients","volume":"5","author":"Yokokawa","year":"1996","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1525-1594.1997.tb00355.x","article-title":"Generation of Nitrate during Dialysis as a Measure of Nitric Oxide Synthesis","volume":"21","author":"Hegbrant","year":"1997","journal-title":"Artif. Organs"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood.V94.8.2569.420k13_2569_2574","article-title":"Uremic Bleeding: Closing the Circle after 30 Years of Controversies?","volume":"94","author":"Noris","year":"1999","journal-title":"Blood"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ki.1993.264","article-title":"Enhanced Nitric Oxide Synthesis in Uremia: Implications for Platelet Dysfunction and Dialysis Hypotension","volume":"44","author":"Noris","year":"1993","journal-title":"Kidney Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/187152906777441821","article-title":"Uremia, Atherothrombosis and Malnutrition: The Role of L-Arginine-Nitric Oxide Pathway","volume":"6","author":"Brunini","year":"2006","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/cs0960067","article-title":"Increased Excretion of Nitric Oxide in Exhaled Air of Patients with Chronic Renal Failure","volume":"96","author":"Matsumoto","year":"1999","journal-title":"Clin. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1681\/ASN.V13suppl_1s62","article-title":"Hemodialysis Membranes: Interleukins, Biocompatibility, and Middle Molecules","volume":"13","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_74","first-page":"60","article-title":"Production of Cytokines and Cytokine Inhibitory Proteins in Patients on Dialysis","volume":"9","author":"Pereira","year":"1994","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cardiores.2006.09.019","article-title":"Platelet Nitric Oxide Synthesis in Uremia and Malnutrition: A Role for L-Arginine Supplementation in Vascular Protection?","volume":"73","author":"Brunini","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0008-6363(00)00267-4","article-title":"Abnormalities in L-Arginine Transport and Nitric Oxide Biosynthesis in Chronic Renal and Heart Failure","volume":"49","author":"Brunini","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.0894-0959.2004.17310.x","article-title":"Nitric Oxide and Hemodialysis","volume":"17","author":"Sarkar","year":"2004","journal-title":"Semin. Dial."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/014107688307600401","article-title":"Prostacyclin","volume":"76","author":"Vane","year":"1983","journal-title":"J. R. Soc. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/ki.1991.55","article-title":"Renal Tubular Arachidonic Acid Metabolism","volume":"39","author":"Bonventre","year":"1991","journal-title":"Kidney Int."},{"key":"ref_80","first-page":"255","article-title":"Platelet-Vessel Wall Interactions, Focal Adhesions, and the Mechanism of Action of Endothelial Factors","volume":"45","author":"Walter","year":"1995","journal-title":"Agents Actions Suppl."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0163-7258(90)90052-4","article-title":"Prostacyclin and Vascular Function: Implications for Hypertension and Atherosclerosis","volume":"48","author":"Dusting","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/1566524016666160316150728","article-title":"Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations","volume":"16","author":"Stitham","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1161\/01.CIR.0000034733.93020.BC","article-title":"Prostacyclin-Deficient Mice Develop Ischemic Renal Disorders, Including Nephrosclerosis and Renal Infarction","volume":"106","author":"Yokoyama","year":"2002","journal-title":"Circulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"F1131","DOI":"10.1152\/ajprenal.00212.2007","article-title":"Prostacyclin in Endotoxemia-Induced Acute Kidney Injury: Cyclooxygenase Inhibition and Renal Prostacyclin Synthase Transgenic Mice","volume":"293","author":"Wang","year":"2007","journal-title":"Am. J. Physiology. Ren. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0140-6736(77)90437-8","article-title":"Prostacyclin-like Activity and Bleeding in Renal Failure","volume":"2","author":"Remuzzi","year":"1977","journal-title":"Lancet"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-0038-1647030","article-title":"Evidence for an Increased Generation of Prostacyclin in the Microvasculature and an Impairment of the Platelet Alpha-Granule Release in Chronic Renal Failure","volume":"60","author":"Kyrle","year":"1988","journal-title":"Thromb. Haemost."},{"key":"ref_87","first-page":"380","article-title":"Prolonged Bleeding Time and Increased Vascular Prostacyclin in Rats with Chronic Renal Failure: Effects of Conjugated Estrogens","volume":"112","author":"Zoja","year":"1988","journal-title":"J. Lab. Clin. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0049-3848(80)90041-9","article-title":"A Plasma Factor in Uraemia Which Stimulates Prostacyclin Release from Cultured Endothelial Cells","volume":"19","author":"Defreyn","year":"1980","journal-title":"Thromb. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bcmd.2005.12.025","article-title":"Ecto-Nucleotidases of the CD39\/NTPDase Family Modulate Platelet Activation and Thrombus Formation: Potential as Therapeutic Targets","volume":"36","author":"Atkinson","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/rth2.12107","article-title":"Integrating Platelet and Coagulation Activation in Fibrin Clot Formation","volume":"2","author":"Swieringa","year":"2018","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11302-017-9596-x","article-title":"CD39-Adenosinergic Axis in Renal Pathophysiology and Therapeutics","volume":"14","author":"Kishore","year":"2018","journal-title":"Purinergic Signal."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11302-012-9342-3","article-title":"The CD39-Adenosinergic Axis in the Pathogenesis of Renal Ischemia-Reperfusion Injury","volume":"9","author":"Roberts","year":"2013","journal-title":"Purinergic Signal."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1084\/jem.185.1.153","article-title":"Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation","volume":"185","author":"Robson","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.107.690180","article-title":"CD39\/Ectonucleoside Triphosphate Diphosphohydrolase 1 Provides Myocardial Protection during Cardiac Ischemia\/Reperfusion Injury","volume":"116","author":"Eckle","year":"2007","journal-title":"Circulation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11302-011-9239-6","article-title":"Liver Damage and Systemic Inflammatory Responses Are Exacerbated by the Genetic Deletion of CD39 in Total Hepatic Ischemia","volume":"7","author":"Sun","year":"2011","journal-title":"Purinergic Signal."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1160\/TH03-06-0373","article-title":"Beneficial Effects of CD39\/Ecto-Nucleoside Triphosphate Diphosphohydrolase-1 in Murine Intestinal Ischemia-Reperfusion Injury","volume":"91","author":"Guckelberger","year":"2004","journal-title":"Thromb. Haemost."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1096\/fj.06-7947com","article-title":"Contribution of E-NTPDase1 (CD39) to Renal Protection from Ischemia-Reperfusion Injury","volume":"21","author":"Grenz","year":"2007","journal-title":"FASEB J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1600-6143.2010.03257.x","article-title":"Transgenic Overexpression of CD39 Protects against Renal Ischemia-Reperfusion and Transplant Vascular Injury","volume":"10","author":"Crikis","year":"2010","journal-title":"Am. J. Transpl."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.111.300166","article-title":"Elevated Ecto-5\u2019-Nucleotidase-Mediated Increased Renal Adenosine Signaling via A2B Adenosine Receptor Contributes to Chronic Hypertension","volume":"112","author":"Zhang","year":"2013","journal-title":"Circ. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0049-3848(03)00178-6","article-title":"Enzymes That Hydrolyze Adenine Nucleotides in Diabetes and Associated Pathologies","volume":"109","author":"Lunkes","year":"2003","journal-title":"Thromb. Res."},{"key":"ref_101","first-page":"351","article-title":"Effect of High Glucose Levels in Human Platelet NTPDase and 5\u2019-Nucleotidase Activities. Diabetes Res","volume":"81","author":"Lunkes","year":"2008","journal-title":"Clin. Pract."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/ATVBAHA.117.309846","article-title":"Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis","volume":"38","author":"Grover","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1128\/IAI.67.5.2540-2546.1999","article-title":"Lipopolysaccharide Induction of Tissue Factor Expression in Rabbits","volume":"67","author":"Erlich","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/jsre.2001.6275","article-title":"The Role of Tissue Factor in Renal Ischemic Reperfusion Injury of the Rat","volume":"102","author":"Ushigome","year":"2002","journal-title":"J. Surg. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1164\/ajrccm.164.10.2105027","article-title":"Coagulation Blockade Prevents Sepsis-Induced Respiratory and Renal Failure in Baboons","volume":"164","author":"Carraway","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ki.2013.133","article-title":"Indolic Uremic Solutes Increase Tissue Factor Production in Endothelial Cells by the Aryl Hydrocarbon Receptor Pathway","volume":"84","author":"Gondouin","year":"2013","journal-title":"Kidney Int."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00204-018-2328-3","article-title":"Mechanisms of Tissue Factor Induction by the Uremic Toxin Indole-3 Acetic Acid through Aryl Hydrocarbon Receptor\/Nuclear Factor-Kappa B Signaling Pathway in Human Endothelial Cells","volume":"93","author":"Addi","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/blood-2016-10-744060","article-title":"Indoxyl Sulfate Induces Platelet Hyperactivity and Contributes to Chronic Kidney Disease-Associated Thrombosis in Mice","volume":"129","author":"Yang","year":"2017","journal-title":"Blood"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.3389\/fimmu.2019.02536","article-title":"DAMPs and NETs in Sepsis","volume":"10","author":"Denning","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/SHK.0000000000000052","article-title":"A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury","volume":"41","author":"Gomez","year":"2014","journal-title":"Shock"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.shk.0000142256.23382.5d","article-title":"Increased Expression of Toll-like Receptor-2 and -4 on Leukocytes from Patients with Sepsis","volume":"22","author":"Mica","year":"2004","journal-title":"Shock"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1203\/01.PDR.0000180544.02537.FD","article-title":"Expression of Toll-like Receptors in Neonatal Sepsis","volume":"58","author":"Viemann","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10863-022-09940-9","article-title":"TLR4 Inhibitor Alleviates Sepsis-Induced Organ Failure by Inhibiting Platelet mtROS Production, Autophagy, and GPIIb\/IIIa Expression","volume":"54","author":"Li","year":"2022","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-3083.2011.02523.x","article-title":"New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries","volume":"73","author":"Castoldi","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/SHK.0000000000000967","article-title":"Mitochondrial DNA Is Released in Urine of SIRS Patients With Acute Kidney Injury and Correlates With Severity of Renal Dysfunction","volume":"49","author":"Jansen","year":"2018","journal-title":"Shock"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/ndt\/gfy372","article-title":"Urinary Mitochondrial DNA Associates with Delayed Graft Function Following Renal Transplantation","volume":"35","author":"Jansen","year":"2020","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"118203","DOI":"10.1016\/j.lfs.2020.118203","article-title":"HMGB1 in Kidney Diseases","volume":"259","author":"Zhao","year":"2020","journal-title":"Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1172\/JCI81660","article-title":"Platelet-Derived HMGB1 Is a Critical Mediator of Thrombosis","volume":"125","author":"Vogel","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets Release Mitochondria Serving as Substrate for Bactericidal Group IIA-Secreted Phospholipase A2 to Promote Inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e24852","DOI":"10.1002\/jcla.24852","article-title":"Pyroptosis in Platelets: Thrombocytopenia and Inflammation","volume":"37","author":"Su","year":"2023","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2215\/CJN.04100321","article-title":"Platelet Abnormalities in CKD and Their Implications for Antiplatelet Therapy","volume":"17","author":"Baaten","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Karbowska, M., Kaminski, T.W., Marcinczyk, N., Misztal, T., Rusak, T., Smyk, L., and Pawlak, D. (2017). The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models. Toxins, 9.","DOI":"10.3390\/toxins9070229"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1681\/ASN.2020121806","article-title":"Role of Platelets in Chronic Kidney Disease","volume":"32","author":"Jain","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41581-018-0072-9","article-title":"Lipid Management in Patients with Chronic Kidney Disease","volume":"14","author":"Ferro","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(82)90050-2","article-title":"Uraemic Bleeding: Role of Anaemia and Beneficial Effect of Red Cell Transfusions","volume":"2","author":"Livio","year":"1982","journal-title":"Lancet"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0026-2862(75)90070-9","article-title":"Platelet Interaction with Subendothelium in a Perfusion System: Physical Role of Red Blood Cells","volume":"9","author":"Turitto","year":"1975","journal-title":"Microvasc. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/192531a0","article-title":"Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets","volume":"192","author":"Gaarder","year":"1961","journal-title":"Nature"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI115032","article-title":"Enhancement of Platelet Reactivity and Modulation of Eicosanoid Production by Intact Erythrocytes. A new approach to platelet activation and recruitment","volume":"87","author":"Santos","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2141.1983.00043.x","article-title":"Binding and Inactivation of Prostacyclin (PGI2) by Human Erythrocytes","volume":"54","author":"Willems","year":"1983","journal-title":"Br. J. Haematol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"39024","DOI":"10.1074\/jbc.M509045200","article-title":"Nitric Oxide Scavenging by Red Blood Cells as a Function of Hematocrit and Oxygenation","volume":"280","author":"Azarov","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"CHOIR Investigators Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease","volume":"355","author":"Singh","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.amjcard.2011.11.049","article-title":"Impact of Anemia on Platelet Response to Clopidogrel in Patients Undergoing Percutaneous Coronary Stenting","volume":"109","author":"Toma","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.amjcard.2016.03.034","article-title":"Impact of Anemia on Platelet Reactivity and Ischemic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study","volume":"117","author":"Giustino","year":"2016","journal-title":"Am. J. Cardiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"108272","DOI":"10.1016\/j.pharmthera.2022.108272","article-title":"Future Perspectives of Anemia Management in Chronic Kidney Disease Using Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors","volume":"239","author":"Sugahara","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Grzeszczak, W., Szczyra, D., and \u015anit, M. (2021). Whether Prolyl Hydroxylase Blocker\u2014Roxadustat\u2014In the Treatment of Anemia in Patients with Chronic Kidney Disease Is the Future?. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041612"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000527835","article-title":"Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia","volume":"9","author":"Li","year":"2023","journal-title":"Kidney Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000522071","article-title":"Threshold of Serum Ferritin to Discriminate against Those at Greater Risk of Platelet Increase during Treatment with Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor","volume":"145","author":"Ogawa","year":"2022","journal-title":"Acta Haematol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2022.04.002","article-title":"Activation of Transcription Factor HIF Inhibits IL-1\u03b2-Induced NO Production in Primary Cultured Rat Hepatocytes","volume":"124","author":"Yoshida","year":"2022","journal-title":"Nitric Oxide"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000510587","article-title":"Hypoxia-Inducible Factor-Proline Hydroxylase Inhibitor in the Treatment of Renal Anemia","volume":"7","author":"Hu","year":"2021","journal-title":"Kidney Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"F1150","DOI":"10.1152\/ajprenal.00310.2001","article-title":"Intravital Videomicroscopy of Peritubular Capillaries in Renal Ischemia","volume":"282","author":"Yamamoto","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41581-021-00394-7","article-title":"Kidney Physiology and Susceptibility to Acute Kidney Injury: Implications for Renoprotection","volume":"17","author":"Scholz","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00424-022-02690-y","article-title":"Renal Blood Flow and Oxygenation","volume":"474","author":"Edwards","year":"2022","journal-title":"Pflug. Arch."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Rustiasari, U.J., and Roelofs, J.J. (2022). The Role of Platelets in Diabetic Kidney Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158270"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Sun, S., Urbanus, R.T., Ten Cate, H., de Groot, P.G., de Laat, B., Heemskerk, J.W.M., and Roest, M. (2021). Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia. Cells, 10.","DOI":"10.3390\/cells10123386"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"981375","DOI":"10.3389\/fimmu.2022.981375","article-title":"The Role of the Complement System in Kidney Glomerular Capillary Thrombosis","volume":"13","author":"Yoshida","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.thromres.2011.11.004","article-title":"Hemodialysis-Associated Acute Systemic Reactions and Heparin-Induced Thrombocytopenia","volume":"129","author":"Warkentin","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"414","DOI":"10.23876\/j.krcp.19.063","article-title":"The Role of Oxidative Stress and Hypoxia in Renal Disease","volume":"38","author":"Honda","year":"2019","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Masselli, E., Pozzi, G., Vaccarezza, M., Mirandola, P., Galli, D., Vitale, M., Carubbi, C., and Gobbi, G. (2020). ROS in Platelet Biology: Functional Aspects and Methodological Insights. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144866"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10157-007-0011-8","article-title":"Blockade of Serotonin 2A Receptor Improves Glomerular Endothelial Function in Rats with Streptozotocin-Induced Diabetic Nephropathy","volume":"12","author":"Kobayashi","year":"2008","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/0024-3205(91)90179-F","article-title":"Increased Urinary Excretion of Platelet Activating Factor in Mice with Lupus Nephritis","volume":"48","author":"Macconi","year":"1991","journal-title":"Life Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000190313","article-title":"Platelets in Glomerular Disease","volume":"77","author":"Barnes","year":"1997","journal-title":"Nephron"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4684-5700-1_10","article-title":"Eicosanoids and Platelet Activating Factor as Possible Mediators of Injury in Experimental Nephropathies","volume":"259","author":"Remuzzi","year":"1989","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_154","first-page":"439","article-title":"Platelets in Renal Scleroderma","volume":"107","author":"Amenta","year":"1983","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM199408113310606","article-title":"Renal Transplantation","volume":"331","author":"Suthanthiran","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00005792-198103000-00001","article-title":"Glomerular Thrombosis in Systemic Lupus Erythematosus: Prevalence and Significance","volume":"60","author":"Kant","year":"1981","journal-title":"Medicine"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Buelli, S., Zoja, C., Remuzzi, G., and Morigi, M. (2019). Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010015"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1172\/JCI106234","article-title":"Intraglomerular Fibrin, Platelet Aggregation, and Subendothelial Deposits in Lipoid Nephrosis","volume":"49","author":"Duffy","year":"1970","journal-title":"J. Clin. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/ndt\/6.1.11","article-title":"Platelet-Derived Growth Factor Mesangial Deposits in Mesangial IgA Glomerulonephritis","volume":"6","author":"Nakajima","year":"1991","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_160","first-page":"288","article-title":"Intraglomerular Localization of Platelet Related Antigens, Platelet Factor 4 and Beta-Thromboglobulin in Glomerulonephritis","volume":"17","author":"Duffus","year":"1982","journal-title":"Clin. Nephrol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Li, S., Wang, F., and Sun, D. (2021). The Renal Microcirculation in Chronic Kidney Disease: Novel Diagnostic Methods and Therapeutic Perspectives. Cell Biosci., 11.","DOI":"10.1186\/s13578-021-00606-4"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2353\/ajpath.2010.091143","article-title":"Platelet Recruitment to the Inflamed Glomerulus Occurs via an alphaIIbbeta3\/GPVI-Dependent Pathway","volume":"177","author":"Devi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/S0024-3205(03)00180-2","article-title":"Role for Thromboxane A2 from Glomerular Thrombi in Nephropathy with Type 2 Diabetic Rats","volume":"72","author":"Okumura","year":"2003","journal-title":"Life Sci."},{"key":"ref_164","first-page":"631","article-title":"In Vivo Prostanoid Formation during Acute Renal Allograft Rejection","volume":"8","author":"Busch","year":"1993","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1172\/JCI112284","article-title":"Increased Renal Thromboxane Production in Murine Lupus Nephritis","volume":"77","author":"Kelley","year":"1986","journal-title":"J. Clin. Investig."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"224S","DOI":"10.1016\/j.transproceed.2004.01.005","article-title":"Cyclosporine-Induced Renal Dysfunction","volume":"36","author":"Paul","year":"2004","journal-title":"Transplant. Proc."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1046\/j.1523-1755.1998.06717.x","article-title":"A Genetic Approach for Studying the Role of Thromboxane A2 in the Kidney","volume":"67","author":"Thomas","year":"1998","journal-title":"Kidney Int. Suppl."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/14728222.2020.1762173","article-title":"New Therapeutic Targets in Chronic Kidney Disease Progression and Renal Fibrosis. Expert Opin","volume":"24","author":"Valdivielso","year":"2020","journal-title":"Ther. Targets"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.RES.0000070111.98158.6C","article-title":"CD40 Is Constitutively Expressed on Platelets and Provides a Novel Mechanism for Platelet Activation","volume":"92","author":"Inwald","year":"2003","journal-title":"Circ. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.2174\/092986707781389664","article-title":"Contribution of Platelet-Derived CD40 Ligand to Inflammation, Thrombosis and Neoangiogenesis","volume":"14","author":"Ferroni","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/jcb.25571","article-title":"CD154 Induces Matrix Metalloproteinase-9 Secretion in Human Podocytes","volume":"117","author":"Rigothier","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1038\/s41598-017-08426-8","article-title":"Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"M\u00f6rtberg, J., Lundwall, K., Mobarrez, F., Wall\u00e9n, H., Jacobson, S.H., and Spaak, J. (2019). Increased Concentrations of Platelet- and Endothelial-Derived Microparticles in Patients with Myocardial Infarction and Reduced Renal Function\u2014A Descriptive Study. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1261-x"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/09537104.2010.500422","article-title":"Soluble CD40 Ligand Is Elevated in Type 1 Diabetic Nephropathy but Not Predictive of Mortality, Cardiovascular Events or Kidney Function","volume":"21","author":"Lajer","year":"2010","journal-title":"Platelets"},{"key":"ref_175","first-page":"570","article-title":"Increased Concentrations of Soluble CD40 Ligand May Help to Identify Type 1 Diabetic Adolescents and Young Adults at Risk for Developing Persistent Microalbuminuria. Diabetes Metab","volume":"24","author":"Chiarelli","year":"2008","journal-title":"Res. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1074878","DOI":"10.3389\/fmed.2023.1074878","article-title":"Platelet, a Key Regulator of Innate and Adaptive Immunity","volume":"10","author":"Yan","year":"2023","journal-title":"Front. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/030098589703400113","article-title":"Cell Adhesion Molecules--Update","volume":"34","author":"Elangbam","year":"1997","journal-title":"Vet Pathol"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000020592","article-title":"Cystic Diseases of the Kidney: Role of Adhesion Molecules in Normal and Abnormal Tubulogenesis","volume":"7","author":"Wilson","year":"1999","journal-title":"Exp. Nephrol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/CS20080394","article-title":"Pathogenic Perspectives for the Role of Inflammation in Diabetic Nephropathy","volume":"116","author":"Rivero","year":"2009","journal-title":"Clin. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000045292","article-title":"Significance of Platelet-Derived Microparticles and Activated Platelets in Diabetic Nephropathy","volume":"81","author":"Omoto","year":"1999","journal-title":"Nephron"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cca.2020.04.042","article-title":"Platelet Activation and Immune Response in Diabetic Microangiopathy","volume":"507","author":"Chen","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s001250050888","article-title":"Increased Expression of Selectins in Kidneys of Patients with Diabetic Nephropathy","volume":"41","author":"Hirata","year":"1998","journal-title":"Diabetologia"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/ki.1997.428","article-title":"In Situ Expression and Soluble Form of P-Selectin in Human Glomerulonephritis","volume":"52","author":"Segawa","year":"1997","journal-title":"Kidney Int."},{"key":"ref_184","first-page":"1084","article-title":"Thrombospondin Immune Regulation and the Kidney","volume":"32","author":"Ponticelli","year":"2017","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.thromres.2009.11.023","article-title":"Role of the Platelet Chemokine Platelet Factor 4 (PF4) in Hemostasis and Thrombosis","volume":"125","author":"Kowalska","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/09537104.2016.1240766","article-title":"Platelet Secretion in Inflammatory and Infectious Diseases","volume":"28","author":"Manne","year":"2017","journal-title":"Platelets"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5002631","article-title":"Increased Mortality in Hemodialysis Patients Having Specific Antibodies to the Platelet Factor 4-Heparin Complex","volume":"73","author":"Carrier","year":"2008","journal-title":"Kidney Int."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF00570365","article-title":"Plasma Beta-Thromboglobulin and Platelet Factor 4 Are Not Increased in Insulin-Dependent Diabetic Patients with Microalbuminuria","volume":"31","author":"Gruden","year":"1994","journal-title":"Acta Diabetol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"885307","DOI":"10.3389\/fimmu.2022.885307","article-title":"Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus","volume":"13","author":"Soliman","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"889931","DOI":"10.3389\/fimmu.2022.889931","article-title":"Identification and Validation of a Urinary Biomarker Panel to Accurately Diagnose and Predict Response to Therapy in Lupus Nephritis","volume":"13","author":"Goliad","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13075-017-1498-3","article-title":"Urinary Angiostatin, CXCL4 and VCAM-1 as Biomarkers of Lupus Nephritis","volume":"20","author":"Mok","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s10753-014-9958-2","article-title":"Platelet Factor 4 Protects Kidney Allograft in a Rat Kidney Transplantation Model","volume":"38","author":"Zhang","year":"2015","journal-title":"Inflammation"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12933-018-0763-3","article-title":"Endothelial Dysfunction and Platelet Hyperactivity in Type 2 Diabetes Mellitus: Molecular Insights and Therapeutic Strategies","volume":"17","author":"Kaur","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4239\/wjd.v6.i3.423","article-title":"Endothelial and Platelet Markers in Diabetes Mellitus Type 2","volume":"6","author":"Kubisz","year":"2015","journal-title":"World J. Diabetes"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ajh.10097","article-title":"A Reliable Plasma Marker of Platelet Activation: Does It Exist?","volume":"70","author":"Gurney","year":"2002","journal-title":"Am. J. Hematol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1620\/tjem.135.349","article-title":"Plasma Beta-Thromboglobulin and Platelet Factor 4 in Patients with Chronic Renal Failure and Effect of Hemodialysis","volume":"135","author":"Endo","year":"1981","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0049-3848(80)90342-4","article-title":"Different Effects of Renal Failure on Beta-Thromboglobulin and High Affinity Platelet Factor 4 (HA-PF4)-Concentrations","volume":"18","author":"Andrassy","year":"1980","journal-title":"Thromb. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/s-0038-1661646","article-title":"Urinary Beta-Thromboglobulin Correlates with Impairment of Renal Function in Patients with Diabetic Nephropathy","volume":"56","author":"Hopper","year":"1986","journal-title":"Thromb. Haemost."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1172\/JCI6042","article-title":"Protease-Activated Receptors 1 and 4 Mediate Activation of Human Platelets by Thrombin","volume":"103","author":"Kahn","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Rwibasira Rudinga, G., Khan, G.J., and Kong, Y. (2018). Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020573"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Bagang, N., Gupta, K., Singh, G., Kanuri, S.H., and Mehan, S. (2023). Protease-Activated Receptors in Kidney Diseases: A Comprehensive Review of Pathological Roles, Therapeutic Outcomes and Challenges. Chem. Biol. Interact., 377.","DOI":"10.1016\/j.cbi.2023.110470"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1042\/CS20200923","article-title":"The PAR-1 Antagonist Vorapaxar Ameliorates Kidney Injury and Tubulointerstitial Fibrosis","volume":"134","author":"Lok","year":"2020","journal-title":"Clin. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.191.3.455","article-title":"Protease-Activated Receptor 1 Mediates Thrombin-Dependent, Cell-Mediated Renal Inflammation in Crescentic Glomerulonephritis","volume":"191","author":"Cunningham","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ki.1986.23","article-title":"Potential Role of Platelet-Activating Factor in Renal Pathophysiology","volume":"29","author":"Camussi","year":"1986","journal-title":"Kidney Int."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/labinvest.2013.155","article-title":"Activation of Platelet-Activating Factor Receptor Exacerbates Renal Inflammation and Promotes Fibrosis","volume":"94","author":"Braga","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_206","first-page":"F85","article-title":"Platelet-Activating Factor Alters Glomerular Barrier Size Selectivity for Macromolecules in Rats","volume":"261","author":"Perico","year":"1991","journal-title":"Am. J. Physiol."},{"key":"ref_207","first-page":"601","article-title":"Platelet-Activating Factor Receptor Blocking Reduces Proteinuria and Improves Survival in Lupus Autoimmune Mice","volume":"258","author":"Morigi","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.kint.2016.08.006","article-title":"Release of Extracellular DNA Influences Renal Ischemia Reperfusion Injury by Platelet Activation and Formation of Neutrophil Extracellular Traps","volume":"91","author":"Jansen","year":"2017","journal-title":"Kidney Int."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Salazar-Gonzalez, H., Zepeda-Hernandez, A., Melo, Z., Saavedra-Mayorga, D.E., and Echavarria, R. (2019). Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases. Medicina, 55.","DOI":"10.3390\/medicina55080431"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.3389\/fimmu.2018.03076","article-title":"Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nm.4462","article-title":"Macrophage Extracellular Trap Formation Promoted by Platelet Activation Is a Key Mediator of Rhabdomyolysis-Induced Acute Kidney Injury","volume":"24","author":"Okubo","year":"2018","journal-title":"Nat. Med."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/imr.13119","article-title":"Platelet Extracellular Vesicles and the Secretory Interactome Join Forces in Health and Disease","volume":"312","author":"Boilard","year":"2022","journal-title":"Immunol. Rev."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/ATVBAHA.120.314644","article-title":"Platelet Extracellular Vesicles: Beyond the Blood","volume":"41","author":"Puhm","year":"2021","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1322454","DOI":"10.1080\/20013078.2017.1322454","article-title":"Platelet Extracellular Vesicles Induce a Pro-Inflammatory Smooth Muscle Cell Phenotype","volume":"6","author":"Vajen","year":"2017","journal-title":"J. Extracell. Vesicles"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1182\/blood.2020004974","article-title":"Fc\u03b3RIIA Expression Accelerates Nephritis and Increases Platelet Activation in Systemic Lupus Erythematosus","volume":"136","author":"Melki","year":"2020","journal-title":"Blood"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Scherlinger, M., Richez, C., Tsokos, G.C., Boilard, E., and Blanco, P. (2023). The Role of Platelets in Immune-Mediated Inflammatory Diseases. Nat. Rev. Immunol., 1\u201316.","DOI":"10.1038\/s41577-023-00834-4"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a Therapeutic Target in Inflammatory Diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41598-018-20479-x","article-title":"Deep Vein Thrombosis in Mice Is Regulated by Platelet HMGB1 through Release of Neutrophil-Extracellular Traps and DNA","volume":"8","author":"Dyer","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3324\/haematol.2016.142471","article-title":"Propagation of Thrombosis by Neutrophils and Extracellular Nucleosome Networks","volume":"102","author":"Pfeiler","year":"2017","journal-title":"Haematologica"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2016-04-710632","article-title":"Disulfide HMGB1 Derived from Platelets Coordinates Venous Thrombosis in Mice","volume":"128","author":"Stark","year":"2016","journal-title":"Blood"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"104434","DOI":"10.1016\/j.yexmp.2020.104434","article-title":"1,25(OH)2D3 Provides Protection against Diabetic Kidney Disease by Downregulating the TLR4-MyD88-NF-\u03baB Pathway","volume":"114","author":"Liu","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2337\/db17-0538","article-title":"RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-\u03b2 and Increasing Resistance to Apoptosis","volume":"67","author":"Hagiwara","year":"2018","journal-title":"Diabetes"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/SHK.0000000000001908","article-title":"Platelets Derived Transthyretin Participate in The Development of Sepsis Associated Acute Kidney Injury by Inducing Oxidative Stress and Apoptosis of Renal Tubular Epithelial Cells","volume":"57","author":"Lv","year":"2022","journal-title":"Shock"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/MNH.0b013e32834db4d3","article-title":"Platelet-Derived Growth Factor and Renal Disease","volume":"21","author":"Nakagawa","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00467-011-1892-z","article-title":"The PDGF Family in Renal Fibrosis","volume":"27","author":"Ostendorf","year":"2012","journal-title":"Pediatr. Nephrol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrneph.2014.184","article-title":"Targeting CTGF, EGF and PDGF Pathways to Prevent Progression of Kidney Disease","volume":"10","author":"Kok","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Karolczak, K., and Watala, C. (2021). Blood Platelets as an Important but Underrated Circulating Source of TGF\u03b2. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094492"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1471-4906(00)01812-3","article-title":"RANTES: A Versatile and Controversial Chemokine","volume":"22","author":"Appay","year":"2001","journal-title":"Trends Immunol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/ndt\/gfh207","article-title":"NF-kappaB Activation and Overexpression of Regulated Genes in Human Diabetic Nephropathy","volume":"19","author":"Mezzano","year":"2004","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/ckj\/sfab186","article-title":"Urinary Sediment CCL5 Messenger RNA as a Potential Prognostic Biomarker of Diabetic Nephropathy","volume":"15","author":"Feng","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000525090","article-title":"Activated Platelets, the Booster of Chronic Kidney Disease and Cardiovascular Complications","volume":"8","author":"Gong","year":"2022","journal-title":"Kidney Dis."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting Renal Fibrosis: Mechanisms and Drug Delivery Systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:01:46Z","timestamp":1760130106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/19\/14724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":232,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["ijms241914724"],"URL":"https:\/\/doi.org\/10.3390\/ijms241914724","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]}}}