{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:02:23Z","timestamp":1782997343319,"version":"3.54.5"},"reference-count":164,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the rapidly evolving field of Alzheimer\u2019s Disease (AD) research, the intricate role of Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both pathological substrates and prospective therapeutic paradigms. While conventional pathophysiological models of AD have primarily emphasized the significance of amyloid-beta (A\u03b2) deposition and tau protein hyperphosphorylation, this targeted systematic review meticulously aggregates and rigorously appraises seminal contributions from the past year elucidating the complex mechanisms of H2S in AD pathogenesis. Current scholarly literature accentuates H2S\u2019s dual role, delineating its regulatory functions in critical cellular processes\u2014such as neurotransmission, inflammation, and oxidative stress homeostasis\u2014while concurrently highlighting its disruptive impact on quintessential AD biomarkers. Moreover, this review illuminates the nuanced mechanistic intimate interactions of H2S in cerebrovascular and cardiovascular pathology associated with AD, thereby exploring avant-garde therapeutic modalities, including sulfurous mineral water inhalations and mud therapy. By emphasizing the potential for therapeutic modulation of H2S via both donors and inhibitors, this review accentuates the imperative for future research endeavors to deepen our understanding, thereby potentially advancing novel diagnostic and therapeutic strategies in AD.<\/jats:p>","DOI":"10.3390\/ijms242015481","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:32:24Z","timestamp":1698057144000},"page":"15481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer\u2019s Disease: A Recent Systematic Review"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-7710","authenticated-orcid":false,"given":"Constantin","family":"Munteanu","sequence":"first","affiliation":[{"name":"Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700454 Ia\u0219i, Romania"},{"name":"Teaching Emergency Hospital \u201cBagdasar-Arseni\u201d (TEHBA), 041915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-2030","authenticated-orcid":false,"given":"Daniel Andrei","family":"Iordan","sequence":"additional","affiliation":[{"name":"Department of Individual Sports and Kinetotherapy, Faculty of Physical Education and Sport, \u2018Dunarea de Jos\u2019 University of Galati, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Hoteteu","sequence":"additional","affiliation":[{"name":"Teaching Emergency Hospital \u201cBagdasar-Arseni\u201d (TEHBA), 041915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Popescu","sequence":"additional","affiliation":[{"name":"Teaching Emergency Hospital \u201cBagdasar-Arseni\u201d (TEHBA), 041915 Bucharest, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d (UMPCD), 020022 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Postoiu","sequence":"additional","affiliation":[{"name":"Teaching Emergency Hospital \u201cBagdasar-Arseni\u201d (TEHBA), 041915 Bucharest, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d (UMPCD), 020022 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-0719","authenticated-orcid":false,"given":"Ilie","family":"Onu","sequence":"additional","affiliation":[{"name":"Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700454 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-8941","authenticated-orcid":false,"given":"Gelu","family":"Onose","sequence":"additional","affiliation":[{"name":"Teaching Emergency Hospital \u201cBagdasar-Arseni\u201d (TEHBA), 041915 Bucharest, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d (UMPCD), 020022 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lanct\u00f4t, K.L., Hahn-Pedersen, J.H., Eichinger, C.S., Freeman, C., Clark, A., Tarazona, L.R.S., and Cummings, J. (2023). Burden of Illness in People with Alzheimer\u2019s Disease: A Systematic Review of Epidemiology, Comorbidities and Mortality. J. Prev. Alzheimer\u2019s Dis., Epub ahead of print.","DOI":"10.14283\/jpad.2023.61"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer\u2019s disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sehar, U., Rawat, P., Reddy, A.P., Kopel, J., and Reddy, P.H. (2022). Amyloid Beta in Aging and Alzheimer\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112924"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tabeshmehr, P., and Eftekharpour, E. (2023). Tau; One Protein, So Many Diseases. Biology, 12.","DOI":"10.3390\/biology12020244"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., and Reddy, P.H. (2022). Phosphorylated Tau in Alzheimer\u2019s Disease and Other Tauopathies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112841"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"Preclinical Alzheimer\u2019s disease: Definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Paul, B.D., and Pieper, A.A. (2023). Protective Roles of Hydrogen Sulfide in Alzheimer\u2019s Disease and Traumatic Brain Injury. Antioxidants, 12.","DOI":"10.3390\/antiox12051095"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dogaru, B.G., and Munteanu, C. (2023). The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612555"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12376","DOI":"10.1002\/trc2.12376","article-title":"State, trait, and accumulated features of the Alzheimer\u2019s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) in mild Alzheimer\u2019s disease","volume":"9","author":"Krance","year":"2023","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Warren, S.L., Reid, E., Whitfield, P., Helal, A.M., Abo Hamza, E.G., Tindle, R., Moustafa, A.A., and Hamid, M.S. (2023). Cognitive and behavioral abnormalities in individuals with Alzheimer\u2019s disease, mild cognitive impairment, and subjective memory complaints. Curr. Psychol., 1\u201311.","DOI":"10.1007\/s12144-023-04281-1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chen, D., Fang, X., and Zhu, Z. (2023). Progress in the correlation of postoperative cognitive dysfunction and Alzheimer\u2019s disease and the potential therapeutic drug exploration. Ibrain, 1\u201317.","DOI":"10.1002\/ibra.12040"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Reekes, T.H., Ledbetter, C.R., Alexander, J.S., Stokes, K.Y., Pardue, S., Bhuiyan, M.A.N., Patterson, J.C., Lofton, K.T., Kevil, C.G., and Disbrow, E.A. (2023). Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer\u2019s disease and related dementias. Redox Biol., 62.","DOI":"10.1016\/j.redox.2023.102633"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Anwal, L. (2020). Comprehensive Review on Alzheimer\u2019s Disease: Causes and Treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.3390\/ijms15034671","article-title":"Tau protein modifications and interactions: Their role in function and dysfunction","volume":"15","author":"Wasik","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1074\/jbc.270.13.7013","article-title":"Amyloid \u03b2 protein (A\u03b2) in Alzheimer\u2019s disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A\u03b240 or A\u03b242(43)","volume":"270","author":"Gravina","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1093\/brain\/awad193","article-title":"Clinical considerations in early-onset cerebral amyloid angiopathy","volume":"146","author":"Banerjee","year":"2023","journal-title":"Brain"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Volloch, V., and Rits-Volloch, S. (2023). The Amyloid Cascade Hypothesis 2.0 for Alzheimer\u2019s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512246"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.4103\/1673-5374.335829","article-title":"The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer\u2019s disease","volume":"17","author":"Zhang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer\u2019s disease: Pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tortorella, I., Argentati, C., Emiliani, C., Morena, F., and Martino, S. (2022). Biochemical Pathways of Cellular Mechanosensing\/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis. Cells, 11.","DOI":"10.3390\/cells11193093"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Rabaneda-Bueno, R., Mena-Montes, B., Torres-Castro, S., Torres-Carrillo, N., and Torres-Carrillo, N.M. (2021). Advances in Genetics and Epigenetic Alterations in Alzheimer\u2019s Disease: A Notion for Therapeutic Treatment. Genes, 12.","DOI":"10.3390\/genes12121959"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Turnea, M.A., and Rotariu, M. (2023). Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis-A Comprehensive One-Year Review. Antioxidants, 12.","DOI":"10.3390\/antiox12091737"},{"key":"ref_24","first-page":"193","article-title":"The effect of hypoxia on Hydrogen Sulfide concentration of brain tissue in AD transgenic mice and its mechanism","volume":"44","author":"Cheng","year":"2023","journal-title":"Neuroendocr. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhou, L., and Wang, Q. (2023). Advances of H2S in Regulating Neurodegenerative Diseases by Preserving Mitochondria Function. Antioxidants, 12.","DOI":"10.3390\/antiox12030652"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hu, Q., and Lukesh, J.C. (2023). H2S Donors with Cytoprotective Effects in Models of MI\/R Injury and Chemotherapy-Induced Cardiotoxicity. Antioxidants, 12.","DOI":"10.3390\/antiox12030650"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Marini, E., Rolando, B., Sodano, F., Blua, F., Concina, G., Guglielmo, S., Lazzarato, L., and Chegaev, K. (2023). Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage. Antioxidants, 12.","DOI":"10.3390\/antiox12020344"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zatsepina, O.G., Chuvakova, L.N., Nikitina, E.A., Rezvykh, A.P., Zakluta, A.S., Sarantseva, S.V., Surina, N.V., Ksenofontov, A.L., Baratova, L.A., and Shilova, V.Y. (2022). Genes Responsible for H2 S Production and Metabolism Are Involved in Learning and Memory in Drosophila melanogaster. Biomolecules, 12.","DOI":"10.3390\/biom12060751"},{"key":"ref_29","first-page":"868","article-title":"Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation","volume":"19","author":"Sun","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Aroca, A., and Gotor, C. (2022). Hydrogen Sulfide: A Key Role in Autophagy Regulation from Plants to Mammalians. Antioxidants, 11.","DOI":"10.3390\/antiox11020327"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Rotariu, M., Turnea, M., Dogaru, G., Popescu, C., Sp\u00eenu, A., Andone, I., Postoiu, R., Ionescu, E., and Oprea, C. (2022). Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)\u2014A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126720"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Roda, B., Zhang, N., Gambari, L., Grigolo, B., Eller-Vainicher, C., Gennari, L., Zappi, A., Giordani, S., Marassi, V., and Zattoni, A. (2022). Optimization of a Monobromobimane (MBB) Derivatization and RP-HPLC-FLD Detection Method for Sulfur Species Measurement in Human Serum after Sulfur Inhalation Treatment. Antioxidants, 11.","DOI":"10.3390\/antiox11050939"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shieh, M., Xu, S., Lederberg, O.L., and Xian, M. (2022). Detection of sulfane sulfur species in biological systems. Redox Biol., 57.","DOI":"10.1016\/j.redox.2022.102502"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Khattak, S., Rauf, M.A., Khan, N.H., Zhang, Q.Q., Chen, H.J., Muhammad, P., Ansari, M.A., Alomary, M.N., Jahangir, M., and Zhang, C.Y. (2022). Hydrogen Sulfide Biology and Its Role in Cancer. Molecules, 27.","DOI":"10.3390\/molecules27113389"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s11064-023-03887-y","article-title":"Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges","volume":"48","author":"Sharif","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Khan, M.S.S., Islam, F., Ye, Y., Ashline, M., Wang, D., Zhao, B., Fu, Z.Q., and Chen, J. (2022). The Interplay between Hydrogen Sulfide and Phytohormone Signaling Pathways under Challenging Environments. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084272"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Majumder, A. (2023). Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment. Antioxidants, 12.","DOI":"10.3390\/antiox12081520"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lin, H., Yu, Y., Zhu, L., Lai, N., Zhang, L., Guo, Y., Lin, X., Yang, D., Ren, N., and Zhu, Z. (2023). Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies. Redox Biol., 59.","DOI":"10.1016\/j.redox.2023.102601"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Shah, H., Dehghani, F., Ramezan, M., Gannaban, R.B., Haque, Z.F., Rahimi, F., Abbasi, S., and Shin, A.C. (2023). Revisiting the Role of Vitamins and Minerals in Alzheimer\u2019s Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12020415"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gentile, M.T., Camerino, I., Ciarmiello, L., Woodrow, P., Muscariello, L., De Chiara, I., and Pacifico, S. (2023). Neuro-Nutraceutical Polyphenols: How Far Are We?. Antioxidants, 12.","DOI":"10.3390\/antiox12030539"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Koyama, Y., Kobayashi, Y., Kobayashi, H., and Shimada, S. (2023). Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant. Antioxidants, 12.","DOI":"10.3390\/antiox12051061"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15188","DOI":"10.1021\/jacs.3c02022","article-title":"Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process","volume":"145","author":"Choudhary","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Andronie-Cioara, F.L., Ardelean, A.I., Nistor-Cseppento, C.D., Jurcau, A., Jurcau, M.C., Pascalau, N., and Marcu, F. (2023). Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer\u2019s Disease Progression. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031869"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-023-00627-2","article-title":"The role of peripheral inflammatory insults in Alzheimer\u2019s disease: A review and research roadmap","volume":"18","author":"Walker","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, S., Jiang, L., Cui, L., Alain, K., Xie, S., and Shao, Z. (2023). Transcriptome Analysis of Cyclooctasulfur Oxidation and Reduction by the Neutrophilic Chemolithoautotrophic Sulfurovum indicum from Deep-Sea Hydrothermal Ecosystems. Antioxidants, 12.","DOI":"10.3390\/antiox12030627"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s43587-022-00269-x","article-title":"Designing the next-generation clinical care pathway for Alzheimer\u2019s disease","volume":"2","author":"Hampel","year":"2022","journal-title":"Nat. Aging"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kurkinen, M., Fu\u0142ek, M., Fu\u0142ek, K., Besz\u0142ej, J.A., Kurpas, D., and Leszek, J. (2023). The Amyloid Cascade Hypothesis in Alzheimer\u2019s Disease: Should We Change Our Thinking?. Biomolecules, 13.","DOI":"10.3390\/biom13030453"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4103\/1673-5374.332127","article-title":"Amyloid-beta peptide and tau protein crosstalk in Alzheimer\u2019s disease","volume":"17","author":"Roda","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1081938","DOI":"10.3389\/fnins.2023.1081938","article-title":"Amyloid-beta aggregation implicates multiple pathways in Alzheimer\u2019s disease: Understanding the mechanisms","volume":"17","author":"Iliyasu","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1088140","DOI":"10.3389\/fnagi.2023.1088140","article-title":"Alzheimer\u2019s disease pathology: Pathways between chronic vascular risk factors and blood-brain barrier dysfunction in a cohort of patients with different types of dementia","volume":"15","author":"Gan","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-022-01055-2","article-title":"Epigenetic regulation in cardiovascular disease: Mechanisms and advances in clinical trials","volume":"7","author":"Shi","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45849","DOI":"10.1021\/acsomega.2c05599","article-title":"Gasotransmitter-Induced Therapeutic Angiogenesis: A Biomaterial Prospective","volume":"7","author":"Robert","year":"2022","journal-title":"ACS Omega"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11427-023-2305-0","article-title":"Biomarkers of aging","volume":"66","author":"Bao","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Fang, Y.C., Hsieh, Y.C., Hu, C.J., and Tu, Y.K. (2023). Endothelial Dysfunction in Neurodegenerative Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032909"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/BST20220830","article-title":"The role of the blood-brain barrier during neurological disease and infection","volume":"51","author":"Patabendige","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Sharma, C., Woo, H., and Kim, S.R. (2022). Addressing Blood-Brain Barrier Impairment in Alzheimer\u2019s Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10040742"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gunes, S., Aizawa, Y., Sugashi, T., Sugimoto, M., and Rodrigues, P.P. (2022). Biomarkers for Alzheimer\u2019s Disease in the Current State: A Narrative Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094962"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Arrigo, E., Comit\u00e0, S., Pagliaro, P., Penna, C., and Mancardi, D. (2023). Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512480"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41569-022-00741-6","article-title":"Sulfide regulation of cardiovascular function in health and disease","volume":"20","author":"Kolluru","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100030","DOI":"10.1016\/j.arres.2022.100030","article-title":"Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases","volume":"4","author":"Sanchez","year":"2022","journal-title":"Adv. Redox Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/CIRCRESAHA.122.321326","article-title":"Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure","volume":"132","author":"Li","year":"2023","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40035-023-00369-7","article-title":"Clinical evidence of human pathogens implicated in Alzheimer\u2019s disease pathology and the therapeutic efficacy of antimicrobials: An overview","volume":"12","author":"Catumbela","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/acschemneuro.7b00312","article-title":"Sulfur Nanoparticles with Novel Morphologies Coupled with Brain-Targeting Peptides RVG as a New Type of Inhibitor Against Metal-Induced A\u03b2 Aggregation","volume":"9","author":"Sun","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"147937","DOI":"10.1016\/j.brainres.2022.147937","article-title":"Factors influencing the blood-brain barrier permeability","volume":"1788","author":"Zhao","year":"2022","journal-title":"Brain Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1126309","DOI":"10.3389\/fchem.2023.1126309","article-title":"H2S-based fluorescent imaging for pathophysiological processes","volume":"11","author":"Jia","year":"2023","journal-title":"Front. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e2216141120","DOI":"10.1073\/pnas.2216141120","article-title":"Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans","volume":"120","author":"Vintila","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"de Bartolomeis, A., Vellucci, L., Austin, M.C., De Simone, G., and Barone, A. (2022). Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics. Biomolecules, 12.","DOI":"10.3390\/biom12070909"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"909178","DOI":"10.3389\/fcvm.2022.909178","article-title":"Development of hydrogen sulfide donors for anti-atherosclerosis therapeutics research: Challenges and future priorities","volume":"9","author":"Yang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/alz.12305","article-title":"Plasma hydrogen sulfide: A biomarker of Alzheimer\u2019s disease and related dementias","volume":"17","author":"Disbrow","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"856376","DOI":"10.3389\/fimmu.2022.856376","article-title":"Microglia in the Neuroinflammatory Pathogenesis of Alzheimer\u2019s Disease and Related Therapeutic Targets","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Megur, A., Baltriukien\u0117, D., Bukelskien\u0117, V., and Burokas, A. (2021). The microbiota\u2013gut\u2013brain axis and Alzheimer\u2019s disease: Neuroinflammation is to blame?. Nutrients, 13.","DOI":"10.3390\/nu13010037"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/2045-9912.208517","article-title":"Hydrogen sulfide therapy in brain diseases: From bench to bedside","volume":"7","author":"Zhang","year":"2017","journal-title":"Med. Gas Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1734-1140(10)70338-8","article-title":"Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB): A new potential therapeutic target in atherosclerosis?","volume":"62","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.2174\/1570159X20666220302101854","article-title":"Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants","volume":"20","author":"Aschner","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"296","DOI":"10.7555\/JBR.27.20120100","article-title":"Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model","volume":"27","author":"Fan","year":"2013","journal-title":"J. Biomed. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"172455","DOI":"10.1016\/j.ejphar.2019.172455","article-title":"Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells","volume":"858","author":"Dai","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tripathi, S.J., Chakraborty, S., Miller, E., Pieper, A.A., and Paul, B.D. (2023). Hydrogen sulfide signaling in neurodegenerative diseases. Br. J. 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Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bioactmat.2022.03.043","article-title":"Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications","volume":"19","author":"Rong","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1159\/000478628","article-title":"Atherosclerosis and the Hydrogen Sulfide Signaling Pathway\u2014Therapeutic Approaches to Disease Prevention","volume":"42","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/14737175.2019.1668270","article-title":"Hydrogen sulfide: A target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety","volume":"20","author":"Chen","year":"2020","journal-title":"Expert Rev. Neurother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6043038","DOI":"10.1155\/2016\/6043038","article-title":"Hydrogen Sulfide and Cellular Redox Homeostasis","volume":"2016","author":"Xie","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.7150\/ijms.36516","article-title":"Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases","volume":"16","author":"Tabassum","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e13065","DOI":"10.1097\/MD.0000000000013065","article-title":"The biologic effect of hydrogen sulfide and its function in various diseases","volume":"97","author":"Xiao","year":"2018","journal-title":"Medicine"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"8360738","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer\u2019s Disease by Preserving Mitochondrial Function in APP\/PS1 Mice and Neurons","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jconrel.2022.10.055","article-title":"On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules","volume":"352","author":"Ge","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","article-title":"Role of cystathionine \u03b3-Lyase\/hydrogen sulfide pathway in cardiovascular disease: A novel therapeutic strategy?","volume":"17","author":"Pan","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Islam, R.K., Donnelly, E., Donnarumma, E., Hossain, F., Gardner, J.D., and Islam, K.N. (2023). H2S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine \u03b2-Synthase and Antioxidant Proteins. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020612"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Coavoy-S\u00e1nchez, S.A., Cerqueira, A.R.A., Teixeira, S.A., Santagada, V., Andreozzi, G., Corvino, A., Scognamiglio, A., Sparaco, R., Caliendo, G., and Severino, B. (2023). Beneficial Effects of Two Hydrogen Sulfide (H2S)-Releasing Derivatives of Dexamethasone with Antioxidant Activity on Atopic Dermatitis in Mice. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071907"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Magli, E., Perissutti, E., Santagada, V., Caliendo, G., Corvino, A., Esposito, G., Esposito, G., Fiorino, F., Migliaccio, M., and Scognamiglio, A. (2021). H2S donors and their use in medicinal chemistry. Biomolecules, 11.","DOI":"10.3390\/biom11121899"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jare.2020.05.015","article-title":"Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches","volume":"27","author":"Citi","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Huang, Y., Omorou, M., Gao, M., Mu, C., Xu, W., and Xu, H. (2023). Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: A comprehensive review. Biomed. Pharmacother., 161.","DOI":"10.1016\/j.biopha.2023.114506"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Pepe, G., Fioriniello, S., Marracino, F., Capocci, L., Maglione, V., D\u2019Esposito, M., Di Pardo, A., and Della Ragione, F. (2023). Blood\u2013Brain Barrier Integrity Is Perturbed in a Mecp2-Null Mouse Model of Rett Syndrome. Biomolecules, 13.","DOI":"10.3390\/biom13040606"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Archie, S.R., Al Shoyaib, A., and Cucullo, L. (2021). Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111779"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e10695","DOI":"10.15252\/emmm.201910695","article-title":"Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology","volume":"11","author":"Ide","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"10","DOI":"10.15252\/emmm.201910983","article-title":"Looking beyond the usual suspects: Sulfide stress in schizophrenia pathophysiology","volume":"11","author":"Simonneau","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Holper, S., Watson, R., and Yassi, N. (2022). Tau as a Biomarker of Neurodegeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137307"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Jebari-Benslaiman, S., Galicia-Garc\u00eda, U., Larrea-Sebal, A., Olaetxea, J.R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., and Mart\u00edn, C. (2022). Pathophysiology of Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063346"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Munteanu, C. (2023). Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098376"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jare.2020.05.007","article-title":"Hydrogen sulfide and vascular regulation\u2014An update","volume":"27","author":"Lv","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"105119","DOI":"10.1016\/j.phrs.2020.105119","article-title":"Hydrogen sulfide: An endogenous regulator of the immune system","volume":"161","author":"Dilek","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"G\u0105ssowska-Dobrowolska, M., Czapski, G.A., Cie\u015blik, M., Zajdel, K., Frontczak-Baniewicz, M., Babiec, L., and Adamczyk, A. (2023). Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087303"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Song, L., Oseid, D.E., Wells, E.A., and Robinson, A.S. (2022). The Interplay between GSK3\u03b2 and Tau Ser262 Phosphorylation during the Progression of Tau Pathology. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911610"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Schreiner, T.G., Creang\u0103-Murariu, I., Tamba, B.I., Lucanu, N., and Popescu, B.O. (2022). In Vitro Modeling of the Blood\u2013Brain Barrier for the Study of Physiological Conditions and Alzheimer\u2019s Disease. Biomolecules, 12.","DOI":"10.3390\/biom12081136"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4939-9528-8_3","article-title":"bao Analysis of vascular hydrogen sulfide biosynthesis","volume":"2007","author":"Lechuga","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Piragine, E., Malanima, M.A., Lucenteforte, E., Martelli, A., and Calderone, V. (2023). Circulating Levels of Hydrogen Sulfide (H2S) in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Biomolecules, 13.","DOI":"10.3390\/biom13071023"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Montanaro, R., Vellecco, V., Torregrossa, R., Casillo, G.M., Manzo, O.L., Mitidieri, E., Bucci, M., Castaldo, S., Sorrentino, R., and Whiteman, M. (2023). Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway. Redox Biol., 62.","DOI":"10.1016\/j.redox.2023.102657"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Custodia, A., Aramburu-N\u00fa\u00f1ez, M., Rodr\u00edguez-Arrizabalaga, M., P\u00edas-Peleteiro, J.M., V\u00e1zquez-V\u00e1zquez, L., Camino-Casti\u00f1eiras, J., Aldrey, J.M., Castillo, J., Ouro, A., and Sobrino, T. (2023). Biomarkers Assessing Endothelial Dysfunction in Alzheimer\u2019s Disease. Cells, 12.","DOI":"10.3390\/cells12060962"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Testa, G., Giannelli, S., Sottero, B., Staurenghi, E., Giaccone, G., Caroppo, P., Gamba, P., and Leonarduzzi, G. (2023). 24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1\/PGC1\u03b1\/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer\u2019s Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12030631"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Cooper, I.D., Kyriakidou, Y., Petagine, L., Edwards, K., and Elliott, B.T. (2023). Bio-Hacking Better Health-Leveraging Metabolic Biochemistry to Maximise Healthspan. Antioxidants, 12.","DOI":"10.3390\/antiox12091749"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e158453","DOI":"10.1172\/JCI158453","article-title":"Biological aging processes underlying cognitive decline and neurodegenerative disease","volume":"132","author":"Gonzales","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Kim, S.Y. (2023). Personalized Explanations for Early Diagnosis of Alzheimer\u2019s Disease Using Explainable Graph Neural Networks with Population Graphs. Bioengineering, 10.","DOI":"10.3390\/bioengineering10060701"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Banerjee, R., and Gunawardena, S. (2023). Glycogen synthase kinase 3\u03b2 (GSK3\u03b2) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1202307"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"674135","DOI":"10.3389\/fnagi.2021.674135","article-title":"The Role of Protein Persulfidation in Brain Aging and Neurodegeneration","volume":"13","author":"Petrovic","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/ars.2023.0352","article-title":"Emerging chemical biology of protein persulfidation","volume":"39","author":"Vignane","year":"2023","journal-title":"Antioxid. Redox Signal."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e2017225118","DOI":"10.1073\/pnas.2017225118","article-title":"Hydrogen sulfide is neuroprotective in Alzheimer\u2019s disease by sulfhydrating GSK3\u03b2 and inhibiting Tau hyperphosphorylation","volume":"118","author":"Giovinazzo","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/acs.jmedchem.0c00931","article-title":"Glycogen Synthase Kinase 3\u03b2: A New Gold Rush in Anti-Alzheimer\u2019s Disease Multitarget Drug Discovery?","volume":"64","author":"Tumiatti","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_123","first-page":"1","article-title":"GSK3\u03b2 and Tau Protein in Alzheimer\u2019s Disease and Epilepsy","volume":"14","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Sayas, C.L., and \u00c1vila, J. (2021). GSK-3 and tau: A key duet in alzheimer\u2019s disease. Cells, 10.","DOI":"10.3390\/cells10040721"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1089\/ars.2019.7777","article-title":"Direct Proteomic Mapping of Cysteine Persulfidation","volume":"33","author":"Fu","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Xi, Y., Zhang, Y., Zhou, Y., Liu, Q., Chen, X., Liu, X., Grune, T., Shi, L., Hou, M., and Liu, Z. (2023). Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP\/PS1 Alzheimer\u2019s Disease model mice: Role of the cystathionine-\u03b2-synthase\/H2S pathway. Redox Biol., 59.","DOI":"10.1016\/j.redox.2022.102595"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Jelleschitz, J., Zhang, Y., Grune, T., Chen, W., Zhao, Y., Jia, M., Wang, Y., Liu, Z., and H\u00f6hn, A. (2022). Methionine restriction\u2014Association with redox homeostasis and implications on aging and diseases. Redox Biol., 57.","DOI":"10.1016\/j.redox.2022.102464"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cophys.2018.03.008","article-title":"Sex differences in the response to dietary restriction in rodents","volume":"6","author":"Kane","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1042\/BCJ20210517","article-title":"Hydrogen sulfide in ageing, longevity and disease","volume":"478","author":"Wilkie","year":"2021","journal-title":"Biochem. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/oby.22721","article-title":"Sexually Dimorphic Effects of Dietary Methionine Restriction are Dependent on Age when the Diet is Introduced","volume":"28","author":"Forney","year":"2020","journal-title":"Obesity"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12680\/balneo.2021.438","article-title":"Hydrogen sulfide (H2S)\u2014Therapeutic relevance in rehabilitation and balneotherapy Systematic literature review and meta-analysis based on the PRISMA paradig","volume":"12","author":"Munteanu","year":"2021","journal-title":"Balneo PRM Res. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"104677","DOI":"10.1016\/j.phrs.2020.104677","article-title":"Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide","volume":"153","author":"Zubcevic","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Hansen, A.W., and Venkatachalam, K.V. (2023). Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome. Biochem. Biophys. Rep., 35.","DOI":"10.1016\/j.bbrep.2023.101529"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Zeng, J., Yang, K., Nie, H., Yuan, L., Wang, S., Zeng, L., Ge, A., and Ge, J. (2023). The mechanism of intestinal microbiota regulating immunity and inflammation in ischemic stroke and the role of natural botanical active ingredients in regulating intestinal microbiota: A review. Biomed. Pharmacother., 157.","DOI":"10.1016\/j.biopha.2022.114026"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Satam, H., Joshi, K., Mangrolia, U., Waghoo, S., Zaidi, G., Rawool, S., Thakare, R.P., Banday, S., Mishra, A.K., and Das, G. (2023). Next-Generation Sequencing Technology: Current Trends and Advancements. Biology, 12.","DOI":"10.3390\/biology12070997"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/cns.13613","article-title":"Gut dysbiosis in stroke and its implications on Alzheimer\u2019s disease-like cognitive dysfunction","volume":"27","author":"Cho","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fneur.2019.00397","article-title":"Stroke dysbiosis index (SDI) in gut microbiome are associated with brain injury and prognosis of stroke","volume":"10","author":"Xia","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Fusco, W., Lorenzo, M.B., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M.C., Gasbarrini, A., and Collado, M.C. (2023). Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota. Nutrients, 15.","DOI":"10.3390\/nu15092211"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2256045","DOI":"10.1080\/19490976.2023.2256045","article-title":"Disruption of the microbiota-gut-brain axis is a defining characteristic of the \u03b1 -Gal A (-\/0) mouse model of Fabry disease","volume":"15","author":"Delprete","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2206504","DOI":"10.1080\/19490976.2023.2206504","article-title":"Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer\u2019s disease progression","volume":"15","author":"Das","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"8034084","DOI":"10.1155\/2017\/8034084","article-title":"Sulphurous mineral waters: New applications for health","volume":"2017","author":"Carbajo","year":"2017","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_143","first-page":"100101","article-title":"Machine learning for metabolomics research in drug discovery","volume":"8","author":"Martinelli","year":"2023","journal-title":"Intell. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41419-019-1525-1","article-title":"Hydrogen sulfide: A gaseous signaling molecule modulates tissue homeostasis: Implications in ophthalmic diseases","volume":"10","author":"Han","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6290931","DOI":"10.1155\/2018\/6290931","article-title":"Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology","volume":"2018","author":"Vicente","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2017.09.011","article-title":"Environmental toxicology of hydrogen sulfide","volume":"71","author":"Pearce","year":"2017","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e02244","DOI":"10.1016\/j.heliyon.2019.e02244","article-title":"Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death","volume":"5","author":"Sakuma","year":"2019","journal-title":"Heliyon"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1039\/C4CC00968A","article-title":"Hydrogen sulfide (H2S) releasing agents: Chemistry and biological applications","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_149","first-page":"538","article-title":"Role of homocysteine in the ischemic stroke and development of ischemic tolerance","volume":"10","author":"Dobrota","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00044-020-02687-1","article-title":"Sulfur-containing therapeutics in the treatment of Alzheimer\u2019s disease","volume":"30","author":"Zhu","year":"2021","journal-title":"Med. Chem. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/ars.2011.4351","article-title":"Hydrogen sulfide: An endogenous mediator of resolution of inflammation and injury","volume":"17","author":"Wallace","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Kumar, R., and Matson, J.B. (2023). Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide. Macromol. Biosci.","DOI":"10.1002\/mabi.202300138"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4236\/aces.2011.12012","article-title":"Kinetics and Modeling of H2S Removal in a Novel Biofilter","volume":"1","author":"Shareefdeen","year":"2011","journal-title":"Adv. Chem. Eng. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Zaorska, E., Tomasova, L., Koszelewski, D., Ostaszewski, R., and Ufnal, M. (2020). Hydrogen sulfide in pharmacotherapy, beyond the hydrogen sulfide-donors. Biomolecules, 10.","DOI":"10.3390\/biom10020323"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zhang, M.Y., Dugbartey, G.J., Juriasingani, S., and Sener, A. (2021). Hydrogen sulfide metabolite, sodium thiosulfate: Clinical applications and underlying molecular mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126452"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"111745","DOI":"10.1016\/j.ejmech.2019.111745","article-title":"Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer\u2019s disease?","volume":"184","author":"Sestito","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/2045-9912.296043","article-title":"Research progress of hydrogen sulfide in Alzheimer\u2019s disease from laboratory to hospital: A narrative review","volume":"10","author":"Peng","year":"2020","journal-title":"Med. Gas Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41386-020-00840-3","article-title":"Systems-based proteomics to resolve the biology of Alzheimer\u2019s disease beyond amyloid and tau","volume":"46","author":"Rayaprolu","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Yang, M., Zhou, Y., Wang, K., Luo, C., Xie, M., Shi, X., and Lin, X. (2023). Review of Chemical Sensors for Hydrogen Sulfide Detection in Organisms and Living Cells. Sensors, 23.","DOI":"10.3390\/s23063316"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1042\/ETLS20210249","article-title":"Applied machine learning in Alzheimer\u2019s disease research: Omics, imaging, and clinical data","volume":"5","author":"Li","year":"2021","journal-title":"Emerg. Top. Life Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41467-021-21330-0","article-title":"Machine learning identifies candidates for drug repurposing in Alzheimer\u2019s disease","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"S611","DOI":"10.3233\/JAD-179935","article-title":"Role of Amyloid-\u03b2 and Tau Proteins in Alzheimer\u2019s Disease: Confuting the Amyloid Cascade","volume":"64","author":"Gulisano","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40035-018-0108-x","article-title":"Hydrogen sulfide, nitric oxide, and neurodegenerative disorders","volume":"7","author":"Panthi","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Sunzini, F., De Stefano, S., Chimenti, M.S., and Melino, S. (2020). Hydrogen sulfide as potential regulatory gasotransmitter in arthritic diseases. Int. J. Mol. 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