{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:11:13Z","timestamp":1782169873951,"version":"3.54.5"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova","award":["26\/18C\/13.07.2021"],"award-info":[{"award-number":["26\/18C\/13.07.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriatic arthritis (PsA) is a heterogenous systemic inflammatory disorder that affects peripheral joints and skin, but also causes inflammation at entheseal sites, digits (dactylitis) and the axial skeleton. Despite considerable advances, our understanding of the pathogenesis and management of PsA is hampered by its complex clinical expression. We enrolled patients who met the ClASsification for Psoriatic Arthritis (CASPAR) criteria for PsA (n = 17), and healthy controls (n = 13). The lipid profile, C-reactive protein (CRP) and Dickkopf-related protein 1 (DKK-1) circulating levels were measured for all subjects. For the patients with PsA, (1) the erosive character of the articular disease was assessed by a musculoskeletal ultrasound and (2) the cardiovascular risk was evaluated using the Systematic Coronary Risk Evaluation (SCORE) chart and the ultrasound measurement of the carotid intima-media thickness. A higher titer of serum DKK-1 was associated with the presence of erosions (p &lt; 0.005) and the cIMT correlated with DKK-1 levels in patients with PsA (r = 0.6356, p = 0.0061). Additionally, we observed a positive correlation between increased cIMT and CRP (r = 0.5186, p = 0.0329). Our results suggest that DKK-1 could be used as an early biomarker for the erosive character of the articular disease and for the assessment of the cardiovascular risk in PsA patients.<\/jats:p>","DOI":"10.3390\/ijms241914970","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:03:03Z","timestamp":1696687383000},"page":"14970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dickkopf-Related Protein 1 (DKK-1) as a Possible Link between Bone Erosions and Increased Carotid Intima-Media Thickness in Psoriatic Arthritis: An Ultrasound Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Cristina-Elena","family":"Bi\u021b\u0103","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218tefan Cristian","family":"Dinescu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca-Lelia","family":"Riza","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"},{"name":"Regional Center for Medical Genetics Dolj, Emergency County Hospital Craiova, 1 Tabaci Street, 200642 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina Lucia","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Emanuela","family":"Mu\u0219etescu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Mihaela","family":"Dumitra\u0219cu","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa Ionela","family":"\u0218uiu","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan Adrian","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Third Internal Medicine Department, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 8 Eroii Sanitari Avenue, 050471 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hora\u021biu Valeriu","family":"Popoviciu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, BFK and Medical Rehabilitation, University of Medicine, Pharmacy, Science and Technology of Targu Mures, 38 Gh. Marinescu Street, 540142 T\u00e2rgu Mure\u0219, Mure\u0219 County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentin Ananu","family":"Vreju","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The Pathogenesis of Psoriatic Arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ncprheum0670","article-title":"Psoriatic Disease\u2014From Skin to Bone","volume":"3","author":"Ritchlin","year":"2007","journal-title":"Nat. Clin. Pract. 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