{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:04:12Z","timestamp":1790841852120,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg\/m2 (n = 34) and obese subjects with a BMI &gt; 30 kg\/m2 (n = 11). Our results showed that obesity was associated with significantly more severe gingival inflammation according to Periodontal Inflamed Surface Area (PISA index). Periodontal microbiota taxonomic analysis showed that the obese (OB) subjects with periodontitis were characterized by a specific signature of subgingival microbiota with an increase in Gram-positive bacteria in periodontal pockets, associated with a decrease in microbiota diversity compared to that of normo-weighted subjects with periodontitis. Finally, periodontal treatment response was less effective in OB subjects with persisting periodontal inflammation, reflecting a still unstable periodontal condition and a risk of recurrence. To our knowledge, this study is the first exploring both salivary and subgingival microbiota of OB subjects. Considering that OB subjects are at higher periodontal risk, this could lead to more personalized preventive or therapeutic strategies for obese patients regarding periodontitis through the specific management of oral microbiota of obese patients.<\/jats:p>","DOI":"10.3390\/ijms242015123","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:46:13Z","timestamp":1697114773000},"page":"15123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota"],"prefix":"10.3390","volume":"24","author":[{"given":"Sylvie","family":"L\u00ea","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019Odontologie, Facult\u00e9 de Sant\u00e9, Universit\u00e9 Paul Sabatier Toulouse III, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse Rangueil, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Laurencin-Dalicieux","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Odontologie, Facult\u00e9 de Sant\u00e9, Universit\u00e9 Paul Sabatier Toulouse III, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse Rangueil, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"INSERM U1295, CERPOP, Epid\u00e9miologie et Analyse en Sant\u00e9 Publique, Risques, Maladies Chroniques et Handicaps, 37 All\u00e9es Jules Guesdes, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Minty","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Odontologie, Facult\u00e9 de Sant\u00e9, Universit\u00e9 Paul Sabatier Toulouse III, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse Rangueil, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Assoulant-Anduze","sequence":"additional","affiliation":[{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul 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Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Nielsen","year":"2013","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Thomas, C., Minty, M., Vinel, A., Canceill, T., Loubi\u00e8res, P., Burcelin, R., Kaddech, M., Blasco-Baque, V., and Laurencin-Dalicieux, S. (2021). Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases. Diagnostics, 11.","DOI":"10.3390\/diagnostics11081376"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1111\/j.1467-789X.2010.00808.x","article-title":"Association between overweight\/obesity and periodontitis in adults. A systematic review","volume":"12","author":"Suvan","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/obr.12668","article-title":"Is overweight\/obesity a risk factor for periodontitis in young adults and adolescents?: A systematic review","volume":"19","author":"Khan","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1902\/jop.2010.100321","article-title":"Association between chronic periodontal disease and obesity: A systematic review and meta-analysis","volume":"81","author":"Chaffee","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_8","first-page":"309","article-title":"Effect of periodontal treatment on serum C-reactive protein level in obese and normal-weight women affected with chronic periodontitis","volume":"33","author":"Alghamdi","year":"2012","journal-title":"Saudi Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1902\/jop.2012.110646","article-title":"Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Patients with and Without Obesity","volume":"84","author":"Altay","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1902\/jop.2011.110230","article-title":"Response to Periodontal Therapy in Patients Who Had Weight Loss After Bariatric Surgery and Obese Counterparts: A Pilot Study","volume":"83","author":"Lakkis","year":"2012","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/jcpe.12840","article-title":"Levels of serum retinol-binding protein 4 before and after non-surgical periodontal treatment in lean and obese subjects: An interventional study","volume":"45","author":"Silvestre","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/jcpe.13030","article-title":"Dietary therapy and non-surgical periodontal treatment in obese patients with chronic periodontitis","volume":"45","author":"Silvestre","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/prd.12326","article-title":"The association of periodontal diseases with metabolic syndrome and obesity","volume":"83","author":"Jepsen","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1002\/JPER.16-0480","article-title":"Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations","volume":"89","author":"Albandar","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1002\/JPER.17-0733","article-title":"Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Jepsen","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1902\/jop.2012.120254","article-title":"Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis","volume":"84","author":"Zimmermann","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1902\/jop.2010.100545","article-title":"The Role of Obesity as a Modifying Factor in Patients Undergoing Non-Surgical Periodontal Therapy","volume":"82","author":"Zuza","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.4103\/ccd.ccd_1_18","article-title":"Evaluation of serum leptin and adiponectin in obese individuals with chronic periodontitis","volume":"9","author":"Boyapati","year":"2018","journal-title":"Contemp. Clin. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/0022034510376402","article-title":"Destructive and protective roles of cytokines in periodontitis: A re-appraisal from host defense and tissue destruction viewpoints","volume":"89","author":"Garlet","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/ajcn\/87.5.1219","article-title":"Energy intake is associated with endotoxemia in apparently healthy men","volume":"87","author":"Amar","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/gutjnl-2015-309897","article-title":"Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response","volume":"66","author":"Garidou","year":"2017","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0757.2010.00358.x","article-title":"Periodontal innate immune mechanisms relevant to atherosclerosis and obesity: Influence of periodontal disease on obesity and atherosclerosis","volume":"54","author":"Zelkha","year":"2010","journal-title":"Periodontol. 2000"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0757.2006.00186.x","article-title":"Metabolic disorders related to obesity and periodontal disease","volume":"43","author":"Saito","year":"2007","journal-title":"Periodontol. 2000"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Thomas, C., Minty, M., Canceill, T., Loubi\u00e8res, P., Azalbert, V., Terc\u00e9, F., Champion, C., Burcelin, R., Barthet, P., and Laurencin-Dalicieux, S. (2021). Obesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study. Diagnostics, 11.","DOI":"10.21203\/rs.3.rs-140494\/v1"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/00016357.2017.1401659","article-title":"Periodontal inflamed surface area and periodontal case definition classification","volume":"76","author":"Leira","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/JPER.17-0236","article-title":"Subgingival microbial profile of obese women with periodontal disease","volume":"89","author":"Colombo","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-051X.2008.01356.x","article-title":"Relation of body mass index, periodontitis and Tannerella forsythia","volume":"36","author":"Haffajee","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/jcpe.12634","article-title":"Does obesity influence the subgingival microbiota composition in periodontal health and disease?","volume":"43","author":"Maciel","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Rahman, B., Al-Marzooq, F., Saad, H., Benzina, D., and Al Kawas, S. (2023). Dysbiosis of the Subgingival Microbiome and Relation to Periodontal Disease in Association with Obesity and Overweight. Nutrients, 15.","DOI":"10.3390\/nu15040826"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1007\/s00784-021-03961-1","article-title":"Association between clinical measures of gingival inflammation and obesity in adults: Systematic review and meta-analyses","volume":"25","author":"Pola","year":"2021","journal-title":"Clin. Oral Invest."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Aoyama, N., Fujii, T., Kida, S., Nozawa, I., Taniguchi, K., Fujiwara, M., Iwane, T., Tamaki, K., and Minabe, M. (2021). Association of Periodontal Status, Number of Teeth, and Obesity: A Cross-Sectional Study in Japan. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020208"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1600-051X.2008.01249.x","article-title":"Periodontal inflamed surface area: Quantifying inflammatory burden","volume":"35","author":"Nesse","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1467-789x.2001.00031.x","article-title":"Beyond body mass index","volume":"2","author":"Prentice","year":"2001","journal-title":"Obes. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ijo.2010.5","article-title":"Diagnostic performance of body mass index to identify obesity as defined by body adiposity: A systematic review and meta-analysis","volume":"34","author":"Okorodudu","year":"2010","journal-title":"Int. J. Obes."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ijo.2009.286","article-title":"Gluteofemoral body fat as a determinant of metabolic health","volume":"34","author":"Manolopoulos","year":"2010","journal-title":"Int. J. Obes."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/oby.2011.401","article-title":"Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance","volume":"20","author":"Amati","year":"2012","journal-title":"Obesity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.26719\/2010.16.4.429","article-title":"Relationship between overall and abdominal obesity and periodontal disease among young adults","volume":"16","author":"Amin","year":"2010","journal-title":"East. Mediterr. Health J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e3136","DOI":"10.1097\/MD.0000000000003136","article-title":"Oxidative Stress and Periodontal Disease in Obesity","volume":"95","author":"Dursun","year":"2016","journal-title":"Medicine"},{"key":"ref_41","first-page":"E335","article-title":"Possible association between obesity and periodontitis in patients with Down syndrome","volume":"23","author":"Silvestre","year":"2018","journal-title":"Med. Oral"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00424-007-0301-8","article-title":"Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes","volume":"455","author":"Wang","year":"2007","journal-title":"Pfl\u00fcg. Arch."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cruz-\u00c1vila, J., Hern\u00e1ndez-P\u00e9rez, E., Gonz\u00e1lez-Gonz\u00e1lez, R., Bologna-Molina, R., and Molina-Frechero, N. (2022). Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review. Dent. J., 10.","DOI":"10.3390\/dj10120225"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s40496-021-00296-4","article-title":"The Link Between Periodontal Inflammation and Obesity","volume":"8","author":"Iwashita","year":"2021","journal-title":"Curr. Oral Health Rep."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Andriankaja, O.M., P\u00e9rez, C.M., Modi, A., Suar\u00e9z, E.L., Gower, B.A., Rodr\u00edguez, E., and Joshipura, K. (2023). Systemic Inflammation, Endothelial Function, and Risk of Periodontitis in Overweight\/Obese Adults. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061507"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ni774","article-title":"TLR4, but not TLR2, mediates IFN-\u03b2\u2013induced STAT1\u03b1\/\u03b2-dependent gene expression in macrophages","volume":"3","author":"Toshchakov","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2337\/db09-0287","article-title":"Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated with Insulin Resistance in Human Obesity","volume":"59","author":"Wentworth","year":"2010","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.2041-1014.2013.12035.x","article-title":"Periodontal Innate Immune Mechanisms Relevant to Obesity","volume":"28","author":"Amar","year":"2013","journal-title":"Mol. Oral Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1902\/jop.2016.160102","article-title":"Macrophages Play a Key Role in the Obesity-Induced Periodontal Innate Immune Dysfunction via Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Pathway","volume":"87","author":"Huang","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.37757\/MR2021.V23.N3.8","article-title":"Wound Chronicity, Impaired Immunity and Infection in Diabetic Patients","volume":"24","author":"Armstrong","year":"2021","journal-title":"MEDICC Rev."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gerber, F.A., Sahrmann, P., Schmidlin, O.A., Heumann, C., Beer, J.H., and Schmidlin, P.R. (2016). Influence of obesity on the outcome of non-surgical periodontal therapy\u2014A systematic review. BMC Oral Health, 16.","DOI":"10.1186\/s12903-016-0272-2"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e20190694","DOI":"10.1590\/1678-7757-2019-0694","article-title":"Clinical and microbiological evaluation of non-surgical periodontal therapy in obese and non-obese individuals with periodontitis: A 9-month prospective longitudinal study","volume":"28","author":"Peralta","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"ref_55","first-page":"e708","article-title":"Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials","volume":"22","author":"Silvestre","year":"2017","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/jcpe.13261","article-title":"Obesity as predictive factor of periodontal therapy clinical outcomes: A cohort study","volume":"47","author":"Suvan","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1210\/clinem\/dgaa757","article-title":"Effect of Treatment of Periodontitis on Incretin Axis in Obese and Nonobese Individuals: A Cohort Study","volume":"106","author":"Suvan","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jcpe.13378","article-title":"Obesity as a risk factor for tooth loss over 5 years: A population-based cohort study","volume":"48","author":"Vallim","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00784-021-04031-2","article-title":"The effect of obesity on periodontitis progression: The 10-year retrospective cohort study","volume":"26","author":"Charupinijkul","year":"2022","journal-title":"Clin. Oral Investig."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Vitkov, L., Singh, J., Schauer, C., Minnich, B., Kruni\u0107, J., Oberthaler, H., Gamsjaeger, S., Herrmann, M., Knopf, J., and Hannig, M. (2023). Breaking the Gingival Barrier in Periodontitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054544"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-030-96881-6_16","article-title":"Non-surgical Periodontal Treatment: SRP and Innovative Therapeutic Approaches","volume":"Volume 1373","year":"2022","journal-title":"Periodontitis"},{"key":"ref_62","first-page":"251","article-title":"Nonsurgical periodontal treatment","volume":"9","author":"Aimetti","year":"2014","journal-title":"Int. J. Esthet. Dent."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/prd.12343","article-title":"Biological strategies for the prevention of periodontal disease: Probiotics and vaccines","volume":"84","author":"Myneni","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/jcpe.12545","article-title":"Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: A systematic review and meta-analysis","volume":"43","author":"Davideau","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"114727","DOI":"10.1016\/j.addr.2023.114727","article-title":"Colonizing microbiota is associated with clinical outcomes in diabetic wound healing","volume":"194","author":"Wang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Park, J.-U., Oh, B., Lee, J.P., Choi, M.-H., Lee, M.-J., and Kim, B.-S. (2019). Influence of Microbiota on Diabetic Foot Wound in Comparison with Adjacent Normal Skin Based on the Clinical Features. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/7459236"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Ruegger, P.R., Lebig, E.G., VanSchalkwyk, S., Jeske, D.R., Hsiao, A., Borneman, J., and Martins-Green, M. (2020). High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00259"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Durand, B.A.R.N., Pouget, C., Magnan, C., Molle, V., Lavigne, J.-P., and Dunyach-Remy, C. (2022). Bacterial Interactions in the Context of Chronic Wound Biofilm: A Review. Microorganisms, 10.","DOI":"10.3390\/microorganisms10081500"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J. Anaesth."},{"key":"ref_70","first-page":"67","article-title":"The DMF index","volume":"88","author":"McGregor","year":"1992","journal-title":"N. Z. Dent. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-051X.2005.00799.x","article-title":"Analytical epidemiology of periodontitis","volume":"32","author":"Borrell","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","article-title":"The Plaque Control Record","volume":"43","author":"Drake","year":"1972","journal-title":"J. Periodontol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdent.2018.10.001","article-title":"Oral health and microbiota status in professional rugby players: A case-control study","volume":"79","author":"Minty","year":"2018","journal-title":"J. Dent."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s13105-020-00757-x","article-title":"Gender-associated differences in oral microbiota and salivary biochemical parameters in response to feeding","volume":"77","author":"Minty","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1038\/s41598-018-24619-1","article-title":"Obese Subjects with Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids","volume":"8","author":"Besnard","year":"2018","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/20\/15123\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:05:52Z","timestamp":1760130352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/20\/15123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":75,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["ijms242015123"],"URL":"https:\/\/doi.org\/10.3390\/ijms242015123","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]}}}