{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:33:36Z","timestamp":1760150016890,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ISCIII RICET","award":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"],"award-info":[{"award-number":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"]}]},{"name":"Institute of Health Carlos III, ISCIII, Spain","award":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"],"award-info":[{"award-number":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"]}]},{"name":"MCIN\/AEI","award":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"],"award-info":[{"award-number":["RD16\/0027\/0018","PI22\/01721","PID2021-127471OB-I00","PID2022-136462NB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Only a small number of infected people are highly susceptible to schistosomiasis, showing high levels of infection or severe liver fibrosis. The susceptibility to schistosome infection is influenced by genetic background. To assess the genetic basis of susceptibility and identify the chromosomal regions involved, a backcross strategy was employed to generate high variation in schistosomiasis susceptibility. This strategy involved crossing the resistant C57BL\/6J mouse strain with the susceptible CBA\/2J strain. The resulting F1 females (C57BL\/6J \u00d7 CBA\/2J) were then backcrossed with CBA\/2J males to generate the backcross (BX) cohort. The BX mice exhibited a range of phenotypes, with disease severity varying from mild to severe disease, lacking a fully resistant group. We observed four levels of infection intensity using cluster and principal component analyses and K-means based on parasitological, pathological, and immunological trait measurements. The mice were genotyped with 961 informative SNPs, leading to the identification of 19 new quantitative trait loci (QTL) associated with parasite burden, liver lesions, white blood cell populations, and antibody responses. Two QTLs located on chromosomes 15 and 18 were linked to the number of granulomas, liver lesions, and IgM levels. The corresponding syntenic human regions are located in chromosomes 8 and 18. None of the significant QTLs had been reported previously.<\/jats:p>","DOI":"10.3390\/ijms241914768","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:57:06Z","timestamp":1696179426000},"page":"14768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Genomic Regions Implicated in Susceptibility to Schistosoma mansoni Infection in a Murine Backcross Genetic Model"],"prefix":"10.3390","volume":"24","author":[{"given":"Juan","family":"Hern\u00e1ndez-Goenaga","sequence":"first","affiliation":[{"name":"Grupo de Enfermedades Infecciosas y Tropicales (e-INTRO), IBSAL-CIETUS (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropica-les de la Universidad de Salamanca), Facultad de Farmacia, Universidad de Salamanca, Ldo. M\u00e9ndez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"L\u00f3pez-Ab\u00e1n","sequence":"additional","affiliation":[{"name":"Grupo de Enfermedades Infecciosas y Tropicales (e-INTRO), IBSAL-CIETUS (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropica-les de la Universidad de Salamanca), Facultad de Farmacia, Universidad de Salamanca, Ldo. M\u00e9ndez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Blanco-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Complejo Asistencial Universitario de Salamanca, Hospital Virgen de la Vega, 37007 Salamanca, Spain"},{"name":"Instituto de Biolog\u00eda Molecular del C\u00e1ncer (IBMCC), Centro de Investigaci\u00f3n del C\u00e1ncer (CIC)\u2014CSIC, Laboratory 20, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Vicente","sequence":"additional","affiliation":[{"name":"Grupo de Enfermedades Infecciosas y Tropicales (e-INTRO), IBSAL-CIETUS (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropica-les de la Universidad de Salamanca), Facultad de Farmacia, Universidad de Salamanca, Ldo. M\u00e9ndez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Burguillo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica-F\u00edsica, Facultad de Farmacia, Universidad de Salamanca, C\/Donantes de Sangre s\/n. Campus Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-624X","authenticated-orcid":false,"given":"Jes\u00fas","family":"P\u00e9rez-Losada","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Complejo Asistencial Universitario de Salamanca, Hospital Virgen de la Vega, 37007 Salamanca, Spain"},{"name":"Instituto de Biolog\u00eda Molecular del C\u00e1ncer (IBMCC), Centro de Investigaci\u00f3n del C\u00e1ncer (CIC)\u2014CSIC, Laboratory 20, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-4740","authenticated-orcid":false,"given":"Antonio","family":"Muro","sequence":"additional","affiliation":[{"name":"Grupo de Enfermedades Infecciosas y Tropicales (e-INTRO), IBSAL-CIETUS (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropica-les de la Universidad de Salamanca), Facultad de Farmacia, Universidad de Salamanca, Ldo. M\u00e9ndez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, Regional, and National Disability-Adjusted Life-Years (DALYs) for 359 Diseases and Injuries and Healthy Life Expectancy (HALE) for 195 Countries and Territories, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Kyu","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pt.2005.12.004","article-title":"Immunopathogenic Mechanisms in Schistosomiasis: What Can Be Learnt from Human Studies?","volume":"22","author":"Abath","year":"2006","journal-title":"Trends Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3024.2009.01098.x","article-title":"Immunopathogenesis of Human Schistosomiasis","volume":"31","author":"Burke","year":"2009","journal-title":"Parasite Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng1096-181","article-title":"Genetic Localization of a Locus Controlling the Intensity of Infection by Schistosoma mansoni on Chromosome 5q31\u2013q33","volume":"14","author":"Marquet","year":"1996","journal-title":"Nat. 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