{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:07:43Z","timestamp":1788548863103,"version":"build-2803163510"},"reference-count":93,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NEXTGENERATIONEU (NGEU)","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"NEXTGENERATIONEU (NGEU)","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]},{"name":"Ministry of University and Research (MUR)","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"Ministry of University and Research (MUR)","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]},{"name":"MNESYS","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"MNESYS","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glaucoma is the leading cause of blindness worldwide. It is classically associated with structural and functional changes in the optic nerve head and retinal nerve fiber layer, but the damage is not limited to the eye. The involvement of the central visual pathways and disruption of brain network organization have been reported using advanced neuroimaging techniques. The brain structural changes at the level of the areas implied in processing visual information could justify the discrepancy between signs and symptoms and underlie the analogy of this disease with neurodegenerative dementias, such as Alzheimer\u2019s disease, and with the complex group of pathologies commonly referred to as \u201cdisconnection syndromes.\u201d This review aims to summarize the current state of the art on the use of advanced neuroimaging techniques in glaucoma and Alzheimer\u2019s disease, highlighting the emerging biomarkers shared by both diseases.<\/jats:p>","DOI":"10.3390\/ijms241914932","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:07:13Z","timestamp":1696554433000},"page":"14932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-8211","authenticated-orcid":false,"given":"Alessio","family":"Martucci","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Experimental Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-183X","authenticated-orcid":false,"given":"Francesca","family":"Di Giuliano","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Minosse","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Pocobelli","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Experimental Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Nucci","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Experimental Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Garaci","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"San Raffaele Cassino, 03043 Frosinone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref_1","first-page":"e11686","article-title":"Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future","volume":"12","author":"Allison","year":"2020","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)01101-1","article-title":"Epidemiology of primary glaucoma: Prevalence, incidence, and blinding effects","volume":"173","author":"Cedrone","year":"2008","journal-title":"Prog. 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