{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:37:46Z","timestamp":1775857066765,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteoarthritis (OA) affects &gt;500 million people globally, and this number is expected to increase. OA management primarily focuses on symptom alleviation, using non-steroidal anti-inflammatory drugs, including Celecoxib. However, such medication has serious side effects, emphasizing the need for disease-specific treatment. The meniscectomy and cranial cruciate ligament transection (CCLx)-treated beagle dog was used to investigate the efficacy of a modified-release formulation of SKI306X (SKCPT) from Clematis mandshurica, Prunella vulgaris, and Trichosanthes kirilowii in managing arthritis. SKCPT\u2019s anti-inflammatory and analgesic properties have been assessed via stifle circumference, gait, incapacitance, histopathology, and ELISA tests. The different SKCPT concentrations and formulations also affected the outcome. SKCPT improved the gait, histopathological, and ELISA OA assessment parameters compared to the control group. Pro-inflammatory cytokines and matrix metalloproteinases were significantly lower in the SKCPT-treated groups than in the control group. This study found that SKCPT reduces arthritic lesions and improves abnormal gait. The 300 mg modified-release formulation was more efficacious than others, suggesting a promising approach for managing OA symptoms and addressing disease pathogenesis. A high active ingredient level and a release pattern make this formulation effective for twice-daily arthritis treatment.<\/jats:p>","DOI":"10.3390\/ijms241914972","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:03:03Z","timestamp":1696687383000},"page":"14972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of SKCPT on Osteoarthritis in Beagle Meniscectomy and Cranial Cruciate Ligament Transection Models"],"prefix":"10.3390","volume":"24","author":[{"given":"Hye-Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-8447","authenticated-orcid":false,"given":"Minseok","family":"Kang","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Seok","family":"Jung","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3623-2949","authenticated-orcid":false,"given":"Wonjae","family":"Choi","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hunseung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JeongHoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Life Science R&D Center, SK Chemicals, 310 Pangyo, Seongnam 13494, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Department of Integrated Drug Development and Natural Products, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2021.11.001","article-title":"Osteoarthritis in year 2021: Biochemical markers","volume":"30","author":"Henrotin","year":"2022","journal-title":"Osteoarthr. 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