{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:13:56Z","timestamp":1790392436259,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer (p = 0.0197), myxomatous aspect (p = 0.0001), and subendothelial layer degeneration (p = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD (p = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD (p = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer.<\/jats:p>","DOI":"10.3390\/ijms242015470","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:54:35Z","timestamp":1698040475000},"page":"15470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Histopathological Gap in Aortic Diseases: A Prospective Analysis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-4357","authenticated-orcid":false,"given":"Cosmin Marian","family":"Banceu","sequence":"first","affiliation":[{"name":"I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Department of Surgery M3, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Emergency Institute for Cardiovascular Diseases and Transplantation Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-5118","authenticated-orcid":false,"given":"Simona","family":"Gurzu","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Research Center for Oncopathology and Translational Medicine (CCOMT), George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Romanian Academy of Medical Sciences, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin-Bogdan","family":"Satala","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Ghiga","sequence":"additional","affiliation":[{"name":"Department of Medical Scientific Research Methodology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Halic","family":"Neamtu","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute of Forest, Snow and Landscape Research WSL, 8903 Birmensdorf, Switzerland"},{"name":"Institute of Environmental Engineering, ETH Zurich, 8039 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Voth","sequence":"additional","affiliation":[{"name":"Sana Cardiac Surgery, Herdweg 2, 70174 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Liebrich","sequence":"additional","affiliation":[{"name":"Sana Cardiac Surgery, Herdweg 2, 70174 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horatiu","family":"Suciu","sequence":"additional","affiliation":[{"name":"Department of Surgery M3, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Emergency Institute for Cardiovascular Diseases and Transplantation Targu Mures, 540136 Targu Mures, Romania"},{"name":"Romanian Academy of Medical Sciences, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.21037\/jtd-21-1863","article-title":"The impact of age and sex on in hospital outcomes in acute type A aortic dissection surgery","volume":"14","author":"Morgan","year":"2022","journal-title":"J. Thorac. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ms61e2007","DOI":"10.54905\/disssi\/v26i120\/ms61e2007","article-title":"Type-A aortic dissection masquerading as acute inferior wall myocardial infarction\u2014A rare case report","volume":"26","author":"Bawiskar","year":"2022","journal-title":"Med. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101249","DOI":"10.1016\/j.cpcardiol.2022.101249","article-title":"Research progress on the pathogenesis of aortic dissection","volume":"48","author":"Yin","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/2048872616682343","article-title":"Diagnosis, management and mortality in acute aortic syndrome: Results of the Spanish Registry of Acute Aortic Syndrome (RESA-II)","volume":"7","author":"Evangelista","year":"2018","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4068\/cmj.2018.54.3.143","article-title":"Role of PET\/CT in the Evaluation of Aortic Disease","volume":"54","author":"Kim","year":"2018","journal-title":"Chonnam Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.21037\/jovs.2018.03.13","article-title":"Malperfusion syndromes in type A aortic dissection: What we have learned from IRAD","volume":"4","author":"Berretta","year":"2018","journal-title":"J. Vis. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11739-020-02354-8","article-title":"Diagnosis and management of acute aortic syndromes in the emergency department","volume":"16","author":"Morello","year":"2021","journal-title":"Intern. Emerg. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.21037\/qims-20-191","article-title":"Acute type A aortic intramural hematoma and type A aortic dissection: Correlation between the intimal tear features and pathogenesis","volume":"10","author":"Li","year":"2020","journal-title":"Quant. Imaging. Med. Surg."},{"key":"ref_9","first-page":"717","article-title":"Medionecrosis Aortae Idiopathica Cystica","volume":"8","author":"Moritz","year":"1932","journal-title":"Am. J. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S0102-76382011000100019","article-title":"Cystic medial necrosis: Pathological findings and clinical implications","volume":"26","author":"Yuan","year":"2011","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/icvts\/ivy046","article-title":"Histopathological evaluation of aortic dissection: A comparison of congenital versus acquired aortic wall weakness","volume":"27","author":"Osada","year":"2018","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.carpath.2016.03.002","article-title":"Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases\u2014Nomenclature and diagnostic criteria","volume":"25","author":"Halushka","year":"2016","journal-title":"Cardiovasc. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13019-022-01785-y","article-title":"Surgical treatment of type A acute aortic dissection with cerebral malperfusion: A systematic review","volume":"17","author":"Wang","year":"2022","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13019-022-01858-y","article-title":"Impact of GERAADA score in patients with acute type A aortic dissection","volume":"17","author":"Sugiyama","year":"2022","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_15","first-page":"816","article-title":"RESA centres. Spanish Registry of Acute Aortic Syndrome (RESA). Changes in therapeutic management and lower mortality in acute aortic syndrome","volume":"75","author":"Iglesias","year":"2022","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.jtcvs.2018.04.086","article-title":"Redefining the histopathologic profile of acute aortic syndromes: Clinical and prognostic implications","volume":"156","author":"Leone","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00595-021-02342-1","article-title":"Relationship between the aortic root Z-score and degree of translamellar mucoid extracellular matrix accumulation","volume":"52","author":"Fujiyoshi","year":"2022","journal-title":"Surg. Today."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jtcvs.2021.04.053","article-title":"The American Association for Thoracic Surgery expert consensus document: Surgical treatment of acute type A aortic dissection","volume":"162","author":"Malaisrie","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jtcvs.2021.07.024","article-title":"Early outcomes of patients with Marfan syndrome and acute aortic type A dissection","volume":"166","author":"Farag","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.20517\/2574-1209.2020.21","article-title":"Risk of aortic dissection in patients with ascending aorta aneurysm: A new biological, morphological, and biomechanical network behind the aortic diameter","volume":"4","author":"Pisano","year":"2020","journal-title":"Vessel. Plus."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.xjon.2020.12.012","article-title":"Aortic dissection is a disease of the vasa vasorum","volume":"5","author":"Haverich","year":"2021","journal-title":"JTCVS Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.xjon.2020.12.015","article-title":"Commentary: Vasa vasorum dysfunction and acute aortic syndromes: When guidelines do not follow the evolution of knowledge","volume":"5","author":"Calafiore","year":"2021","journal-title":"JTCVS Open"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2020.04.011","article-title":"Impact of histopathological changes in ascending aortic diseases","volume":"311","author":"Amemiya","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.semtcvs.2018.10.022","article-title":"Incidence of Aortitis in Surgical Specimens of the Ascending Aorta Clinical Implications at Follow-Up","volume":"31","author":"Ballestracci","year":"2019","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tcm.2021.08.008","article-title":"Update in aortic dissection","volume":"32","author":"Juraszek","year":"2021","journal-title":"Trends. Cardiovasc. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ajem.2021.10.016","article-title":"Management of acute aortic syndromes from initial presentation to definitive treatment","volume":"51","author":"Mehta","year":"2022","journal-title":"Am. J. Emerg. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.mpmed.2022.04.010","article-title":"Acute aortic syndrome","volume":"50","author":"Yuan","year":"2022","journal-title":"Medicine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1177\/2048872620976508","article-title":"New clues for optimal diagnosis and treatment of an old foe: The acute aortic syndrome","volume":"9","author":"Bonaca","year":"2020","journal-title":"Eur. Heart. J. Acute. Cardiovasc. Care."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.athoracsur.2021.01.027","article-title":"Moderate Versus Deep Hypothermia in Type A Acute Aortic Dissection Repair: Insights from the International Registry of Acute Aortic Dissection","volume":"112","author":"Pupovac","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Freundt, M., Kolat, P., Friedrich, C., Salem, M., Gruenewald, M., Elke, G., P\u00fchler, T., Cremer, J., and Haneya, A. (2021). Preoperative Predictors of Adverse Clinical Outcome in Emergent Repair of Acute Type A Aortic Dissection in 15 Year Follow Up. J. Clin. Med., 10.","DOI":"10.3390\/jcm10225370"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/ejhf.325","article-title":"Acute heart failure in patients with acute aortic syndrome: Pathophysiology and clinical-prognostic implications","volume":"17","author":"Vagnarelli","year":"2015","journal-title":"Eur. J. Heart. Fail."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.23736\/S0021-9509.21.11816-6","article-title":"Update on the genetic risk for thoracic aortic aneurysms and acute aortic dissections: Implications for clinical care","volume":"62","author":"Milewicz","year":"2021","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0041-1730295","article-title":"Initiating a New Era of Cardiovascular Diagnosis and Therapy in Acute Aortic Syndromes: The Mainz-Essen Experience (Part I)-Imaging and Biomarkers","volume":"9","author":"Bossone","year":"2021","journal-title":"Aorta"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yamamoto, T., Endo, D., Shimada, A., Matsushita, S., Asai, T., and Amano, A. (2022). Surgical treatment of acute aortic dissection in a patient with SLE and prior antiphospholipid syndrome on therapy for over 30 years: A case report. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02659-w"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41598-019-56841-w","article-title":"Impact of Relative Change in Temperature and Atmospheric Pressure on Acute Aortic Syndrome Occurrence in France","volume":"10","author":"Nusinovici","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.athoracsur.2021.03.100","article-title":"Sex-Based Aortic Dissection Outcomes From the International Registry of Acute Aortic Dissection","volume":"113","author":"Huckaby","year":"2022","journal-title":"Ann. Thorac. Surg."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/20\/15470\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:10Z","timestamp":1760130610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/20\/15470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":36,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["ijms242015470"],"URL":"https:\/\/doi.org\/10.3390\/ijms242015470","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]}}}