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The addition of low-molecular-weight PLGA did not change the release mechanism of microspheres, but sped up the drug release of microspheres and drastically shortened the lag phase. The in vitro degradation results show that the release of microspheres consisted of a combination of pore diffusion and erosion, and especially autocatalysis played an important role in this process. Furthermore, an accelerated release method was also developed to reduce the period for drug release testing within one month. The pharmacokinetic results demonstrated that MOX-MS could be released for at least 60 days with only a slight blood drug concentration fluctuation. In particular, F3 displayed the highest AUC and plasma concentration (AUC0\u2013t = 596.53 ng\/mL\u00b7d, Cave\u00a0(day\u00a030-day\u00a060) = 8.84 ng\/mL), making it the optimal formulation. Overall, these results indicate that using polymer blends could easily adjust hydrophobic drug release from microspheres and notably reduce the lag phase of microspheres.<\/jats:p>","DOI":"10.3390\/ijms241914729","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:48:13Z","timestamp":1695966493000},"page":"14729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Polymer Blends on the In Vitro Release\/Degradation and Pharmacokinetics of Moxidectin-Loaded PLGA Microspheres"],"prefix":"10.3390","volume":"24","author":[{"given":"Hongjuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-6299","authenticated-orcid":false,"given":"Baocheng","family":"Hao","sequence":"additional","affiliation":[{"name":"Key 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730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-5855","authenticated-orcid":false,"given":"Wanxia","family":"Pu","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"},{"name":"Shandong Provincial Animal and Poultry Green Health Products Creation Engineering Laboratory, Institute of Poultry Science, Shandong Academy of Agricultural Science, Jinan 250023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofeng","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-5059","authenticated-orcid":false,"given":"Shengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project, Gansu Province\/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs\/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, 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