{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:45:28Z","timestamp":1786621528322,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sambucus nigra (SN) berry extract is characterized by high antioxidant and anti-inflammatory activity. The current study aimed to investigate the effect of SN berry extract against indomethacin (IND)-induced gastric ulcer in rats and the mechanism involved. SN berry extract alleviated IND-induced gastric ulcers, as shown by assessing pathological manifestations in the gastric mucosa. These protective effects are attributed to attenuated oxidative damage to the gastric mucosa, correlated to increased activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), enhanced glutathione (GSH) levels, total antioxidant capacity (TAC), and upregulation of the Nrf2\/HO-1 cascade. Moreover, oxidative stress markers, including malondialdehyde (MDA) and total oxidant status (TOS), were downregulated in SN-extract-treated animals. Furthermore, SN berry extract suppressed gastric mucosal inflammation by downregulating interleukin (IL)-33, IL-1\u03b2, IL-6, and tumor necrosis factor-alpha (TNF-\u03b1) levels, and attenuating myeloperoxidase (MPO) activity. The protective effects of SN berry extract were similar to those exerted by esomeprazole (ESO), an acid-secretion-suppressive drug. In conclusion, SN berry extract has antiulcerative effects, alleviating oxidative stress and inflammation.<\/jats:p>","DOI":"10.3390\/ijms242015486","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:32:24Z","timestamp":1698057144000},"page":"15486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Flavonoid-Rich Sambucus nigra Berry Extract Enhances Nrf2\/HO-1 Signaling Pathway Activation and Exerts Antiulcerative Effects In Vivo"],"prefix":"10.3390","volume":"24","author":[{"given":"Betul","family":"Cicek","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Dan\u0131sman","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-3367","authenticated-orcid":false,"given":"Serkan","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary, Atat\u00fcrk University, 25240 Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Yuce","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-7399","authenticated-orcid":false,"given":"Dragana","family":"Nikitovic","sequence":"additional","affiliation":[{"name":"Laboratory of Histology-Embryology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Bolat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary, Atat\u00fcrk University, 25240 Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-7687","authenticated-orcid":false,"given":"Mehmet","family":"Kuzucu","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertu\u011frul","family":"Ceyran","sequence":"additional","affiliation":[{"name":"Central Research and Application Laboratory, Agri Ibrahim Cecen University, 41000 Agri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Bardas","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-2281","authenticated-orcid":false,"given":"Kirill S.","family":"Golokhvast","sequence":"additional","affiliation":[{"name":"Siberian Federal Scientific Centre of Agrobiotechnology RAS, 2B Centralnaya Street, 630501 Krasnoobsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-2462","authenticated-orcid":false,"given":"Aristidis","family":"Tsatsakis","sequence":"additional","affiliation":[{"name":"Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-0324","authenticated-orcid":false,"given":"Ali","family":"Taghizadehghalehjoughi","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Bilecik \u015eeyh Edebali University, 11230 Bilecik, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/187152312803476255","article-title":"Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review","volume":"11","author":"Bacchi","year":"2012","journal-title":"Anti-Inflamm. 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