{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:30:45Z","timestamp":1788481845414,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heart and Stroke Foundation of Canada in partnership with the Canadian Institutes of Health Research and from Fondation de France"},{"name":"The Canadian Hypertension Society and Pfizer"},{"name":"Heart &amp; Stroke Foundation of Quebec"},{"name":"Canadian Institutes of Health Research"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Hypertension Art\u00e9rielle (SFHTA)"},{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>NTPDase1\/CD39, the major vascular ectonucleotidase, exerts thrombo-immunoregulatory function by controlling endothelial P2 receptor activation. Despite the well-described release of ATP from endothelial cells, few data are available regarding the potential role of CD39 as a regulator of arterial diameter. We thus investigated the contribution of CD39 in short-term diameter adaptation and long-term arterial remodeling in response to flow using Entpd1\u2212\/\u2212 male mice. Compared to wild-type littermates, endothelial-dependent relaxation was modified in Entpd1\u2212\/\u2212 mice. Specifically, the vasorelaxation in response to ATP was potentiated in both conductance (aorta) and small resistance (mesenteric and coronary) arteries. By contrast, the relaxing responses to acetylcholine were supra-normalized in thoracic aortas while decreased in resistance arteries from Entpd1\u2212\/\u2212 mice. Acute flow-mediated dilation, measured via pressure myography, was dramatically diminished and outward remodeling induced by in vivo chronic increased shear stress was altered in the mesenteric resistance arteries isolated from Entpd1\u2212\/\u2212 mice compared to wild-types. Finally, changes in vascular reactivity in Entpd1\u2212\/\u2212 mice were also evidenced by a decrease in the coronary output measured in isolated perfused hearts compared to the wild-type mice. Our results highlight a key regulatory role for purinergic signaling and CD39 in endothelium-dependent short- and long-term arterial diameter adaptation to increased flow.<\/jats:p>","DOI":"10.3390\/ijms242015038","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:14:04Z","timestamp":1696918444000},"page":"15038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NTPDase1\/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow"],"prefix":"10.3390","volume":"24","author":[{"given":"Julie","family":"Favre","sequence":"first","affiliation":[{"name":"MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, 49045 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8528-9995","authenticated-orcid":false,"given":"Charlotte","family":"Roy","sequence":"additional","affiliation":[{"name":"MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, 49045 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Guihot","sequence":"additional","affiliation":[{"name":"MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, 49045 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Drouin","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Surgery, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 1C8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Laprise","sequence":"additional","affiliation":[{"name":"Animal Physiology Service, Institut de Recherches Cliniques de Montreal (IRCM), Montreal, QC H2W 1R7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Gillis","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Surgery, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 1C8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-0194","authenticated-orcid":false,"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thorin","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Surgery, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 1C8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-1600","authenticated-orcid":false,"given":"Jean","family":"S\u00e9vigny","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 4G2, Canada"},{"name":"D\u00e9partement de Microbiologie-Infectiologie et D\u2019immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-0285","authenticated-orcid":false,"given":"Daniel","family":"Henrion","sequence":"additional","affiliation":[{"name":"MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, 49045 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-8305","authenticated-orcid":false,"given":"Gilles","family":"Kauffenstein","sequence":"additional","affiliation":[{"name":"MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, 49045 Angers, France"},{"name":"INSERM UMR 1260\u2014Regenerative Nanomedicine, CRBS, Strasbourg University, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-F","article-title":"Non-Invasive Detection of Endothelial Dysfunction in Children and Adults at Risk of Atherosclerosis","volume":"340","author":"Celermajer","year":"1992","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"H2","DOI":"10.1152\/ajpheart.00471.2010","article-title":"Assessment of Flow-Mediated Dilation in Humans: A Methodological and Physiological Guideline","volume":"300","author":"Thijssen","year":"2011","journal-title":"Am. 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