{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:33:15Z","timestamp":1784896395202,"version":"3.55.0"},"reference-count":67,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID, Chile, Project Fondecyt Initiation","award":["11220147"],"award-info":[{"award-number":["11220147"]}]},{"name":"ANID, Chile, Project Fondecyt Initiation","award":["1211344"],"award-info":[{"award-number":["1211344"]}]},{"name":"ANID, Chile, Project Fondecyt Regular","award":["11220147"],"award-info":[{"award-number":["11220147"]}]},{"name":"ANID, Chile, Project Fondecyt Regular","award":["1211344"],"award-info":[{"award-number":["1211344"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lactose intolerance (LI) and vitamin D deficiency (VDD) have been linked to inflammatory bowel disease (IBD). We conducted an observational study in 192 Chilean IBD patients to investigate the prevalence of a specific gene variant (LCT-13910 CC genotype) associated with LI and the prevalence of VDD\/Vitamin D Receptor (VDR) gene variants. Blood samples were analyzed using Illumina\u2019s Infinium Global Screening Array. The LCT-13910 CC genotype was found in 61% of IBD patients, similar to Chilean Hispanic controls and lower than Chilean Amerindian controls. The frequency of the LCT-13910-C allele in Chilean IBD patients (0.79) was comparable to the general population and higher than Europeans (0.49). Regarding VDR and VDD variants, in our study, the rs12785878-GG variant was associated with an increased risk of IBD (OR = 2.64, CI = 1.61\u20134.32; p-value = 0.001). Sixty-one percent of the Chilean IBD cohort have a genetic predisposition to lactose malabsorption, and a significant proportion exhibit genetic variants associated with VDD\/VDR. Screening for LI and VDD is crucial in this Latin American IBD population.<\/jats:p>","DOI":"10.3390\/ijms241914866","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:28:29Z","timestamp":1696318109000},"page":"14866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Tamara","family":"P\u00e9rez-Jeldres","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"},{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile"},{"name":"Fundaci\u00f3n Diagnosis, Santiago 7500580, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Segovia-Melero","sequence":"additional","affiliation":[{"name":"Red Salud Arauco, Santiago 7560994, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"},{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Magne","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-3194","authenticated-orcid":false,"given":"Gabriel","family":"Ascui","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Immunology, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Uribe","sequence":"additional","affiliation":[{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de Alimentos, Facultad de Medicina Universidad de Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Az\u00f3car","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi\u00e1n","family":"Hern\u00e1ndez-Rocha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Estela","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"De La Vega","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Arriagada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian-Franco","family":"Onetto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Escobar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Borja Arriar\u00e1n, Santiago 8360160, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-7747","authenticated-orcid":false,"given":"Pablo","family":"Baez","sequence":"additional","affiliation":[{"name":"Center of Medical Informatics and Telemedicine, University of Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Zazueta","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Pavez-Ovalle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"\u00c1lvarez-Lobos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1039\/C8FO00555A","article-title":"Lactose malabsorption and intolerance: A review","volume":"9","year":"2018","journal-title":"Food Funct."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1136\/gutjnl-2019-318404","article-title":"Update on lactose malabsorption and intolerance: Pathogenesis, diagnosis and clinical management","volume":"68","author":"Misselwitz","year":"2019","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nardone, O.M., Manfellotto, F., D\u2019onofrio, C., Rocco, A., Annona, G., Sasso, F., De Luca, P., Imperatore, N., Testa, A., and de Sire, R. (2021). Lactose intolerance assessed by analysis of genetic polymorphism, breath test and symptoms in patients with inflammatory bowel disease. Nutrients, 13.","DOI":"10.3390\/nu13041290"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1086\/520705","article-title":"Evidence of Still-Ongoing Convergence Evolution of the Lactase Persistence T-13910 Alleles in Humans","volume":"81","author":"Enattah","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/BF02088058","article-title":"Prevalence of lactose maldigestion","volume":"39","author":"Rao","year":"1994","journal-title":"Dig. Dis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S2468-1253(17)30154-1","article-title":"Country, regional, and global estimates for lactose malabsorption in adults: A systematic review and meta-analysis","volume":"2","author":"Storhaug","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e000125","DOI":"10.1136\/bmjopen-2011-000125","article-title":"The European lactase persistence genotype determines the lactase persistence state and correlates with gastrointestinal symptoms in the Hispanic and Amerindian Chilean population: A case-control and population-based study","volume":"1","author":"Morales","year":"2011","journal-title":"BMJ Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000363229","article-title":"Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study","volume":"90","author":"Latorre","year":"2014","journal-title":"Digestion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2036.2011.04799.x","article-title":"Association of lactose sensitivity with inflammatory bowel disease\u2014Demonstrated by analysis of genetic polymorphism, breath gases and symptoms","volume":"34","author":"Eadala","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12937-016-0183-8","article-title":"Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases","volume":"15","author":"Szilagyi","year":"2016","journal-title":"Nutr. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cgh.2019.06.030","article-title":"Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review","volume":"18","author":"Kotze","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1093\/jcag\/gwy053","article-title":"The Impact of Inflammatory Bowel Disease in Canada 2018: Extra-intestinal Diseases in IBD","volume":"2","author":"Bernstein","year":"2019","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_13","first-page":"41","article-title":"Low bone mineral density in Greek patients with inflammatory bowel disease: Prevalence and risk factors","volume":"24","author":"Koutroubakis","year":"2011","journal-title":"Ann. Gastroenterol."},{"key":"ref_14","first-page":"447","article-title":"Prevalence of osteoporosis and osteopenia in a population of patients with inflammatory bowel diseases from the Wielkopolska Region","volume":"128","author":"Michalak","year":"2018","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"De Martinis, M., Allegra, A., Sirufo, M.M., Tonacci, A., Pioggia, G., Raggiunti, M., Ginaldi, L., and Gangemi, S. (2021). Vitamin D deficiency, osteoporosis and effect on autoimmune diseases and hematopoiesis: A review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168855"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cgh.2016.05.035","article-title":"Low Serum Vitamin D during Remission Increases Risk of Clinical Relapse in Patients with Ulcerative Colitis","volume":"15","author":"Gubatan","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sahay, T., and Ananthakrishnan, A.N. (2014). Vitamin D deficiency is associated with community-acquired clostridium difficile infection: A case\u2013control study. BMC Infect. Dis., 14.","DOI":"10.1186\/s12879-014-0661-6"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1159\/000502515","article-title":"Distinct Association of Serum Vitamin D Concentration with Disease Activity and Trough Levels of Infliximab and Adalimumab during Inflammatory Bowel Disease Treatment","volume":"101","author":"Mechie","year":"2020","journal-title":"Digestion"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/apt.13936","article-title":"Higher 25-hydroxyvitamin D levels are associated with greater odds of remission with anti-tumour necrosis factor-\u03b1 medications among patients with inflammatory bowel diseases","volume":"45","author":"Winter","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_20","first-page":"1921","article-title":"Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn\u2019s Disease","volume":"19","author":"Ananthakrishnan","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cgh.2013.10.011","article-title":"Association between Reduced Plasma 25-Hydroxy Vitamin D and Increased Risk of Cancer in Patients with Inflammatory Bowel Diseases","volume":"12","author":"Ananthakrishnan","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1053\/j.gastro.2011.11.040","article-title":"Higher Predicted Vitamin D Status Is Associated with Reduced Risk of Crohn\u2019s Disease","volume":"142","author":"Ananthakrishnan","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Del Pinto, R., Ferri, C., and Cominelli, F. (2017). Vitamin D axis in inflammatory bowel diseases: Role, current uses and future perspectives. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112360"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ecco-jcc\/jjy025","article-title":"Role of Vitamin D in the Natural History of Inflammatory Bowel Disease","volume":"12","author":"Nielsen","year":"2018","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5217\/ir.2018.00022","article-title":"Vitamin D deficiency is associated with disease activity in patients with Crohn\u2019s disease","volume":"17","author":"Ko","year":"2019","journal-title":"Intest. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fimmu.2016.00697","article-title":"Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential","volume":"7","author":"Dankers","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gois, P.H.F., Ferreira, D., Olenski, S., and Seguro, A.C. (2017). Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?. Nutrients, 9.","DOI":"10.3390\/nu9070651"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2147\/JIR.S363840","article-title":"The Role of Vitamin D in Immune System and Inflammatory Bowel Disease","volume":"15","author":"Wu","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_31","unstructured":"NIH (2023, July 17). GWAS Catolog. Vitamin D deficiency. EFO_0003762. Available online: https:\/\/www.ebi.ac.uk\/gwas\/efotraits\/EFO_0003762."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/nu5103898","article-title":"The Role of Vitamin D Level and Related Single Nucleotide Polymorphisms in Crohn\u2019s Disease","volume":"5","author":"Carvalho","year":"2013","journal-title":"Nutrients"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clinre.2016.09.001","article-title":"The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population","volume":"41","author":"Zheng","year":"2017","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/gut.47.2.211","article-title":"Vitamin D receptor gene polymorphism: Association with Crohn\u2019s disease susceptibility","volume":"47","author":"Simmons","year":"2000","journal-title":"Gut"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/MEG.0b013e328349283e","article-title":"Common variation in the vitamin D receptor gene and risk of inflammatory bowel disease in an Irish case\u2013control study","volume":"23","author":"Hughes","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1097\/MIB.0000000000000524","article-title":"Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases","volume":"21","author":"Ananthakrishnan","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ibd.22966","article-title":"Associations between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn\u2019s Disease","volume":"19","author":"Xue","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/ibd\/izaa292","article-title":"Vitamin D Receptor Gene Single Nucleotide Polymorphisms and Association with Vitamin D Levels and Endoscopic Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Study","volume":"27","author":"Thomas","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1365-2036.2011.04588.x","article-title":"Vitamin D receptor gene polymorphism associated with inflammatory bowel disease in New Zealand males","volume":"33","author":"Bentley","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.cgh.2023.05.006","article-title":"Breaking Barriers in Dietary Research: Strategies to Diversify Recruitment in Clinical Studies and Develop Culturally Tailored Diets for Hispanic Communities Living with Inflammatory Bowel Disease","volume":"21","author":"Damas","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2014.09.026","article-title":"Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south\u2013central Italy patients","volume":"439","author":"Santonocito","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.dld.2008.09.020","article-title":"Genetic test for lactase non-persistence and hydrogen breath test: Is genotype better than phenotype to diagnose lactose malabsorption?","volume":"41","author":"Terulla","year":"2009","journal-title":"Dig. Liver Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/gutjnl-2012-304066","article-title":"Functional bowel symptoms in quiescent inflammatory bowel diseases: Role of epithelial barrier disruption and low-grade inflammation","volume":"63","author":"Bzioueche","year":"2014","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Morton, H., Pedley, K.C., Stewart, R.J.C., and Coad, J. (2020). Inflammatory Bowel Disease: Are Symptoms and Diet Linked?. Nutrients, 12.","DOI":"10.3390\/nu12102975"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111043","DOI":"10.1016\/j.nut.2020.111043","article-title":"Lactose intolerance in patients with inflammatory bowel diseases and dietary management in prevention of osteoporosis","volume":"82","author":"Ratajczak","year":"2021","journal-title":"Nutrition"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Szilagyi, A., and Ishayek, N. (2018). Lactose Intolerance, Dairy Avoidance, and Treatment Options. Nutrients, 10.","DOI":"10.3390\/nu10121994"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/15548627.2015.1072670","article-title":"VDR\/vitamin D receptor regulates autophagic activity through ATG16L1","volume":"12","author":"Sun","year":"2016","journal-title":"Autophagy"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/15548627.2015.1017187","article-title":"ATG16L1: A multifunctional susceptibility factor in Crohn disease","volume":"11","author":"Salem","year":"2015","journal-title":"Autophagy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e977176","DOI":"10.4161\/21688370.2014.977176","article-title":"Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation","volume":"3","author":"Luettig","year":"2015","journal-title":"Tissue Barriers"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/00365521.2016.1185463","article-title":"Vitamin D regulates the tight-junction protein expression in active ulcerative colitis","volume":"51","author":"Stio","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mce.2016.11.028","article-title":"The endocrine vitamin D system in the gut","volume":"453","author":"Larriba","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1096\/fj.04-3284com","article-title":"Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3","volume":"19","author":"Gombart","year":"2005","journal-title":"FASEB J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1074\/jbc.C109.071225","article-title":"Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2\/CARD15-Defensin \u03b22 Innate Immune Pathway Defective in Crohn Disease","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jaci.2017.01.045","article-title":"Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells","volume":"141","author":"Konya","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10787-012-0168-y","article-title":"25-Hydroxy vitamin D3 modulates dendritic cell phenotype and function in Crohn\u2019s disease","volume":"21","author":"Bartels","year":"2013","journal-title":"Inflammopharmacology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10787-013-0197-1","article-title":"Oral vitamin D3 supplementation reduces monocyte-derived dendritic cell maturation and cytokine production in Crohn\u2019s disease patients","volume":"22","author":"Bartels","year":"2014","journal-title":"Inflammopharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/0148607113506013","article-title":"Vitamin D and Crohn\u2019s Disease in the Adult Patient","volume":"38","author":"Basson","year":"2014","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.intimp.2007.09.016","article-title":"1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn\u2019s disease","volume":"7","author":"Bartels","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.3748\/wjg.v20.i17.4934","article-title":"Vitamin D improves inflammatory bowel disease outcomes: Basic science and clinical review","volume":"20","author":"Reich","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/eji.200838216","article-title":"1,25-dihydroxyvitamin D3 promotes IL-10 production in human B cells","volume":"38","author":"Heine","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.plipres.2016.09.003","article-title":"DHCR7: A vital enzyme switch between cholesterol and vitamin D production","volume":"64","author":"Prabhu","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.M115.699546","article-title":"Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis","volume":"291","author":"Prabhu","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/aur.2279","article-title":"Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder","volume":"13","author":"Guerini","year":"2020","journal-title":"Autism Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.bbi.2011.05.015","article-title":"Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals","volume":"25","author":"Agliardi","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG Clinical Guideline: Ulcerative Colitis in Adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ajg.2018.27","article-title":"ACG Clinical Guideline: Management of Crohn\u2019s Disease in Adults","volume":"113","author":"Lichtenstein","year":"2018","journal-title":"Am. J. Gastroenterol. Am. J. 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