{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:42Z","timestamp":1787028522023,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical School of University of Pecs","award":["RRF-2.3.1-21-2022-00011"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00011"]}]},{"name":"National Laboratory for Translational Neuroscience (TINL)","award":["RRF-2.3.1-21-2022-00011"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathophysiology and consequences of early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) remain incompletely understood. This study aims to investigate the role of orosomucoid (ORM) in aSAH, its potential as a marker for assessing the extent of EBI-induced damage, and its correlation with delayed cerebral ischemia (DCI) and functional recovery over a 3-month period. We collected serum specimens 72 h post-aSAH to measure ORM levels. The study included 151 aSAH patients and 105 healthy subjects. The serum ORM levels within the patient cohort significantly exceeded those in the control group (p &lt; 0.001). The ORM value showed significant correlation with the admission WFNS (p &lt; 0.0001) and mFS scores (p &lt; 0.05). Substantially elevated serum ORM levels at 72 h post-aSAH were detected among patients experiencing DCI, as well as those with poor functional outcomes after 3 months (p = 0.009 and p &lt; 0.001). Binary logistic regression analyses revealed that serum ORM at 72 h post-SAH was independently associated with DCI and 3-month functional outcome after adjusting for confounders. The early stage events of aSAH influence the level of ORM. ORM serves as a marker for assessing the extent of damage during EBI and is linked to the occurrence of DCI as well as unfavorable long-term functional outcomes.<\/jats:p>","DOI":"10.3390\/ijms242015267","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:08:33Z","timestamp":1697530113000},"page":"15267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Phase Protein Orosomucoid (Alpha-1-Acid Glycoprotein) Predicts Delayed Cerebral Ischemia and 3-Month Unfavorable Outcome after Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-4167","authenticated-orcid":false,"given":"Laszlo","family":"Zavori","sequence":"first","affiliation":[{"name":"Emergency Department, Saudi German Hospital, Dubai 391093, United Arab Emirates"},{"name":"Doctoral School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-3955","authenticated-orcid":false,"given":"Reka","family":"Varnai","sequence":"additional","affiliation":[{"name":"Department of Primary Health Care, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-9787","authenticated-orcid":false,"given":"Tihamer","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Szirmay","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-6527","authenticated-orcid":false,"given":"Nelli","family":"Farkas","sequence":"additional","affiliation":[{"name":"Institute of Bioanalysis, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-2481","authenticated-orcid":false,"given":"Peter","family":"Csecsei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/00006123-200211000-00001","article-title":"The probability of sudden death from rupture of intracranial aneurysms: A meta-analysis","volume":"51","author":"Huang","year":"2002","journal-title":"Neurosurgery"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Alsbrook, D.L., Di Napoli, M., Bhatia, K., Desai, M., Hinduja, A., Rubinos, C.A., Mansueto, G., Singh, P., Domeniconi, G.G., and Ikram, A. 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